scholarly journals Adjuvant drugs in management of osteoarthritis: spotlight on type II collagen

2019 ◽  
Vol 5 (4) ◽  
pp. 753
Author(s):  
Vijay Kakatkar ◽  
A. K. Pal ◽  
Raghuveer Reddy ◽  
Ravi Dashputra ◽  
Sanjay Kamble ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Symptoms ◽  
Joint Damage ◽  
Joint Stiffness ◽  
Type Ii Collagen ◽  
Special Focus ◽  
Type Ii ◽  
Inflammatory Drugs ◽  
Undenatured Type Ii Collagen

<p>Osteoarthritis (OA) is a common musculoskeletal disorder that affects large and small joints and is seen in all ages due to diverse aetiologies. Pain, joint stiffness and limitation of daily activities affects the quality of life of individuals with OA. Conventional analgesics like non-steroidal anti-inflammatory drugs affect pain and inflammatory component but do not target the disease pathogenesis. Damage to the joint cartilage is central to the pathogenesis of OA. Better understanding of the pathogenesis has led to evolution of various adjuvant drugs in management of OA. Among them, undenatured type II collagen induces immune tolerance and thereby provide benefits by reducing the joint damage. Studies assessing efficacy and safety of undenatured type II collagen in OA have shown to reduce clinical symptoms like pain, joint stiffness and improvement in physical activities, and thus improving the quality of life. It is well tolerated and safe for use in OA. This article discusses the pathophysiology of OA with inflammation and beyond, and overviews the various drugs that are used as adjuvants in the management of OA with special focus on the use of type 2 collagen.</p>

scholarly journals Undenatured collagen type II for the treatment of osteoarthritis: a review

2018 ◽  
Vol 4 (5) ◽  
pp. 684 ◽  
Author(s):  
Ram Prabhoo ◽  
Gauri Billa
Keyword(s):  
Collagen Type ◽  
Disease Process ◽  
Type Ii Collagen ◽  
Underlying Disease ◽  
Degree Of Hydrolysis ◽  
Type Ii ◽  
Collagen Type Ii ◽  
Inflammatory Drugs ◽  
Immunological Factors ◽  
Undenatured Type Ii Collagen

<p class="abstract">Osteoarthritis is a prevalent musculoskeletal condition worldwide with rising rates in elderly people. Both mechanical and immunological factors are implicated in the pathogenesis of osteoarthritis resulting in destruction of the articular cartilage. Non-steroidal anti-inflammatory drugs (NSAIDs) commonly used for the treatment of osteoarthritis, are associated with several adverse events and also do not affect the underlying disease process. Clinicians and patients both seek options which are safe and effective in the treatment of osteoarthritis. Collagen derivatives represent a suitable option in such cases. Collagen is the most abundant component of the cartilage. Collage derivatives have shown to have disease modifying action in osteoarthritis. Depending on the degree of hydrolysis and molecular weight, collage derivatives are classified into undenaured collagen, gelatin and collage hydrolysate. Collagen derivatives are well tolerated without major safety concerns. Undenatured type II collagen has shown to provide significant improvement in patients with osteoarthritis. In this article we discuss, the pathophysiology of osteoarthritis with focus on immunological factors and evidence for the use of undenatured collagen type II in osteoarthritis.</p><p class="abstract"> </p>

Potentarea efectului tratamentului cu voltaren gel prin utilizarea ultrasunetelor cu frecvente de 1 MHz

2018 ◽  
Vol 69 (7) ◽  
pp. 1749-1751 ◽  
Author(s):  
Sinziana Calina Silisteanu ◽  
Loredana Mitariu ◽  
Remus Ranga ◽  
Elisabeta Antonescu ◽  
Corina Lavinia Duica ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Peripheral Nerves ◽  
Pain Threshold ◽  
Drug Class ◽  
Joint Stiffness ◽  
Moderate Increase ◽  
Joint Mobility ◽  
Quality Of Life Index ◽  
Inflammatory Drugs

