Clinical profile of patients of acute  pulmonary thromboembolism

Background: Pulmonary embolism is a common and potentially life threatening condition. Most patients who succumb to pulmonary embolism do so within the first few hours of the event. The aim of the study was to observe the clinical profile, management and outcome in patients of pulmonary embolism.Methods: A prospective observational study was conducted in the Department of Medicine in a Tertiary care hospital in Western Maharashtra for a period of two years. 55 patients with confirmed diagnosis on CTPA (Computed tomography pulmonary angiography) were included in our study. A detailed history, examination and investigations like D dimer were done in all cases.Results: Mean age of the study cases was 44.98 years with 40% of the cases between 31-50 years of age. Overall male predominance was seen (83.6%). Most common associated co-morbidity was diabetes (32.7%). The commonest risk factor seen in the present study was history of smoking (29.1%). Dyspnoea was the most common presenting complaint (72.7%). Commonest presenting sign was tachycardia (43.6%). In present study, mortality rate among cases of pulmonary embolism was observed as 3.6%..Conclusions: Mean age of the study cases was 44.98 years with 40% of the cases between 31-50 years of age. Overall male predominance was seen (83.6%). Most common associated co-morbidity was diabetes (32.7%). The commonest risk factor seen in the present study was history of smoking (29.1%). Dyspnoea was the most common presenting complaint (72.7%). Commonest presenting sign was tachycardia (43.6%). In present study, mortality rate among cases of pulmonary embolism was observed as 3.6%.

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A prospective study of peripheral arterial diseases in chronic kidney disease patient attending tertiary care hospital Andhra Pradesh

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20212410 ◽

2021 ◽

Vol 8 (7) ◽

pp. 974

Author(s):

Ramswarup K. Jawaharlal ◽

Vamsi Krishna Mootha

Keyword(s):

Chronic Kidney Disease ◽

Risk Factor ◽

Kidney Disease ◽

Tertiary Care ◽

Ankle Brachial Index ◽

Disease Patient ◽

Care Hospital ◽

Male Predominance ◽

Peripheral Arterial Diseases ◽

History Of

Background: Around 10% populations worldwide develop chronic kidney disease and two million people require frequent dialysis due to it1. Cardiovascular diseases related complications are more common in chronic kidney patients and responsible for greater morbidity and mortality. This study is designed to determine the peripheral artery disease in patients with chronic kidney disease in our clinical setup and risk factor associated with them.Methods: In present study 140 patients with chronic kidney disease were enrolled for this study. Demographic profile of each patient was recorded. Detailed history of patients regarding claudication was taken. Ankle-brachial index was calculated in each patient with CKD for diagnosis of PAD based on American heart association guideline.Results: There was male predominance. History of smocking was present in 80 (57.14%) patients and absent in 60 (42.85%) patients. Symptom of PAD was present in 28 (20%) patients and absent in 114(80%) patients. Ankle-Brachial Index was positive in 38(27.14%) patients and absent in 102 (72.85%) patients. 80 (57.14%) patients were in stage 3 and 24 (17.14%) patients were in stage 4. Diabetes mellitus was present in 26 (18.57%) patients, Hypertension was present in 64 (45.71%), IHD was present in 22 (15.71%) remaining have no risk factor.Conclusions: From present study we can conclude that PAD was common in CKD patients more than 50 years of age and here is male predominance. It is more common in smoker and in most of the patients it was asymptomatic. Prevalence of PAD was 27.14% in CKD patients. In our study PAD was more common in stage 3 CKD and least common in stage 2, and cardiovascular risk factor was more common in PAD patients then CKD in general.

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Clinical Profile of Haemophilia In Children in A Tertiary Care Hospital

Bangladesh Journal of Child Health ◽

10.3329/bjch.v37i2.17266 ◽

2013 ◽

Vol 37 (2) ◽

pp. 90-96 ◽

Cited By ~ 3

Author(s):

MA Karim ◽

R Siddique ◽

CY Jamal ◽

A Islam

Keyword(s):

