scholarly journals SIMULATION OF MORPHOLOGICAL AND FUNCTIONAL PROPERTIES OF ERYTHROCYTE MEMBRANE

2017 ◽  
Vol 19 (9.1) ◽  
pp. 177-190
Author(s):  
Yu.S. Nagornov ◽  
I.V. Zhilyaev
Keyword(s):  
Finite Element Analysis ◽  
Experimental Study ◽  
Atomic Force Microscopy ◽  
Finite Element ◽  
Erythrocyte Membrane ◽  
Optimization Methods ◽  
Element Analysis ◽  
Erythrocyte Morphology ◽  
Force Microscopy ◽  
Atomic Force

The paper presents a model for the calculation of morphofunctional erythrocyte properties. The model represents the erythrocyte as a homogeneous elastic body with elastic depending on the distance to the center of symmetry of the erythrocyte. The data for modeling were taken from the experimental study, which were used by atomic force microscopy (measuring the elasticity of the membrane of erythrocytes and morphology) and the Coulter method. In the developed model, the elasticity of the membrane to change depending on the distance to the center within 1-1,6 kPa. The calculation of the elastic properties is made by two methods - finite element analysis and optimization methods. In the model the dependence of erythrocyte morphology on the membrane pressure was obtained. Pressure difference across the erythrocyte membrane varied in the range of 0,5-2 kPa.

scholarly journals Finite element analysis of V-shaped cantilevers for atomic force microscopy under normal and lateral force loads

2006 ◽  
Vol 38 (6) ◽  
pp. 1090-1095 ◽  
Author(s):  
Matthias Müller ◽  
Thomas Schimmel ◽  
Pascal Häußler ◽  
Heiko Fettig ◽  
Ottmar Müller ◽  
...  
Keyword(s):  
Finite Element Analysis ◽  
Atomic Force Microscopy ◽  
Finite Element ◽  
Lateral Force ◽  
Element Analysis ◽  
Force Microscopy ◽  
Atomic Force

Mass Transfer Limitations at Crystallizing Interfaces in an Atomic Force Microscopy Fluid Cell:  A Finite Element Analysis

Langmuir ◽  
2006 ◽  
Vol 22 (15) ◽  
pp. 6578-6586 ◽  
Author(s):  
David Gasperino ◽  
Andrew Yeckel ◽  
Brian K. Olmsted ◽  
Michael D. Ward ◽  
Jeffrey J. Derby
Keyword(s):  
Mass Transfer ◽  
Finite Element Analysis ◽  
Atomic Force Microscopy ◽  
Finite Element ◽  
Element Analysis ◽  
Force Microscopy ◽  
Atomic Force ◽  
Fluid Cell

A Novel Plate-Like Sensor Utilizing Curvature-Based Stiffening for Nanometrology Applications

2020 ◽  
Author(s):  
Rafiul Shihab ◽  
Tasmirul Jalil ◽  
Burak Gulsacan ◽  
Matteo Aureli ◽  
Ryan C. Tung
Keyword(s):  
Finite Element Analysis ◽  
Atomic Force Microscopy ◽  
Natural Frequencies ◽  
Piezoelectric Actuators ◽  
Static Stiffness ◽  
Element Analysis ◽  
Force Microscopy ◽  
Transverse Curvature ◽  
Atomic Force

Abstract In this study, we propose a novel plate-like sensor which utilizes curvature-based stiffening effects for enhanced nanometrology. In the proposed concept, the stiffness and natural frequencies of the sensor can be arbitrarily adjusted by applying a transverse curvature via piezoelectric actuators, thereby enabling resonance amplification over a broad range of frequencies. The concept is validated using a macroscale experiment. Then, a microscale finite element analysis is used to study the effect of applied curvature on the microplate static stiffness and natural frequencies. We show that imposed transverse curvature is an effective way to tune the in-situ static stiffness and natural frequencies of the plate sensor system. These findings will form the basis of future curvature-based stiffening microscale studies for novel scenarios in atomic force microscopy.

