scholarly journals Metastatic mucoepidermoid carcinoma of the lung: A case report

2021 ◽  
Vol 8 (3) ◽  
pp. 433-435
Author(s):  
Shylashree ◽  
Divya B M ◽  
Kush Nimron
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Lung Metastases ◽  
Left Lung ◽  
Low Grade ◽  
High Grade ◽  
Aggressive Form ◽  
Positron Emission ◽  
Lung Malignancy ◽  
Histological Characteristics ◽  
Chemotherapy Initiation

Mucoepidermoid carcinoma (MEC) is a rare form of lung malignancy that is classified into high-grade and low-grade according to its histological characteristics. High-grade mucoepidermoid carcinoma (HMC) is more aggressive form of malignancy which involves lymph node and distant metastasis. Here, we report a 62-year-old female with complaints of dry cough and generalized weakness was diagnosed to have high grade mucoepidermoid carcinoma of lung metastases to lymph nodes, pleura, left adrenal and skeleton. Diagnosis was confirmed by Computed Tomography (CT) which showed numerous lung nodules, biopsy revealing metastatic deposit of mucoepidermoid and Positron Emission Tomography (PET) indicating primary left lung malignancy with metastasis. Despite chemotherapy initiation, the prognosis remained poor.

Different effects of bronchoscopic interventions on children and adults with tracheobronchial mucoepidermoid carcinoma

2021 ◽  
pp. 030089162199589
Author(s):  
Zhang Jieli ◽  
Zhou Yunzhi ◽  
Zhang Nan ◽  
Zou Heng ◽  
Wang Hongwu ◽  
...  
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Argon Plasma Coagulation ◽  
Survival Rates ◽  
Argon Plasma ◽  
Rigid Bronchoscopy ◽  
Low Grade ◽  
High Grade ◽  
Adult Group ◽  
Histologic Grading ◽  
Comprehensive Therapy

Aims: To investigate the efficacy and safety of minimally invasive bronchoscopic interventions for patients with tracheobronchial mucoepidermoid carcinoma (MEC). Methods: Patients with tracheobronchial MEC were included in this retrospective study, and the clinical features, histologic grading, treatments, and cumulative survival rates were calculated. Patients were categorized into child (n = 16) and adult (n = 19) group according to their ages. Histologic grading, treatments, and survival status were compared between the two groups. Results: In pathology, high-grade MEC counts for 6.77% and 42.10% in the child and adult group, respectively. As tumor growth pattern was concerned, 93.33% and 21.05% tumors in the child and adult group present intratracheal type. Multiple bronchoscopic interventions were conducted, including rigid bronchoscopy, argon plasma coagulation (APC), dioxide carbon cryotherapy, and electric loop. Tumors could be removed by multiple bronchoscopic interventions. Bronchoscopy-associated complications were rare, including an oral mucosa injury and a glottis edema. In the child group, one patient underwent left upper lung lobectomy. In the adult group, lobectomy and/or chemotherapy and/or radiotherapy were conducted in seven patients. The 5-year survival rate was 100% and 68.90% in the child and the adult group, respectively. Conclusions: Almost all children have low-grade and intratracheal MEC; 2/5 adults have invasive high-grade MEC. Multiple bronchoscopic interventions are effective in erasing low-grade intratracheal MEC without severe complications. For high-grade invasive MEC, aggressive and comprehensive therapy should be considered.

scholarly journals Pulmonary mucoepidermoid carcinoma: Clinicopathological characteristics of 20 cases and a literature review

2020 ◽  
Author(s):  
Jing Zhang ◽  
Yan Xiao Chen ◽  
Jun Zi Qian ◽  
Ping Yue ◽  
Jialei Wang ◽  
...  
Keyword(s):  
Tumor Markers ◽  
Medical Records ◽  
Mucoepidermoid Carcinoma ◽  
Clinicopathological Characteristics ◽  
Smoking History ◽  
Categorical Variables ◽  
Low Grade ◽  
High Grade ◽  
Alk Rearrangement ◽  
Ki 67

