Clinicopathological evaluation of thyroid swelling in patient attending Hamidia Hospital Bhopal

Background: The prevalence of thyroid nodule ranges from 4-10% in general population. Its treatment includes either conservative management or surgical excision of gland. Fine needle aspiration cytology (FNAC) has emerged as most accepted, accurate diagnostic procedure and considered the gold standard diagnostic test in evaluation of thyroid nodule, other tests like ultrasound, nuclear scan used in conjunction with FNAC. The aim of study was to study the spectrum of diseases in thyroid swelling and accuracy of FNAC in the diagnosis.Methods: A prospective study, with total 50 patients, was conducted during period from 2017-2019 in department of surgery, Gandhi Medical College Bhopal. All patients who underwent thyroid surgeries were selected for study. All patients underwent detailed history, clinical examination, routine investigations, thyroid function test, FNAC, ultrasonography neck and histopathological examination.Results: Of 50 cases female to male ratio was 9.2:1, with median age group was 38.6 years. Among all, 42 (84%) were benign, 3 (6%) malignant and 5 (10%) suspicious. Of 5 suspicious lesions, only 1 (5%) case found malignant. Hemi thyroidectomy was common surgery performed, followed by subtotal/near total and total thyroidectomy.Conclusions: Thyroid swellings are common in females occur in 3rd and 4th decade most commonly. FNAC is very useful and indispensable in the diagnosis. Most common non neoplastic and neoplastic lesion was solitary thyroid nodule and papillary carcinoma respectively.

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A Study on Clinical Evaluation and Management Modalities in Benign Breast Diseases

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/32 ◽

2021 ◽

Vol 8 (03) ◽

pp. 168-171

Author(s):

Ajay Chanakya V ◽

Sreekanth Kotagiri ◽

Gogineni Tarun Chowdary ◽

Sriram K.V.V.S.D. ◽

Ch. Vasu Reddy ◽

...

Keyword(s):

Surgical Oncology ◽

Needle Aspiration ◽

Breast Diseases ◽

Study Group ◽

Psychological Burden ◽

Diagnosis And Management ◽

Medical College ◽

Benign Breast Diseases ◽

Needle Aspiration Cytology ◽

A Prospective Study

BACKGROUND Benign breast diseases (BBDs) are a common cause of breast problems in up to 30 % of women. The pathogenesis of BBD involves disturbances in the breast physiology. There is a necessity for thorough comprehensive, prompt diagnosis and management of the benign conditions to reduce the physical and psychological illness of the patients who are anxious about the possibility of the disease being a malignant one. METHODS This was a prospective study conducted in the Department of Surgical Oncology, GSL medical college from October 2016 to July 2018. Females presenting with breast lump, confirmed with fine needle aspiration cytology (FNAC), aged between 12 – 55 years and fit for surgery were included in the study. Those who did not submit the informed consent were excluded. Statistical analysis was performed by SPSS version-21 and MS Excel 2013. RESULTS Most (74 %) of the patients were between 20 and 40 years of age, 56 % were diagnosed to be fibroadenoma. In the study group, 82 % (41) participants with BBD were married. The most common presenting complaint in the study group was lump (50 %) in the breast followed by lump associated with pain (28 %). Patients with fibroadenoma mass had well defined features. CONCLUSIONS Lump was the most common clinical presentation followed by lump with pain. Based on the FNAC report, decision is made for management. Comprehensive and prompt preoperative diagnosis and management of the benign conditions is necessary to reduce the physical and psychological burden on the patients who are anxious about the possibility of malignancy. KEYWORDS Breast, Participants, Study, Age

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Comparison between histopathology and fine needle aspiration cytology in the case of breast lumps

International Surgery Journal ◽

10.18203/2349-2902.isj20195129 ◽

2019 ◽

Vol 6 (11) ◽

pp. 4095

Author(s):

Vishnu V. K. ◽

Ashwini R. K. ◽

S. Rajagopalan

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Diagnostic Method ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Medical College ◽

