scholarly journals Merkel cell carcinoma associated with chronic treatment with hydroxyurea: a case report

2021 ◽  
Vol 7 (2) ◽  
pp. 289
Author(s):  
Saulo Esteves Saraiva ◽  
Virgínia Mareco ◽  
André Florindo ◽  
Diogo Delgado ◽  
Maria Filomena De Pina
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Poor Prognosis ◽  
Neuroendocrine Tumour ◽  
External Beam Radiotherapy ◽  
Primary Treatment ◽  
Postoperative Treatment ◽  
Merkel Cell ◽  
Primary Treatment Modality ◽  
Scalp Lesion

<p class="abstract">Merkel cell carcinoma is a rare neuroendocrine tumour of the skin, that shows a quickly and aggressive behaviour and carries a poor prognosis. Surgery is the standard primary treatment modality, while radiotherapy plays a role in postoperative treatment. Radiotherapy is also an alternative to unresectable lesions or patients who are unfit to surgery. Here we report a 90-year-old male with polycythemia vera that was chronically treated with hydroxyurea for about 30 years. The patient presented a purple and exophytic frontal scalp lesion, which had recurred after primary wide excision. This recurrence had been considered inoperable and the patient was treated with external beam radiotherapy to the lesion and locoregional lymph nodes, showing a complete clinical response after 12 weeks. However, disease progressed rapidly, and the patient died from distant metastasis 4 months later. This report is the second described case in literature of Merkel cell carcinoma as complication of chronic hydroxyurea and highlights the need for these patients to undergo regular and close dermatological evaluation.</p>

Merkel Cell Carcinoma of the Eyelid: A Case Report

2000 ◽  
Vol 10 (2) ◽  
pp. 173-176 ◽  
Author(s):  
L. Collaço ◽  
J.P. Silva ◽  
M. Gonçalves ◽  
P. Abrantes
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Neuroendocrine Tumour ◽  
The Elderly ◽  
Primary Site ◽  
Wide Resection ◽  
Merkel Cell ◽  
Unique Case ◽  
Upper Eyelid

A 22-year-old woman who presented with a tumour of the upper eyelid with clinical, histological, immunohistochemical and ultrastructural features of a Merkel cell carcinoma is reported. This is a unique case of Merkel cell carcinoma in such a young patient. This neuroendocrine tumour is typically found in the elderly. It can grow rapidly, has the potential for local recurrence and early metastatic spread. The authors recommend wide resection of the primary site, which proved effective in this case.

scholarly journals 131 Loss of PD-L1 expression in metastatic Merkel cell carcinoma strongly correlates with a poor prognosis

2019 ◽  
Vol 139 (5) ◽  
pp. S23
Author(s):  
M. Nakamura ◽  
Y. Teramoto ◽  
M. Yasuda ◽  
H. Wada ◽  
T. Ozawa ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Poor Prognosis ◽  
Merkel Cell

Merkel Cell Carcinoma of the Genitourinary Tract

2011 ◽  
Vol 135 (8) ◽  
pp. 1067-1071 ◽  
Author(s):  
Manju Aron ◽  
Ming Zhou
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Causative Agent ◽  
Targeted Therapies ◽  
Poor Prognosis ◽  
Accurate Diagnosis ◽  
Genitourinary Tract ◽  
Merkel Cell ◽  
Urothelial Carcinomas ◽  
Aggressive Tumor

Merkel cell carcinomas are rare cutaneous neoplasms that are known to metastasize to various mucosal sites, including the genitourinary tract. Primary Merkel cell carcinomas of the genitourinary tract are extremely rare and may be mistaken for other more common carcinomas of the genitourinary tract, including urothelial carcinomas and prostatic carcinomas. However, primary Merkel cell carcinoma of the genitourinary tract is a very aggressive tumor with poor prognosis. Accurate diagnosis is crucial for appropriate clinical treatment. The discovery of the Merkel cell polyomavirus as a possible causative agent adds a new dimension in the understanding of the pathogenesis and diagnosis, and possible targeted therapies for this tumor.

