scholarly journals The Effect of Biscuits Made From Pumpkin Seeds Flour on Serum Zinc Levels and Weight in Malnutrition Wistar Rats

2020 ◽  
Vol 8 (A) ◽  
pp. 428-433
Author(s):  
Aminuddin Syam ◽  
Fitrah Khaerani Burhan ◽  
Veni Hadju ◽  
C. Citrakesumasari ◽  
Andi Muhammad Akhmar
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Serum Zinc ◽  
Zinc Content ◽  
Control Group ◽  
Test Results ◽  
Pumpkin Seed ◽  
Seed Flour ◽  
Zinc Levels ◽  
Serum Zinc Levels

BACKGROUND: Serum zinc levels are found to be low in children of protein energy malnutrition globally. Pumpkin seed flour has a high zinc content of 6.88 mg/100 g, has been formulated biscuits made from pumpkin seed flour with a zinc content of 1.52 mg/100 g. AIM: This study aims to determine the effect of giving biscuits made from pumpkin seed flour to serum zinc levels and body weight in malnutrition Wistar rats. METHODS: This research is a true experiment with pre-post-test with control group design. Subjects were 28 male Wistar strain rats induced by fasting malnutrition for 3 days and then given biscuits with a zinc dose of 0.027 mg; 0.054 mg; and 0.081 mg/BW/day and in the control group without biscuits for 2 weeks. Serum zinc levels were examined using the atomic absorption spectrophotometry method. Data were analyzed using paired t-test and one-way ANOVA test. RESULTS: Paired t-test results on serum zinc levels obtained p > 0.05 and on body weight obtained p < 0.05. One-way ANOVA test results on serum zinc levels after the intervention obtained p > 0.05 and at body weight obtained p < 0.05 followed by post hoc least significant difference test found that there were significant differences between the control group and the P1 group, a dose of 0.027 mg (p = 0.015) and P2 groups, doses of 0.054 mg (p = 0.012). Greater weight gain was found in the P1 group with an increase of 38.85%. CONCLUSION: The provision of biscuits made from pumpkin seed flour has an effect on increasing body weight of malnutrition Wistar rats and has no effect on serum zinc levels, so further research is expected to use different doses.

scholarly journals Zinc Supplementation as Adjunctive Therapy in Adults with Tuberculosis in Calabar, Nigeria: A Randomized Controlled Trial

2019 ◽  
pp. 1-13
Author(s):  
Regina I. Ejemot-Nwadiaro ◽  
Edisua H. Itam ◽  
Emmanuel N. Ezedinachi
Keyword(s):  
Zinc Supplementation ◽  
Intervention Group ◽  
Serum Zinc ◽  
Drug Regimen ◽  
Haematological Parameters ◽  
Control Group ◽  
Tb Treatment ◽  
Zinc Levels ◽  
The Impact ◽  
Serum Zinc Levels

