scholarly journals Effects of sensory stimulation on balance and postural control in diabetic neuropathy: systematic review

2021 ◽  
Vol 9 (7) ◽  
pp. 2090
Author(s):  
Hetal S. Giri ◽  
Pradeep Borkar
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Peripheral Neuropathy ◽  
Diabetic Neuropathy ◽  
Postural Control ◽  
Diabetic Peripheral Neuropathy ◽  
Sensory Stimulation ◽  
Noncommunicable Disease ◽  
Type I ◽  
Significant Difference

Diabetic peripheral neuropathy is a complication of Diabetes Mellitus and is the most common noncommunicable disease. It involves decreases in the sensations and Lower extremity strength leading to reduce dynamic stability in balance and postural control. The purpose of the study is to review the effects of sensory stimulation interventions on Balance and Postural control in Diabetic peripheral neuropathy. A systematic review was conducted following the centers for Goggle scholar, PUBMED and science direct database using the keywords Sensory Stimulation, Balance, Postural control, Diabetic neuropathy. The time frame of the search was from 2006 to 2021. The review resulted in search of 18 articles with duration from 1 day to 26 weeks with a total population of 1,422 diabetes Mellitus type I and type II patients from the year 2006 to 2021. There were strong evidences of effects of sensory stimulation on postural control and Balance with noticeable difference in DPN. Based on our analysis results, most of the study stated that Vibration, Plantar Massages, Kinesiotaping, Rocker shoe, Vibromedical insole, Conventional exercises with proprioception stimulation, Mechanical noise have shown significant difference on balance and postural control. Whereas, offloading devices did not show any remarkable variance. The currently existing studies require a clear recommendation on whether which intervention is more effective. Thus, longer duration studies are required to improve balance and postural control in Diabetic Neuropathy.

scholarly journals Vitamin B12 and Holotranscobalamin Levels in Diabetic Peripheral Neuropathy Patients

2016 ◽  
Vol 20 (1) ◽  
pp. 16-20
Author(s):  
Mohammed Noorjahan ◽  
Kandregula Madhavi ◽  
Chandran Priscilla ◽  
Shaik A Jabeen
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Neuropathy ◽  
Vitamin B12 ◽  
Diabetic Peripheral Neuropathy ◽  
Vitamin B12 Deficiency ◽  
Biologically Active ◽  
Significant Difference ◽  
B12 Deficiency ◽  
Vitamin B12 Supplementation

ABSTRACT Diabetic neuropathy is the most common and debilitating microvascular complication leading to nontraumatic amputations. Identifying the role of vitamin B12 in the etiology of neuropathy is crucial because simple vitamin B12 replacement may reverse neurologic symptoms if confirmed. Large proportion of vegetarians and patients on metformin have been associated with lowering of vitamin B12 levels. We have undertaken study on 60 vegetarian subjects between the age of 30 and 60 years, 20 healthy controls, 20 type 2 diabetes mellitus patients who were on metformin with peripheral neuropathy (DMWN), and 20 diabetics without peripheral neuropathy (DMWON). Vitamin B12, homocysteine, and folate levels were measured, and holotranscobalamin (holoTC) is also included, to improve the diagnosis of tissue vitamin B12 status, as holoTC is the biologically active fraction and more sensitive index of vitamin B12 status than total vitamin B12 itself. Complete history and clinical evaluation for neuropathy and electroneuromyography were recorded. Results In the DMWN group, vitamin B12 levels were significantly higher than in the DMWON group and controls [1013 (564-1501) pmol/l, 387 (245-731) pmol/l, and 305 (234-472) pmol/l respectively]. Similarly, serum holoTC was also found to be significantly higher in the DMWN [203.8 (129-300) pmol/l] group compared with the DMWON [94.4 (42.2-230.6) pmol/l] group and controls [74 (40-170) pmol/l]. Whereas mean levels of homocysteine and folate did not show any significant difference between groups, significant increase in fasting blood sugar and HbA1c was seen in the DMWN group compared with DMWON group and controls. Duration of diabetes is also significantly more in DMWN group compared with DMWON group. Conclusion We found that vitamin B12 and holoTC levels were high in patients with DMWN and DMWON groups compared with controls. Our study demonstrated that peripheral neuropathy was not associated with vitamin B12 deficiency in diabetics. These findings merit further research on a larger population to investigate into the cause of diabetic neuropathy, the factors involved, and benefit of vitamin B12 supplementation in these patients. Key messages Vitamin B12 status has no association with diabetic peripheral neuropathy. How to cite this article Noorjahan M, Madhavi K, Priscilla C, Jabeen SA. Vitamin B12 and Holotranscobalamin Levels in Diabetic Peripheral Neuropathy Patients. Indian J Med Biochem 2016;20(1):16-20.

scholarly journals Diabetic Peripheral Neuropathy in Ethiopia: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Degena Bahrey Tadesse ◽  
Gebremeskel Tukue Gebrewahd ◽  
Abrha Hailay ◽  
Woldu Aberhe ◽  
Guesh Mebrahtom ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Meta Analysis ◽  
World Health ◽  
Pooled Prevalence ◽  
Inconsistency Index ◽  
Patients With Diabetes ◽  
National Prevalence