Needle Aspiration Cytology ◽

Breast Lumps ◽

A Prospective Study

Background: Breast lump is one of the common pathologies seen in surgical practice. Hence it is of importance to have a reliable diagnostic method to distinguish between benign and malignant lumps. Aim of this study was to bring out fine needle aspiration cytology (FNAC) as a rapid, inexpensive, accurate and least invasive diagnostic method for this purpose.Methods: A prospective study conducted between December 2017 to November 2018 on all 30 patients admitted at Rajarajeswari Medical College and Hospital with breast lumps. Patients were subjected to clinical examination FNAC and Histopathology.Results: Clinically 64% were categorized as benign lumps and 36% malignant. On FNAC 64% were fibroadenoma, 30% suggestive of malignancy and 6% suspicious of malignancy. On Histopathology 60% were fibroadenoma, 33% turned out to be carcinoma and 7% benign phyllodes. 4% of benign lesions on FNAC turned out malignant on histopathology.Conclusions: Although son mammography is the conventional approach with a sensitivity of 76.5% and specificity of 90.48%, in this study FNAC was found to have sensitivity of 96.6% and specificity of 100% and can be a reliable tool for early diagnosis in the case of breast lumps.

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Study of benign neck swellings of anterior neck triangle at a tertiary care centre

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20192709 ◽

2019 ◽

Vol 5 (4) ◽

pp. 941 ◽

Cited By ~ 1

Author(s):

Pradipkumar Digambar Khokle ◽

Vinod Tukaram Kandakure ◽

Ujjwala Madhukar Kolekar

Keyword(s):

Tertiary Care ◽

Surgical Excision ◽

Lateral Neck ◽

Neck Swelling ◽

Thyroglossal Cyst ◽

Tertiary Care Centre ◽

Medical College ◽

Wide Range ◽

Thyroid Swelling ◽

A Prospective Study

Background: Tumors of the neck are interesting to surgeons especially because of the complex neck anatomy and difficult differential diagnosis. The aim is to study different types of neck swellings i.e. thyroid swelling, salivary gland swelling, other neck swellings such as thyroglossal cyst, branchial cyst, lymphangioma and also the miscellaneous and rare lumps in the neck. The study also discusses their age and sex-wise distribution, clinical features, presentation, diagnostic modalities and treatment.Methods: This is a prospective study, conducted at our institute Government Medical College, Latur from June 2017 to May 2018 for a duration of one year. Results: A total of 57 patients were studied during this period. Out of the 57 patients, 47 of them were midline swellings (82.45%) and 10 among them were lateral neck swellings (17.55%). People over a wide range of age group between 5-60 years were affected. Midline neck swelling were more common than lateral neck swellings.Conclusions: Among the midline benign neck swellings, thyroid swelling was found to be the commonest followed by thyroglossal cyst. Thyroid swellings occur more commonly in the females than males. Ultrasound guided FNAC is the most common, effective and safe investigation that aids in the diagnosis. Treatment of choice for benign, non-inflammatory and non-malignant neck swelling is mostly surgical excision rather than medical management.

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Role of fine needle aspiration cytology in Metastatic lymphadenopathy

Journal of Nobel Medical College ◽

10.3126/jonmc.v5i2.16312 ◽

2016 ◽

Vol 5 (2) ◽

pp. 26-31

Author(s):

Niraj Nepal

Keyword(s):

Cell Carcinoma ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Needle Aspiration ◽

Small Cell ◽

Aspiration Cytology ◽

Fine Needle ◽

Medical College ◽

Neoplastic Lesion ◽

Needle Aspiration Cytology

Background The most common site for metastases is lymph nodes for various types of cancers. It is a reliable and easy approachable as well as inexpensive method of diagnosis for the patient as well as for the pathologist. So, the recognition and establishing a preliminary diagnosis on patients presenting clinically with lymphadenopathy is of importance and especially categorizing whether it is an inflammatory lesion or metastatic or primary neoplastic lesion itself of the lymphnode.Material and Methods A prospective study in 1000 patients was performed of all presenting with cervical lymphadenopathies. This study was performed in the department of pathology, Nobel Medical College and Teaching hospital, Biratnagar, Nepal from the period of January 2013 to January 2016.Results Total number of cases included was 1000 of fine needle aspiration cytology in patients presenting with cervical lymphadenopathies. Out of the total 1000 cases 800 cases were benign lesions, 110 were malignant lesions, 70 cases were inflammatory lesions while 20 cases were inconclusive. Out of the 110 malignant cases, most common malignancy was squamous cell carcinoma, adenocarcinoma followed by ductal carcinoma of breast, small cell and non-small cell carcinoma, papillary carcinoma of thyroid and few cases of malignant melanoma and undifferentiated carcinoma.Journal of Nobel Medical College Vol.5(2) 2016; 26-31

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Prevalence of malignancy in thyroid nodule at People’s Medical College Hospital (PMCH) Nawabshah.