Introduction: Tuberculosis (TB) still remains a leading killer from a single infectious agent worldwide, especially in Asia and Africa. Achieving the Sustainable Development Goal (SDG) 3 will be contingent on addressing ways of reducing the impact of TB to the health, socio-economic and health system of populations most at risk. Micronutrients supplementation is increasingly being recognized as having great potentials to that effect. Objective: This study thus assessed the potential benefits or otherwise of zinc supplementation on tuberculosis treatment outcomes in Calabar, Nigeria. Methods: Eligible patients (81) out of the 182 assessed were randomized to receive anti-TB drug regimen plus oral administration of individual zinc, 25 mg daily for 60 days (intervention group), while the control group received anti-tuberculosis drug regimen only for 60 days. Both qualitative and quantitative data were collected. Clinical examination, Karnofsky performance scale index, direct sputum examination, anthropometric measurements and blood collection for haematological and zinc assessment were carried out before and 2 months after anti-TB treatment began.  Difference in treatment effects between and within groups for continuous variables was tested using t-test. Mantel-Haenszel summary estimate of the relative risk (RR) was used to test the clinical effectiveness of the intervention. The Pearson test was applied to determine the correlation between variables. Main Results: The mean serum zinc levels at 2 months of TB treatment were significantly higher in the intervention group (14.4 ± 0.37µmol/L) in comparison with the control (12.9 ± 0.37 µmol/L); (p = 0.004). A significant difference (p = 0.010) in the serum concentrations of zinc was observed between the two groups when adjustments were made for TB-HIV co-infection. Risk reduction of about 41% for acid fast bacilli (AFB) positivity (RR: 0.59; 95% CI 0.23 to 1.46) was observed after 2 months of anti-TB treatment in favour of the intervention group. Similarly, intervention group had significantly (p = 0.005) lower proportion of patients with serum zinc levels < 10.7 µmol/L (intervention: 5; Control 10) and (p = 0.030) BMI < 18.5 kg /m2 below the lower ranges ((intervention: 9; Control 16). There was a significant improvement in the haematological parameters as evidenced by significant higher proportion of patients in the intervention group than the control group with values above the lower ranges for these parameters with risk reductions in favour of the intervention group for lower ranges as 34%, 12%, 73% and 58% respectively for haemoglobin, albumin, serum total protein and globulins. Conclusion: Irrespective of HIV status in individuals with tuberculosis, zinc micronutrient supplementation significantly increases clinical outcomes, haematological parameters, improves nutritional status as proxied by anthropometric indices and leads to faster sputum smear conversion. The study adds to the growing body of evidence in support of the beneficial role of zinc in TB control.

scholarly journals Decreasing Zinc Levels in Stunting Toddlers in Lampung Province, Indonesia

2019 ◽  
Vol 12 (1) ◽  
pp. 239-243
Author(s):  
Khairun Nisa Berawi ◽  
Maya Nurul Hidayati ◽  
Susianti Susianti ◽  
Roro Rukmi W. Perdami ◽  
Tiwuk Susantiningsih ◽  
...  
Keyword(s):  
Univariate Analysis ◽  
Serum Zinc ◽  
Zinc Content ◽  
Zinc Level ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
The Mean ◽  
The Difference ◽  
Zinc Levels ◽  
Serum Zinc Levels

Stunting is a condition of chronic malnutrition in children that causes the posture is not optimal and triggers other disorders such as deacreasing of immunity and intelligence. The level of adequacy of zinc is one of the factors that influence the incidence of stunting. Zinc is needed to activate and begin the synthesis of Growth Hormone (GH) so that children with zinc deficiency cause GH receptors to be disrupted and GH production to be resistant. This study aims to examine the decrease in zinc levels by looking at the difference in mean zinc levels in stunting and non-stunting toddlers. The research method was carried out observational analytic with a cross sectional approach used in this study. The study sample was 40 toddlers aged 24-60 months with 18 stunting toddlers and 22 non-stunting toddlers in Gunung Sugih District, Central Lampung Regency. The results of univariate analysis revealed that the average zinc level of toddlers serum was 52.60 ug / dl with the largest value of 76 ug / dl and the lowest value was 24 ug / dl. The results of bivariate analysis showed that there were significant differences in the mean zinc levels of stunting and non-stunting children (p = 0.01). The mean zinc content of stunting infants was 45.06 ± 12.21 lower than the mean zinc level of non-stunting infants 58.77 ± 12.98. There is a decrease in serum zinc levels in stunting toddlers compared to non stunting toddlers.

scholarly journals Low Serum Zinc Level May be Related to Higher Doses of EPO in Hemodialysis Patients

2015 ◽  
Vol 12 (1) ◽  
pp. 40-44
Author(s):  
Itir Yegenaga ◽  
Zeki Aydin
Keyword(s):  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Inadequate Response ◽  
Recombinant Erythropoietin ◽  
Serum Zinc Level ◽  
Human Recombinant Erythropoietin ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

