scholarly journals Giant fibroadenoma of the breast: a benign breast mass mimicking malignancy

2021 ◽  
Vol 8 (4) ◽  
pp. 1391
Author(s):  
Nusrat Jabeen ◽  
Hussain Adnan Abdulla ◽  
Mohamed Ayed Abushwemeh ◽  
Asma Alqaseer ◽  
Amal Alrayes
Keyword(s):  
Benign Lesion ◽  
Left Breast ◽  
Breast Mass ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Breast Clinic ◽  
Immediate Reconstruction ◽  
Young Females ◽  
Areola Complex ◽  
Giant Fibroadenoma

Fibroadenoma is a common benign lesion of the breast that usually occurs in young females. Giant fibroadenoma of the breast is a rare benign pathology, which is defined as fibroadenoma greater than 5 cm in size and/or weighs more than 500 g. It is usually found in adolescent women. A 37-year-old woman undergoing treatment for infertility was referred to the breast clinic with an ulcerating left breast lump that had progressively increased in size. Examination showed a fungating left breast mass that obliterated the nipple-areola complex. Ultrasound showed a large soft tissue mass in the left breast with enlarged left axillary lymph nodes. Computed tomographic (CT) scan showed a 13×17 cm left breast mass. Core biopsy of this mass reported possibility of phyllodes tumor, while axillary fine-needle aspiration cytology (FNAC) showed no evidence of malignancy. Total mastectomy with immediate reconstruction using silicone implant was performed. Final histopathology reported giant fibroadenoma. Most cases on giant fibroadenoma reported in literature are limited to adolescent or young females, however, our patient was relatively old, which makes this a rare case.

Massive inflammatory reaction following the removal of a ruptured silicone implant masking the invasive breast cancer – case report and literature review

2016 ◽  
Vol 88 (1) ◽  
Author(s):  
Piotr Nowaczyk ◽  
Aleksandra Budnicka ◽  
Mateusz Wichtowski ◽  
Paweł Kurzawa ◽  
Dawid Murawa
Keyword(s):  
Breast Cancer ◽  
Histopathological Examination ◽  
Breast Implants ◽  
Breast Cancer Case ◽  
Left Breast ◽  
Cancer Case ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Breast Cancers ◽  
Inflammatory Infiltration

AbstractThis paper presents a case of a patient with invasive ductal breast cancer following breast augmentation. Following breast implants rupture in March 2013 the breast implants have been removed – histopathological examination revealed leaked silicone with inflammatory infiltration, without evidence of cancerous lesions. Diagnostic imaging revealed multiple encapsulated silicone particles and clusters of post-inflammatory macrocalcifications in both breasts. In January 2014 the patient presented with symptoms of massive inflammation of the left breast. Following surgical consultation the patient had undergone radical left-sided mastectomy with lymphadenectomy. Postoperative histopathological examination revealed a multifocal advanced invasive ductal cancer G3 pT3pN3a (vascular invasion, metastases in 11 of 12 examined axillary lymph nodes). Following surgery the patient was qualified for further treatment – chemotherapy, radiotherapy, hormone therapy. The discussion includes a review of literature on the risk evaluation of co-occurrence of breast cancers in women with silicone breast implants and presents diagnostic challenges of breast cancer in this patient group.

scholarly journals The Role of Postmastectomy Radiotherapy in Locally Advanced Breast Cancer After Pathological Complete Response to Neoadjuvant Chemotherapy

ONCOLOGY ◽  
2021 ◽  
pp. 139-143
Author(s):  
Christian Haydeé Flores-Balcázar ◽  
Francisco Javier Castro-Alonso ◽  
Tania Patricia Hernández-Barragán ◽  
Jesús Delgado-de la Mora ◽  
Antonio Daidone ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Neoadjuvant Treatment ◽  
Left Breast ◽  
Tumor Board ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Outer Quadrant ◽  
Normal Morphology ◽  
Axillary Nodes