Background. Currently, diabetic peripheral neuropathy (DPN) is one of the most severe complications of diabetes mellitus (DM). Despite the seriousness of this problem, limited evidence is available on the prevalence of diabetic peripheral neuropathy among patients with diabetes mellitus in Ethiopia. In Ethiopia, there were no updated studies that estimate the national prevalence of DPN. Hence, this systematic review and meta-analysis provided a national prevalence of diabetic peripheral neuropathy among patients with diabetes mellitus in Ethiopia. Methods. This study was submitted for registration with the International Prospective Register of Systematic Reviews (PROSPERO) in March 2020 and accepted with the registration number CRD42020173831. Different database searching engines were searched online to retrieve related articles, including PubMed, Scopus, Google Scholar, African Journals Online, World Health Organization (WHO) Afro Library, and Cochrane Review. The reviewers used the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guideline in the reviewing process. In this systematic review and meta-analysis, all published and unpublished articles were analyzed. The reviewers used the random effects model to estimate the pooled prevalence of diabetic peripheral neuropathy among diabetes mellitus patients. The reviewers conducted the statistical analysis using the R version 3.5.3 and RStudio version 1.2.5033 software for Windows. The reviewers evaluated the heterogeneity across the included studies by the inconsistency index ( I 2 ). The reviewers examined the publication bias by the funnel plot. Results. The search of the databases produced 245 papers. After checking the inclusion and exclusion criteria, 38 articles with 14029 total patients with diabetes mellitus were found suitable for the review. Except for three (retrospective cohort study), all studies were cross-sectional. The overall pooled prevalence of diabetic peripheral neuropathy was 22% (95% CI 18% to 26%). The subgroup analysis of diabetic peripheral neuropathy among patients with diabetes in the different regions was 23% (95% CI 17% to 29%) in Addis Ababa, 27% (95% CI 16% to 38%) in Oromia, 16% (95% CI 14% to 18%) in South nation and nationalities, and 15% (95% CI 6% to 24%) in Amhara. Conclusions. More than one-fifth of patients with diabetes have diabetic peripheral neuropathy. According to this study, the prevalence of diabetic peripheral neuropathy in Ethiopia is considerably high. This evidence suggests that attention should be given to patients with diabetes in monitoring patients’ blood glucose.

scholarly journals Prevalence of diabetic peripheral neuropathy in Africa: A systematic review and meta-analysis

2019 ◽  
Author(s):  
Wondimeneh Shibabaw Shiferaw ◽  
Tadesse Yirga ◽  
Yeshamble Work ◽  
Yared Asmare Aynalem
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Meta Analysis ◽  
Cochrane Review ◽  
Random Effect Model ◽  
Preventive Strategy ◽  
Pooled Prevalence ◽  
Inconsistency Index

AbstractIntroductionDiabetes mellitus is a global health care problem and financially costly. Diabetic peripheral neuropathy is common and frequent cause of morbidity and disability. Despite its serious complications, limited evidence is available on the magnitude of diabetic peripheral neuropathy among patient with diabetes mellitus. Hence, the objective of this systematic review and meta-analysis was to estimate the pooled prevalence of diabetic peripheral neuropathy among patients with diabetes mellitus in Africa.MethodsPubMed, Scopus, Google Scholar, Africa journal online, WHO afro library and Cochrane review were systematically searched online to retrieve related articles. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guideline was followed. Heterogeneity across the included studies was evaluated by inconsistency index (I2). Publication bias was examined by funnel plot and Egger’s regression test. The random-effect model was fitted to estimate the pooled prevalence of diabetic peripheral neuropathy among diabetes mellitus patients. All statistical analysis was done using STATA version 14 software for windows.ResultsTwenty-three studies which comprises of 269,691 participants were included in the meta-analysis. The overall pooled prevalence of diabetic peripheral neuropathy was 46% (95% CI:36.21-55.78%). Based on the subgroup analysis, the highest magnitude of diabetic peripheral neuropathy was reported in West Africa 49.4% (95% CI: 32.74, 66.06).ConclusionThis study revealed that the overall prevalence of diabetic peripheral neuropathy is relatively high in Africa. Hence, diabetic peripheral neuropathy needs situation based intervention and preventive strategy depending on their country context. Furthermore, further meta-analysis study is needed to identify associated factors for the occurrence of diabetic peripheral neuropathy.

scholarly journals Prevalence of Various Sign and Symptoms of Diabetic Peripheral Neuropathy

BioSight ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 24-30
Author(s):  
Kahkshan Asif ◽  
Qurat ul ain
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Diabetic Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Large Scale ◽  
Health Management ◽  
Clinical Findings ◽  
Foot Ulcers ◽  
Foot Care ◽  
Relative Deficiency