Abstract Background: Pulmonary mucoepidermoid carcinoma is a rare tumor of the lung. The clinicopathological characteristics of pulmonary mucoepidermoid carcinoma are not well defined due to the low incidence. This study was performed to provide more supplementary clues for the identification and understanding of pulmonary mucoepidermoid carcinoma. Methods: We reviewed the medical records since January 1, 2000 to December 31, 2018. The patients’ medical records，including age at the time of diagnosis , gender, smoking history, preoperative evaluations, operative procedures, tumor location, tumor size, tumor stage, lymph node metastasis, pathological markers, prognosis and survival information were extracted and reviewed. Categorical variables were presented as parameters and percentages. A comparison was performed between patients with high and low grade of pulmonary mucoepidermoid carcinoma. Results: 20 patients were identified and the age span is from 18 to 67 year-old with the average age is 45. Mucoepidermoid carcinomas were commonly found in men（60%）. 80% patients had clinical presentations and the positive rate of tumor markers was 78%, although no specific tumor markers were found. TTF-1 were negative in all cases. ALK rearrangement was identified in a non-smoking woman with high grade pulmonary mucoepidermoid carcinoma. Surgery is the main procedure. 3-year survival rate is 72% and 80% patients achieved disease-free alive. High-grade patients tend to harbor older age (p=0.035), larger tumor volume (p=0.026) and higher index of ki-67(p=0.0005). Conclusions: Pulmonary mucoepidermoid carcinoma could occur in a wide age span. Early diagnosis and complete surgical resection may promise a good prognosis. Grading is a key factor to predict the overall survival time. Combined TTF-1 and MAML2 will benefit the identification of pulmonary mucoepidermoid carcinoma from other lung tumors. Future prospective randomized controlled trials and larger, multi-centric series are needed.

scholarly journals Rapid metastasis of stage IA primary pulmonary high-grade mucoepidermoid carcinoma with a cystic airspace: a case report and reflection

2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110381
Author(s):  
Yi Chen ◽  
Fangbiao Zhang ◽  
Xiaomei Chen ◽  
Liping Yan ◽  
Xiangyan Zhang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Surgical Resection ◽  
Mucoepidermoid Carcinoma ◽  
Histopathological Examination ◽  
Left Lung ◽  
High Grade ◽  
Early Metastasis ◽  
Node Metastasis ◽  
Stage Ia

Primary pulmonary high-grade mucoepidermoid carcinoma (MEC) with a cystic airspace is uncommon, and early metastasis is extremely rare. In such cases, however, it is clinically important for clinicians to consider whether the tumor has spread to the lymph nodes through the cystic airspace. A 77-year-old man presented to our hospital with cough and hemoptysis. Chest computed tomography showed a 25-mm-diameter mass with a cystic airspace located in the upper lobe of the left lung. The possibility of malignancy was considered. Without a definitive preoperative diagnosis, left upper lobectomy and mediastinal lymphadenectomy were performed. Histopathological examination revealed the typical histological characteristics of high-grade MEC (stage IA) and no lymph node metastasis. However, lymph node metastasis was found 6 months after surgical resection, and radiochemotherapy was performed. The patient developed widespread metastatic disease 4 months following completion of radiochemotherapy and died 2 months later. Primary pulmonary MEC with a cystic airspace is a rare malignant disease with uncommon imaging findings. Complete surgical resection is the main treatment method for high-grade MEC. In this case, we hypothesize that early metastasis was caused by seeding of tumor cells through the cystic airspace.

Use of FDG-PET Imaging for Patients with Disseminated Cancer of the Appendix

2010 ◽  
Vol 76 (12) ◽  
pp. 1338-1344 ◽  
Author(s):  
Payam Rohani ◽  
Stephen D. Scotti ◽  
Perry Shen ◽  
John H. Stewart ◽  
Gregory B. Russell ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Fdg Pet ◽  
Peritoneal Dissemination ◽  
Low Grade ◽  
High Grade ◽  
Positron Emission ◽  
Pet Ct ◽  
The Mean ◽  
Ct Data ◽  
Abdominal Quadrant

The goal of this study is to evaluate the use of positron emission tomography (PET) in evaluation of patients with peritoneal dissemination of carcinoma of appendiceal origin (PDA). Thirty-three patients with PDA, who had preoperative PET or PET/CT imaging, were analyzed. Using operative, pathology, and PET ± CT data, presence or absence of disease in each abdominal quadrant was noted and the use of 18fluoro-deoxy-glucose (FDG) PET for each quadrant was evaluated. The mean age was 52, and there were 17 males; 58 per cent had low-grade lesions. PET was positive in only 35 per cent of cases overall (30 and 41% sensitivity for low-grade and high-grade, respectively). PET without CT sensitivity for low-grade and high-grade lesions was 21 and 8 per cent, respectively. PET imaging has limited use for patients with PDA. We do not recommend the use of FDG-PET for patients with PDA from cancer of the appendix.

scholarly journals Mucoepidermoid Carcinoma: A Demographic and Histopathological Profile

2020 ◽  
Vol 9 (4) ◽  
pp. 298-302
Author(s):  
Zainab Niazi
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumors ◽  
Anatomical Site ◽  
Low Grade ◽  
High Grade ◽  
Male Patients ◽  
Histopathological Grading ◽  
Malignant Salivary Gland Tumors

