scholarly journals Clinical profile and neuropsychological assessment of childhood absence epilepsy: a descriptive study

2018 ◽  
Vol 5 (4) ◽  
pp. 1606 ◽  
Author(s):  
Vindhiya K. ◽  
Viswanathan V. ◽  
Padma Balaji
Keyword(s):  
Neuropsychological Assessment ◽  
Visual Memory ◽  
Tertiary Care ◽  
Absence Epilepsy ◽  
Clinical Profile ◽  
Care Hospital ◽  
Childhood Absence Epilepsy ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Co Morbidity

Background: The objectives of the study was to observe the clinical profile and neuropsychological assessment of childhood absence epilepsy.Methods: Children attending Neurology Department of tertiary care hospital diagnosed with Childhood Absence Epilepsy underwent validated structured proforma. Neuropsychological assessment included IQ, Behaviour and learning disability. Comparison was made between group with mono and dual therapy.Results: Number of children studied was 29 with mean age of 6.24years. 20 (68.9%) children were treated with Sodium Valproate. 9 (31.1%) required add on therapy with Lamotrigine. Seizures were well controlled in all children. Mean IQ derived was 101.6 which mean average IQ.  Mean CBCL was 25.1 indicating increased behavior problems. There was significant co morbidity like Inattentiveness in 18 (62.1%), Inadequate language ability in 14 (48.3%), Inadequate arithmetic ability in 12 (41.4%) and visual memory was Inadequate in 9 (31%).Conclusions: Though Children with Absence Epilepsy has average or above average IQ, it is associated with significant co-morbidity which if addressed early can improve the long-term outcome. IQ and behavior has statistically significant association with the numbers of drugs.

Clinical Profile and Short-Term Outcome of Neonatal Seizures in a Tertiary Care Hospital, Kuppam – A Retrospective Study

2021 ◽  
Vol 8 (27) ◽  
pp. 2381-2386
Author(s):  
Poojitha Kancherla ◽  
Harsha P.J. ◽  
Gowtham R. ◽  
Dowlath Anwar Basha ◽  
Chandran G.P ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Clinical Profile ◽  
Hypoxic Ischemic Encephalopathy ◽  
Care Hospital ◽  
Neonatal Seizures ◽  
Metabolic Disturbances ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome ◽  
Ischemic Encephalopathy

BACKGROUND Neonates presenting with seizures require long term stay in hospital and have higher chances of neuro-developmental delay later. Seizures in neonates are mostly subtle and difficult to diagnose. We wanted to study the clinical profile and short-term outcome on term and later pre-term neonates presenting with seizures. METHODS The study was a retrospective observational study done from November to December 2020 at PES Hospital, Kuppam. Retrospective data of neonatal seizures from May 2019 to April 2020 was considered for study. Details from the case records of neonates with seizures was collected. RESULTS Neonatal seizures (NS) were most common in females (53.8 %, 72/134). Subtle seizures were most common form of seizures in neonates which was seen in 64.2 % (86/134) babies followed by tonic seizures in 22.4 % (30/134). Neonatal seizures were most commonly seen in babies with hypoxic ischemic encephalopathy in 63.4 % (85/134) followed by metabolic disturbances in 15.6 % (21/134) and meningitis in 13.5 % (18/134). In babies with hypoxic ischemic encephalopathy, metabolic and meningitis subtle seizures were observed to be more common. Seizures were seen most commonly in first 72 hours of life (82.85 %, 111/134). Seizures in babies with hypoxic ischemic encephalopathy, metabolic causes most commonly occurred within first 24 hours of birth. Seizures in babies with meningitis most commonly occurred after 7 days of birth. Babies with neonatal seizures with sequelae was seen in 17.96 % (24/134) and 11.94 % babies died (16/134). CONCLUSIONS Subtle seizures were most common form and hypoxic ischemic encephalopathy was most common risk factor. Most neonatal seizures present within 72 hours of birth. Babies with meningitis presented with seizures most commonly after 72 hours of birth. KEYWORDS Hypoxic Ischemic Encephalopathy, Neonatal Seizures, Newborn, Aetiology, Outcome

scholarly journals Clinical profile of patients of acute pulmonary thromboembolism