A previously healthy woman, aged 32 years, presented to the oncology clinic with a 6-month history of left-breast tumor, mastalgia, and swollen axillary nodes. Physical examination was relevant for a 6-cm palpable mass in the upper outer quadrant of the left breast and an ipsilateral 2-cm, nonfixed axillary lymph node. Mammography showed a 1-cm mass in the upper outer quadrant, a 5.2-cm mass in the lower outer quadrant, and enlarged pathologic lymph nodes (BI-RADS category 5 disease). Breast ultrasound revealed 3 axillary lymph nodes with cortical thickening and loss of normal morphology (the largest with a 2.6-cm length in the long axis) (Figure 1A-B). The breast's core biopsy revealed a grade 3 apocrine invasive carcinoma with lymphovascular invasion; immunohistochemistry testing showed HER2-negative, hormone receptor-negative disease (estrogen receptor, 0%; progesterone receptor, 0%; HER2-negative, Ki67, 50%) (Figure 2A-B). A fine-needle aspiration biopsy of the axillary lymph nodes showed invasive breast carcinoma as well. Bone scintigraphy and a chest/abdomen CT scan ruled out metastatic disease. Upon initial diagnosis, clinical stage was deemed as cT3N1M0 (American Joint Committee on Cancer 8th edition: anatomic stage IIIA, clinical prognostic stage IIIC). After a multidisciplinary tumor board discussion, the patient underwent neoadjuvant chemotherapy with weekly paclitaxel, followed by 4 cycles of dosedense doxorubicin plus cyclophosphamide. After completing neoadjuvant treatment, clinical examination was relevant for a residual 1-cm palpable left breast mass and no palpable axillary nodes. Mammography and breast ultrasound showed a 77% partial response in the primary tumors, and axillary nodes with normal morphology and size (Figure 1C-D). Due to multicentric tumor disease, breast-conserving surgery would not confer satisfactory cosmetic results on her, and a modifi ed radical mastectomy with intraoperative sentinel lymph node biopsy (and second-stage breast reconstruction) was planned. However, during surgery, the surgeons failed to identify the mapped lymph node, and level I-III axillary lymph node dissection was performed. The pathology report described complete pathological response: Miller and Payne criteria grade 5 response with the absence of malignant cells within the mastectomy specimen and in 24 lymph nodes (Figure 2C-E). Pathological staging after neoadjuvant treatment concluded ypT0N0M0 disease. Subsequent treatment for this patient was discussed in another tumor board.

scholarly journals METAPLASTIC CARCINOMA OF BREAST : A CASE REPORT

2021 ◽  
pp. 39-40
Author(s):  
Manju Singh ◽  
S N Gole ◽  
S L Nirala ◽  
T Narasimha Murty
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptors ◽  
Left Breast ◽  
Metaplastic Carcinoma ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Metaplastic Breast Cancer ◽  
Biopsy Report ◽  
Simple Mastectomy ◽  
Cell Variant

Metaplastic breast cancer constitute nearly 1 % of all breast carcinoma cases. There is metaplasia of normal epithelial components of the breast into other types. They are highly aggressive with very poor prognosis. Here we present a case of 30 year old female who presented with a breast lump in her left breast associated with dull aching pain. It was 10 x 10 cm in size involving upper inner, upper outer, lower outer quadrants and retroareolar area of left breast. USG was suugestive of BIRADS VI lesion. Axillary lymph nodes were not found enlarged clinically or radiologically. Core biopsy report showed Phylloides tumor of breast. The patient underwent simple mastectomy of left breast and histopathology revealed spindle cell variant of metaplastic breast cancer. The cell blocks sent for immunohistochemistry were negative for estrogen, progesterone receptors and Her2neu receptor. The post surgical treatment of this type of breast cancer is still under study.

scholarly journals A rare case of unilateral breast filariasis mimicking chronic mastitis

2021 ◽  
Vol 8 (7) ◽  
pp. 2228
Author(s):  
Varsha A. Sharma ◽  
Manmohan M. Kamat ◽  
Jeena K. Sathyan ◽  
Seema Barman ◽  
Shravani Shetye
Keyword(s):  
Benign Lesion ◽  
Rare Condition ◽  
Surgical Excision ◽  
Axillary Lymph Nodes ◽  
Excision Biopsy ◽  
Axillary Lymph ◽  
Presumptive Diagnosis ◽  
Lower Quadrant ◽  
History Of ◽  
The Right

Filariasis of the breast is a very rare condition. In India, largest number (around 600 million) of people live in endemic areas. Despite the huge number, it is quite rare to find microfilaria in routine smears and body fluids and it is even more rare to find it in breasts. A 40 years old female, presented with a history of lump in the right breast approximately 3x3 cm in size in the right lower quadrant. Findings were confirmed by clinical examination which did not reveal any palpable ipsilateral or contralateral axillary lymph nodes. FNAC showed it as a benign lesion. After local excision, histopathology revealed a filarial worm. Filariasis of the breast is a rare disease. The presence of microfilaria in breasts using FNAC has been reported at times but the presence of the filarial worms can only be confirmed on histopathology, hence a core biopsy or an excision biopsy is a must in all the cases. A presumptive diagnosis of filariasis can be made on sonography if the worms are alive and active, the typical presentation on USG is the filarial dance. Surgical excision of the lump followed by DEC therapy is the treatment of choice for filarial lump of the breast.