BACKGROUND: Diabetes mellitus (DM) is a chronic metabolic syndrome marked by hyperglycemia due to absolute or relative deficiency of insulin hormone. Diabetic neuropathy is a complication of both type 1 and type 2 diabetes. Although pain is one of the most dominant symptoms of diabetic neuropathy, its pathophysiological mechanisms yet unknown. Toxic effects of high glucose levels play an important role in the development of this complication. METHODOLOGY: Data was collected through the questionnaire regarding Clinical findings, medical records, weight, age, family history, different habits, and psychogenic behavior. All the patients with the mentioned diseases are included in this study, excluding the mentally ill patients and the pregnant women. RESULT:  The result of the present study showed that diabetic neuropathy is the most common complication of diabetes mellitus. It has been observed that most of the patients due to lack of awareness are suspected to the elevated or extreme blood sugar level which leads to neuropathy. Due to the Diabetic Peripheral Neuropathy (DPN) most of the patients suffering from foot problems, foot ulcers and then amputations. Lack of awareness, lack of health management, obesity, blood pressure changes, less care plays a key role in increasing the chances of diabetic neuropathy. COCLUSION: Diabetic neuropathy had very bad influence on a person’s health and daily activities. The Patient education programs need to emphasize on large scale. The ultimate aim of this study is the foot care education for people with the diabetes and to prevent foot ulcers and amputation.

A systematic review and meta-analysis on efficacy of exercise on posture and balance in patients suffering from Diabetic Neuropathy

2020 ◽  
Vol 16 ◽  
Author(s):  
Neerja Thukral ◽  
Jaspreet Kaur ◽  
Manoj Malik
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Neuropathy ◽  
Meta Analysis ◽  
Berg Balance Scale ◽  
Risk Of Bias ◽  
Core Stability ◽  
Balance Scale ◽  
Eyes Closed ◽  
Significant Difference ◽  
Eyes Open

Background: Peripheral neuropathy is a major and chronic complication of diabetes mellitus affecting more than 50% of patients suffering from diabetes. There is involvement of both large and small diameter nerve fibres leading to altered somatosensory and motor sensations, thereby causing impaired balance and postural instability. Objective: To assess the effects of exercises on posture and balance in patients suffering from diabetes mellitus. Method: Mean changes in Timed Up and Go test(TUGT), Berg Balance Scale and Postural Sway with eyes open and eyes closed on Balance System were primary outcome measures. RevMan 5.3 software was used for the meta-analyses. Eighteen randomized controlled trials met the selection criteria and were included in the study. All the studies ranked high on PEDro Rating scale. Risk of bias was assessed by Cochrane collaboration tool of risk of bias. Included studies had low risk of bias. Sixteen RCT’s were included for the meta-analysis. Result: Results of meta-analysis showed that there was statistically significant improvement in TUGT with p≤ 0.05 and substantial heterogeneity (I 2 = 84%, p < 0.00001) in experimental group as compared to control group. There was statistically significant difference in Berg Balance Scale scores and heterogeneity of I 2 = 62%, p < 0.00001 and significant changes in postural stability (eyes open heterogeneity of I 2 = 100%, p =0.01 and eyes closed, heteogeneity I 2 = 0%, p =0.01). Sensitivity analysis causes change in heterogeneity. Conclusion: It can be concluded that various exercises like balance training, core stability, Tai-Chi, proprioceptive training etc. have a significant effect in improving balance and posture in diabetic neuropathy.

scholarly journals Cost of Management of Diabetes Mellitus: A Pan India Study

2021 ◽  
pp. 097275312199849
Author(s):  
Raghuram Nagarathna ◽  
M Madhava ◽  
Suchitra S Patil ◽  
Amit Singh ◽  
K. Perumal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Urban Areas ◽  
Noncommunicable Disease ◽  
Cost Of Treatment ◽  
Rural And Urban Areas ◽  
Cost Of Disease ◽  
Rural And Urban ◽  
Significant Difference ◽  
The Cost ◽  
Prevalence Of Diabetes Mellitus

Background: Diabetes mellitus is a major noncommunicable disease. While mortality rates are increasing, the costs of managing the disease are also increasing. The all-India average monthly expenditure per person (pppm) is reported to be ₹ 1,098.25, which translates to an annual expenditure of ₹13,179 per person. Purpose: While a number of studies have gone into the aspect of the cost of disease management, we do not find any study which has pan-India reach. We also do not find studies that focus on differences (if any) between rural and urban areas, age or on the basis of gender. We planned to report the cost of illness (COI) in diabetes individuals as compared to others from the data of a pan-India trial. Methods: Government of India commissioned the Indian Yoga Association to study the prevalence of diabetes mellitus in India in 2017. As part of the questionnaire, the cost of treatment was also captured. Data collected from 25 states and union territories were analyzed using the analysis of covriance (ANCOVA) test on SPSS version 21. Results: There was a significant difference ( P < .05) between the average expenses per person per month (pppm) of individuals with self-reported known diabetes (₹1,357.65 pppm) and others (unknown and/or nondiabetes individuals–₹ 999.91 pppm). Similarly, there was a significant difference between rural (₹2,893 pppm) and urban (₹4,162 pppm) participants and between those below (₹1,996 pppm) and above 40 years (₹5,059 pppm) of age. Conclusion: This preliminary report has shown that the COI because of diabetes is significantly higher than others pointing to an urgent need to promote disease-preventive measures.

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