2019 ◽  
Vol 6 (4) ◽  
pp. 1089
Author(s):  
Arundhati Diwan ◽  
Supriya Barsode ◽  
Chandrakant Chavan ◽  
Rohit Jakhotia ◽  
Krishnapriya Vadlapatla
Keyword(s):  
Pulmonary Embolism ◽  
Risk Factor ◽  
Mortality Rate ◽  
Tertiary Care ◽  
Pulmonary Angiography ◽  
Clinical Profile ◽  
Care Hospital ◽  
Male Predominance ◽  
Co Morbidity ◽  
History Of

Background: Pulmonary embolism is a common and potentially life threatening condition. Most patients who succumb to pulmonary embolism do so within the first few hours of the event. The aim of the study was to observe the clinical profile, management and outcome in patients of pulmonary embolism.Methods: A prospective observational study was conducted in the Department of Medicine in a Tertiary care hospital in Western Maharashtra for a period of two years. 55 patients with confirmed diagnosis on CTPA (Computed tomography pulmonary angiography) were included in our study. A detailed history, examination and investigations like D dimer were done in all cases.Results: Mean age of the study cases was 44.98 years with 40% of the cases between 31-50 years of age. Overall male predominance was seen (83.6%). Most common associated co-morbidity was diabetes (32.7%). The commonest risk factor seen in the present study was history of smoking (29.1%). Dyspnoea was the most common presenting complaint (72.7%). Commonest presenting sign was tachycardia (43.6%). In present study, mortality rate among cases of pulmonary embolism was observed as 3.6%..Conclusions: Mean age of the study cases was 44.98 years with 40% of the cases between 31-50 years of age. Overall male predominance was seen (83.6%). Most common associated co-morbidity was diabetes (32.7%). The commonest risk factor seen in the present study was history of smoking (29.1%). Dyspnoea was the most common presenting complaint (72.7%). Commonest presenting sign was tachycardia (43.6%). In present study, mortality rate among cases of pulmonary embolism was observed as 3.6%.

Long-term outcome of childhood absence epilepsy: Dutch Study of Epilepsy in Childhood

2009 ◽  
Vol 83 (2-3) ◽  
pp. 249-256 ◽  
Author(s):  
Petra M.C. Callenbach ◽  
Paul A.D. Bouma ◽  
Ada T. Geerts ◽  
Willem Frans M. Arts ◽  
Hans Stroink ◽  
...  
Keyword(s):  
Absence Epilepsy ◽  
Childhood Absence Epilepsy ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Dutch Study

scholarly journals Long term outcome of Wilms' tumor in tertiary care hospital

2020 ◽  
Vol 7 (10) ◽  
pp. 3234
Author(s):  
Jeevarathi T. ◽  
Gomathi Vadivelu
Keyword(s):  
Wilms Tumor ◽  
Tertiary Care ◽  
Fumarate Hydratase ◽  
Stage I ◽  
High Rate ◽  
Stage Iii ◽  
Care Hospital ◽  
Term Outcome ◽  
Long Term Outcome

