scholarly journals Angiopoietin 2 in type 2 diabetes mellitus patients and those with complications: an observational comparative study

2020 ◽  
Vol 7 (5) ◽  
pp. 733
Author(s):  
Kishan Raj K.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Study Groups ◽  
Diabetic Patients ◽  
Duration Of Diabetes ◽  
Angiopoietin 2

Background: Angiopoietin 2 levels in blood signifies neo vascularization. Only biomarker available now for routine check up is HbA1c. However, it doesn’t suggest if patient is more prone to get into complications than the other. Here, we try to bring in another biomarker Angiopoietin 2 and elucidate if it can identify patients going in for complications of type 2 diabetes mellitus early.Methods: Total 60 diabetic patients were studied over a span of 1 year. 30 were diabetic without any complciations and another 30 were with complications (Diabetic foot ulcer, Diabetic retinopathy, Diabetic nephropathy, Diabetic neuropathy). Angiopoietin 2 levels were estimated in both the groups and compared.Results: Analysis showed Mean duration of Diabetes was significantly lower in patients without complication than those with complications. Human angiopoietin 2 levels were elevated in both the study groups. More so, in the study group with Diabetic patients with complications. It was statistically significant. (p<0.001).There was no significant relationship between duration of diabetes and Human angiopoietin 2 levels.Conclusions: It was found that angiopoietin 2 is also a good biomarker for diabetes as HbA1c. It also helps in detection of complications earlier and thus may help in reducing morbidity as well as mortality. Further studies are required to strengthen the information got from this study to compare efficacy of HbA1c and angiopoietin 2 as well as how early can we detect the patients who may land up in complications. 

scholarly journals Comparison Pai-1 Level in Type 2 Diabetes Mellitus with and Without Diabetic Foot Ulcer

2018 ◽  
Vol 1 (1) ◽  
pp. 1-5
Author(s):  
Alfi Dewi Sholat ◽  
Dairion Gatot ◽  
Savina Handayani ◽  
Andri Iskandar Mardia ◽  
Santi Syafril
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Diabetic Patients ◽  
Significant Difference ◽  
Pai 1

In type 2 diabetes mellitus, there are changes in hemostasis components, including overexpression of PAI-1. By these facts, the authors are interested in conducting the study of PAI-1 level in diabetic patients with and without foot ulcer. Methods: The sample of this research was collected cross-sectionally on 20 type 2 diabetic patients with foot ulcer and 20 without foot ulcer. Blood samples were taken to measure serum PAI-1 level, complete blood count and hemostasis screening test. Results: Statistical analysis showed there are significant differences in hemoglobin, trombosit, Fibrinogen and D-dimer levels in the ulcer and non-ulcer groups but no significant difference in PAI-1 level. Conclusions: No higher PAI – 1 level were found in diabetic foot ulcer group than those without diabetic foot ulcer. There was no significant difference between PAI-1 level and grade of diabetic foot ulcer.

scholarly journals The result of treadmill test in asymptomatic type 2 diabetes mellitus

2017 ◽  
Vol 3 (6) ◽  
pp. 166 ◽  
Author(s):  
Anil Shrinivasrao Joshi ◽  
Chandrakant Gunaji Lahane ◽  
Akshay Arvind Kashid
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Early Detection ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Duration Of Diabetes ◽  
Asymptomatic Patients ◽  
Cardiovascular Morbidity And Mortality

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">To study the prevalence of silent myocardial ischaemia in asymptomatic patients with type 2 DM</span>.</p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">The present study was conducted in the Govt. Medical College and Hospital Aurangabad. During December 2012 to November 2014 with 50 patients. It was two year cross sectional study with the patients of asymptomatic type 2 diabetes mellitus without clinical and electrocardiographic evidence of coronary artery disease. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">12 (24%) out of 50 subjects had positive TMT. It correlated with years of duration of diabetes (9 positive TMT cases with duration of diabetes more than 10 years). 5 (25%) out of 20 had serum cholesterol levels &gt;240, Number of positive TMT were higher in patients with LDL &gt;160 [5 (25%) out of 20]</span>.</p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Diabetic patients are at very high risk for cardiovascular morbidity and mortality. Early detection of IHD is very important so that pharmacological therapy, which may improve outcome, can be established. Tread mill exercise TMT being a non-invasive test with high safety, has an important role in early detection of IHD. It is recommended that TMT should be a part of routine management in asymptomatic patients with type II DM. </span></p>

scholarly journals Correlation of Pulmonary Function Tests with Anthropometry and Glycaemic Control in Type 2 Diabetes Mellitus-A Cross-sectional Study