Determination of Strain-Rate-Dependent Mechanical Behavior of Living and Fixed Osteocytes and Chondrocytes Using Atomic Force Microscopy and Inverse Finite Element Analysis

2014 ◽  
Vol 136 (10) ◽  
Author(s):  
Trung Dung Nguyen ◽  
YuanTong Gu
Keyword(s):  
Finite Element Analysis ◽  
Atomic Force Microscopy ◽  
Strain Rate ◽  
Mechanical Behavior ◽  
Strain Rates ◽  
Element Analysis ◽  
Force Microscopy ◽  
Rate Dependent ◽  
Atomic Force ◽  
Inverse Finite Element Analysis

The aim of this paper is to determine the strain-rate-dependent mechanical behavior of living and fixed osteocytes and chondrocytes, in vitro. First, atomic force microscopy (AFM) was used to obtain the force–indentation curves of these single cells at four different strain-rates. These results were then employed in inverse finite element analysis (FEA) using modified standard neo-Hookean solid (MSnHS) idealization of these cells to determine their mechanical properties. In addition, a FEA model with a newly developed spring element was employed to accurately simulate AFM evaluation in this study. We report that both cytoskeleton (CSK) and intracellular fluid govern the strain-rate-dependent mechanical property of living cells whereas intracellular fluid plays a predominant role on fixed cells' behavior. In addition, through the comparisons, it can be concluded that osteocytes are stiffer than chondrocytes at all strain-rates tested indicating that the cells could be the biomarker of their tissue origin. Finally, we report that MSnHS is able to capture the strain-rate-dependent mechanical behavior of osteocyte and chondrocyte for both living and fixed cells. Therefore, we concluded that the MSnHS is a good model for exploration of mechanical deformation responses of single osteocytes and chondrocytes. This study could open a new avenue for analysis of mechanical behavior of osteocytes and chondrocytes as well as other similar types of cells.

Procaine Effect on Human Erythrocyte Membrane Explored by Atomic Force Microscopy

2011 ◽  
Vol 14 (4) ◽  
pp. 237-247 ◽  
Author(s):  
Ulpiu Vlad Zdrenghea ◽  
Gheorghe Tomoaia ◽  
Daniela-Vasilica Pop-Toader ◽  
Aurora Mocanu ◽  
Ossi Horovitz ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Erythrocyte Membrane ◽  
Human Erythrocyte ◽  
Human Erythrocyte Membrane ◽  
Force Microscopy ◽  
Atomic Force

Failure analysis of simple overlap bonding joints and numerical investigation of the adhered tip geometry effect on the joint strength

2021 ◽  
Vol 63 (11) ◽  
pp. 1007-1011
Author(s):  
İsmail Saraç
Keyword(s):  
Finite Element Analysis ◽  
Experimental Study ◽  
Finite Element ◽  
Reference Model ◽  
Lap Joints ◽  
Shear Stresses ◽  
Element Analysis ◽  
Single Lap Joints ◽  
Failure Loads ◽  
Previous Experimental Study

Abstract This study was carried out in two stages. In the first step, a numerical study was performed to verify the previous experimental study. In accordance with the previous experimental study data, single lap joints models were created using the ANSYS finite element analysis program. Then, nonlinear stress and failure analyses were performed by applying the failure loads obtained in the experimental study. The maximum stress theory was used to find finite element failure loads of the single lap joints models. As a result of the finite element analysis, an approximate 80 % agreement was found between experimental and numerical results. In the second step of the study, in order to increase the bond strength, different overlap end geometry models were produced and peel and shear stresses in the adhesive layer were compared according to the reference model. As a result of the analyses, significant strength increases were calculated according to the reference model. The strength increase in model 3 and model 5 was found to be 80 % and 67 %, respectively, relative to the reference model.

Sensor Egregium – An Atomic Force Microscope Sensor for Continuously Variable Resonance Amplification

2021 ◽  
pp. 1-23
Author(s):  
Rafiul Shihab ◽  
Tasmirul Jalil ◽  
Burak Gulsacan ◽  
Matteo Aureli ◽  
Ryan Tung
Keyword(s):  
Finite Element Analysis ◽  
Atomic Force Microscope ◽  
Natural Frequencies ◽  
Proof Of Concept ◽  
Element Analysis ◽  
Force Microscopy ◽  
Atomic Force ◽  
Wide Range ◽  
Curve Veering ◽  
Dynamic Phenomena

Abstract Numerous nanometrology techniques concerned with probing a wide range of frequency dependent properties would benefit from a cantilevered sensor with tunable natural frequencies. In this work, we propose a method to arbitrarily tune the stiffness and natural frequencies of a microplate sensor for atomic force microscope applications, thereby allowing resonance amplification at a broad range of frequencies. This method is predicated on the principle of curvature-based stiffening. A macroscale experiment is conducted to verify the feasibility of the method. Next, a microscale finite element analysis is conducted on a proof-of-concept device. We show that both the stiffness and various natural frequencies of the device can be highly controlled through applied transverse curvature. Dynamic phenomena encountered in the method, such as eigenvalue curve veering, are discussed and methods are presented to accommodate these phenomena. We believe that this study will facilitate the development of future curvature-based microscale sensors for atomic force microscopy applications.

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