The Professional Medical Journal ◽

10.29309/tpmj/2020.27.10.3962 ◽

2020 ◽

Vol 27 (10) ◽

pp. 2072-2075

Author(s):

Inayat Ali Zardari ◽

Zulfiqar Ali Imtiaz Memon ◽

Mashooque Ali Khowaja ◽

Naeem Ul Karim Bhatti ◽

Altaf Hussain Ghumro ◽

...

Keyword(s):

Thyroid Nodule ◽

Needle Aspiration ◽

Cross Sectional Study ◽

College Hospital ◽

Cross Sectional ◽

Medical College ◽

Thyroid Adenomas ◽

Needle Aspiration Cytology ◽

Thyroid Profile ◽

Study Setting

Objectives: The purpose of study is to ascertain the prevalence of malignancy in thyroid single/multiple nodules after ascertaining the features of nodules on different criteria. Study Design: Cross Sectional Study. Setting: Department of Surgical at PMCH Nawabshah. Period: April 2015 to April 2018. Material & Methods: All patients got admission from OPD and they were investigated for the disease. All biochemical examinations were done. Thyroid profile with thyroid scan was obtained. Fine Needle Aspiration Cytology (FNAC) was done to diagnose the type of cells either benign/ malignant. The decision of the surgical procedure was done according to the FNAC report of the thyroid nodule. Results: Total 80 patients were investigated. 55 (68.75%) females, 35 (43.75%) male and 60 (75%) showed the benign cells and 20 (25%) patient’s reports had malignant cells. Biopsies were sent for histopathology. 60 (75%) showed thyroid adenomas after biopsy. 10(12.5%) patients papillary carcinoma, 7 (8.75%) follicular, 2 (2.5%) medullary, 1 (1.25%) anaplastic, 0 for thyroid lymphoma, 0 thyroid carcinoma. 0 for squamous cell carcinoma. 40 (50%) were treated conservatively with thyroxine, 20 (25%) were operated for lobectomy. All malignant cases were undergone for total thyroidectomy. Conclusion: it is summed up that the prevalence of malignancy in thyroid nodules in our setup is only 25% that is the lower one as compared to other studies.

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The reliability of fine needle aspiration cytology in the diagnosis of thyroid swelling

International Surgery Journal ◽

10.18203/2349-2902.isj20175121 ◽

2017 ◽

Vol 4 (12) ◽

pp. 3827

Author(s):

Obaid Syed ◽

Anand Auti

Keyword(s):

Needle Aspiration ◽

Benign Lesions ◽

Aspiration Cytology ◽

Medical College ◽

Malignant Case ◽

Female Predominance ◽

Thyroid Swelling ◽

Needle Aspiration Cytology ◽

Benign Thyroid ◽

Thyroid Lesions

Background: For a thyroid swelling, FNAC is the primary investigation. In most of the lesions, after excision, the Histopathology remains the same, but at times a few surprises do occur when FNAC reported benign lesions are found to be malignant on histopathology. The study aims to find reliability of FNAC in diagnosing Thyroid Lesions.Methods: This prospective study was conducted on 111 patients with thyroid swelling attending IIMSR, Medical College, Jalna during a period of two years. These patients with thyroid lesions were subjected to FNAC and then following the surgery correlated with the histopathology report.Results: Majority of the patients were in the age group of 30-50 years with female predominance. Out of 111 patients studied with FNAC, 1 sample was inadequate. Among remaining 110 cases 99 were benign thyroid lesions, 6 were malignant and 5 were highly suspicious of malignancy. HPE of thyroid specimen confirmed 101 cases as benign and 9 cases as malignant. Case in which inadequate material was obtained on FNAC was not included in study.Conclusions: FNAC is about 98.18 % reliable in diagnosing thyroid lesions. FNAC is easy, reliable and accurate investigation for all thyroid swellings.