Neonatal Period ◽

Severe Disease ◽

Tertiary Care ◽

Clinical Profile ◽

Haemophilia A ◽

Care Hospital ◽

Initial Manifestation ◽

Haemophilia B ◽

Pediatric Hematology ◽

History Of

Introduction : Haemophilias are the most common inherited coagulation disorders transmitted by X- linked recessive fashion affecting the males and females are the carriers of the disease. Haemophilias are distributed worldwide and have heterogeneous presentation depending upon its severity starting from neonatal period. Knowledge of spectrum of presentation of haemophilia helps in early diagnosis and planning of management. Objectives : To observe the clinical presentation of haemophilia in children Methodology : This observational study was carried out in the Department of Pediatric Hematology and Oncology, Bangabandhu Sheikh Mujib Medical University for a period of one year from 1st July 2007 to 30th June 2008. Clinical profile of 50 diagnosed cases of haemophilia <15 years of age was analyzed. Result: All the 50 cases of haemophilia were male. Mean age of the patients was 6.62±3.87 years with an age range of 6 months to 14 years. Forty (80%) cases were haemophilia A and 10 (20%) cases were Haemophilia B. Only 40% cases had family history of bleeding. Among the Haemophilia A, 52.5% cases had mild, 47.5% cases had moderate disease and among the Haemophilia B, 40% cases had mild, 50% cases had moderate and 10% cases had severe disease. Heamarthrosis of knee joint was the major presentation followed by oral cavity bleeding, bleeding following tooth extraction and circumcision. Sixty two percent cases had initial bleeding episode before 1 year of age and by 5 years of age 94% of cases had produced symptoms. No patient had history of bleeding during neonatal period. Bruises and hematoma were the most common initial manifestation followed by joint bleeding, cut injury of lips and chin, scalp and facial hematoma. Conclusion: Bruises, hematoma and joint bleeding either spontaneous or after trauma were the main feature at initial presentation of haemophilia in children, so presence of these features in an otherwise normal child should be considered for evaluation of haemophilia. More vigilance is to be needed for detection of haemophilia in newborn. DOI: http://dx.doi.org/10.3329/bjch.v37i2.17266 BANGLADESH J CHILD HEALTH 2013; VOL 37 (2) : 90-96

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A PROSPECTIVE STUDY OF CLINICAL PROFILE OF STROKE IN A TERTIARY CARE HOSPITAL

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2016.v9s3.13622 ◽

2016 ◽

Vol 9 (9) ◽

pp. 178 ◽

Cited By ~ 1

Author(s):

Sattanathan K ◽

Chachu Kuriakose ◽

Naseem Shifafiya M ◽

Nelta S Tharakan ◽

Sambath Kumar R

Keyword(s):

Low Socioeconomic Status ◽

Parietal Lobe ◽

Tertiary Care ◽

Underlying Disease ◽

Clinical Profile ◽

Periventricular White Matter ◽

Care Hospital ◽

Circadian Pattern ◽

Average Delay ◽

Male Predominance

ABSTRACTObjective: The objective of the work was to study the clinical profile of stroke in a tertiary care hospital.Methods: A prospective observational study on stroke was carried out for a period of 6-month (May 2015 to October 2015). A total of 241 inpatientsfrom Shri Preethi Hospital were incorporated in the study. The data were collected and evaluated by reviewing case files and patient interview.Result and Conclusion: Out of 241 patients, an incidence of ischemic stroke was found to be higher. The occurrence of stroke steeply rises with agewith male predominance. The burden of stroke tends to be more in rural, illiterate, and low socioeconomic status population. The study reveals riskfactors such as sedentary lifestyle, previous and family history of stroke, underlying disease like hypertension, diabetes. The circadian pattern in onsetshowed a significant peak in morning (6 am-12 pm) for Ischemic and afternoon (12 pm-6 pm) for hemorrhagic stroke. Topographic distribution ofcerebral infract and hemorrhage was found to be in parietal lobe and periventricular white matter, respectively. Mostly prescribed medication forischemic and hemorrhagic patients was antihypertensive and mannitol, respectively. The contraindication for thrombolytic therapy was found to below economic status and average delay in time of presentation to hospital. The study highlights the need for aggressive management of traditionalrisk factors, need for extensive work up in patient to find etiologies and need for more active interventions in community for the prevention of stroke.Keywords: Ischemic, Hemorrhagic, Circadian pattern, Antihypertensive.

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Overview of 254 mild cases of COVID-19 in Bangladeshi cohort: a cross-sectional observation

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20211896 ◽

2021 ◽

Author(s):

Tahmina Zahan ◽

Morshed Nasir ◽

Rawshan Ara Perveen ◽

Afzal Akhtar ◽

A. F. M. Mohibur Rahman ◽

...

