scholarly journals Combined phacoemulsification and anterior vitrectomy in a case of anterior megalophthalmos with open-angle glaucoma and high myopia

2021 ◽  
Vol 8 (33) ◽  
pp. 3084-3089
Author(s):  
Ram Kumar Jaiswal ◽  
Ramyash Singh Yadav ◽  
Mridula Ranjan ◽  
Dipti Wahi ◽  
Chiranji Rai

BACKGROUND Myopia is a complex trait including both genetic and environmental factors as well as gene-environment interactions. It has been recognized as a risk factor for development of glaucoma. Both Myopia and raised IOP are known to increase mechanical stress at optic nerve head leading to glaucomatous nerve damage. This study intends to evaluate the clinical profile of myopic subjects and its correlation with Primary open angle glaucoma (POAG). METHODS A prospective observational study done from November 2019 to December 2020 after taking proper informed consent and ethical clearance. 164 eyes of 96 patients studied were divided into three groups, Group 1: low myopia (< -3.00D), Group 2: moderate myopia (-3.00 D to -5.75 D), Group 3: high myopia (≥ -6.00 D). A complete ocular examination was performed. Intraocular pressure was measured using Goldmann applanation tonometer. Visual field analysis using Humphrey automated perimetry was done in patients with suspected primary open angle glaucoma (POAG). Angle parameters and central corneal thickness (CCT) were measured using anterior segment optical coherence tomography (AS-OCT). RESULTS 164 eyes of 96 Myopic subjects were studied with no dropout during study period. Mean age was 46.05 yr. (range: 25-75 yr.). The refraction ranged from -0.50 DS to -17.00 DS. There was no statistically significant difference between Intraocular pressure (IOP), Central corneal thickness (CCT), corrected IOP and Nasal and Temporal Trabecular-iris Angle (TIA) between male and female of same age group. Mean IOP and mean CCT were found to vary significantly with age and with higher degree of myopia. Corrected IOP, Nasal and Temporal TIA increase significantly with higher degree of myopia. Cup-disc ratio (CDR) was found to be significantly higher in patients with moderate to high degree of Myopia. CONCLUSIONS Myopia is an important risk factor for development of primary open angle glaucoma, with its incidence increasing in patients with moderate to high myopia. KEYWORDS Myopia, Primary Open Angle Glaucoma, Intraocular Pressure, Central Corneal Thickness, Trabecular Iris Angle


2016 ◽  
Vol 60 (6) ◽  
pp. 446-453 ◽  
Author(s):  
Daisuke Tanaka ◽  
Hideo Nakanishi ◽  
Masanori Hangai ◽  
Tadamichi Akagi ◽  
Satoshi Morooka ◽  
...  

2016 ◽  
Vol 60 (2) ◽  
pp. 78-85 ◽  
Author(s):  
Takaiko Yoshino ◽  
Takeo Fukuchi ◽  
Tetsuya Togano ◽  
Yuta Sakaue ◽  
Masaaki Seki ◽  
...  

2017 ◽  
Vol Volume 11 ◽  
pp. 599-604 ◽  
Author(s):  
Koji Nitta ◽  
Kazuhisa Sugiyama ◽  
Ryotaro Wajima ◽  
Gaku Tachibana

Author(s):  
Aghafekokhian B. Osaiyuwu ◽  
Genesis D. Edokpa

Background: Increasing evidence suggests that high myopia is salient in the pathologic process of POAG, and IOP (Primary Open Angle Glaucoma (POAG), and Intra-ocular Pressure (IOP)) remains the crucial risk factor for this condition. Still, some other studies have signified that glaucoma was diagnosed in myopes independent of IOP, suggesting that predisposition to glaucoma in myopes may not be dependent on mechanisms related to high pressures. The aim of this study was therefore to compare the intraocular pressure in myopes and hyperopes in a Nigerian population just diagnosed with POAG to ascertain if proclivity to glaucoma in myopes is mainly dependent on IOP.Methods: This research was conducted as a retrospective study in the Optometry/Ophthalmology Department at Stella Obasanjo Women and Children Hospital, Benin City, Nigeria. The sample consisted of cases seen between 2011 and 2013. A total of 166 eyes with glaucoma and refractive errors (80 (48.19%) with myopia, and 86 (51.81%) with hyperopia) with an age range of 10 to 85 years, were used for this study.Results: Newly diagnosed glaucomatous myopes had a significantly higher mean IOP than recently diagnosed hyperopes (unpaired t- test, p= 0.004). Also, a significant inverse correlation was obtained between refractive errors and intraocular pressure (Pearson correlation, r = -.245, p = 0.001) i.e. as refractive errors progressed deeply into more minus (myopic) regions, IOP increased.Conclusions: The relationship between glaucoma and myopia is pressure mediated. The ascending levels of intraocular pressure that occurred with increasing extents of myopia demonstrate that POAG evolves too soon in participants with high myopia than in hyperopia and accentuates the seriousness of glaucoma surveillance in the myopic population.


1970 ◽  
Vol 10 (1) ◽  
pp. 35-39
Author(s):  
S Bhattarai ◽  
K Sapkota ◽  
SMN Prabhudesai ◽  
JK Shrestha ◽  
AK Sharma

Background: Primary open angle glaucoma (POAG), a chronic, slowly progressive, optic neuropathy, is insidious in onset and painless, until it has caused a significant loss of vision and visual field. Diabetes mellitus and high myopia are the major risk factor of POAG. Objectives: To determine correlation of diabetes mellitus and high myopia in POAG and to estimate the duration of onset of POAG from the diagnosis of diabetes mellitus and high myopia. Method: This retrospective and cross sectional study was conducted in Prabhudesai eye clinic, Pune, India. All the patients diagnosed as POAG from 1st September 2008 to 1st March 2009 AD were included in this study. Association of high myopia with diabetes mellitus was determined by SPSS 13 software. The average duration of onset of POAG after the diagnosis of diabetes mellitus and high myopia was calculated. Results: There were 63.3% (38) male and 36.7% (22) female out of 60 patients of POAG with mean age 54.4±15.4 years. Among them, 27 (45.0%) patients had diabetes mellitus or high myopia. Onset of POAG was found to occur after 11.1±8.3 years of the diagnosis of diabetes and 10.6±3.2 years after the diagnosis of high myopia. Conclusion: The incidence of diabetes mellitus and high myopia was high and significantly associated in primary open angle glaucoma. POAG was detected soon after the onset of diabetes mellitus and high myopia. DOI: http://dx.doi.org/10.3126/hren.v10i1.6005 HREN 2012; 10(1): 35-39


1992 ◽  
Vol 2 (1) ◽  
pp. 33-35 ◽  
Author(s):  
L. Mastropasqua ◽  
L. Lobefalo ◽  
A. Mancini ◽  
M. Ciancaglini ◽  
S. Palma

In this study concerning the prevalence of myopia in patients with open angle glaucoma, its distribution was analyzed within the sample tested in relation to the refraction defect size, compared with a control group of non-glaucomatous myopic subjects. The overall myopic rate was 17.2% of the glaucomatous patients; high myopia was more frequent in the subjects with open angle glaucoma (p<0.001) than in the myopic patients, thus appearing as a possible risk factor for the development of glaucoma.


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