The effects of nonsteroidal anti-inflammatory drugs (NSAIDs) in abarticular conditions are well known. The aim was to compare the efficacy of NSAIDs, of Diclofenac drug class (Voltaren gel, in this case) applied topically, with and without ultrasound, for a period of 10 days in abarticular rheumatic diseases. The following parameters have been aimed at: pain, functional impotence and quality of life index. One gram of gel was applied daily for an area of 100 cm�. The treatment was applied to patients in an outpatient regime. Therapeutic ultrasound frequencies were used. Among the effects of selective warming of the areas exposed to ultrasound, we mention: decreased joint stiffness, increased pain threshold of peripheral nerves and nerve endings, moderate increase of blood flow, increased joint mobility.

scholarly journals The use of Lactobacillus casei DG® prevents symptomatic episodes and reduces the antibiotic use in patients affected by chronic bacterial prostatitis: results from a phase IV study

2021 ◽  
Author(s):  
Tommaso Cai ◽  
Luca Gallelli ◽  
Erika Cione ◽  
Gianpaolo Perletti ◽  
Francesco Ciarleglio ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Symptoms ◽  
Clinical Status ◽  
Well Being ◽  
Antibiotic Use ◽  
Chronic Bacterial Prostatitis ◽  
Symptomatic Recurrence ◽  
Bacterial Prostatitis ◽  
Phase Iv

Abstract Purpose To evaluate the efficacy of Lactobacillus paracasei CNCM I-1572 (L. casei DG®) in both prevention of symptomatic recurrences and improvement of quality of life in patients with chronic bacterial prostatitis (CBP). Methods Patients with CBP attending a single Urological Institution were enrolled in this phase IV study. At enrollment, all patients were treated with antibiotics in agreement with EAU guidelines and then were treated with L. casei DG® (2 capsules/day for 3 months). Clinical and microbiological analyses were carried out before (enrollment, T0) and 6 months (T2) after the treatment. Both safety and adherence to the treatment were evaluated 3 months (T1) after the enrollment. NIH Chronic Prostatitis Symptom Index (CPSI), International Prostate Symptom Score (IPSS) and Quality of Well-Being (QoL) questionnaires were used. The outcome measures were the rate of symptomatic recurrence, changes in questionnaire symptom scores and the reduction of antibiotic use. Results Eighty-four patients were included. At T2, 61 patients (72.6%) reported a clinical improvement of symptoms with a return to their clinical status before symptoms. A time dependent improvement in clinical symptoms with significant changes in NIH-CPSI, IPSS and QoL (mean difference T2 vs T0: 16.5 ± 3.58; − 11.0 ± 4.32; + 0.3 ± 0.09; p < 0.001), was reported. We recorded that L. casei DG® treatment induced a statistically significant decrease in both (p < 0.001) symptomatic recurrence [1.9/3 months vs 0.5/3 months] and antibiotic use [− 7938 UDD]. No clinically relevant adverse effects were reported. Conclusions L. casei DG® prevents symptomatic recurrences and improves the quality of life in patients with CBP, reducing the antibiotic use.

scholarly journals Individual quality of life and the environment – towards a concept of livable areas for persons with disabilities in Poland

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Izabela Grabowska ◽  
Radosław Antczak ◽  
Jan Zwierzchowski ◽  
Tomasz Panek
Keyword(s):  
Quality Of Life ◽  
Environmental Conditions ◽  
Basic Research ◽  
Research Problem ◽  
Individual Characteristics ◽  
Living Conditions ◽  
Special Focus ◽  
Persons With Disabilities ◽  
The Relationship