Keyword(s):

Platelet Count ◽

Large Scale ◽

Tertiary Care ◽

Care Hospital ◽

Male Predominance ◽

Neutrophil Lymphocyte Ratio ◽

Prognostic Features ◽

Lymphocyte Ratio ◽

Co Morbidity ◽

D Dimer

Background: The first recognition of a cluster of COVID-19 patients in China in late 2019, has become a major concern due to its greater transmissibility and vulnerability of the patient to turn to fever, cough, breathlessness, pneumonia then eventually severe acute respiratory distress syndrome requiring intensive care unit (ICU) support. But most of the affected patients get cured following mild symptoms and very only a few of them get hospitalized. The objective of the study was to observe the demographic characteristics, clinical symptoms, comorbidities, and biomarkers (hematological, inflammatory, hepatic, renal, and metabolic) of mild cases of COVID-19 infected patients admitted to the hospital during the peak four months of the pandemic.Methods: Age, sex, symptoms, comorbidities, and biomarkers (Hb%, WBC, lymphocyte, neutrophil, platelet count, HCT(hematocrit), NLR(neutrophil-lymphocyte ratio, d-NLR derived neutrophil-lymphocyte ratio, PLR(platelet-lymphocyte-ratio), d-Dimer, ferritin, CRP(C-reactive protein), PT(prothrombin time), INR(international normalized ratio), SGPT, S.creatinine, HbA1C of all rt-PCR positive mild cases were recorded in this retrospective observational study in a tertiary care hospital dedicated to COVID-19 at Dhaka, Bangladesh was done from 15th May to 9th September, 2020. Age, sex, symptoms, and comorbidities were compared by chi-square test and biomarkers were compared by one-way ANOVA. Results: Out of 254 cases 44 were female and 210 were male with a ratio of 1:4.77. Average age was 39.04. Largest population belongs to the 30-39 years of age range. Among the symptoms, anorexia (18.5%), fever (17.71%), and anosmia (16.9%) were most prevalent symptoms among the mild cases. However, diabetes mellitus (DM) and hypertension (HTN) were predominant comorbidities. Mostly all the biomarkers were significant among groups (Hb%, Total WBC, neutrophil count, platelet count, HCT, NLR, d-NLR, d-Dimer, ferritin, CRP, PT, SGPT, creatinine, HbA1C except lymphocyte count, PLR, and INR. The severity of disease progression depends on the co-morbidity and hyper-responsiveness inflammatory or immunological biomarkers to predict.Conclusions: In mild cases of COVID-19 male predominance was more and the most affected group was 30-39 years. They suffered more from anorexia and fever and DM and HTN were common comorbidities. Mostly all the biomarkers were significant. Moreover, further large-scale studies are needed to evaluate the number of mild cases and their prognostic features to develop and modify the treatment strategy and public health awareness time to time.

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Clinical profile and neuropsychological assessment of childhood absence epilepsy: a descriptive study

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20182573 ◽

2018 ◽

Vol 5 (4) ◽

pp. 1606 ◽

Cited By ~ 1

Author(s):

Vindhiya K. ◽

Viswanathan V. ◽

Padma Balaji

Keyword(s):

Neuropsychological Assessment ◽

Visual Memory ◽

Tertiary Care ◽

Absence Epilepsy ◽

Clinical Profile ◽

Care Hospital ◽

Childhood Absence Epilepsy ◽

Term Outcome ◽

Long Term Outcome ◽

Co Morbidity

Background: The objectives of the study was to observe the clinical profile and neuropsychological assessment of childhood absence epilepsy.Methods: Children attending Neurology Department of tertiary care hospital diagnosed with Childhood Absence Epilepsy underwent validated structured proforma. Neuropsychological assessment included IQ, Behaviour and learning disability. Comparison was made between group with mono and dual therapy.Results: Number of children studied was 29 with mean age of 6.24years. 20 (68.9%) children were treated with Sodium Valproate. 9 (31.1%) required add on therapy with Lamotrigine. Seizures were well controlled in all children. Mean IQ derived was 101.6 which mean average IQ. Mean CBCL was 25.1 indicating increased behavior problems. There was significant co morbidity like Inattentiveness in 18 (62.1%), Inadequate language ability in 14 (48.3%), Inadequate arithmetic ability in 12 (41.4%) and visual memory was Inadequate in 9 (31%).Conclusions: Though Children with Absence Epilepsy has average or above average IQ, it is associated with significant co-morbidity which if addressed early can improve the long-term outcome. IQ and behavior has statistically significant association with the numbers of drugs.

