scholarly journals Serum zinc levels and effect of zinc and vitamin A supplementation in children with diarrhea: a randomized control study

2017 ◽  
Vol 4 (4) ◽  
pp. 1501
Author(s):  
Nageswara Rao Kalvakuri ◽  
Sushma Nalisetty
Keyword(s):  
Vitamin A ◽  
Acute Diarrhea ◽  
Acute Diarrhoea ◽  
Serum Zinc ◽  
Control Group ◽  
Vitamin A Supplementation ◽  
Randomized Control ◽  
Zinc Levels ◽  
Control Study ◽  
Serum Zinc Levels

Background: Zinc deficiency affects about two billion people in the developing world and is associated with many diseases. Zinc is crucial for normal development and function of cells mediating nonspecific immunity such as neutrophils and natural killer cells. Zinc supplementation has been shown to be effective for preventing diarrhea in children. Vitamin A helps to regulate the immune system, which helps to prevent or fight off infections by making white blood cells that destroy harmful bacteria and viruses.Methods: In this randomized control study 82 children aged 6months to 5 years were randomized 52 in the group of acute diarrhoea and 30 in the control group. Blood samples were drawn for estimation of serum zinc levels. Children in the acute diarrhoea group 23 received zinc alone and 23 received zinc and vitamin A and followed up for 6 months.Results: The serum zinc levels were significantly lower in children with acute diarrhea (66.7µg/dl) as compared to that of the children in the control group (80.5433 µg/dl) (p=<0.001). The children with malnourishment had a mean zinc level that was significantly lesser (p=<0.01). In the acute diarrhea group, children receiving zinc supplementation alone, 10 of the children had at least 1 episode of diarrhea over the next 6 months. Children receiving zinc and vitamin A supplementation, there were only 5 such children with at least 1 episode of acute diarrhea.Conclusions: Combination of zinc and vitamin A supplementation in acute diarrhea decreases the chances of recurrence of diarrhoea and reduces the hospital stay significantly.

scholarly journals The Effect of Biscuits Made From Pumpkin Seeds Flour on Serum Zinc Levels and Weight in Malnutrition Wistar Rats

2020 ◽  
Vol 8 (A) ◽  
pp. 428-433
Author(s):  
Aminuddin Syam ◽  
Fitrah Khaerani Burhan ◽  
Veni Hadju ◽  
C. Citrakesumasari ◽  
Andi Muhammad Akhmar
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Serum Zinc ◽  
Zinc Content ◽  
Control Group ◽  
Test Results ◽  
Pumpkin Seed ◽  
Seed Flour ◽  
Zinc Levels ◽  
Serum Zinc Levels

BACKGROUND: Serum zinc levels are found to be low in children of protein energy malnutrition globally. Pumpkin seed flour has a high zinc content of 6.88 mg/100 g, has been formulated biscuits made from pumpkin seed flour with a zinc content of 1.52 mg/100 g. AIM: This study aims to determine the effect of giving biscuits made from pumpkin seed flour to serum zinc levels and body weight in malnutrition Wistar rats. METHODS: This research is a true experiment with pre-post-test with control group design. Subjects were 28 male Wistar strain rats induced by fasting malnutrition for 3 days and then given biscuits with a zinc dose of 0.027 mg; 0.054 mg; and 0.081 mg/BW/day and in the control group without biscuits for 2 weeks. Serum zinc levels were examined using the atomic absorption spectrophotometry method. Data were analyzed using paired t-test and one-way ANOVA test. RESULTS: Paired t-test results on serum zinc levels obtained p > 0.05 and on body weight obtained p < 0.05. One-way ANOVA test results on serum zinc levels after the intervention obtained p > 0.05 and at body weight obtained p < 0.05 followed by post hoc least significant difference test found that there were significant differences between the control group and the P1 group, a dose of 0.027 mg (p = 0.015) and P2 groups, doses of 0.054 mg (p = 0.012). Greater weight gain was found in the P1 group with an increase of 38.85%. CONCLUSION: The provision of biscuits made from pumpkin seed flour has an effect on increasing body weight of malnutrition Wistar rats and has no effect on serum zinc levels, so further research is expected to use different doses.

SERUM ZINC LEVELS IN CHILDREN HOSPITALIZED WITH PNEUMONIA: A CASE CONTROL STUDY

2014 ◽  
Vol 1 (12) ◽  
pp. 1553-1558
Author(s):  
Deepthi D ◽  
Shubha Jayaram ◽  
Savitha M R ◽  
Manjunath S N ◽  
Sreenivas N ◽  
...  
Keyword(s):  
Case Control Study ◽  
Serum Zinc ◽  
Case Control ◽  
Zinc Levels ◽  
Control Study ◽  
Serum Zinc Levels

scholarly journals Serum zinc levels and its association with vitamin A levels among tuberculosis patients

