scholarly journals Limited fasciotomy in dupuytren contracture: a case report

2020 ◽  
Vol 8 (12) ◽  
pp. 4499
Author(s):  
Kadek Gede Bakta Giri ◽  
Made Bramantya Karna ◽  
Anak Agung Gde Yuda Asmara ◽  
Putu Feryawan Meregawa
Keyword(s):  
Side Effects ◽  
Hand Function ◽  
Minimal Invasive ◽  
Good Choice ◽  
Dupuytren’S Disease ◽  
Fast Recovery ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Clostridium Histolyticum Collagenase ◽  
Dupuytren Contracture

Dupuytren's disease is a benign fibroproliferative disorder usually isolated affects the palmar fascia. The condition usually has a progressive course, from the appearance of a nodule, to the formation of a fibrous cord which pulls the finger in a flexion posture. Management from dupuytren's disease has developed, from conservatifly, surgery, and minimal invasive. One of the conventional treatments that can be done is fasciotomy. A man, 72 years old, an Australian patient with Dupuytren's disease that affects his 4th MCP joint. From the history it was found that the complaint had been felt since 8 years ago. Patients were do limited fasciotomy and get recovered his hand function with good result. Dupuytren's disease is a disorder of the palmar and digital fascia that can decrease the function of patient hands. Many therapies have been developed for the treatment of this disease. From conventional treatments such as fasciotomy, to minimal invasive such as the injection of clostridium histolyticum collagenase. All of these therapies give different results and side effects. We would like to say that conventional management, especially limited fasciotomy, is still a good choice in view of the return of hand function and the minimum side effects. Limited fasciotomy gives good results, fast recovery of hand function, with minimal side effects.

scholarly journals An effectiveness evaluation of the palmar fascia irradiation of patients suffering from Dupuytren’s disease

2017 ◽  
Vol 67 (3) ◽  
pp. 162-167 ◽  
Author(s):  
Tomasz Latusek ◽  
Leszek Miszczyk ◽  
Grzegorz Gierlach ◽  
Piotr Zając
Keyword(s):  
Dupuytren’S Disease ◽  
Effectiveness Evaluation ◽  
Palmar Fascia ◽  
Dupuytren's Disease

scholarly journals Dupuytren'S Contracture; Increased Cellularity — Proliferation, is There Equality?

2005 ◽  
Vol 94 (1) ◽  
pp. 71-75
Author(s):  
M. Forsman ◽  
L. Kallioinen ◽  
M. Kallioinen ◽  
J. Ryhänen
Keyword(s):  
Inflammatory Process ◽  
Dupuytren’S Disease ◽  
Palmar Fascia ◽  
Ki 67 ◽  
Dupuytren's Disease ◽  
Chronic Inflammatory Process ◽  
Proliferative Phase ◽  
Palmar Aponeurosis ◽  
Histological Characteristics ◽  
Control Samples

Background: Dupuytren's disease is a chronic inflammatory process which causes contractures of the fingers by shortening and thickening the palmar fascia. During the proliferative phase, fibroblasts transform into myofibroblasts apparently under the influence of several different factors. The disease usually develops slowly, but in some patients it tends to develop aggressively. The pathogenesis of Dupuytren's disease remains unsolved. In this study, we analyzed some histological characteristics that seem to predict rapid recurrence. Material and Methods: 21 patients were divided into two groups. In 11 patients the disease was classified as aggressive because it had recurred within two years after an operation. In 10 cases it was non-aggressive, as no recurrence had been seen. Five control samples were taken from healthy palmar aponeurosis. The differences in cellularity, collagen, Ki-67, MSA, alpha-SMA and tenascin between the specimens were analyzed using immunohistochemistry. Results: Alpha-SMA and Ki-67 were present more often in the aggressive specimens. Immunohistochemical stainings for macrophages and lymphocytes were negative. Conclusion: There may be differences in the histology and/or immunohistochemical appearance of pathological palmar connective tissue cords in aggressive and normal Dupuytren's disease. Further studies are needed to elucidate the pathogenesis of this disease.

scholarly journals Periostin differentially induces proliferation, contraction and apoptosis of primary Dupuytren's disease and adjacent palmar fascia cells

