A Prospective Study of Corneal Ulcers and Their Microbiological Profile among Patients in a Government Hospital in Ajmer, Rajasthan

BACKGROUND Significant causes of corneal blindness worldwide are ocular trauma and corneal ulceration that are often under reported. They may be responsible for 1.5 - 2.0 million new cases of monocular blindness every year. Corneal ulceration in developing countries has only recently been recognised as a silent epidemic. Infectious keratitis is one of the leading causes of blindness but in most cases these infections represent preventable or treatable ophthalmic diseases. Important predisposing factors related to corneal ulcers are trauma, chronic ocular surface disease, contact lens usage, ocular surgery, corneal anaesthetics abuse, diabetes mellitus, vitamin deficiency and immuno-deficiencies. This work is proposed to study the prevalence, clinical and lab diagnosis and management of suppurative corneal ulcer. We wanted to study the socio-demographic profile, microbiological investigation and treatment outcome of patients with corneal ulcer. METHODS This is a prospective study conducted among patients presenting with corneal ulcer at a tertiary level Government Medical College, Ajmer, Rajasthan. RESULTS Trauma comes out as a major predisposing factor for the development of corneal ulcer. 18.1 % of the study subjects had bacterial corneal ulcer and 37.7 % had fungal ulcer. More than half of the patients showed good prognosis on follow up. There was good response in most of patients, 51.2 % improved in first week which increased to 57.4 % at the time of second follow up. The most common bacterial species responsible for corneal ulcer was found to be staphylococcus followed by pseudomonas. CONCLUSIONS Bacteria and fungi are a frequent cause of ulcerative keratitis. Microbiological work up is an essential tool in the diagnosis of these infections which should not be under-rated. Timely administration of species-specific treatment certainly results in early resolution of keratitis followed by satisfactory visual outcome. Late or inappropriate treatment worsens the condition resulting in corneal perforation and increased morbidity. KEYWORDS Prospective, Corneal Ulcer, Bacterial, Fungal, Infectious

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Study of keratomycosis at a tertiary care teaching hospital

IP International Journal of Medical Microbiology and Tropical Diseases ◽

10.18231/j.ijmmtd.2021.015 ◽

2021 ◽

Vol 7 (2) ◽

pp. 65-70

Author(s):

Veluri Gayathri ◽

Ami Jeswin

Keyword(s):

Corneal Ulcer ◽

Fusarium Species ◽

Tertiary Care ◽

Fungal Keratitis ◽

Care Hospital ◽

Predisposing Factor ◽

Corneal Ulcers ◽

Detection And Identification ◽

Bacterial Aetiology ◽

A Prospective Study

Corneal infections are one of the leading causes of ocular morbidity and blindness world-wide. If normal defence mechanisms of the eye are compromised, almost any microorganism can invade the cornea. It is important to know the exact aetiology of corneal ulcer to institute appropriate therapy in time, least serious consequences may follow. To isolate and identify the fungi from corneal scrapings of suspected keratitis patients. A prospective study of Fungal keratitis was conducted at Al-Azhar Medical College & Super Speciality Hospital in Thodupuzha, Kerala a tertiary care hospital with a capacity of 650 beds. The duration of the study was two years from January 2018 to January 2020. Patients with suspected fungal corneal ulcers presenting in the Out-Patient Department (OPD) of Ophthalmology were investigated for fungal etiology in the Department of Microbiology were included in this study. Each patient was examined with slit lamp. Data collected from history given by patient and patient examination. Using standard techniques. The specimens collected were then smeared on two slides, which were stained with Gram stain (for bacterial keratitis) and 10% potassium hydroxide preparation (for fungal keratitis) studied under light microscope. Of the 866 patients with corneal ulcer investigated, 83 cases with fungal and 36 with bacterial aetiology was identified. Males were more commonly affected and were mostly in the age group of 31-40 year. It was seen that trauma was the most common predisposing factor especially in the agriculturists and the farmers. Among the identified fungi, most were hyaline. Of the 83 positive specimens, the most frequent agent isolated was Fusarium species in 31 (37.3%) cases. 23 (27.7%) was the second most common followed by , ., . Candida albicans were 5 (6%) followed by 1 (1.2%). Fungal Keratitis is a serious problem usually following corneal trauma, it requires rapid detection and identification of fugal agents for treatment to prevent disastrous consequences.