AbstractIntroduction.Anemia is a complication of chronic renal failure observed in patients on hemodialysis (HD) affecting morbidity and mortality of these patients. It is associated with erythropoietin (EPO) deficiency and can be treated by human recombinant erythropoietin (hrEPO). Iron deficiency has been reported as the first line cause for inadequate response to this treatment. Zinc deficiency in hemodialysis (HD) patients was previously reported and the relationship between iron and zinc deficiencies has been known for years. The aim of this study was to find out the relationship between serum zinc level, anemia and rhEPO consuming in HD patients.Methods.A total of 69 HD patients and 34 healthy individuals were included in the study. Serum zinc levels, clinical, hematologic, biochemical parameters and rhEPO doses were evaluated.Results.Serum zinc levels were found to be lower in HD patients in comparison to those in the control group (29.92±12.94, 44.82±27.69μg/dL, respectively) (p<0.001). There was a positive correlation between serum zinc and hemoglobin (Hb) in the control group (R2=0.06). In HD patients who needed less then 8000U/week rhEPO, Hb levels (p<0.05) and serum zinc levels were higher. Serum zinc and Hb levels were found to be higher in patients who were under HD treatment for more than 12 months (10.05±1.06 vs 10.69±1.29; p=0.022 and 26.96±13.29 vs 30.88±12.61; p=0.178).Conclusions.HD patients who needed lower dose of EPO had higher serum zinc levels. Although the difference was not statistically significant, these results provide evidence that serum zinc level should be taken into consideration especially in HD patients resistant to EPO therapy.

scholarly journals Relationship between Painful Crisis and Serum Zinc Level in Children with Sickle Cell Anaemia

Anemia ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Edamisan Olusoji Temiye ◽  
Edem Samuel Duke ◽  
Mbang Adeyemi Owolabi ◽  
James Kweku Renner
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Clinical Manifestations ◽  
Haemoglobin Concentration ◽  
Serum Zinc ◽  
Qualitative Assessment ◽  
Control Group ◽  
Zinc Levels ◽  
Serum Zinc Levels ◽  
Painful Crisis

Sickle cell anaemia (SCA) is associated with zinc deficiency; zinc supplementation may ameliorate some of its clinical manifestations including the relief of painful crisis.Subjects and Methods. Serum zinc levels were determined in 71 children with SCA and painful crisis and in equal numbers in steady state. Seventy-one children with AA genotype acted as controls. Qualitative assessment of zinc content of 24-hour dietary recall and the last meal consumed before blood was drawn was taken. Serum zinc was determined using atomic absorption spectrophotometer. Haemoglobin concentration and packed cell volume (PCV) were determined using standard methods.Results. The mean serum zinc concentration in the study was less than international reference range. The controls had significantly higher serum zinc concentrations than the SCA group (42.7±13.6versus32.3±14.0 μg/dL,P<.000); this difference was due to the significantly lower values of serum zinc in SCA with painful crisis compared with the remaining two groupsF=30.9,P<.000. There was a positive correlation between serum zinc and haemoglobin concentration only in the control group (r=0.4;P=.001).Conclusion. The serum zinc levels in this study were low. Painful crisis in SCA may exert greater demand for zinc utilization in children with SCA thereby resulting in lower serum levels.

scholarly journals A study of serum zinc levels in children admitted with pneumonia in a tertiary care hospital in India