Adjuvant chemotherapy with doxorubicin plus cyclophosphamide, methotrexate, and fluorouracil in the treatment of resectable breast cancer with more than three positive axillary nodes.

1991 ◽  
Vol 9 (12) ◽  
pp. 2134-2140 ◽  
Author(s):  
R Buzzoni ◽  
G Bonadonna ◽  
P Valagussa ◽  
M Zambetti
Keyword(s):  
Breast Cancer ◽  
Left Breast ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Free Survival ◽  
Postoperative Irradiation ◽  
High Risk Breast Cancer ◽  
High Risk Breast ◽  
Risk Breast Cancer

To improve current adjuvant results in high-risk breast cancer, in February 1982 we activated a prospective randomized trial using both intravenous cyclophosphamide, methotrexate, and fluorouracil (CMF) and Adriamycin (doxorubicin; Farmitalia-Carlo Erba, Milan, Italy) involving patients with resectable mammary carcinoma and more than three positive axillary lymph nodes. The objective of the study was to assess the effectiveness of four courses of Adriamycin followed by eight courses of CMF versus two courses of CMF alternated with one course of Adriamycin for a total of 12 courses. All drug courses were recycled every 3 weeks. Rather than temporarily reducing doses in the event of myelosuppression on the planned day of treatment, drug administration was delayed for 1 to 2 weeks. At a median follow-up of 59 months, treatment outcome was significantly superior for patients who received Adriamycin followed by CMF (Adriamycin----CMF) than for those given alternating regimens (CMF/Adriamycin). The 5-year relapse-free survival was superior post-Adriamycin----CMF (61%) compared with post-CMF/Adriamycin administration (38%; P = .001). The corresponding figures for the 5-year total survival were 78% and 62%, respectively (P = .005). The benefit of Adriamycin----CMF was observed in all patient subsets. Treatment was fairly well tolerated, and we documented only one case of fatal congestive heart failure in a patient who received postoperative irradiation to the left breast in addition to Adriamycin. Present findings indicate that in women with extensive nodal involvement, Adriamycin----CMF yielded superior results compared with CMF/Adriamycin.

scholarly journals The clavipectoral fascia as the unique anatomical criteria for distinguishing breast parenchymal lesions from axillary lymph node metastasis

2019 ◽  
Vol 2019 (5) ◽  
Author(s):  
Antonios Patrinos ◽  
Maria Zarokosta ◽  
John Tsiaoussis ◽  
George Noussios ◽  
Τheodoros Piperos ◽  
...  
Keyword(s):  
Breast Tumors ◽  
Left Breast ◽  
Axillary Lymph Node Metastasis ◽  
Primary Adenocarcinoma ◽  
Preoperative Imaging ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Node Metastasis ◽  
Post Menopausal ◽  
Caucasian Female

Abstract Diagnosing primary breast tumors of the axillary tail of Spence may be extremely challenging, since several lesions may be located in the axillary fossa. In the presented case, a 54-year-old post-menopausal Caucasian female patient presented to our institution complaining about a lump in her left axilla. The preoperative imaging modalities could not clarify whether the tumor is part of the tail of Spence or metastasis of the axillary lymph nodes. The diagnosis of primary adenocarcinoma of the axillary tail of Spence was made during a quadrantectomy of the left breast after the clavipectoral fascia, which constitutes the sole anatomical boundary between breast and axilla, was identified.

scholarly journals Ovarian Cancer Metastatic to Breast and Axilla: A Case Report

2020 ◽  
pp. 88-92
Author(s):  
Mehdi Ghelichkhani ◽  
Nahid Naffisi ◽  
Farshid Ghasemi Meydansar ◽  
Zahra Rahimi ◽  
Masoud Haghighikian ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Nodes ◽  
Left Breast ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Case Presentation ◽  
Cancer Metastases ◽  
History Of ◽  
Unnecessary Procedures ◽  
Breast Malignancies

Background: Metastases to breast and axilla from extramammary sites are uncommon and have been reported in only 2% of breast malignancies. Ovarian cancer metastatic to breast and axillary lymph nodes is extremely rare and only accounts for 0.03%-0.6% of all breast neoplasms. The most common histologic feature of ovarian cancer metastatic to breast is papillary serous adenocarcinoma. Differentiating the secondary breast malignancies from primary ones is crucial as the treatment and prognosis are different, which could avoid many unnecessary procedures. Prognosis is generally poor because most patients have simultaneous spread of the disease. Case presentation: A 67-year-old woman with a history of ovarian cancer, undergoing chemotherapy presented with redness and swelling in her left breast and pathologic axillary lymph nodes. Work ups revealed ovarian cancer metastases to breast and axillary lymph nodes. She underwent chemotherapy with second line chemotherapeutics. The results were satisfying and the patient is well. Conclusion: The history of cancer in patients with a breast mass, even if clinically benign, may give rise to potential metastases. Screening with physical examination and serial mammography for patients with ovarian cancer could be beneficial. Early and accurate diagnosis of breast metastatic tumors is critical for proper management and preventing unnecessary and possibly harmful procedures.