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Uni- and Bilateral Instrumented Posterolateral Fusion of the Lumbar Spine With Local Bone Grafting: A Prospective Study With a 2-Year Follow-up

Yearbook of Neurology and Neurosurgery ◽

10.1016/j.yneu.2012.04.003 ◽

2012 ◽

Vol 2012 ◽

pp. 299-301

Author(s):

R. Riesenburger

Keyword(s):

Lumbar Spine ◽

Prospective Study ◽

Bone Grafting ◽

Posterolateral Fusion ◽

Local Bone ◽

A Prospective Study

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Spinal Cord Stimulator Improves Pain in Patients with Failed Back Surgery Syndrome: A Prospective Study with up to 2 Years of Follow-up

10.1055/s-0040-1717411 ◽

2020 ◽

Author(s):

S Weidert ◽

R Ibrahim ◽

D Habersatter ◽

Becker CA ◽

A Greiner ◽

...

Keyword(s):

Spinal Cord ◽

Prospective Study ◽

Failed Back Surgery Syndrome ◽

Spinal Cord Stimulator ◽

Failed Back Surgery ◽

Back Surgery ◽

A Prospective Study

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Faculty Opinions recommendation of Long-term follow-up of patients with papillary and follicular thyroid cancer: a prospective study on 715 patients.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9701956.10381054 ◽

2011 ◽

Author(s):

Sebastiano Filetti ◽

Cosimo Durante

Keyword(s):

Thyroid Cancer ◽

Prospective Study ◽

Follicular Thyroid Cancer ◽

Long Term Follow Up ◽

A Prospective Study

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A Prospective Study of Posterior (Transpedicular) Approach versus Anterior (Transthoracic/Thoracoabdominal) Approach for Posttraumatic Compression Fracture of Thoracolumbar Vertebra in a Tertiary Care Center: Comparison of Clinical and Radiological Outcomes

Indian Journal of Neurotrauma ◽

10.1055/s-0040-1714188 ◽

2020 ◽

Author(s):

Rahul Varshney ◽

Parthasarathi Datta ◽

Pulak Deb ◽

Santanu Ghosh

Keyword(s):

Prospective Study ◽

Posterior Approach ◽

Spinal Injuries ◽

Anterolateral Approach ◽

Kyphotic Angle ◽

Posterior Group ◽

Thoracoabdominal Approach ◽

A Prospective Study ◽

Anterior Group

Abstract Objective The aim of this article was to analyze the clinical and radiological outcomes of transpedicular decompression (posterior approach) and anterolateral approach in patients with traumatic thoracolumbar spinal injuries. Methods It was a prospective study of patients with fractures of dorsolumbar spine from December 2011 to December 2013. A total of 60 patients with traumatic spinal injuries were admitted during the study period (December 2011–2013), of which 51 cases were finally selected and taken for operations while 3 were eventually lost in follow-up. Twenty patients were operated by anterolateral approach, titanium mesh cage, and fixation with bicortical screws. Twenty-eight patients were treated with posterior approach and transpedicular screw fixation. Clinical and radiographic evaluations were performed on all 48 patients before and after surgery. Results There were 48 patients of thoracolumbar burst fractures with 40 male and 8 female patients. Range of follow-up was from 1 month to 20 months, with a mean of 7.4. Preoperatively in anterior group, 65% of the patients were bed ridden, 20% patients were able to walk with support, and 15% of the patients were able to walk without support. In posterior group, 78.57% patients were bed ridden, 10.71% were able to walk with support, and 10.71% patients were able to walk without support. Kyphotic angle changes were seen in 16 patients out of 18 in anterior group and 20 patients in posterior group out of 25. Out of 18 patients in anterior group, 14 showed reduction in kyphotic angle of 10 to 100 (improvement), with mean improvement of 4.070. In posterior group, 7 patients showed improvement of 10 to 80 (reduction in kyphotic angle) whereas 13 patients showed deterioration of 1 to 120. The mean improvement was 2.140 in 7 patients and mean deterioration was 4.920. No statistical difference was found (p > 0.05) regarding improvement in urinary incontinence during the follow-up period. Conclusion There are significant differences in anterior and posterior approaches in terms of clinical improvement. Compared with posterior approach, the anterolateral approach can reduce fusion segment and well maintain the kyphosis correction. The selection of treatment should be based on clinical and radiological findings, including neurological deficit.

