Epidemiological predictor variables in relation to the outcome of pregnancy in an urban setting

Background: Fetal weight at birth is the singular parameter resonant of maternal health and is measured with reasonable precision, while measuring preterm birth or IUGR requires a valid estimate of gestational age. Notwithstanding the relevance of mortality and morbidity as measures of adverse pregnancy outcome, proxy markers like low birth weight (LBW), preterm birth, intrauterine growth restriction (IUGR) and congenital anomalies have been used in the past. This exercise aims to study the epidemiological predictor variables in pregnant women attending ante-natal clinic and its association with birth outcome.Methods: This prospective study was carried out over a one-year period at a tertiary care teaching hospital. Data was collected using structured questionnaire, investigation reports and ante-natal cards. The outcome of delivery in all registered women was recorded by following them up till delivery.Results: The variables having a statistically significant association with an adverse pregnancy outcome were maternal and paternal education, family income, socioeconomic status (SES), gravidity, maternal complications, level of physical activity, rest during pregnancy, trimester of initiation of ANC visits, diet, iron supplementation, maternal weight gain, exposure to tobacco/environmental tobacco smoke and gestational age.Conclusions: Parental education, good antenatal care, early detection of high risk pregnancy, light physical activity and adequate rest, adequate nutrition with supplementation and exposure to ETS markedly influence the pregnancy outcome and intervention in these areas would result in an improved birth outcome. Factors having marginal scope of intervention include age of the pregnant women, adequate inter-pregnancy interval, maternal weight gain and socioeconomic status.

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Inflammatory bowel disease: risk factors for adverse pregnancy outcome and the impact of maternal weight gain

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.3109/14767058.2012.684176 ◽

2012 ◽

Vol 25 (11) ◽

pp. 2256-2260 ◽

Cited By ~ 31

Author(s):

Galia Oron ◽

Yariv Yogev ◽

Smadar Shkolnik ◽

Moshe Hod ◽

Gerald Fraser ◽

...

Keyword(s):

Risk Factors ◽

Inflammatory Bowel Disease ◽

Weight Gain ◽

Disease Risk ◽

Adverse Pregnancy Outcome ◽

Maternal Weight Gain ◽

Maternal Weight ◽

Inflammatory Bowel ◽

Adverse Pregnancy ◽

The Impact

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Proteomic biomarkers of adverse pregnancy outcome in preterm birth: a theranostics opportunity

Expert Review of Obstetrics & Gynecology ◽

10.1586/17474108.2.6.743 ◽

2007 ◽

Vol 2 (6) ◽

pp. 743-753 ◽

Cited By ~ 2

Author(s):

Catalin S Buhimschi ◽

Irina A Buhimschi

Keyword(s):

Preterm Birth ◽

Pregnancy Outcome ◽

Adverse Pregnancy Outcome ◽

Adverse Pregnancy

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Multidimensional System Biology: Genetic Markers and Proteomic Biomarkers of Adverse Pregnancy Outcome in Preterm Birth

American Journal of Perinatology ◽

10.1055/s-2008-1061497 ◽

2008 ◽

Vol 25 (3) ◽

pp. 175-187 ◽

Cited By ~ 24

Author(s):

Catalin Buhimschi ◽

Victor Rosenberg ◽

Antonette Dulay ◽

Stephen Thung ◽

Anna Sfakianaki ◽

...

Keyword(s):

Preterm Birth ◽

Pregnancy Outcome ◽

Genetic Markers ◽

System Biology ◽

Adverse Pregnancy Outcome ◽

Multidimensional System ◽

Adverse Pregnancy

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Gestational weight gain and neonatal adiposity in the hyperglycemia and adverse pregnancy outcome study-North American region

Obesity ◽

10.1002/oby.20742 ◽

2014 ◽

Vol 22 (7) ◽

pp. 1731-1738 ◽

Cited By ~ 29

Author(s):

Sylvia E. Badon ◽

Alan R. Dyer ◽

Jami L. Josefson ◽

Keyword(s):

Weight Gain ◽

Pregnancy Outcome ◽

Gestational Weight Gain ◽

North American ◽

Adverse Pregnancy Outcome ◽

Outcome Study ◽

Gestational Weight ◽

Neonatal Adiposity ◽

Adverse Pregnancy ◽

American Region

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Heat Shock Proteins and Heat Shock Protein-Antibody Complexes in Placental Tissues

Infectious Diseases in Obstetrics and Gynecology ◽

10.1155/s1064744999000307 ◽

1999 ◽

Vol 7 (4) ◽

pp. 180-185 ◽

Cited By ~ 25

Author(s):

M. Ziegert ◽

S. S. Witkin ◽

I. Sziller ◽

H. Alexander ◽

E. Brylla ◽

...