2021 ◽  
Author(s):  
Aiswarya Roy Karintholil ◽  
Akshatha Rao Aroor ◽  
Joel Sabu ◽  
Joshua Chacko
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycaemic Control ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Duration Of Diabetes ◽  
Lung Functions ◽  
Type 2 Diabetic

Introduction: Diabetic patients are found to have reduced lung functions compared to their controls and their relationship with the duration of diabetes, glycaemic control, and Body Mass Index (BMI) is poorly characterised. Aim: To determine the correlation between the pulmonary function abnormalities with anthropometry, glycaemic control, and duration of diabetes in type 2 diabetic patients. Materials and Methods: A total of 80 type 2 diabetic patients were studied. BMI, Waist Circumference (WC), Waist-Hip Ratio (WHR), Fasting, postprandial blood sugar and glycosylated haemoglobin (HbA1c) were assessed from July to September 2018. Spirometry was done in accordance with the guidelines from the American Thoracic Society (ATS). Reduced pulmonary functions were defined as patients with restrictive (FEV1/FVC≥0.7 and FVC< 80% predicted) or obstructive (FEV1/FVC<0.7) impairment. Statistical analysis was done using ANOVA test and Karl Pearson Correlation coefficient. Results: The mean values of FEV1/FVC (0.8±0.08) and FVC% predicted (60.29±11.39) showed a restrictive pattern. FEF (25-75%) (r=0.241, p=0.031) and PEFR (r=0.245, p=0.029) positively correlated with duration of diabetes. BMI had a negative correlation with FVC% predicted (r=0.239, p=0.033). A negative correlation between FEV1% and Waist Circumference (WC) was observed (r=-0.232, p=0.038). HbA1c negatively correlated to FEV1/FVC (r=-0.227, p=0.043). Conclusion: Patients with type 2 Diabetes Mellitus (DM) were found to have an asymptomatic restrictive pulmonary impairment. Increased duration of diabetes, increased BMI, increased WC was associated with decreased lung functions in diabetics.

scholarly journals Awareness of diabetic nephropathy in patients with type 2 diabetes mellitus: the Indian scenario

2018 ◽  
Vol 7 (2) ◽  
pp. 90-97 ◽  
Author(s):  
Chirag Bansal ◽  
Reshma Kaushik ◽  
Rajeev Mohan Kaushik
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Diabetic Patients ◽  
Patient Awareness ◽  
Duration Of Diabetes ◽  
Rural And Urban ◽  
Control Of Diabetes

Introduction: Diabetic nephropathy is an important complication of diabetes mellitus leading to significant morbidity and mortality. Objectives: To study the awareness of diabetic nephropathy in patients with type 2 diabetes mellitus (T2DM) and the factors influencing patient awareness of diabetic nephropathy. Patients and Methods: Four hundred subjects, aged above 18 years with T2DM as per American Diabetes Association (ADA) criteria, were selected. Patient awareness regarding diabetic nephropathy was assessed as per a prefixed questionnaire. Results: Awareness of basic information concerning diabetes was present in more than 60% of patients. No significant differences were seen between awareness scores of male and female (P = 0.385), rural and urban (P = 0.120) and literate and illiterate (P = 0.567) diabetic patients. Awareness scores were higher in diabetic patients exceeding 50 years of age (P = 0.004) and patients having diabetes for more than10 years (P < 0.0001), controlled diabetes (P = 0.026) and diabetic nephropathy (P < 0.0001). Awareness of diabetic nephropathy was independently associated with duration of diabetes (P = 0.010) and diabetic nephropathy (P = 0.011) but not with age (P = 0.754) and control of diabetes (P = 0.229). Conclusion: A substantial proportion of diabetic patients are still unaware of the basic facts about diabetes and diabetic nephropathy. Awareness of diabetic nephropathy depended upon duration of diabetes and presence of diabetic nephropathy and requires promotion during early stages of diabetes to improve control of diabetes and prevent diabetic nephropathy.

scholarly journals Is Uric Acid elevation a random finding or a causative agent of diabetic nephropathy?

