The diagnostic dilemma of the most common malignancy in orofacial region involving maxillary tuberocity: A case report

Oral squamous cell carcinoma (OSCC) is the most common malignancy affecting the oral cavity. OSCC presents diverse clinical features including small ulcerative lesion to a large growth. The treatment modality of OSCC depends upon the severity, progress and spread of the disease. The purpose of this case report is to emphasize the etiological factors, clinical features as well as the management protocols of OSCC.

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Managementof squamos cell carcinoma of tongue in young men: case report

Journal of Case Reports in Dental Medicine ◽

10.20956/jcrdm.v1i1.95 ◽

2019 ◽

Vol 1 (1) ◽

pp. 21

Author(s):

Israyani Israyani ◽

Ayu F. Argadianti ◽

Hening Tuti Hendarti ◽

Adiastuti E. P

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Oral Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Malignant Neoplasm ◽

Ventral Surface ◽

Drinking Habits ◽

Deep Ulceration

Background: Oral Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity, usually affecting individuals over 50 years of age. It rarely occurs in patients who are less than 40 years old. Purpose: This case report aim is to focuses on establishment of diagnosis, differential diagnosis, predisposition, and treatment planning related to the case. Case: This report describes a case of oral squamous cell carcinoma, staged T1N1M0 (stage III), involving the lateral border and ventral surface of the tongue of a 32-year old male patient, with no smoking or drinking habits. Initial tumor presentation was of deep ulceration and intense pain. Case Management: Patient has examination with autofluorence LED light, presence of bacterial growth, and FNA for establised diagnosis. Patient was given chlorine dioxide mouthwash and education for further treatment one of them is tomoterapi. Conclusions: Clinical features of deep ulceration, pain and induration may be a suspicious feature of oral cavity cancer, therefore early diagnosis of oral squamous cell carcinoma determines prognosis.Keywords: malignant, autofluoresence, tomoterap

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Aggressive Squamous Cell Carcinoma Oral and Immediate Implant: Case Report

Journal of Dentistry and Oral Sciences ◽

10.37191/mapsci-2582-3736-2(3)-040 ◽

2020 ◽

Author(s):

Roberto da Silva de Almeida

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Oral Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Oral Rehabilitation ◽

Immediate Implant ◽

Subsequent Rehabilitation

The objective of this work was to describe clinically, surgically and immediate oral rehabilitation of a patient with aggressive oral squamous cell carcinoma, or the most frequent in the oral cavity, in which the majority are frequent and treated with resection and subsequent rehabilitation.

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Epigenetic Alterations Associated with the Overall Survival and Recurrence Free Survival among Oral Squamous Cell Carcinoma Patients

Journal of Clinical Medicine ◽

10.3390/jcm9041035 ◽

2020 ◽

Vol 9 (4) ◽

pp. 1035 ◽

Cited By ~ 1

Author(s):

Yasmen Ghantous ◽

Aysar Nashef ◽

Imad Abu-Elnaaj

Keyword(s):

Overall Survival ◽

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Clinical Features ◽

Squamous Cell ◽

Methylation Status ◽

Recurrence Free Survival ◽

Epigenetic Alterations ◽

Free Survival

Oral squamous cell carcinoma (OSCC) is a fatal disease caused by complex interactions between environmental, genomic, and epigenetic alterations. In the current study, we aimed to identify clusters of genes whose promoter methylation status correlated with various tested clinical features. Molecular datasets of genetic and methylation analysis based on whole-genome sequencing of 159 OSCC patients were obtained from the The Cancer Genome Atlas (TCGA) data portal. Genes were clustered based on their methylation status and were tested for their association with demographic, pathological, and clinical features of the patients. Overall, seven clusters of genes were revealed that showed a significant association with the overall survival/recurrence free survival of patients. The top ranked genes within cluster 4, which showed the worst prognosis, primarily acted as paraneoplastic genes, while the genes within cluster 6 primarily acted as anti-tumor genes. A significant difference was found regarding the mean age in the different clusters. No significant correlation was found between the tumor staging and the different clusters. In conclusion, our result provided a proof-of-principle for the existence of phenotypic diversity among the epigenetic clusters of OSCC and demonstrated the utility of the use epigenetics alterations in devolving new prognostic and therapeutics tools for OSCC patients.

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