scholarly journals A clinico-dermatoscopic study of 100 cases of melasma in a tertiary care hospital

2018 ◽  
Vol 4 (1) ◽  
pp. 41 ◽  
Author(s):  
Simplepreet Kaur ◽  
Jasleen Kaur ◽  
Saurabh Sharma ◽  
Manisha Sharma ◽  
Ameesha Mahajan ◽  
...  
Keyword(s):  
Distribution Pattern ◽  
Clinical Diagnosis ◽  
Therapeutic Efficacy ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Common Pattern ◽  
Non Invasive ◽  
Diagnosis And Prognosis ◽  
Surface Changes

<p class="abstract"><strong>Background:</strong> Melasma is one of the most common hyperpigmentary disorders seen among Indian patients. Dermatoscope is a non-invasive tool that helps in visualization of surface and sub-surface changes. Recognition of characteristic dermatoscopic patterns of melasma helps in differentiating it from other hyperpigmentary disorders. The present study was carried out to study clinical and dermatoscopic patterns of melasma.</p><p class="abstract"><strong>Methods:</strong> A total of 100 patients with clinical diagnosis of melasma were enrolled in this study. These patients were first examined clinically and then under dermatoscope. All the findings were recorded.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of total 100 patients, 91 were females and 9 were males. Mean age of presentation was 34.86 years. Malar distribution pattern was the most common pattern observed in 54% patients. On dermatoscopic examination, 58% cases had epidermal melasma, 23% had dermal melasma and 19% had mixed melasma. Accentuated pseudoreticular network was the most common pattern seen in 88% cases.</p><p><strong>Conclusions:</strong> Melasma is a distressing hyperpigmentary disorder. Dermatoscope helps in diagnosis and prognosis of melasma. Therapeutic efficacy of various modalities can be monitored using dermatoscope. It has reduced the need of invasive interventions like biopsy from face for histopathology. </p>

TO DETERMINE THE ROLE OF CA125 IN THE DIAGNOSIS OF ACUTE APPENDICITIS

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Vinod Kumar ◽  
Bhupen Songra ◽  
Richa Jain ◽  
Deeksha Mehta
Keyword(s):  
Acute Appendicitis ◽  
Clinical Diagnosis ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Ca 125 ◽  
Care Hospital ◽  
Serum Samples ◽  
Roc Curve Analysis ◽  
Surgery Department

Background: the present study was under taken to determine the role of CA-125 in the diagnosis of acute appendicitis (AA), to prevent its complications and also in preventing negative appendicectomies in tertiary care hospital. Methods: The study was conducted at a tertiary care and research center between 01/03/2018 to 30/06/2019. Patients admitted to the surgery department with diagnosis of AA were considered for the study. After informed consent, a, standardized history was obtained as a case Performa. Serum samples from all the cases with clinical diagnosis of AA were obtained and stored. Only the cases with histopathologically approved AA were included in the study. Cases operated for clinical diagnosis of AA, but not histopathologically proven AA was not included in the study. CA125 levels in cases with definitive diagnosis of AA were measured. Results: In present study, ROC curve analysis revealed the sensitivity of 87.27 % and specificity of 90.91 % when the CA 125 cut-off value of > 16.8 was taken to diagnose acute appendicitis. AUC was 0.911 with a standard error of 0.0292. Conclusion: In this study we have observed that CA125 showed a positive correlation with acute appendicitis, that was statistically not significant (P>0.05). We didn’t evaluate the correlation with the disease severity. We consider that CA125 can be used as a marker in acute appendicitis cases although further research is still needed. Keywords: CA125, Acute Appendicitis, Surgery.