Background: To find the frequency and clinico-pathological presentation of mucoepidermoid carcinoma (MEC).Materials and Methods:In this study, we included all the malignant salivary gland tumors. Among these the frequency of mucoepidermoid carcinoma was considered. Age, gender, histopathological grading and anatomical site of tumor were included in data analysis.Results:Out of 60 malignant salivary gland tumors reported to the histopathology department, 30 tumors were diagnosed as mucoepidermoid carcinomas. The patient’s age having mucoepidermoid carcinoma ranged from 6 to 88 years, mean age of 44.9±19.2SD. The male patients were 23 in number while female were 7. Out of 30 cases, 73.3% patients had tumor in parotid gland, while13.3% patients in submandibular gland . Other tumors were in palate, retromolar area, and in posterior 1/3rdof tongue (13.3%). According to histopathological grading 26.6% cases of MEC were of high grade, 26.6 % were intermediate grade and 36.6% were low grade.Conclusions:According to this study, the frequency of MEC was 50% among all salivary gland tumors. MEC was mostly found in parotid gland and histopathologically low grade type was the most common.

scholarly journals Dedifferentiated Osteosarcoma of the Distal Ulna: A Case Report

2021 ◽  
pp. 1228-1236
Author(s):  
Ryosuke Tsujisaka ◽  
Robert Nakayama ◽  
Tetsuya Sekita ◽  
Naofumi Asano ◽  
Kazutaka Kikuta ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Bone Tumor ◽  
Lung Metastases ◽  
Low Grade ◽  
Parosteal Osteosarcoma ◽  
High Grade ◽  
Distal Ulna ◽  
Initial Surgery ◽  
High Grade Osteosarcoma ◽  
Over 40 Years

Osteosarcoma is the most common malignant primary bone tumor that occurs most frequently in the second decade of life but rarely in patients over 40 years of age. The most common primary sites of osteosarcoma are the distal femur followed by proximal tibia and proximal humerus, and involvement of the wrist is extremely rare. Moreover, dedifferentiated osteosarcoma is also a rare condition that progresses to high-grade osteosarcoma from low-grade osteosarcoma, usually central low-grade osteosarcoma or parosteal osteosarcoma that bears MDM2 and/or CDK4 gene amplifications. We herein report an extremely rare case of dedifferentiated osteosarcoma arising in the distal ulna of an adult over 40 years of age. The patient was a 46-year-old man with a 2-month history of pain in his left swollen wrist. The initial radiological findings suggested a benign bone tumor in the distal ulna, and the lesion was marginally excised at the nearby hospital. Although the pathological diagnosis at the nearby hospital suggested a benign cartilaginous tumor, the tumor recurred in an aggressive manner 8 months after the initial surgery. The patient was referred to our hospital, and an incisional biopsy showed a high-grade osteosarcoma. The primary tumor was retrospectively re-evaluated at our hospital and diagnosed as low-grade osteosarcoma. Since neoadjuvant chemotherapy failed to shrink the tumor, the patient had to undergo below the elbow amputation to cure the disease. Although the tumor was negative for MDM2 nor CDK4, the definitive diagnosis of dedifferentiated osteosarcoma was made according to the clinical course and the histological findings. Lung metastases were found 10 months after the amputation, which were successfully treated by neoadjuvant chemotherapy and surgery. The patient has been doing well with no evidence of disease for 1 year and 6 months. Surprisingly, the literature review revealed that many low-grade osteosarcomas of the distal ulna progressed to high-grade dedifferentiated osteosarcomas. One should bear in mind that the diagnosis and treatment for bone-forming tumors of the distal ulna should be made very carefully because, although rare, it is possible that the tumor may initially appear as a benign or low-grade malignant tumor and may progress to high-grade osteosarcoma.

Low-Grade and High-Grade Mucoepidermoid Carcinoma of the Lung: CT Findings and Clinical Features of 17 Cases

2015 ◽  
Vol 205 (6) ◽  
pp. 1160-1166 ◽  
Author(s):  
Yiqi Q. Wang ◽  
Yunxian X. Mo ◽  
Sheng Li ◽  
Rongzhen Z. Luo ◽  
Siyue Y. Mao ◽  
...  
Keyword(s):  
Clinical Features ◽  
Mucoepidermoid Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Ct Findings ◽  
Lung Ct

scholarly journals Mucoepidermoid Carcinoma of the Lung: A Case Report and Literature Review

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
S. Alsidawi ◽  
J. C. Morris ◽  
K. A. Wikenheiser-Brokamp ◽  
S. L. Starnes ◽  
N. A. Karim
Keyword(s):  
Lung Cancer ◽  
Surgical Resection ◽  
Mucoepidermoid Carcinoma ◽  
Primary Treatment ◽  
Pathological Examination ◽  
Low Grade ◽  
High Grade ◽  
Lobe Bronchus ◽  
Rare Type ◽  
The Right