scholarly journals Gene Expression Differences Predict Treatment Outcome of Merkel Cell Carcinoma Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Loren Masterson ◽  
Bryan J. Thibodeau ◽  
Laura E. Fortier ◽  
Timothy J. Geddes ◽  
Barbara L. Pruetz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Poor Prognosis ◽  
Prognostic Significance ◽  
Rna Isolation ◽  
Merkel Cell ◽  
Mucin 1 ◽  
Neurofilament Protein ◽  
Significant Differential Expression

Due to the rarity of Merkel cell carcinoma (MCC), prospective clinical trials have not been practical. This study aimed to identify biomarkers with prognostic significance. While sixty-two patients were identified who were treated for MCC at our institution, only seventeen patients had adequate formalin-fixed paraffin-embedded archival tissue and followup to be included in the study. Patients were stratified into good, moderate, or poor prognosis. Laser capture microdissection was used to isolate tumor cells for subsequent RNA isolation and gene expression analysis with Affymetrix GeneChip Human Exon 1.0 ST arrays. Among the 191 genes demonstrating significant differential expression between prognostic groups, keratin 20 and neurofilament protein have previously been identified in studies of MCC and were significantly upregulated in tumors from patients with a poor prognosis. Immunohistochemistry further established that keratin 20 was overexpressed in the poor prognosis tumors. In addition, novel genes of interest such as phospholipase A2 group X, kinesin family member 3A, tumor protein D52, mucin 1, andKITwere upregulated in specimens from patients with poor prognosis. Our pilot study identified several gene expression differences which could be used in the future as prognostic biomarkers in MCC patients.

scholarly journals Immunotherapy with imiquimod and interferon alfa for metastasized Merkel cell carcinoma

2016 ◽  
Vol 23 (2) ◽  
pp. 150 ◽  
Author(s):  
R.U. Wahl ◽  
T. Braunschweig ◽  
A. Ghassemi ◽  
A. Rübben
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Lymph Node Metastases ◽  
Neuroendocrine Tumour ◽  
Regional Lymph Node ◽  
Pegylated Interferon ◽  
Interferon Alfa ◽  
Merkel Cell ◽  
Node Metastases

Merkel cell carcinoma (mcc) is a highly aggressive neuroendocrine tumour of the skin. Remission rates are high with chemotherapy in patients with metastasis, but without any improvement in overall survival.We present the case of a 90-year-old woman with facial mcc. After radiation and surgery, the mcc recurred with widespread cutaneous and regional lymph node metastases. The metastases were treated with weekly intralesional injections of 1–2×106 IU interferon alfa-2a, accompanied by topical imiquimod 5% cream 3 times weekly. After partial regression, subcutaneous pegylated interferon alfa-2b was added at a dose of 30 μg weekly, which was then increased to 50 μg weekly. At 4 months after the start of immunotherapy, all cutaneous metastases and the intralesionally treated lymph node metastases receded. Interruption or reduction of systemic interferon application resulted in locoregional relapses that were successfully treated with surgery or intralesional interferon injections. The patient remains alive 30 months after initiation of immunotherapy, suggesting that locally metastasized mcc might be able to be controlled with local and systemic immunotherapy.

Giant Merkel Cell Carcinoma of the Lower Limb: Case Report and Review of the Literature

2013 ◽  
Vol 17 (5) ◽  
pp. 351-355 ◽  
Author(s):  
Andrea Marchesi ◽  
Pier Camillo Parodi ◽  
Marco Brioschi ◽  
Giorgio Sileo ◽  
Matteo Marchesi ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Poor Prognosis ◽  
Lymph Node Biopsy ◽  
Lower Limbs ◽  
Merkel Cell ◽  
Review Of The Literature ◽  
Node Biopsy ◽  
Surgical Excisions

Background:Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine malignancy that usually grows rapidly at the head and neck. Giant forms at the lower limbs are rarely reported and usually affect patients in the eighth decade or older.Methods:We report the case of a 60-year-old man who presented with a giant MCC on his right thigh. We managed this case by applying the 2012 updated guidelines and reviewed all cases of giant MCC of the lower limbs reported in the literature.Results:At the 4-month follow-up, the patient showed complete remission.Conclusion:Giant forms of MCC are still treated as typical cases of MCC, when these patients show a very poor prognosis. In young and adult people, such as our case, wide surgical excisions, sentinel lymph node biopsy in clinically negative node cases, radiotherapy of the regional drain area, and a strict follow-up should be routinely performed to improve patients' survival.

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