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A study on newer technique for reconstruction of pre auricular soft tissue defect with temporo-parietal fascia flap (Khabeer’s flap)

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20184364 ◽

2018 ◽

Vol 4 (6) ◽

pp. 1485

Author(s):

Ahmed Abdul Khabeer ◽

Phani Bhushan Ivaturi ◽

Y. L. Ravi Jadhav ◽

Venkatesh Dasoju

Keyword(s):

Dead Space ◽

Superficial Temporal Artery ◽

Surgical Excision ◽

Temporal Artery ◽

Sinus Tract ◽

Soft Tissue Defect ◽

Medical College ◽

Gandhi Medical College ◽

A Prospective Study ◽

Fascia Flap

Background: A pre auricular sinus is a congenital abnormality, which occurs due to failure of fusion of primitive tubercles from which pinna develops. Pre auricular sinuses are usually asymptomatic and when symptomatic present usually as discharging sinus, associated with abscess formation anterior to root of helix. Symptomatic pre auricular sinus requires surgical excision to prevent recurrence and reinfection. Treatment of pre auricular sinus by conventional methods usually presents a dead space due to removal of sinus tract. The present study is to overcome this defect by a superficial temporalartery based temporo-parietal fascia flap or Khabeer’s flap. The objective of this study is to describe a novel technique for excision of pre auricular sinus using supra auricular approach and using a temporo-parietal fascia flap for covering the defect created after excision of pre auricular sinus.Methods: A prospective study was carried out in Department of Otorhinolaryngology, Gandhi Medical College/Gandhi Hospital Secunderabad from 2014 to 2017. All the patients admitted with symptomatic pre auricular sinus underwent surgical excision by supra auricular approach and at the end superficial temporal artery based flap was placed to fill the dead space. Results: A total of 20 pre auricular sinuses were operated during the study period. There were no recurrences, no collection of serous fluid and no cosmetic defect post operatively in any of the study subject.Conclusions: The newer approach was found to be safe as it does not confer any complications post operatively and can be used for management of pre auricular sinus.

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Correlation of Fine Needle Aspiration Cytology with Histopathological Findings in the Diagnosis of Thyroid Swellings – A One Year Study in a Tertiary Care Hospital, Hyderabad

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/239 ◽

2021 ◽

Vol 8 (18) ◽

pp. 1246-1251

Author(s):

Keerthana Muppidi ◽

Vidya Kedarisetti ◽

Kanya Kumari Mahankali

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Histopathological Examination ◽

Surgical Excision ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Nodular Goitre ◽

Fine Needle ◽

Thyroid Swelling ◽

Needle Aspiration Cytology

BACKGROUND Most of the thyroid swellings are non-neoplastic and with normal thyroid hormone. So, it doesn't require any surgical excision, even though the thyroid swelling is an indication for surgical excision. The present study was done to evaluate the accuracy of fine needle aspiration cytology (FNAC) for the thyroid swellings and correlate it with the histopathological findings. METHODS This is a prospective study. A total of 47 cases were studied. Fine needle aspiration cytology was done, slides were made and studied. Histopathological examination of the corresponding 47 cases was also done and correlated with FNAC findings. Sensitivity, specificity and accuracy were calculated. RESULTS Age of the patients varied from 20 - 69 yrs. Most of them were in the age group of 30 - 39 years and 50 - 59 years. The ratio of male to female was 1:4.9. Swelling of the neck was the most common presentation in most of the patients. On FNAC 33 (70.2 %) cases were diagnosed as colloid nodular goitre, 04 (8.5 %) as autoimmune thyroiditis, 08 (17.0 %) as follicular neoplasm, 01 (2.1 %) as suspicious of malignancy, 01 (2.1 %) as papillary carcinoma. On histopathological examination 25 (53.2 %) cases were diagnosed as colloid nodular goitre, 01 (2.1 %) as fibrous thyroiditis, 01 (2.1 %) as Graves’ disease, 07 (14.9 %) as Hashimoto’s’ thyroiditis, 06 (12.8 %) as follicular adenoma, 01 (2.1 %) as follicular carcinoma, 04 (8.5 %) as papillary carcinoma and 02 (4.2 %) as NIFTP (noninvasive follicular thyroid neoplasm with papillary like nuclear features). The overall sensitivity was 69.2 %, specificity was 97.0 % and accuracy was 89.3 %. CONCLUSIONS FNAC is a minimally invasive, highly accurate and cost-effective procedure. FNAC helps the clinician to diagnose malignant lesions with confidence. It has high rates of specificity and accuracy but comparatively has less sensitivity. However, it is very important for the management of patients with thyroid swelling. KEYWORDS Fine Needle Aspiration, Prospective Study, Sensitivity, Specificity, Thyroid Swelling

