Comparison Study of Effect of Ivabradine versus Beta Blockers in Early Management of Acute Coronary Syndrome with Left Ventricular Systolic Dysfunction in a Tertiary Care Hospital of West Bengal

Objectives. We sought to assess the comparative value of inflammatory markers on the occurrence of left ventricular systolic dysfunction (LVSD) after an acute coronary syndrome (ACS).Methods. During 2006–2008, 760 patients with an ACS were enrolled. C-reactive protein (CRP) and white blood cell (WBC) count were measured during the first 12 hours of hospital admission.Results. CRP levels and WBC count were significantly higher in those who developed LVSD compared to those who did not. The analysis revealed that a 10 mg/dL increase of CRP levels and a 1000/L increase in WBC are associated with a 6% and a 7% increase in the likelihood of developing LVSD, respectively. Furthermore, WBC count at entry and CRP have almost the same predictive value for development of LVSD after an ACS ( versus ).Conclusions. Serum CRP levels and WBC count at entry are almost equally powerful independent predictors of LVSD, after an ACS.

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Association Between Mortality and Persistent Use of Beta Blockers and Angiotensin-Converting Enzyme Inhibitors in Patients With Left Ventricular Systolic Dysfunction and Coronary Artery Disease

Yearbook of Cardiology ◽

10.1016/s0145-4145(09)79647-9 ◽

2010 ◽

Vol 2010 ◽

pp. 417-421

Author(s):

M.D. Cheitlin

Keyword(s):

Enzyme Inhibitors ◽

Left Ventricular Systolic Dysfunction ◽

Beta Blockers ◽

Systolic Dysfunction ◽

Angiotensin Converting Enzyme Inhibitors ◽

Left Ventricular ◽

Converting Enzyme ◽

Ventricular Systolic Dysfunction ◽

Converting Enzyme Inhibitors ◽

Artery Disease

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Abstract: P1168 EXCLUSIVE OLIVE OIL CONSUMPTION IS ASSOCIATED WITH LOWER LIKELIHOOD OF DEVELOPING LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN ACUTE CORONARY SYNDROME PATIENTS

Atherosclerosis Supplements ◽

10.1016/s1567-5688(09)71161-4 ◽

2009 ◽

Vol 10 (2) ◽

pp. e1196

Author(s):

C-M Kastorini ◽

C Chrysohoou ◽

D Panagiotakos ◽

P Aggelopoulos ◽

C Liontou ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Olive Oil ◽

Left Ventricular Systolic Dysfunction ◽

Systolic Dysfunction ◽

Left Ventricular ◽

Ventricular Systolic Dysfunction ◽

Oil Consumption ◽

Coronary Syndrome ◽

Lower Likelihood

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Exclusive Olive Oil Consumption Is Associated with Lower Likelihood of Developing Left Ventricular Systolic Dysfunction in Acute Coronary Syndrome Patients: The Hellenic Heart Failure Study

Annals of Nutrition and Metabolism ◽

10.1159/000261898 ◽

2010 ◽

Vol 56 (1) ◽

pp. 9-15 ◽

Cited By ~ 6

Author(s):

Christina Chrysohoou ◽

Christina-Maria Kastorini ◽

Demosthenes Panagiotakos ◽

Panagiotis Aggelopoulos ◽

Dimitris Tsiachris ◽

...

Keyword(s):

Heart Failure ◽

Acute Coronary Syndrome ◽

Olive Oil ◽

Left Ventricular Systolic Dysfunction ◽

Systolic Dysfunction ◽

Left Ventricular ◽

Ventricular Systolic Dysfunction ◽

Oil Consumption ◽

Coronary Syndrome ◽

Lower Likelihood

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P168 PLANT AND ANIMAL PROTEIN CONSUMPTION ARE ASSOCIATED WITH LIKELIHOOD OF DEVELOPING LEFT VENTRICULAR SYSTOLIC DYSFUNCTION, IN ACUTE CORONARY SYNDROME PATIENTS

Atherosclerosis Supplements ◽

10.1016/s1567-5688(10)70235-x ◽

2010 ◽

Vol 11 (2) ◽

pp. 51

Author(s):