Keyword(s):

Preterm Birth ◽

Heat Shock ◽

Heat Shock Proteins ◽

Pregnancy Outcome ◽

Preterm Labor ◽

Adverse Pregnancy Outcome ◽

Increased Risk ◽

Circulating Antibodies ◽

Adverse Pregnancy ◽

Shock Proteins

Objective:The relationship between pregnancy outcome and expression of the heat shock proteins (hsps) or hsp-antibody complexes of 60kD (hsp60), 70kD (hsp70), and 90kD (hsp90) in placental tissue and circulating antibodies to hsps was evaluated.Method:Expression of hsp60, hsp70, and hsp90 in placentae from 12 women with preterm birth, eight with intrauterine growth restriction (IUGR), and 10 with term birth, as well as the presence of the corresponding antibodies, was investigated by a new carbocyanine double fluorescence technique. Results were compared with microbiological findings and circulating antibodies to hsps in sera.Results:In each placental specimen examined, hsp60, hsp70, and hsp90 were identified. However, hsp70-antibody complexes were detected in only four of the preterm labor cases. Similarly, hsp60-antibody complexes were detected in only five preterm labor patients and in one patient with IUGR. None of the placentae contained hsp90-antibody complexes. In the preterm birth group, all patients with hsp60-antibody complexes were also positive for circulating antibodies to hsp60. The presence of hsp70-antibody complexes also correlated with hsp70 antibody in sera.Conclusions:Formation of hsp60- and hsp70-antibody complexes in the placenta may contribute to the induction of preterm birth. Women sensitized to these antibodies may be at increased risk for adverse pregnancy outcome. Infect. Dis. Obstet. Gynecol. 7:180–185, 1999.

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Similar Adverse Pregnancy Outcome in Native and Nonnative Dutch Women with Pregestational Type 2 Diabetes: A Multicentre Retrospective Study

ISRN Obstetrics and Gynecology ◽

10.1155/2013/361435 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 9

Author(s):

Bart Groen ◽

Thera P. Links ◽

Paul P. van den Berg ◽

Marieke Hellinga ◽

Sharon Moerman ◽

...

Keyword(s):

Type 2 Diabetes ◽

Preterm Birth ◽

Pregnancy Outcome ◽

Perinatal Mortality ◽

Congenital Malformations ◽

Adverse Pregnancy Outcome ◽

Easy Access ◽

Local Health ◽

Adverse Pregnancy

Objective. To assess the incidence of adverse pregnancy outcome in native and nonnative Dutch women with pregestational type 2 diabetes (T2D) in a multicenter study in The Netherlands. Methods. Maternal characteristics and pregnancy outcome were retrospectively reviewed and the influence of ethnicity on outcome was evaluated using independent t-test, Mann-Whitney U-test, and chi-square test. Results. 272 pregnant women (80 native and 192 non-native Dutch) with pregestational T2D were included. Overall outcome was unfavourable, with a perinatal mortality of 4.8%, major congenital malformations of 6.3%, preeclampsia of 11%, preterm birth of 19%, birth weight >90th percentile of 32%, and a Caesarean section rate of 42%. In nonnative Dutch women, the glycemic control was slightly poorer and the gestational age at booking somewhat later as compared to native Dutch women. However, there were no differences in incidence of preeclampsia/HELLP, preterm birth, perinatal mortality, macrosomia, and congenital malformations between those two groups. Conclusions. A high incidence of adverse pregnancy outcomes was found in women with pregestational T2D, although the outcome was comparable between native and non-native Dutch women. This suggests that easy access to and adequate participation in the local health care systems contribute to these comparable outcomes, offsetting potential disadvantages in the non-native group.

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