2014 ◽  
Vol 5 (1) ◽  
pp. 130 ◽  
Author(s):  
Irfan Ahmad ◽  
VinodKumar Srivastava ◽  
Rajendra Prasad ◽  
Ram AvadhSingh Kushwaha ◽  
Mohd Saleem ◽  
...  
Keyword(s):  
Vitamin A ◽  
Serum Zinc ◽  
Tuberculosis Patients ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Serum zinc levels in acute diarrhoea and pneumonia in children aged 6 months to 6 years

2019 ◽  
Vol 6 (7) ◽  
pp. 337-343
Author(s):  
Dr. Vinay Kumar Lakkoju ◽  
◽  
Dr. Nalluru Lakshmi Sravanthi ◽  
Dr. Vijayalakshmi Bhimireddy ◽  
Dr. Kanta Kumari Pinnamaneni ◽  
...  
Keyword(s):  
Acute Diarrhoea ◽  
Serum Zinc ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Correlation of Serum Zinc Levels with Postpartum Depression- A Case- control Study in North Karnataka

2021 ◽  
Author(s):  
MM Kavitha ◽  
Shravya Dharambhat ◽  
Narayan Mutalik ◽  
SH Chandrashekaraya ◽  
SV Kashinakunti
Keyword(s):  
Postpartum Depression ◽  
Postnatal Depression ◽  
Case Control Study ◽  
Mode Of Delivery ◽  
Serum Zinc ◽  
Case Control ◽  
Healthy Controls ◽  
Zinc Levels ◽  
Control Study ◽  
Serum Zinc Levels

Introduction: Pregnancy is an important event in reproductive mother. At the same time it is associated with stress, which exaggerates the depression. Many factors leads to depression, among them nutrient deficiency like zinc, selenium, iron, calcium, folic acid and vitamin B12 plays a major role. Aim: To estimate and compare serum zinc levels in females with postpartum depression subjects and healthy controls. To find the relationship between serum zinc levels and extent of postpartum depression. Materials and Methods: The present study was a hospital- based case-control study, conducted over a period of three months. It included 40 postpartum depression cases and 40 healthy controls. All the participants were subjected to serum zinc levels estimation. Edinburgh Postnatal Depression Scale (EPDS) score was applied. The individuals who scored greater than 10 were taken as cases and those scoring less than 10 were taken as controls. Data was tabulated and results expressed as mean±SD, student’s t-test and Pearson correlation test was applied for correlation. Results: The present study found decreased serum zinc levels in postpartum depression cases compared to controls. It was found serum zinc levels in cases were 21.63±15.73 μg/dL and 54.16±19.72 μg/dL in controls. There was a negative correlation between the severity of postnatal depression and the serum zinc levels. Not only this, but certain risk factors were also identified, such as age of the mother, months of postpartum, mode of delivery, and the education of the mother. Conclusion: Decreased serum zinc levels do indeed correlate to a change in maternal mental health, and then the knowledge would not only help in diagnosis by tests, but also further patient care.

scholarly journals Zinc Supplementation as Adjunctive Therapy in Adults with Tuberculosis in Calabar, Nigeria: A Randomized Controlled Trial

2019 ◽  
pp. 1-13
Author(s):  
Regina I. Ejemot-Nwadiaro ◽  
Edisua H. Itam ◽  
Emmanuel N. Ezedinachi
Keyword(s):  
Zinc Supplementation ◽  
Intervention Group ◽  
Serum Zinc ◽  
Drug Regimen ◽  
Haematological Parameters ◽  
Control Group ◽  
Tb Treatment ◽  
Zinc Levels ◽  
The Impact ◽  
Serum Zinc Levels

Introduction: Tuberculosis (TB) still remains a leading killer from a single infectious agent worldwide, especially in Asia and Africa. Achieving the Sustainable Development Goal (SDG) 3 will be contingent on addressing ways of reducing the impact of TB to the health, socio-economic and health system of populations most at risk. Micronutrients supplementation is increasingly being recognized as having great potentials to that effect. Objective: This study thus assessed the potential benefits or otherwise of zinc supplementation on tuberculosis treatment outcomes in Calabar, Nigeria. Methods: Eligible patients (81) out of the 182 assessed were randomized to receive anti-TB drug regimen plus oral administration of individual zinc, 25 mg daily for 60 days (intervention group), while the control group received anti-tuberculosis drug regimen only for 60 days. Both qualitative and quantitative data were collected. Clinical examination, Karnofsky performance scale index, direct sputum examination, anthropometric measurements and blood collection for haematological and zinc assessment were carried out before and 2 months after anti-TB treatment began.  Difference in treatment effects between and within groups for continuous variables was tested using t-test. Mantel-Haenszel summary estimate of the relative risk (RR) was used to test the clinical effectiveness of the intervention. The Pearson test was applied to determine the correlation between variables. Main Results: The mean serum zinc levels at 2 months of TB treatment were significantly higher in the intervention group (14.4 ± 0.37µmol/L) in comparison with the control (12.9 ± 0.37 µmol/L); (p = 0.004). A significant difference (p = 0.010) in the serum concentrations of zinc was observed between the two groups when adjustments were made for TB-HIV co-infection. Risk reduction of about 41% for acid fast bacilli (AFB) positivity (RR: 0.59; 95% CI 0.23 to 1.46) was observed after 2 months of anti-TB treatment in favour of the intervention group. Similarly, intervention group had significantly (p = 0.005) lower proportion of patients with serum zinc levels < 10.7 µmol/L (intervention: 5; Control 10) and (p = 0.030) BMI < 18.5 kg /m2 below the lower ranges ((intervention: 9; Control 16). There was a significant improvement in the haematological parameters as evidenced by significant higher proportion of patients in the intervention group than the control group with values above the lower ranges for these parameters with risk reductions in favour of the intervention group for lower ranges as 34%, 12%, 73% and 58% respectively for haemoglobin, albumin, serum total protein and globulins. Conclusion: Irrespective of HIV status in individuals with tuberculosis, zinc micronutrient supplementation significantly increases clinical outcomes, haematological parameters, improves nutritional status as proxied by anthropometric indices and leads to faster sputum smear conversion. The study adds to the growing body of evidence in support of the beneficial role of zinc in TB control.