Abstract Background The United Nations Convention on the Rights of Persons with Disabilities [1] highlights the need to create proper socioeconomic and political conditions for persons with disabilities, with a special focus on their immediate living conditions. According to the Convention, these conditions should be built to ensure that persons with disabilities have the potential to enjoy a high quality of life (QoL), and this principle is reflected in the notion of livable areas. The crucial aspect of this framework is the relationship between the individual QoL and the environment, broadly understood as the socioeconomic as well as the technical conditions in which persons with disabilities function. Methods The basic research problem was to assess the relationship between individual QoL for the population with disabilities as a dependent variable and livability indicators as independent variables, controlling for individual characteristics. The study used a dataset from the EU-SILC (European Union Statistics on Income and Living Conditions) survey carried out in 2015 in Poland. The research concept involved several steps. First, we created a variable measuring the QoL for the entire population with disabilities. To measure the multidimensional QoL, we used Sen’s capability approach as a general concept, which was operationalized by the MIMIC (multiple indicators multiple causes) model. In the second step, we identified the livability indicators available in the official statistics, and merged them with survey data. Finally, in the last step, we ran the regression analysis. We also checked the data for the nested structure. Results We confirmed that the general environmental conditions, focused on creating livable areas, played a significant role in shaping the QoL of persons with disabilities; i.e., we found that the higher the level of the local Human Development Index, the higher the quality of life of the individuals living in this area. This relationship held even after controlling for the demographic characteristics of the respondents. Moreover, we found that in addition to the general environmental conditions, the conditions created especially for persons with disabilities (i.e., services for this group and support for their living conditions) affected the QoL of these individuals. Conclusions The results illustrate the need to strengthen policies aimed at promoting the QoL of persons with disabilities by creating access to community assets and services that can contribute to improving the life chances of this population.

Correlation Between Muscle Strength and Functional Improvement After a Neuromuscular Electrical Strengthening Associated with Undenatured Type II Collagen in Knee Osteoarthritis

2021 ◽  
Vol 3 (5) ◽  
pp. 1122-1132
Author(s):  
Ana Paula Costa ◽  
Carlos Monteiro ◽  
Verine Cunha Teixeira ◽  
Bruno da Silva Schwarstzhoupt ◽  
Patrícia Mota Ferreira ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Knee Osteoarthritis ◽  
Type Ii Collagen ◽  
Functional Improvement ◽  
Type Ii ◽  
Undenatured Type Ii Collagen

Quality of Life in Patients With Behçet Disease and Its Relation With Clinical Symptoms and Disease Activity

2021 ◽  
Vol 17 (1) ◽  
pp. 1-6
Author(s):  
Alireza Khabbazi ◽  
Vahideh Ebrahimzadeh Attari ◽  
Mohammad Asghari Jafarabadi ◽  
Aida Malek Mahdavi
Keyword(s):  
Quality Of Life ◽  
Disease Activity ◽  
Clinical Symptoms ◽  
Behçet Disease ◽  
Behcet Disease

scholarly journals The quality of life in the relatives of Wolfram’s syndrome patients

2014 ◽  
Vol 5 (1) ◽  
pp. 89-97
Author(s):  
Gema Esteban ◽  
Mónica Ruano ◽  
Isabel Motero
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Genetic Basis ◽  
Clinical Symptoms ◽  
Daily Life ◽  
Wolfram Syndrome ◽  
Clinical Aspects ◽  
The Family ◽  
Low Prevalence

Wolfram Syndrome (WS) is a rare disease (RD) with an estimated prevalence of 1/770,000 inhabitants. It is considered a multisystemic, chronic and progressive disease.WS diagnosis implies devastating consequences at physical, educational and emotional levels. WS is also known by the acronym DIDMOAD, derived from the first letters of the main clinical symptoms: Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness. Rare diseases are characterized by their low prevalence and the lack of knowledge on the pathophysiology and treatment of them. Interestingly, around 80% of RD have a genetic basis, and this fact causes doubts and uncertainties in the couples, about the idea of having another child. The existence of a RD in a family, alters significantly the relationships and the quality of life within the family. The present work remarks the huge value of psychosocial aspects in order to pay an adequate attention to these patients, not only taking care of the clinical aspects. The main purpose of this study has been to ascertain the quality of life of Wolfram’s syndrome affected patients, and its impact in the daily life.

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