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Clinical and biomarker profile of COVID-19 patients admitted in a tertiary care hospital

Biomedicine ◽

10.51248/.v41i2.794 ◽

2021 ◽

Vol 41 (2) ◽

pp. 268-273

Author(s):

Archana Bhat ◽

Don Gregory Mascarenhas ◽

J Manjunath ◽

Anand Kumar R ◽

Sucharitha Suresh ◽

...

Keyword(s):

Disease Severity ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Clinical Signs ◽

Signs And Symptoms ◽

Care Hospital ◽

Male Predominance ◽

Co Morbidity ◽

Clinical Signs And Symptoms ◽

D Dimer

Introduction and Aim:A novel beta-coronavirus emerged in Wuhan, China during the early December 2019 and spread globally. The clinical signs and symptoms and the disease severity in people infected with COVID-19 can be varied. The present study was conducted to study the biomarker profile and their association with disease severity in COVID-19. Materials and Methods:This was a single-centre Cohort study of data regarding epidemiological, clinical and biomarker parameters, and outcome of COVID-19 patients admitted in a tertiary care hospital in South India. CDC guidelines were followed for assessing disease severity. Results:A total of 336 COVID-19 patients were admitted during the study period. Of these 16 were excluded and 320 cases were analysed. Mean age of patients was 44.82 years. A male predominance was observed. Diabetes mellitus was the most common co-morbidity. Asymptomatic, Mild, moderate, severe and critical disease was seen in 15%, 52.5%, 20.3%, 6.3% and 5.9% patients respectively. ICU care was required in 15.3%. Overall mortality was 5.3%. The mean NLR, ALC, CRP, LCR, LDH, Ferritin and D-dimer in the severe group vs non-severe groupwere19.03 vs 4.2, 1025cells/cumm vs 1740cells/cumm, 185.8mg/L vs 31.7mg/L, 17.1 vs 996.3, 552.8IU/L vs 252.7IU/L, 2531.9ng/ml vs 414.1ng/ml and 2245.5ng/ml vs 339.4ng/ml respectively. Conclusion:An increased NLR, CRP, LDH, Ferritin and D-dimer and a reduced ALC and LCR are significantly associated with disease severity, need for ICU and mortality. These biomarkers will be useful adjunct to clinical assessment in better categorising and management of COVID-19 patients.

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Clinical profile of acne vulgaris: an observational study from a tertiary care institution in Northern Kerala, India

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20192135 ◽

2019 ◽

Vol 5 (3) ◽

pp. 476

Author(s):

Jisy S. Raghavan ◽

Sharim Fathima ◽

Suhaiba Ameera ◽

Kunnummal Muhammed

Keyword(s):

South India ◽

Acne Vulgaris ◽

Tertiary Care ◽

Clinical Profile ◽

Common Disease ◽

Care Hospital ◽

Medical College ◽

History Of ◽

Grade 3 ◽

Epidemiological Profile

Background: Acne is one of the most common disease affecting adolescence. Although prior studies have evaluated epidemiologic patterns of acne in different ethnicities and regions, literature is lacking from this part of the country. The objectives of the study were to delineate the clinical and epidemiological profile of acne vulgaris in a population from northern Kerala in South India.Methods: The study was carried out for 6 months and it included 100 patients. Epidemiology including pattern, aggravating factors, seasonal variation, diet, smoking, markers of androgenecity and associations were evaluated in all newly diagnosed cases of acne vulgaris who attended the outpatient department in Kannur Medical College, Kannur, Kerala, India from January 2018 to June 2018.Results: Out of 100 patients females (74%) outnumbered males (26%) and although the majority affected belonged to the age group of 21-25 years (38%), adult acne was observed in 28%. Grade 3 acne was the commonest (44%), followed by grade 2 (30%) and grade 4 (18%). Face was affected in all patients with cheeks (91%), followed by forehead (72%), mandible (36%) and chin (28%) and trunk (23%). Scarring was found in 34% and pigmentation in 40%. Family history of acne was observed in 33%.Conclusions: This study brings out the clinical profile of acne in a tertiary care hospital in South India.