2022 ◽  
Vol 8 (12) ◽  
pp. 426-429
Author(s):  
Ashrin A Naushad ◽  
Ashrin A Naushad ◽  
Lalitha Kailas ◽  
Sreekanth K Sivaraman
Keyword(s):  
Risk Factors ◽  
Tertiary Care ◽  
Serum Zinc ◽  
Nutritional Risk ◽  
World Health ◽  
Control Group ◽  
Care Hospital ◽  
Age Group ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Worldwide, pneumonia is a leading cause of morbidity and mortality in children under 5 years of age; especially, in developing countries. Objectives: The objective of the study is to investigate whether zinc deficiency and other nutritional factors are related to pneumonia in children between 6 months and 5 years old. Methodology: In this casecontrol study, a valid written consent was obtained from mothers of enrolled children. The cases included 75 children fulfilling the World Health Organization criteria for pneumonia, between the age group of 6 months and 5 years. They were interrogated for potential nutritional risk factors as per a predesigned proforma followed by a measurement of serum zinc levels. In the control group, 75 children of the same age group who were siblings of admitted children were included along with other children of the same age group admitted for non-respiratory complaints. A detailed case history was obtained and physical examination was done according to a predesigned proforma to elicit various potential risk factors. A semi-auto analyzer was used to measure the serum zinc levels through colorimetric methods using 5-bromo-PAS. Results: Significant nutritional risk factors identified were low serum zinc level, malnutrition, and anemia. Conclusion: The present study has identified various nutritional risk factors for pneumonia which can be tackled through effective education of the community and appropriate initiatives.

scholarly journals Evaluation of Serum Zinc Levels in Cattle with Trichophytosis According to Extensiveness of Trichophytosis

2020 ◽  
Vol 8 (11) ◽  
pp. 2416-2420
Author(s):  
Taner Şimay ◽  
Basaran Karademir
Keyword(s):  
Serum Zinc ◽  
The Body ◽  
Control Group ◽  
Group 4 ◽  
Healthy Cattle ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Zinc Levels ◽  
Serum Zinc Levels

This study aimed to reveal relationship between the extensiveness of trichophytosis on the body and serum zinc levels in cattle. This study was carried out on 92 cattle with trichophytosis and 50 healthy ones. Serum zinc levels of healthy cattle were evaluated as control. The cattle with trichophytosis separated into 5 groups according to diffusiveness of the diseases. Experimental groups of this study were designed as follows; Group 1: up to 1 cm, Group 2: 1-5 cm, Group 3: 5-10 cm, Group 4: 10-20 cm and Group 5: widespread on the body. Serum zinc levels measured by atomic absorption spectrophotometer equipped with flame system. In general, the mean level of Zn in trichophytosis groups (0.613±0.013 mg Zn/L) was statistically lower than healthy ones (0.900±0.017 mg Zn/L). A negative correlation was determined between the diffusiveness degree of trichophytosis and serum zinc levels (r = -0.772). Serum Zinc levels were statistically decreased from the control group to group 3. However, a stable course was observed from 3 to 5. Therefore, the value of group 3 (0.6 mgZn/L) was determined as a critical value for the cattle with trichophytosis. According to regression analysis results, it was observed that the extensiveness of the trichophytosis lesions affected the levels of serum Zn levels significantly (r2=59.6%). Consequently, serum zinc levels of cattle decreased in an inversely proportional manner to the diffusiveness degree of trichophytosis and stabilization was observed at the level of 0.6 mg Zn/L.

scholarly journals Serum zinc levels and effect of zinc and vitamin A supplementation in children with diarrhea: a randomized control study

2017 ◽  
Vol 4 (4) ◽  
pp. 1501
Author(s):  
Nageswara Rao Kalvakuri ◽  
Sushma Nalisetty
Keyword(s):  
Vitamin A ◽  
Acute Diarrhea ◽  
Acute Diarrhoea ◽  
Serum Zinc ◽  
Control Group ◽  
Vitamin A Supplementation ◽  
Randomized Control ◽  
Zinc Levels ◽  
Control Study ◽  
Serum Zinc Levels