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Use of Plasma Rich in Growth Factors and ReGeneraTing Agent Matrix for the Treatment of Corneal Diseases

Vision ◽

10.3390/vision5030034 ◽

2021 ◽

Vol 5 (3) ◽

pp. 34

Author(s):

Ronald M. Sánchez-Ávila ◽

Edmar Uribe-Badillo ◽

Carlos Fernández-Vega González ◽

Francisco Muruzabal ◽

Borja de la Sen-Corcuera ◽

...

Keyword(s):

Growth Factors ◽

Corneal Ulcer ◽

Disease Index ◽

Eye Drops ◽

Analog Scale ◽

Ocular Surface Disease Index ◽

Corneal Ulcers ◽

Corrected Visual Acuity ◽

The Mean

This study aimed to investigate the use of Plasma Rich in Growth Factors (PRGF) associated with tissue ReGeneraTing Agent (RGTA) drops for the treatment of noninfectious corneal ulcers. RGTA treatment was applied (one drop every two days); however, if ulcer closure was not achieved, PRGF eye drops treatment was added (four times/day). The time taken to reach the ulcer closure, the Best Corrected Visual Acuity (BCVA), intraocular pressure (IOP), Visual Analog Scale (VAS, in terms of frequency and severity of symptoms), and Ocular Surface Disease Index (OSDI) were evaluated. Seventy-four patients (79 eyes) were included, and the mean age was 56.8 ± 17.3 years. The neurotrophic corneal ulcer was the most frequent disorder (n = 27, 34.2%), mainly for herpes virus (n = 15, 19.0%). The time of PRGF eye drops treatment associated with the RGTA matrix was 4.2 ± 2.2 (1.5–9.0) months, and the follow-up period was 44.9 ± 31.5 months. The ulcer closure was achieved in 76 eyes (96.2%). BCVA, VAS and OSDI improved from the baseline (p < 0.001), and IOP remained unchanged (p = 0.665). RGTA and PRGF in noninfectious ulcers were effective and could be a therapeutic alternative for this type of corneal disease.

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326 Effects of local laser treatment on vulvovaginal atrophy for women with breast cancer: a prospective study with long-term follow-up

10.1136/ijgc-2020-esgo.166 ◽

2020 ◽

Author(s):

Lucie Veron ◽

Delphine Wehrer ◽

Gisèle Annerose-Zephir ◽

Dan Chaltiel ◽

Suzette Delaloge ◽

...

Keyword(s):

Breast Cancer ◽

Prospective Study ◽

Laser Treatment ◽

Vulvovaginal Atrophy ◽

Long Term Follow Up ◽

A Prospective Study

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Customised gold weight eyelid implantation in paralytic lagophthalmos

The Journal of Laryngology & Otology ◽

10.1017/s0022215108001886 ◽

2008 ◽

Vol 122 (10) ◽

pp. 1088-1091 ◽

Cited By ~ 7

Author(s):

N Jayashankar ◽

K P Morwani ◽

M J Shaan ◽

S R Bhatia ◽

K T Patil

Keyword(s):

Visual Acuity ◽

Prospective Study ◽

Study Design ◽

Study Group ◽

Upper Eyelid ◽

Eyelid Closure ◽

Gold Weight ◽

One Year ◽

A Prospective Study

AbstractGold eyelid implantation is widely considered the procedure of choice to reanimate the upper eyelid in paralytic lagophthalmos. Commercially supplied implants are not readily available in all places and are sometimes cumbersome to import.Objective:We aimed to devise a method whereby every surgeon performing gold eyelid implantation could have easy and quick access to the implant. Furthermore, we aimed to develop a means of creating an implant of the exact weight required for complete eyelid closure.Study design and setting:A prospective study was performed from 1997 to 2005 in a tertiary research hospital, involving 50 subjects requiring gold upper eyelid implantation and using the technique in question.Results:Only patients with a minimum follow up of one year were included in the study group. Symptoms improved in 96 per cent of subjects, who were able to dispense with eyedrops and eye ointments. Visual acuity improved in 92 per cent of patients. There were two extrusions amongst the early cases.Conclusion and significance:Customised gold eyelid implantation offers an alternative in regions where commercial implants are not easily obtained.

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