Introduction. Mucoepidermoid carcinoma (MEC) of the lung is a rare form of lung cancer that is classified into low grade and high grade based on histological features. Surgical resection is the primary treatment for low-grade MEC with excellent outcomes, while high-grade MEC is a more aggressive form of malignancy.Clinical Case. We report a case of a 46-year-old woman who presented with dyspnea on exertion. Imaging studies revealed a mass involving the right upper lobe bronchus. Bronchoscopy, surgical resection, and pathological examination revealed a low-grade MEC with tumor-free margins. No adjuvant treatment was given.Discussion. Primary pulmonary MEC is a rare type of lung cancer with only few reported cases. This patient illustrates a typical presentation for low-grade MEC wherein surgical resection is considered curative. In contrast, high-grade MEC is a more aggressive malignancy with a poorer outcome. The role of targeted therapy directed against EGFR or a novel CRTC1-MAML2 fusion protein expressed in some high-grade tumors is yet to be determined.

scholarly journals Mucoepidermoid Carcinoma: Unusual Localisation

2020 ◽  
pp. 1-2
Author(s):  
Zouhair Najib ◽  
Mohamed Roubal ◽  
Mohamed Mahtar ◽  
Redalah Elarabi Abada ◽  
Sami Rouadi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Case Report ◽  
Clinical Examination ◽  
Mucoepidermoid Carcinoma ◽  
Hard Palate ◽  
Histological Grade ◽  
Young Patients ◽  
Low Grade ◽  
Resonance Imaging ◽  
Histological Characteristics

Introduction: Mucoepidermoid carcinoma (MEC) is a rare malignant tumor that develops from the salivary glands. Its treatment includes surgery associated or not with radiotherapy depending on the histological grade. We report the case of a 38-year-old patient. Methods: We report a case of a mucoepidermoid carcinoma of the palate, and we specify the clinical, therapeutic and progressive characteristics of this attack. Case Report: She is a 38-year-old woman with no significant medical history. The clinical examination revealed a localized mass at the level of the hard palate, with a smooth normal-looking mucosa measuring 4 cm in long axis, the rest of the clinical examination was normal. Pathology examination confirmed the diagnosis of low-grade CME. Magnetic resonance imaging was performed objectifying a lesion localized at the level of the submucosa of the palate without bone extension either to the tongue or to the nasal cavity. The treatment consisted in excision of the lesion with margin, with monthly monitoring for 6 months with good progress. Conclusion: The discovery of a CME in young patients is rare. This observation makes it possible to take stock of the management of this type of cancer according to histological characteristics.

scholarly journals High-grade mucoepidermoid carcinoma in thyroglossal cyst: Post-surgical histological surprise and dilemmas

2021 ◽  
Vol 12 (12) ◽  
pp. 177-180
Author(s):  
Ravindran Chirukandath ◽  
CR Nimisha ◽  
PJ Babu ◽  
Puthukatt Muraleedharan Arya ◽  
RS Lekshmi ◽  
...  
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Early Stage ◽  
Anaplastic Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Thyroglossal Cyst ◽  
Thyroglossal Duct ◽  
Aggressive Surgical Approach ◽  
Thyroglossal Duct Cysts ◽  
Thyroglossal Duct Remnant

Occurrence of malignancy in the TG cyst has been rarely reported, though rare, and papillary carcinoma predominates the common type but squamous cell carcinomas, anaplastic carcinoma, and medullary have been reported rarely. Mucoepidermoid carcinomas are most commonly seen in salivary glands, and as per the available literature, there was only two cases reported in thyroglossal cyst. We are presenting a 67-year-old lady presented with a 6×8 cm hard swelling below symphysis menti with no thyromegaly and moving on protrusion of tongue, and on MRI, it was found to be thyroglossal cyst with infiltration of strap muscles. Cytological investigation revealed it to be a TG cyst malignancy. The patient underwent total thyroidectomy and radical Sistrunk’s operation. Histopathological and immunohistochemistry revealed it to be a histological examination revealed a low-grade mucoepidermoid carcinoma consistent with origin in a thyroglossal duct remnant it invaded the hyoid bone and adjacent strap muscles. Various diagnostic and treatment dilemmas in the treatment of TG cyst malignancy are discussed with reference to mucoepidermoid carcinoma. We are reporting an usual histological surprise in a thyroglossal cyst malignancy being the only second reported case of TG cyst mucoepidermoid carcinoma this case highlights the importance of removal of thyroglossal duct cysts at an early stage and aggressive surgical approach in high-grade tumors.

Sign in / Sign up

Export Citation Format

Share Document