scholarly journals Enfermedad coronaria asintomática en pacientes con diabetes mellitus tipo 2

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
José Augusto Urrego Díaz ◽  
Claudia Yadira Obando León ◽  
María Claudia Vivero Mogollón
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Diabetes Mellitus Type 2 ◽  
Coronary Vessels ◽  
Palabras Clave ◽  
Factores De Riesgo ◽  
Asymptomatic Diseases ◽  
Artery Disease

Introducción: la enfermedad coronaria es una de las principales causas de morbimortalidad a nivel mundial; se sabe que la diabetes mellitus tipo 2 (DM2) es un factor de riesgo importante para esta patología y que puede producir una forma asintomática o con manifestaciones atípicas. Objetivos: exponer los principales datos epidemiológicos, pronósticos y determinantes de la enfermedad coronaria asintomática en DM2 y discutir las formas de tamización y su utilidad en diabéticos asintomáticos. Materiales y métodos: se realizó una búsqueda en PubMed, LILACS y SciELO usando las palabras clave “Diabetes Mellitus, type 2”, “Coronary disease”, “Coronary Artery Disease”, “Coronary Vessels”, “Atherosclerosis”, “Arteriosclerosis”, “Asymptomatic Diseases”, “Asymptomatic”, “Silent” y “Myocardcial infarction”, ajustando la búsqueda según las necesidades de cada base de datos. Se incluyeron artículos que cumplieran los criterios de inclusión y no los de exclusión, a consideración de los autores, así como algunas referencias adicionales. Resultados: se revisó el título y resumen de 504 artículos encontrados en las bases de datos, tras lo cual se escogieron 81 para su lectura total. De ellos, 56 fueron incluidos, así como 48 publicaciones adicionales conocidas por los autores o referenciados en las artículos leídos, lo que dio un total de 104 artículos incluidos en la revisión final. Conclusiones: los pacientes con DM2 presentan altas prevalencias de enfermedad coronaria asintomática que aumentan en presencia de otros factores de riesgo cardiovascular o de mayor duración o progresión de la DM2. Si bien existen varios métodos anatómicos o funcionales para su detección, la tamización de esta población no ha mostrado beneficio alguno, por lo que no puede recomendarse de rutina en asintomáticos.

scholarly journals ROLE OF HYPERCORTISOLEMIA IN PROGRESSION OF THE COMORBID COURSE OF CORONARY ARTERY DISEASE, DIABETES MELLITUS TYPE 2 AND ANEMIA

2019 ◽  
Vol 7 ◽  
pp. 794-797
Author(s):  
Nataliia Pavliukovych ◽  
Oleksandr Pavliukovych ◽  
Oleksandr Buriak ◽  
Tamara Kopchuk ◽  
Volodymyr Vivsyannuk
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Diabetes Mellitus Type 2 ◽  
Chronic Hypoxia ◽  
Diabetes Mellitus Type ◽  
Control Group ◽  
Artery Disease ◽  
Degree Of Severity

INTRODUCTION: Hyperactivation of stress-limiting mechanisms of the organism is a unique physiological response of the human being to chronic hypoxia of different origins. OBJECTIVES: Investigation of dynamics of cortisol synthesis changes in patients with coronary artery disease with comorbid diabetes mellitus type 2 and anemic syndrome in patients of older age groups. METHODS: Blood cortisol level was measured in 40 old and senile coronary artery disease patients with comorbid diabetes mellitus type 2 and anemic syndrome of different degrees of severity. The control group consisted of 12 patients with coronary artery disease without comorbidities that were not significantly different through gender and age from the patients of the research groups. Possible effects of telmisartan on the degree of chronic hypoxia were also investigated. RESULTS: In patients of old and senile age with coronary artery disease  and comorbid anemic syndrome, same as in case of coronary artery disease and anemic syndrome on the background of diabetes mellitus type 2, activation of the cortisol synthesis is observed, likely in response to hypoxia as a stress factor in anemia. The degree of severity of the detected changes was different depending on the degree of anemia severity. There was no normalization of cortisol content in blood in any of the major experimental groups regardless the prescribed treatment with ACE inhibitors or telmisartan. CONCLUSIONS: In patients with coronary artery disease, same as in the case of a comorbid course of coronary artery disease and diabetes mellitus type 2, an increase of cortisol secretion in response to anemic hypoxia was observed. As the degree of severity of the anemic syndrome progressed, gradual decreasing of cortisol blood level was detected. Reduction of the intensity of stress-limiting systems in the organism by telmisartan prescription may help to eliminate the adverse effects of hypercortisolemia on the progression of coronary artery disease, especially on the background of comorbid diabetes mellitus type 2 and anemia.

scholarly journals LASER STOKES-POLARIMETRY OF THE ERYTHROCYTES SUSPENSION AT COMORBID COURSE OF CORONARY ARTERY DISEASE, DIABETES MELLITUS TYPE 2 AND ANEMIA

2017 ◽  
Vol 5 ◽  
pp. 998-1004
Author(s):  
Nataliia Pavlyukovich ◽  
Oleksandr Pavlyukovich ◽  
Marta Garazdiuk ◽  
Oleg Wanchuliak ◽  
Oleksandr Garazdiuk
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Early Detection ◽  
Diabetes Mellitus Type 2 ◽  
Objective Assessment ◽  
Diabetes Mellitus Type ◽  
Laser Polarimetry ◽  
Artery Disease

Introduction: Investigation of the rheological properties of the erythrocytes is one of the crucial issues in the pathogenesis of most diseases of internal organs. Changes in the morphological structure of the red blood cell membrane serve as an early diagnostic criterion of coronary artery disease, diabetes mellitus type 2 and anaemia, thus a search for modern methods of investigation which can be used for early detection of erythrocytes membrane disorders is of great importance. Methods of laser polarimetry of the erythrocytes suspension smear are crucial in this area.Objectives: Investigation of the possible structural changes of the erythrocytes membranes in patients with coronary artery disease, diabetes mellitus type 2 and anaemia of different degrees of severity.Methods: For the objective assessment of the structural state of erythrocytes membrane laser polarimetry of the red cell suspension smear was applied. Set of the statistical points of the 1st-4th grades was calculated and their effectiveness in the early pre-clinical detection of the erythrocytes membrane disorder was established.Results: Images of the erythrocytes suspension samples, registered in the co-axial and crossed planes of the polarizer and analyser transmissions, regardless of the investigated group, are coordinating heterogeneous. However, obvious signs of the changes of the images structure depending on the presence and type of pathology are not visually detected. As the basis of an objective approach, a statistical analysis with histograms of the coordinate distributions of the random variables and a statistical calculation of the statistical points of the 1st-4th grades should be used. All statistical points, which describe the coordinate distributions of the various parameters of the Stokes vector, have individual sets of values and may be used for the differential diagnosis of the coronary artery disease, diabetes mellitus type 2 and anaemia.Conclusions: Interconnections between the values of the sets of the statistical points of the 1st-4th grades, which characterized coordinate distributions of the intensity, azimuth and ellipticity of the polarization of the erythrocytes suspension laser images of the elderly and senile patients with comorbidity were established by means of laser polarimetry. The most sensitive were asymmetry and kurtosis, which can be used for early detection of the erythrocytes membrane disorder when routine methods of its visualization and estimation still are not able to be applied.

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