Background: Zinc deficiency affects about two billion people in the developing world and is associated with many diseases. Zinc is crucial for normal development and function of cells mediating nonspecific immunity such as neutrophils and natural killer cells. Zinc supplementation has been shown to be effective for preventing diarrhea in children. Vitamin A helps to regulate the immune system, which helps to prevent or fight off infections by making white blood cells that destroy harmful bacteria and viruses.Methods: In this randomized control study 82 children aged 6months to 5 years were randomized 52 in the group of acute diarrhoea and 30 in the control group. Blood samples were drawn for estimation of serum zinc levels. Children in the acute diarrhoea group 23 received zinc alone and 23 received zinc and vitamin A and followed up for 6 months.Results: The serum zinc levels were significantly lower in children with acute diarrhea (66.7µg/dl) as compared to that of the children in the control group (80.5433 µg/dl) (p=<0.001). The children with malnourishment had a mean zinc level that was significantly lesser (p=<0.01). In the acute diarrhea group, children receiving zinc supplementation alone, 10 of the children had at least 1 episode of diarrhea over the next 6 months. Children receiving zinc and vitamin A supplementation, there were only 5 such children with at least 1 episode of acute diarrhea.Conclusions: Combination of zinc and vitamin A supplementation in acute diarrhea decreases the chances of recurrence of diarrhoea and reduces the hospital stay significantly.

scholarly journals Zinc Serum Maternal Levels as a Risk Factor for Preeclampsia

2021 ◽  
Vol 5 (4) ◽  
pp. 1110-1118
Author(s):  
Abarham Martadiansyah ◽  
Peby Maulina ◽  
Putri Mirani ◽  
Tia Kaprianti ◽  
Theodorus
Keyword(s):  
Pregnant Women ◽  
Dietary Habits ◽  
Serum Zinc ◽  
Zinc Level ◽  
Maternal Serum ◽  
Control Group ◽  
Case Group ◽  
Serum Zinc Level ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background. Preeclampsia is defined as gestational hypertension and proteinuria which can be measured by the elevation of liver transaminases to twice normal concentration, and the symptoms of increased intracranial pressure such as dizziness, blurred vision, and seizures. Zinc is an essential mineral for many biological functions and one of the trace elements that is directly involved in the oxidative/antioxidant balance, a pathogenesis process in preeclampsia that is highly dependent on dietary habits and supplements. This study was aimed to assess the association between serum zinc level with preeclampsia (PE). Methods: This observational, case-control study was performed on 90 women with singleton pregnancies at 28 to 42 weeks of gestation which were referred to the Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin General Hospital, Palembang, between August 2020 to November 2020. 30 pregnant women with PE were selected as cases and 60 healthy pregnant women were selected as controls. Maternal serum zinc samples were collected. The collected data were entered into the master table. Tabulation, coding, and statistical data analysis were performed using SPSS version 20.0 for Windows. Results: The mean serum zinc levels in the case group and control group were 43,90 ± 15,79 µg/dL (ranged from 15 to 86 µg/dL) and 48,77 ± 10,54 µg/dL (ranged from 22 to 83 µg/dL), respectively. A value of serum zinc levels with the best sensitivity and specificity was 45,5 µg/dL. Conclusion: There was a significant association between maternal serum zinc level with PE. The risk of PE was 3,2 times higher in pregnant women with serum zinc levels of ≤45,5 mcg/dL compared to pregnant women with serum zinc levels of >45,5 mcg/dL. In this case it is necessary to supplement zinc earlier in pregnancy to reduce the risk of preeclampsia.

scholarly journals Supplementation of Zinc Sulphate Decrease for Cytokine Levels TNF-Α, IL-1β and IL-6 in Multibacillary Leprosy Patients