C.-M. Kastorini ◽

C. Chrysohoou ◽

D.B. Panagiotakos ◽

P. Aggelopoulos ◽

C. Pitsavos ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Left Ventricular Systolic Dysfunction ◽

Systolic Dysfunction ◽

Left Ventricular ◽

Animal Protein ◽

Ventricular Systolic Dysfunction ◽

Protein Consumption ◽

Coronary Syndrome

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EFFECT OF PREHOSPITAL SYSTEMIC THROMBOLYSIS ON LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN ST-SEGMENT ELEVATION ACUTE MYOCARDIAL INFARCTION

10.54185/tbem/vol14_iss3/a4 ◽

2021 ◽

Vol 14 (3) ◽

Author(s):

A Alavi ◽

S Kenzhaev ◽

I Kakharov

Keyword(s):

Standard Therapy ◽

Left Ventricular Systolic Dysfunction ◽

Myocardial Dysfunction ◽

Systolic Dysfunction ◽

Left Ventricular ◽

Control Group ◽

Ventricular Systolic Dysfunction ◽

St Segment Elevation ◽

Coronary Syndrome ◽

St Segment

Objective: to study the effect of prehospital thrombolysis on left ventricular systolic dysfunction in patients with acute ST-segment elevation coronary syndrome.Material and methods: The study included 70 patients with acute coronary syndrome with ST-segment elevation. Patients were randomized into two groups: control (group A) - 35 patients receiving standard therapy, and hospital TLT. Group B included 35 patients who underwent standard therapy and prehospital TLT. All 70 patients underwent echocardiography 1 day after myocardial revascularization and 3 months later.Results: the use of early myocardial reperfusion in patients with STEMI had a positive effect on central hemodynamics, reduced the development of LV volume overload, as a result of which end-diastolic and systolic volumes did not change during 3 months of follow-up. LVEF grew in both groups, and its growth was more pronounced in group B.Conclusion: timely prehospital reperfusion reduces the severity of myocardial damage and thus prevents the development of severe systolic myocardial dysfunction LV.

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A Comparative Open Labelled Study on Ivabradine and Bisoprolol Prescribed in Combination Versus Maximum Dose Titration of Bisoprolol in Patients with Systolic Heart Failure and Left Ventricular Systolic Dysfunction

Cardiology Open Access ◽

10.33140/coa.04.03.03 ◽

2019 ◽

Vol 4 (3) ◽

Keyword(s):

Heart Failure ◽

Left Ventricular Systolic Dysfunction ◽

Beta Blockers ◽

Systolic Dysfunction ◽

Systolic Heart Failure ◽

Left Ventricular ◽

Functional Class ◽

Ventricular Systolic Dysfunction ◽

Nyha Functional Class ◽

Group 2

Background: Increased resting heart rate is associated with cardiovascular outcomes in patients with heart failure and reduced ejection fraction (HFrEF). Despite high volume prescribers of beta blockers patients does not achieve recommended target heart rate. The primary objective of this study was to assess the efficacy of ivabradine as adjunct therapy with beta blockers in south east Asian population systolic heart failure and left ventricular systolic dysfunction. Methodology: This single center, open labelled, randomized study included 113 patients in sinus rhythm with HFrEF and left ventricular systolic dysfunction from outpatient department. Ivabradine was initiated in 45% patients with SR. Patients with LVEF < 35% by Teichholz method, NHYA class II-III, sinus rhythm and resting HR > 70 bpm, already on bisoprolol 5 mg were divided into 2 groups; Group 1 (n= 56) patients were uptitrated to bisoprolol 10 mg and Group 2 (n= 57) patients received ivabradine 5 mg b.i.d in addition to bisoprolol 5 mg. Blood samples for NTproBNP level, an ECG, echocardiogram, NYHA functional class, systolic and diastolic BP were taken at baseline and at the end of 6 months follow-up in both groups Results: After 6 months HR decreased significantly from 94.82±7.03 to 68.75±5.35 bpm (p < 0.0001), with more patients in NHYA functional Class I than Class II and III and decrease in BNP level from 969.8.3±348.9 to 348.6±230.2 pg/ml (p < 0.0001) in group 2 patients. A significant increase in LVEF was observed with the addition of ivabradine from 31.40±5.37 to 41.68±5.33 % (p < 0.0001). However, mean systolic and diastolic blood pressure was not affected by the addition of ivabradine. Conclusion: This study concludes that patients with HFrEF demonstrated good tolerability, efficacy and NYHA functional class with the combination of ivabradine and bisoprolol therapy.

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