2009 ◽  
Vol 315 (20) ◽  
pp. 3574-3586 ◽  
Author(s):  
Linda Vi ◽  
Lucy Feng ◽  
Rebecca D. Zhu ◽  
Yan Wu ◽  
Latha Satish ◽  
...  
Keyword(s):  
Dupuytren’S Disease ◽  
Palmar Fascia ◽  
Dupuytren's Disease

Dupuytren’s disease

2011 ◽  
Author(s):  
Peter Burge
Keyword(s):  
Surgical Treatment ◽  
Steroid Injection ◽  
Treatment Options ◽  
Genetic Component ◽  
Dupuytren’S Disease ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Collagenase Injection ◽  
Operative Complications ◽  
Non Surgical Treatment

♦ Dupuytren’s disease is characterised by contracture of a finger resulting from thickening and shortening of the palmar fascia♦ A genetic component to the aetiology is apparent, smoking, alcohol and diabetes can increase the risk♦ The pathogenesis of Dupuytren’s disease remains elusive♦ Non-surgical treatment options include splintage, steroid injection and collagenase injection♦ Surgery cannot cure the disease but can straighten bent digits and minimize recurrence♦ Operative methods can be considered with regards to incision, management of the diseased fascia and closure techniques♦ Operative complications include injury of digital nerves and arteries

An Investigation into the Role of Inflammatory Cells in Dupuytren’s Disease

1991 ◽  
Vol 16 (3) ◽  
pp. 267-271 ◽  
Author(s):  
J. G. ANDREW ◽  
S. M. ANDREW ◽  
A. ASH ◽  
B. TURNER
Keyword(s):  
Inflammatory Cells ◽  
Dupuytren’S Disease ◽  
Dupuytren’S Contracture ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Dupuytren's Contracture ◽  
Microvascular Changes ◽  
Macrophage Marker ◽  
Fibrotic Diseases

An immunohistochemical study was performed on nodules excised from the palmar fascia of patients with Dupuytren’s contracture. In cellular nodules, antibodies to actin (used as a marker for myofibroblasts), desmin, vimentin, Mac 387 (a macrophage marker) and leucocyte common antigen were used. A correlation was demonstrated between the numbers of macrophages and the presence of myofibroblasts. The presence of myofibroblasts is generally considered to indicate the active stage of the disease. Inflammatory cells other than macrophages were largely absent from the nodules, although lymphocytes were frequent in the tissue around the nodules. Microvascular changes were prominent in the nodules and pericyte proliferation was observed around occluded capillaries. Release of growth factors from macrophages may be important in Dupuytren’s contracture, as is the case in other fibrotic diseases. The possible role of macrophages in the aetiology of Dupuytren’s disease is discussed.

scholarly journals Recent advances in the understanding of Dupuytren’s disease

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 231 ◽  
Author(s):  
Thomas Layton ◽  
Jagdeep Nanchahal
Keyword(s):  
Hand Function ◽  
Therapeutic Targets ◽  
Therapeutic Options ◽  
Dupuytren’S Disease ◽  
Treatment Modalities ◽  
Dupuytren's Disease ◽  
Recent Advances ◽  
Cellular Factors ◽  
Fibrotic Disorder ◽  
Novel Therapeutic

Dupuytren’s disease (DD) is a common fibrotic disorder of the hand and can significantly impair hand function. Although the exact pathogenesis of this disorder remains to be elucidated, immunological, genetic and cellular factors likely interact. In this review, we summarise recent advances in the understanding of DD pathogenesis and look to the future for potential novel therapeutic targets. In addition, we discuss the therapeutic options in DD with a focus on the need for more rigorous evidence to allow a meaningful comparison of different treatment modalities.

scholarly journals Connective Tissue Degeneration: Mechanisms of Palmar Fascia Degeneration (Dupuytren’s Disease)

2016 ◽  
Vol 2 (3) ◽  
pp. 133-140 ◽  
Author(s):  
S. Karkampouna ◽  
M. Kreulen ◽  
M. C. Obdeijn ◽  
P. Kloen ◽  
A. L. Dorjée ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Dupuytren’S Disease ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Tissue Degeneration
Sign in / Sign up

Export Citation Format

Share Document