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Clinical Profile of Acute Cerebrovascular Accidents

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i47b33219 ◽

2021 ◽

pp. 966-973

Author(s):

R. M. Bala Ashwathy ◽

N. Deepthi

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Dietary Habits ◽

Tertiary Care ◽

Clinical Profile ◽

Care Hospital ◽

Cerebrovascular Accidents ◽

Risk Factor Management ◽

Associated Risk Factors ◽

A Prospective Study

Background: Acute cerebrovascular disease or stroke is one of the most leading causes of morbidity and mortality. Due to change in dietary habits and life style factors, there is increase in co-morbid conditions like diabetes and hypertension. This in turn increases the risk for developing stroke. Aim: To study the cerebrovascular accident patients by analyzing and comparing their clinical profile. Materials and Methods: A prospective study was conducted in a tertiary care hospital in stroke patients. The type of stroke, associated risk factors and prognosis of the patients were studied. Results: A total of 50 patients were included in the study, for a period of 4 months from January 1, 2021 to April 30, 2021. Both male and female were included in the study. The mean age of the patients was 56.86 years. Thrombotic stroke was the most common (50%) followed by embolic and hemorrhagic stroke. Hypertension was the most commonly associated risk factor (80%), followed by diabetes (60%), smoking (52%), dyslipidemia (34%) and alcohol (28%). The comparatively higher incidence of cerebrovascular accidents in age less than 60 years is attributed to the rise in risk factors in the young age (P<0.05). The average duration of hospitalization was 6.58 days. There is no in-hospital mortality. Conclusion: With prevalence of risk factors on rise, younger individuals are also affected. Proper risk factor management will help in preventing stroke and its recurrence.

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Study of clinical profile of tuberculosis patients admitted in respiratory medicine ward at a tertiary care hospital in Marathwada

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20180003 ◽

2018 ◽

Vol 5 (1) ◽

pp. 68

Author(s):

Rakesh B. Bilagi ◽

Hafiz Deshmukh

Keyword(s):

Retrospective Study ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Clinical Profile ◽

Care Hospital ◽

Female Ratio ◽

Tuberculosis Patients ◽

Male Predominance ◽

Male Female Ratio ◽

One Year

Background: Tuberculosis is one of the most important cause of most of the respiratory diseases. It is estimated that about one-third of the world's population is infected with mycobacterium tuberculosis. It is important to know about the clinical profile of these patients. There are many studies which are done among OPD patients but fewer among indoor patients hence, the current study was planned.Methods: Retrospective study of the patients admitted in the inpatient department of the study area were taken as the sample size from May 2016 to April 2017, who were diagnosed as TB patients.Results: a retrospective study was conducted among admitted patients, which included data of one year. There was male predominance with male: female ratio of 2.89. major cause of admission was extrapulmonary causes. The HIV patients were more predisposed to extrapulmonary and diabetes than pulmonary tuberculosis.Conclusions: There is male predominance for admission cases. There is also increased cases of extrapulmonary TB admitted than pulmonary cases.

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Etiology, outcomes and co-morbidities among cerebral palsy children attending tertiary care hospital, India: a prospective study

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20191437 ◽

2019 ◽

Vol 6 (3) ◽

pp. 1023

Author(s):

N. Dushyanth Subramaniam ◽

Antony Jenifer ◽

Uma Devi L. ◽

Suresh P.

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Cerebral Palsy ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Birth Asphyxia ◽

Care Hospital ◽

Maternal Risk ◽

Prolonged Labour ◽

History Of

Background: Cerebral palsy is the most common aetiology for motor dysfunction among children worldwide. It is associated with range of co-morbid conditions that affects the quality of life. Cerebral palsy has been studied extensively in western countries and there are only few articles available on epidemiological information in developing countries and low resource settings. This study focuses on the aetiology, risk factors, types and co-morbidities in cerebral palsy.Methods: Cerebral palsy children attending tertiary care hospital were prospectively recruited into the study. The study was conducted during January 2017 to July 2018. The cross-sectional study included complete prenatal, natal and postnatal history of the participants, BERA and Ophthalmological examinations were done.Results: One hundred and fifty children with cerebral palsy were enrolled. The mean age of participants were 36±30 months. Male to female ratio was 2.19:1. The most common maternal risk factor among study participants was consanguinity in marriage (23.33%). 16% had prolonged labour and 10% had toxaemia during pregnancy. 47% of the children were born by institutional normal vaginal delivery. The most common neonatal risk factor was Birth Asphyxia (23%), low birth weight (20%) and neonatal sepsis (21%). 122 had spastic type of cerebral palsy. The most common morbidity associated with cerebral palsy was Gastro intestinal disturbances in 61% of the participants.Conclusions: History of prolonged labour and birth asphyxia were risk factors for cerebral palsy. Spastic CP is the most common type. Malnutrition, Gross Motor delay, Seizures, Mental retardation were the most common morbidities associated with CP.

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