2019 ◽  
Vol 65 (9) ◽  
pp. 1155-1160 ◽  
Author(s):  
Mehmet Zahid Kocak ◽  
Gulali Aktas ◽  
Tuba T. Duman ◽  
Burcin M. Atak ◽  
Haluk Savli
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Diabetic Nephropathy ◽  
Study Groups ◽  
Diabetic Patients ◽  
Study Participants ◽  
The Relationship

SUMMARY OBJECTIVE In this study, we aimed to analyze the relationship between serum uric acid (UA) and microalbuminuria as a marker of renal injury in type 2 diabetes mellitus. METHODS A total of 100 patients with type 2 diabetes mellitus were enrolled in the study. Participants were divided into two groups according to the urinary microalbumin/creatinine ratio: diabetic nephropathy and non-nephropathy group. UA and microalbuminuria were compared between the study groups. RESULTS Serum UA levels of diabetic nephropathy patients were significantly higher than those in the non-nephropathy group (UA in patients with diabetic nephropathy groups: 6.3 (1.82) mg/dl, UA in patients of the non-nephropathic group: 4.85 (1.92) mg/dl) (p<0.001). There was a correlation between microalbuminuria and UA (r=0.238). This correlation was statistically significant (p=0.017). CONCLUSION UA levels may be an important predictor of nephropathy in diabetic patients.

scholarly journals Microalbumin Status in Relation to Glycated Haemoglobin and Duration of Type 2 Diabetes Mellitus

2015 ◽  
Vol 1 (1) ◽  
pp. 21-24 ◽  
Author(s):  
Kumananda Acharya ◽  
Sangita Regmi ◽  
Alina Shri Sapkota ◽  
Mithileshwer Raut ◽  
Bharat Jha
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Hba1c Level ◽  
Diabetic Patients ◽  
Endocrine Disorders ◽  
Duration Of Diabetes ◽  
Study Results

BACKGROUND: Diabetes mellitus (DM) is one of  the most common endocrine disorders, characterized by hyperglycemia. Diabetic nephropathy is a consequence of long- standing diabetes and urinary microalbumin (Uma) status predicts progression to diabetic nephropathy. This study was conducted to know the status of Uma in relation to duration of diabetes and HbA1c level in patients with Type 2 diabetes mellitus (T2DM). METHODS: This prospective cross-sectional descriptive study was conducted from July 1, 2014 to January 15, 2015 at TUTH, Kathmandu. Ninety-six known T2DM patients with age 35– 83 years were included in the study. EDTA venous blood and spot urine sample were collected for analysis of HbA1c and Uma respectively. Only those patients having HbA1c concentration ≥ 6.3% and duration of diabetes ≥ 6 months were included under the study. RESULTS: Overall prevalence of microalbuminuria (MAU) was 39.6 %. MAU had a highly significant correlation with duration of diabetes (r =0.471, p<0.05). Present study has shown positive correlation of MAU with HbA1c level, although statistically insignificant (r=0.245, p>0.05). CONCLUSIONS: Prolonged exposure to hyperglycemia-induced advanced glycosylation end products accumulations contributes for the development of MAU. So, duration of diabetes mellitus is main contributing factor for the development of MAU rather than HbA1c level alone. Screening for MAU to prevent renal impairment and measuring HbA1c level on a regular basis for good glycemic control are important in diabetic patients. DOI: http://dx.doi.org/10.3126/acclm.v1i1.12310 Ann. Clin. Chem. & Lab. Med. 1(1) 2015: 21-24

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