Background: Nephroblastoma, or Wilms’ tumor, is an embryonal tumor that develops from remnants of the immature kidney. It is the most common renal tumor of childhood. The aim is to analyze the long term outcome in Wilms’ tumor in perplex situations as double moiety and to correlate with multiple organ defects.Methods: It is a combined perspective and retrospective study that pediatric urology outpatient department (OPD) at the Institute of Child Health and Hospital for Children, Madras Medical College, Chennai. The study included patients with Wilms, who attended the pediatric surgery during the ten years, from March 2008 to February 2011. The patients were subjected to detailed clinical examination and relevant investigations were performed.Results: Among patients with stage I–II fumarate hydratase (FH) tumors, the relative risk (RR) of relapse and death were increased for loss of heterozygosity (LOH) 1p only (RR=2.2 for relapse; RR=4.0 for death), for LOH 16q only (RR=1.9 and RR=1.4), and LOH for both regions (RR=2.9 and RR=4.3) in comparison with patients lacking LOH at either locus.Conclusions: Stage I and II have a good prognosis. Stage III and IV need close surveillance since they have a high rate of recurrence. Stage V has a bad prognosis. Stage IV Wilms need lung irradiation. Neoadjuvant chemotherapy reduces tumor spillage in stage III and IV. 

PREVALENCE AND CLINICAL PROFILE OF FUNCTIONAL CONSTIPATION IN CHILDREN WITH PERSISTENT GASTROINTESTINAL SYMPTOMS

2021 ◽  
pp. 30-32
Author(s):  
Sushma Keshav ◽  
Santosh Kondekar
Keyword(s):  
Tertiary Care ◽  
Gastrointestinal Symptoms ◽  
Growth Failure ◽  
Functional Constipation ◽  
Abdominal Distension ◽  
Care Hospital ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Female Ratio ◽  
Abdominal Symptoms

Background: Constipation is a common pediatric problem worldwide affecting the quality of life of children and parents. But only few children with constipation seek medical help. Alonger duration of constipation before diagnosis has been associated with complications like malnutrition, changes in behavior and growth failure and poorer long-term outcome. Methods: Children up to 12 years of age presenting to the Pediatric outpatient of a tertiary care hospital with persistent abdominal symptoms were enrolled over a period of one year. Their clinical prole was recorded and analyzed. Prevalence of functional constipation was calculated as a percentage and the association of persistent abdominal symptom with constipation was studied. Results: Amongst the 500 children studied, 84 were found to have functional constipation according to ROME IV criteria, the prevalence being 16.8%. Demographically, the mean age for cases with functional constipation was 5.19 years and the male female ratio was 1.6:1. Abdominal symptoms that were signicantly associated with functional constipation were hard stools (p 0.0001), fussy eaters (p 0.0072), abdominal distension (p 0.0053), pain abdomen (p 0.03) and decreased appetite (p0.0305). The common treatment received by these children were lactulose in 27 (32.24%), diet modication in 20 (23.8%), enema in 07 (08.33%), polyethylene glycol in 05 (05.95%) and least common was glycerin suppositories in 3 (03.57%). Conclusion: To conclude, persistent abdominal symptoms in children cannot be neglected and functional constipation must be evaluated in children coming to the outpatient with persistent abdominal symptoms.

scholarly journals Clinical profile and outcome of children admitted with acute encephalitis syndrome

2020 ◽  
Vol 8 (1) ◽  
pp. 60
Author(s):  
Arpita Adhikari ◽  
Mona Gajre ◽  
Rini Kothari ◽  
Nayan Chaudhari ◽  
Deepali Sangale
Keyword(s):  
Tertiary Care ◽  
Case Definition ◽  
Clinical Profile ◽  
Abnormal Behavior ◽  
Care Hospital ◽  
Term Outcome ◽  
Mortality And Morbidity ◽  
Acute Encephalitis Syndrome ◽  
Acute Encephalitis ◽  
Wide Range