2020 ◽  
Vol 3 (4) ◽  
pp. 191-197
Author(s):  
Joko Kurnianto ◽  
Hertanto W S ◽  
Prasetyowati Prasetyowati ◽  
Suharyo H. S.
Keyword(s):  
Proinflammatory Cytokines ◽  
Zinc Sulfate ◽  
Zinc Sulphate ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
Control Group ◽  
Tnf Α ◽  
Leprosy Patients ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: The role of zinc as an anti-oxidant and anti-inflammatory has been widely proven, this substance is relatively inexpensive and easily available to the public. Serum zinc levels of leprosy patients and patients with leprosy reactions are lower compared to healthy people, and proinflammatory cytokines including TNF-α, IL-1β and IL-6 play a role in the mechanism of leprosy reactions. Research on the effect of zinc supplementation on leprosy sufferers who have not experienced a reaction has not been done. Objective: To analyze the effect of 40 mg / day dose of zinc sulphate supplementation for 12 weeks on the levels of proinflammatory cytokines levels TNF-α, IL-1β and IL-6 in type MB leprosy patients. Method: This is an experimental study using a randomized control group pretest and posttest design. The study participants were MB patients with 121 patients who did not experience a leprosy reaction, the sample was taken randomly as many as 31 patients as a supplementation group (treatment), and 31 patients as Control group. BMI measurements, food intake by re-call method, Hb level using Hematology Analyzer, serum zinc levels using Atomic Absorption Spectrophotometry (AAS) method, TNF-α, IFN-γ, and IL-1β levels used the ELISA method. Data were analysed using chi-square and t-tests. Results: Zinc sulfate supplementation dose of 40 mg / day for 12 weeks in type MB leprosy patients was able to maintain a decrease in zinc levels of 1.22 pg / dL higher than leprosy patients who did not receive zinc supplementation, reduce levels of IL-1β (p=0.032). However, statistically there is insufficient evidence to reduce levels of TNF-α (p=0.063) and IL-6 (p=0.389) and risk factors. Conclusion: The study confirmed that 40 mg / day supplementation of zinc sulfate for 12 weeks in type MB leprosy patients able to maintain a decrease in serum zinc levels, reduce IL-1β levels. Keywords: Supplementation, Cytokines, Type MB leprosy

scholarly journals Zinc Serum Maternal Levels as a Risk Factor for Preeclampsia

2021 ◽  
Vol 5 (7) ◽  
pp. 693-701
Author(s):  
Abarham Martadiansyah ◽  
Peby Maulina ◽  
Putri Mirani ◽  
Tia Kaprianti ◽  
Theodorus
Keyword(s):  
Pregnant Women ◽  
Dietary Habits ◽  
Serum Zinc ◽  
Zinc Level ◽  
Maternal Serum ◽  
Control Group ◽  
Case Group ◽  
Serum Zinc Level ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background. Preeclampsia is defined as gestational hypertension and proteinuria which can be measured by the elevation of liver transaminases to twice normal concentration, and the symptoms of increased intracranial pressure such as dizziness, blurred vision, and seizures. Zinc is an essential mineral for many biological functions and one of the trace elements that is directly involved in the oxidative/antioxidant balance, a pathogenesis process in preeclampsia that is highly dependent on dietary habits and supplements. This study was aimed to assess the association between serum zinc level with preeclampsia (PE). Methods: This observational, case-control study was performed on 90 women with singleton pregnancies at 28 to 42 weeks of gestation which were referred to the Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin General Hospital, Palembang, between August 2020 to November 2020. 30 pregnant women with PE were selected as cases and 60 healthy pregnant women were selected as controls. Maternal serum zinc samples were collected. The collected data were entered into the master table. Tabulation, coding, and statistical data analysis were performed using SPSS version 20.0 for Windows. Results: The mean serum zinc levels in the case group and control group were 43,90 ± 15,79 µg/dL (ranged from 15 to 86 µg/dL) and 48,77 ± 10,54 µg/dL (ranged from 22 to 83 µg/dL), respectively. A value of serum zinc levels with the best sensitivity and specificity was 45,5 µg/dL. Conclusion: There was a significant association between maternal serum zinc level with PE. The risk of PE was 3,2 times higher in pregnant women with serum zinc levels of ≤45,5 mcg/dL compared to pregnant women with serum zinc levels of >45,5 mcg/dL. In this case it is necessary to supplement zinc earlier in pregnancy to reduce the risk of preeclampsia.

Sign in / Sign up

Export Citation Format

Share Document