EP.FRI.479 Clinical accuracy of u/sound combined with inflammatory markers in Acute Appendicitis

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Nadia Gulnaz ◽  
Sadia Tasleem ◽  
Farooq Abdullah
Keyword(s):  
Acute Appendicitis ◽  
Clinical Diagnosis ◽  
Inflammatory Markers ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Negative Appendectomy ◽  
Care Hospital ◽  
Clinical Accuracy ◽  
Negative Appendicectomy ◽  
Sensitivity Specificity

Abstract Traditionally acute appendicitis has been a clinical diagnosis based on patients' history and physical examination, but the accuracy of clinical diagnosis ranges from 70-95%. Pre-operative diagnosis of acute appendicitis still remains an enigmatic challenge, because no single test alone can reduce the rate of negative appendectomy. Hence some authors have recommended a combination of two or more investigations to increase accuracy and therefore the use of imaging is gaining support. The objective of the study was to determine the clinical accuracy of ultrasound, combined with inflammatory markers such as CRP, WBC, and neutrophilia keeping histopathology as the gold standard. Methods The study was conducted in a Tertiary care hospital in Peshawar from September 2014 to March 2015 on 250 patients who were clinically diagnosed with acute appendicitis. All these patients underwent u/sound scanning in addition to blood tests. Findings In this study, WBC had the highest sensitivity (77.68%) followed by neutrophil% (69.96%), CRP(67.10%), and U/Sound (62.96%) respectively. While U/Sound had the highest specificity (70.59%) followed by CRP and TLC (64.71% each) and neutrophil% (58.82%) respectively. When all the four tests were combined the sensitivity, specificity, (99.17% and 98.45%) increased significantly. When all four tests were negative, appendicitis could be safely ruled out. Conclusion Acute appendicitis is very unlikely and surgery can be safely deferred in these patients when all tests are negative thereby reducing the negative appendicectomy rates. 

scholarly journals Risk of COVID-19 Infection in Healthcare Workers Exposed During Use of Non-invasive Ventilation in a Tertiary Care Hospital in OmanRisk of COVID-19 Infection in Healthcare Workers Exposed During Use of Non-invasive Ventilation in a Tertiary Care Hospital in Oman

2021 ◽  
Vol 36 (2) ◽  
pp. e236-e236
Author(s):  
Adil Al Lawati ◽  
Faryal Khamis ◽  
Samiha Al Habsi ◽  
Khazina Al Dalhami
Keyword(s):  
High Risk ◽  
Healthcare Workers ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Significant Risk ◽  
High Risk Population ◽  
Care Hospital ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation

Objectives: Healthcare workers (HCWs), especially those working on the front line, are considered to be at high risk of nosocomial acquisition of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). Little is known about the effectiveness of the recommended protective methods as few reports have described spread of the disease in hospital settings among this high-risk population. We describe the hospital-based transmission of SARS-CoV-2 related to non-invasive ventilation (NIV) in one of the main tertiary care hospitals in Oman. Methods: All exposed patients and HCWs from Royal Hospital were screened, quarantined, and underwent telephone interviews to stratify their risk factors, clinical symptoms, and exposure risk assessment. Results: A total of 46 HCWs and patients tested positive for SARS-CoV-2 after exposure to an index case who received 48 hours of NIV before diagnosing COVID-19 infection. Over half of the exposed (56.5%; n = 26) were nurses, 26.1% (n = 12) were patients, and 15.2% (n = 7) were doctors. None of the HCWs required hospitalization. Sore throat, fever, and myalgia were the most common symptoms. Conclusions: NIV poses a significant risk for SARS-CoV-2 transmission within hospital settings if appropriate infection control measures are not taken.

scholarly journals Serological testing reveals the hidden COVID-19 burden among healthcare workers experiencing a SARS-CoV-2 nosocomial outbreak.

2021 ◽  
Author(s):  
Yu Nakagama ◽  
Yuko Komase ◽  
Katherine Candray ◽  
Sachie Nakagama ◽  
Fumiaki Sano ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Nucleic Acid Amplification ◽  
Care Hospital ◽  
Case Detection ◽  
Serological Testing ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Serological Diagnostics

We describe the results of testing healthcare workers from a tertiary care hospital in Japan, which had experienced a COVID-19 outbreak during the first peak of the pandemic, for SARS-CoV-2 specific antibody seroconversion. Using two chemiluminescent immunoassays and a confirmatory surrogate virus neutralization test, serological testing unveiled that a surprising 42.2% (27/64) of overlooked COVID-19 diagnoses had occurred when case detection had relied solely on SARS-CoV-2 nucleic acid amplification testing. This undetected portion of the COVID-19 iceberg beneath the surface may potentially have led to silent transmissions and triggered the spread. A questionnaire-based risk assessment was further indicative of exposures to specific aerosol-generating procedures, i.e. non-invasive ventilation, having had conveyed the highest transmission risks and served as the origin of outbreak. Our observations are supportive of a multi-tiered testing approach, including the use of serological diagnostics, in order to accomplish exhaustive case detection along the whole COVID-19 spectrum.