scholarly journals Serum Zinc Levels in Iron Deficient Women: A Case-Control Study

2016 ◽  
Vol 33 (2) ◽  
pp. 156-158 ◽  
Author(s):  
Onur Özhan ◽  
Neslihan Erdem ◽  
İsmet Aydoğdu ◽  
Mehmet Ali Erkurt ◽  
İrfan Kuku
Keyword(s):  
Case Control Study ◽  
Serum Zinc ◽  
Case Control ◽  
Iron Deficient ◽  
Zinc Levels ◽  
Control Study ◽  
Serum Zinc Levels

scholarly journals Serum zinc levels in hospitalized children with pneumonia: a hospital-based case–control study

2019 ◽  
Vol 13 (5) ◽  
pp. 730
Author(s):  
HamadaK Fayed ◽  
AmiraM.M Hamed ◽  
YasserT Kassem ◽  
AhmedM Solaiman
Keyword(s):  
Case Control Study ◽  
Serum Zinc ◽  
Case Control ◽  
Hospitalized Children ◽  
Zinc Levels ◽  
Control Study ◽  
Serum Zinc Levels

Serum Zinc Levels in Hidradenitis Suppurativa: A Case–Control Study

2018 ◽  
Vol 19 (5) ◽  
pp. 771-777 ◽  
Author(s):  
Inés Poveda ◽  
Eva Vilarrasa ◽  
Antonio Martorell ◽  
Francisco Javier García-Martínez ◽  
Juan Manuel Segura ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Case Control Study ◽  
Serum Zinc ◽  
Case Control ◽  
Zinc Levels ◽  
Control Study ◽  
Serum Zinc Levels

scholarly journals Low Serum Zinc Level May be Related to Higher Doses of EPO in Hemodialysis Patients

2015 ◽  
Vol 12 (1) ◽  
pp. 40-44
Author(s):  
Itir Yegenaga ◽  
Zeki Aydin
Keyword(s):  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Inadequate Response ◽  
Recombinant Erythropoietin ◽  
Serum Zinc Level ◽  
Human Recombinant Erythropoietin ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

AbstractIntroduction.Anemia is a complication of chronic renal failure observed in patients on hemodialysis (HD) affecting morbidity and mortality of these patients. It is associated with erythropoietin (EPO) deficiency and can be treated by human recombinant erythropoietin (hrEPO). Iron deficiency has been reported as the first line cause for inadequate response to this treatment. Zinc deficiency in hemodialysis (HD) patients was previously reported and the relationship between iron and zinc deficiencies has been known for years. The aim of this study was to find out the relationship between serum zinc level, anemia and rhEPO consuming in HD patients.Methods.A total of 69 HD patients and 34 healthy individuals were included in the study. Serum zinc levels, clinical, hematologic, biochemical parameters and rhEPO doses were evaluated.Results.Serum zinc levels were found to be lower in HD patients in comparison to those in the control group (29.92±12.94, 44.82±27.69μg/dL, respectively) (p<0.001). There was a positive correlation between serum zinc and hemoglobin (Hb) in the control group (R2=0.06). In HD patients who needed less then 8000U/week rhEPO, Hb levels (p<0.05) and serum zinc levels were higher. Serum zinc and Hb levels were found to be higher in patients who were under HD treatment for more than 12 months (10.05±1.06 vs 10.69±1.29; p=0.022 and 26.96±13.29 vs 30.88±12.61; p=0.178).Conclusions.HD patients who needed lower dose of EPO had higher serum zinc levels. Although the difference was not statistically significant, these results provide evidence that serum zinc level should be taken into consideration especially in HD patients resistant to EPO therapy.

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