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Fine needle aspiration cytology accuracy in diagnosis of thyroid lesions: a comparative study with histopathological examination of thyroid swellings

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20182702 ◽

2018 ◽

Vol 4 (4) ◽

pp. 1002

Author(s):

Shivani Nautiyal ◽

Alok Jain ◽

Shashwat Tiwari ◽

Kumar Ashutosh

Keyword(s):

Prospective Study ◽

Fine Needle Aspiration ◽

Predictive Value ◽

High Specificity ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Thyroid Swelling ◽

Needle Aspiration Cytology ◽

A Prospective Study

Background: Thyroid enlargement, whether diffuse or in the form of a nodule, leads to a battery of investigations to be done. Fine needle aspiration cytology (FNAC) is usually the first line of investigation but the limitations of cytology are well recognized in the diagnosis of some thyroid malignancies, in particular it is not able to differentiate between follicular adenoma and carcinoma. We conducted a prospective study to assess the role of FNAC in diagnosing the nature of thyroid swelling and comparing its result with histopathology finding.Methods: This was a prospective study conducted on 100 consecutive patients presented with thyroid swelling in department of otorhinolaryngology. Results: The present data show high specificity (96.29%) of FNAC as compared to sensitivity, which came out to be (78.9%). Positive and negative predictive value is 93.75% and 95.23%. This is quite similar to previous studies.Conclusions: FNAC has high specificity (96.29%), sensitivity (78.9%), positive predictive value (93.75%), negative predictive value (95.23%) and accuracy (95%) therefore it can be reliably used as initial investigation. A benign FNAC diagnosis should be viewed with caution as false negative results do occur and these patients should be followed up clinico-radiologically for any progression that will require repeated FNAC and/or surgery.

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Role of fine needle aspiration cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm

Bangladesh Journal of Otorhinolaryngology ◽

10.3329/bjo.v19i2.17634 ◽

2014 ◽

Vol 19 (2) ◽

pp. 110-118

Author(s):

Mohammad Amzad Hossain ◽

Md Zahedul Alam ◽

Md Rojibul Haque ◽

Md Nazmul Haque ◽

KM Nurul Alam ◽

...

Keyword(s):

Submandibular Gland ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

False Negative ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Medical College ◽

Preoperative Diagnostic ◽

Needle Aspiration Cytology

Objective: To evaluate the role of Fine Needle Aspiration Cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm. Methods: This cross sectional study on 50 cases was conducted in the Department of Otolaryngology and Head-Neck Surgery of Sir Salimullah Medical College Mitford Hospital and Dhaka Medical College Hospital from January2009 to June 2010. Results: Fine needle aspiration cytology findings of our all 50 cases were compared with postoperative histopathological reports. Out of the 50 cases, in 36(72%) cases of benign neoplasm and 7(14%) cases of malignant neoplasm, pre-operative FNAC findings and post operative histopathological findings were same. In 7 cases, FNAC and post operative histopathological findings did not matched. These were 2 (4%) false positive and 5 (10%) false negative result.In our study sensitivity of FNAC for reporting malignancy was 58.33%, specificity to rule out malignancy was 94.73% and overall accuracy in detecting malignant tumour was 86%. Positive predictive value and negative value were 77.77% and 87.80% respectively. It can be concluded that fine needle aspiration cytology is a safe, cheap and useful preoperative diagnostic tool in the diagnosis of malignancy in parotid and submandibular gland, but as fine needle aspiration cytology partly depends on operator skill, it may give false negative and false positive result. Conclusion: FNAC is a useful preoperative diagnostic tool for malignant parotid and submandibular glands with high specificity and sensitivity. DOI: http://dx.doi.org/10.3329/bjo.v19i2.17634 Bangladesh J Otorhinolaryngol 2013; 19(2): 110-118

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