scholarly journals Case Report: Sarcoidosis in the lymph nodes of a breast cancer patient

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1853
Author(s):  
Perwasha Kerio ◽  
Zain Abid ◽  
Masooma Abid ◽  
Desaar Zehra ◽  
Ghulam Haider
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Stage Iv ◽  
Left Breast ◽  
The Body ◽  
Mediastinal Lymphadenopathy ◽  
Axillary Lymph Nodes ◽  
Simultaneous Occurrence ◽  
Axillary Lymph ◽  
Multiple Organs

Background: Sarcoidosis is an inflammatory disease that affects multiple organs in the body, especially the lungs and lymph nodes. The coexistence of sarcoidosis and breast cancer has been reported, but the coexistence of both diseases in the same patient often leads to misdiagnosis. Case: We report a case of a 36-year-old woman who presented with concerns of a lump in her left breast along with pain and discharge from the nipple. On examination a 3-cm hard and tender mass was noted in the upper medial quadrant of the left breast with no palpable axillary lymph nodes. The patient was diagnosed with an infiltrating ductal cell carcinoma of the left breast with T2N0M1 Stage IV disease, due to positive mediastinal lymphadenopathy on positron emission tomography scan. The biopsy of mediastinal lymph nodes allowed us to diagnose sarcoidosis and correctly stage her disease as T2N0M0 Stage IIA breast cancer. The patient underwent lumpectomy followed by adjuvant chemo radiotherapy and hormonal therapy - corticosteroids given for sarcoidosis up to 1 year. The patient is doing well 18 months later without recurrence of disease. Conclusion: The simultaneous occurrence of both diseases in the same patient is the risk for misdiagnosis and mismanagement, therefore it is of utmost importance to correctly stage the disease with appropriate investigations and histologic confirmation prior to initiate the treatment for breast cancer.

scholarly journals Carcinoma en Cuirasse from Recurrent Breast Cancer seen on FDG-PET/CT

2015 ◽  
Vol 5 ◽  
pp. 35 ◽  
Author(s):  
Aung Zaw Win ◽  
Carina Mari Aparici
Keyword(s):  
Breast Cancer ◽  
Fdg Pet ◽  
Ductal Carcinoma ◽  
Recurrent Breast Cancer ◽  
Left Breast ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Pet Ct ◽  
Recurrent Breast ◽  
Fdg Pet Ct

Our patient was a 36-year-old female diagnosed with Grade II ER+/PR−/Her-2 − ductal carcinoma in situ (DCIS) in the left breast. She underwent left lumpectomy and received treatment with tamoxifen and radiotherapy. Three years later, she presented with multiple diffused skin nodules on the chest and upper left arm. 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) exam showed widespread metastasis in the chest, upper left arm, left axillary lymph nodes, and left suprascapular muscle. FDG-PET/CT imaging of breast carcinoma en cuirasse is very rare. FDG-PET/CT is useful in detecting recurrent breast cancer.

Primary Neuroendocrine Small Cell Carcinomaof the Breast

2000 ◽  
Vol 124 (2) ◽  
pp. 296-298
Author(s):  
Billur Samli ◽  
Selma Celik ◽  
Turkkan Evrensel ◽  
Bulent Orhan ◽  
Ismet Tasdelen
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Radical Mastectomy ◽  
Left Breast ◽  
Small Cell ◽  
Primary Breast Tumor ◽  
Axillary Lymph Nodes ◽  
Turkish Woman ◽  
Axillary Lymph ◽  
Carcinoma Of The Breast

Abstract A 60-year-old Turkish woman presented with a left breast mass, which was considered for neoadjuvant chemotherapy. By the end of the treatment cycles, the tumor had decreased in size, and the patient underwent modified radical mastectomy with axillary lymph node dissection. Pathologic examination of the tumor revealed a small cell carcinoma with neuroendocrine features confirmed by immunohistochemical stains. Multiple axillary lymph nodes were involved by metastatic small cell carcinoma carrying the same morphologic characteristics noted in the primary breast tumor. We hereby present this case as a primary neuroendocrine small cell carcinoma of the breast. This entity occurs very rarely in the breast, and fewer than a dozen cases have been reported in the literature. Extrapulmonary small cell carcinoma of the breast is reportedly a very aggressive tumor for which no consensus for treatment has yet been drawn.

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