scholarly journals Patterns of Lesions in Hysterectomy Specimens in a Tertiary Care Hospital

2015 ◽  
Vol 53 (197) ◽  
pp. 18-23 ◽  
Author(s):  
Sujan Vaidya ◽  
Sapana Amatya Vaidya
Keyword(s):  
Clinical Diagnosis ◽  
Tertiary Care Hospital ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Abnormal Uterine Bleeding ◽  
Operative Management ◽  
Uterovaginal Prolapse ◽  
Care Hospital ◽  
Ovarian Tumours ◽  
Operative Indications

Introduction: Hysterectomy is one of the most common gynaecological procedures performed all over the world. The most frequent indications for hysterectomy are fibroids, abnormal uterine bleeding uterovaginal prolapse and endometriosis. The objective of this study was to present the histopathological patterns of various uterine and adnexal pathologies in the hysterectomy specimens and also to correlate its pre-operative clinical diagnosis with histopathology. Methods: This is a two-year descriptive study of hysterectomy specimens carried out in the Department of Pathology, Patan Academy of Health Sciences (PAHS), Lalitpur, Nepal. Data of all the hysterectomy specimens collected during this period was analyzed.   Results: Out of the 533 cases, fibroid was the most common indication for hysterectomy that was seen in 229 (42.94%) cases followed by uterovaginal prolapse in 101 (18.93%) cases. Leiomyoma was the most common pathology reported in 250 (46.90%) hysterectomy specimens, followed by ovarian tumours in 95 (17.82%) cases. In 17.82% (95/533) cases, no pathology was seen. Overall, the pre-operative indications in 533 cases of hysterectomy were histopathologically verifiable in 487 (91.37%) cases. Conclusions: Though the histopathological examination correlates well with the pre-operative clinical diagnosis, a number of lesions were also encountered as pure incidental findings. Hence, it is mandatory that every hysterectomy specimen should be subjected to histopathological examination so as to ensure better post-operative management. Keywords: adenomyosis; hysterectomy; leiomyoma; tumour; uterovaginal prolapse.  

scholarly journals Time to Act: Set Up for Non-Invasive ventilation in Tertiary Care Hospital

1970 ◽  
Vol 9 (1) ◽  
pp. 54-55
Author(s):  
SS Dhakal ◽  
N Bhatta ◽  
S Rijal
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Set Up

DOI: 10.3126/hren.v9i1.4365Health Renaissance, 2011: Vol.9 No.1:54-55

scholarly journals A CLINICO-EPIDEMOLOGICAL STUDY OF MELASMA IN A TERTIARY CARE HOSPITAL

2020 ◽  
pp. 1-3
Author(s):  
Aman Goyal
Keyword(s):  
Tertiary Care Hospital ◽  
Age Of Onset ◽  
Tertiary Care ◽  
Sun Exposure ◽  
Care Hospital ◽  
Common Pattern ◽  
Familial Predisposition ◽  
Study Results ◽  
Duration Of Disease ◽  
The Mean

BACKGROUND: Melasma is a common acquired hyperpigmentary disorder characterized by irregular light or dark brown macules in sunexposed areas of skin. It is a consequence of specific hyperfunctional melanocytes that cause excessive melanin deposition in skin. AIMS – Our present research aims to study the clinico-epidemological profile and precipitating and aggravating factors of melasma. MATERIAL AND METHODS – Three hundred patients of melasma attending out-patient department of dermatology were included in the study. RESULTS – The mean age of melasma patient in our study was 32.3 years with the female to male ratio of 3:1.The mean age of onset was 26.87 years.The mean duration of disease in present study was 6.23 years. Centrofacial melasma and epidermal type were the most common pattern seen. Familial predisposition, pregnancy, sun-exposure were the most common triggering factors observed. CONCLUSION – The study indicates was melasma has a wide variation in its clinico-epidemological profile and many factors are involved in its etiopathogenesis.

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