Background: Acute encephalitis syndrome (AES) is an important cause of mortality and morbidity in children. We undertook this study for better understanding of clinical profile and outcome of AES in our settings.Methods: It was a prospective observational study. We studied 15 patients of AES admitted in a tertiary care hospital from December 2016 to May 2017. For investigating AES cases, WHO case definition was adopted. Clinically a case of AES is defined as fever or recent history of fever with change in mental status (including confusion, disorientation, coma, or inability to talk) and/or new onset of seizures (excluding simple febrile seizures). Other early clinical findings could include an increase in irritability, somnolence or abnormal behavior greater than that seen with usual febrile illness. We evaluated their clinical characteristics and outcomes at the time of discharge.Results: Fever, altered sensorium, seizures and headache were the most common symptoms observed in this study. Among 15 cases of AES patients, 6 (40%) recovered completely, while 5 (33.33%) cases had neurological sequelae with a wide range of severity varying from mild to severe at the time of discharge, 4 (26.66%) patient died in the hospital.  Conclusions: This study offers a description of the present etiology, clinical presentation and short-term outcome of AES. Use of mechanical ventilation, lower Glasgow coma score, and concurrent seizures are predictors for a poor outcome. Reporting and appropriate workup of all cases would strengthen the AES surveillance and help in reducing the morbidity and mortality due to this disorder.

scholarly journals Efficacy of preoperative chemoradiotherapy in downstaging rectal cancer and its impact on the long-term outcome

2019 ◽  
Vol 08 (02) ◽  
pp. 098-101
Author(s):  
Janaki Gururajachar Manur ◽  
Rahil Bharatbhai Patel ◽  
Sathish Chandramouli
Keyword(s):  
Rectal Cancer ◽  
Tertiary Care ◽  
Disease Status ◽  
Complete Response ◽  
Preoperative Chemoradiotherapy ◽  
Care Hospital ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Tumor Downstaging

Abstract Introduction: Response to preoperative chemoradiation (PRTCT) for rectal cancer predicts the long-term outcome. Context: Tertiary care hospital. Aims: The aim is to study the factors affecting the response to chemoradiation. Settings and Design: Retrospective. Materials and Methods: Twenty-three patients of rectal cancer undergoing PRTCT followed by surgery and adjuvant chemotherapy were followed up for 20–56 months. Postoperative response, tumor downstaging and nodal downstaging were correlated with the disease status. Results: Tumor downstaging was seen in 11 (50%) and nodal downstaging in 12 (63.15%) patients. Nodal downstaging was statistically significant with P = 0.004. Pathological complete response (PCR) was seen in one patient and partial response (PR) in 17 patients. Thirteen (72.2% of patients) were alive and disease free and the negative nodal status correlated with long-term control with P = 0.04. Conclusion: Most patients of rectal cancer show PR to PRTCT, and the benefit is more for node-positive patients. Nodal PCR is associated with a higher chance of long-term disease control.

Long-Term Outcome of Facial Growth after Functional Endoscopic Sinus Surgery

2002 ◽  
Vol 126 (6) ◽  
pp. 628-634 ◽  
Author(s):  
Marcella R. Bothwell ◽  
Jay F. Piccirillo ◽  
Rodney P. Lusk ◽  
Brock D. Ridenour
Keyword(s):  
Statistical Significance ◽  
Tertiary Care ◽  
Sinus Surgery ◽  
Care Hospital ◽  
Facial Growth ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Facial Plastic

OBJECTIVE: We sought to determine whether functional endoscopic sinus (FES) surgery performed in children with chronic rhinosinusitis alters facial growth. STUDY DESIGN AND SETTING: This was a retrospective age-matched cohort outcome study performed at a tertiary care hospital. RESULTS: Sixty-seven children participated. There were 46 boys and 21 girls, and the mean age was 3.1 years at presentation and 13.2 years at follow-up. There were 46 children who underwent FES surgery and 21 children who did not undergo FES surgery. Quantitative anthropomorphic analysis was performed using 12 standard facial measurements. A facial plastic expert performed qualitative facial analysis. Both quantitative and qualitative analyses showed no statistical significance in facial growth between children who underwent FES surgery and those who did not undergo FES surgery. CONCLUSIONS: In this study, there was no evidence that FES surgery affected facial growth. SIGNIFICANCE: These results will aid physicians when discussing with parents the risks of FES surgery.

Sign in / Sign up

Export Citation Format

Share Document