Increasing Seroprevalence of Hepatitis C Virus among Blood Donors - A 3 Year Study in North India

2021 ◽  
Vol 8 (07) ◽  
pp. 379-383
Author(s):  
Jagjeewan Ram ◽  
Namrata Nigam ◽  
Aparna Singh ◽  
Lubna Khan
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Transfusion ◽  
Blood Donors ◽  
Tertiary Care ◽  
North India ◽  
Enzyme Linked Immunosorbent Assay ◽  
Care Hospital ◽  
Hepatitis C Infection ◽  
Case Volume

BACKGROUND The primary aspect of blood transfusion lies in the availability of blood and blood components which are tested and reported negative for transfusion transmitted infections (TTI’s). The increased seroprevalence of TTI’s indicate their prevalence in general public. The study was conducted to analyse the increasing seroprevalence of hepatitis C virus (HCV) over a period of 3 years. The objectives of the study determine the seroprevalence of hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV) among the voluntary blood donors at a tertiary care hospital & associated blood bank. METHODS This cross-sectional study was done at the Department of Transfusion Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, over a period of 3 years from July 2017 to June 2020. The samples collected were screened by enzyme-linked immunosorbent assay (ELISA) tests. RESULTS A total of 69561 blood units were collected during this 3-year study from July 2017 to June 2020. Of all the blood bags screened, the highest prevalence was seen for HBV followed by HCV and HIV. 949 (1.4 %) were reactive for HBV, 75 (0.1 %) were reactive for HIV and 332 (0.5 %) were reactive for HCV. The results show a remarkable increase in the seropositivity for hepatitis C infection. CONCLUSIONS The seroprevalence of HCV has seen an increase in case load over the years as compared to HBV and HIV. This increase in case volume is indicative of impending liver diseases progressing to chronic stage over the years. Thus, it is imperative to create awareness in the general population to help reduce the risk factors responsible for HCV infection. KEYWORDS Blood Transfusion, Voluntary Donors, HCV, HBV, HIV, Seroprevalence, Transfusion Transmitted Infections (TTI’s)

scholarly journals Seroprevalence of human immunodeficiency virus, hepatitis B and hepatitis C among blood donors at a tertiary care hospital in North India

2020 ◽  
Vol 9 (11) ◽  
pp. 1671
Author(s):  
Kanwaljit Kaur ◽  
Ramneek Locham ◽  
Smriti Kaur Aulakh ◽  
Rajni Bassi ◽  
Jiteshwar Singh Pannu
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Blood Donors ◽  
Tertiary Care ◽  
North India ◽  
Care Hospital ◽  
Donor Pool ◽  
Immunodeficiency Virus ◽  
First Time

Background: The prevalence of transfusion transmitted infections (TTIs), in blood transfusion services are a major problem across blood banks and hospitals in the world. In, India, the effort to provide safe transfusion to patients is a heightened problem for various reasons. In this study, seroprevalence of Transfusion transmitted infections such as human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) was investigated in a pool of blood donors.Methods: The data collection was carried out for a period of two years from, January 2017 to December 2018, and total sample size of donors was 38,142. We studied the frequency, gender wise distribution, donor (first time vs repeat) wise distribution and yearly trend of seroprevalence of TTIs in blood units donated at our hospital.Results: A total of 37,457 (98.2%) males and 685 (1.79%) females donated blood during the study period. The results suggest that among the blood donors, the prevalence of HCV was highest (0.77%) followed by HBV (0.46%) and HIV (0.13%). Seropositivity was found to be more in first-time donors (0.83%) as compared to repeat-donors (0.52%). Seropositivity was found to be more among males (1.35%) than females (0.01%). The discussion suggests underlying reasons for the results along-with future direction of research.Conclusions: The need of the hour is to encourage repeat voluntary blood donors in order to maintain safe supply of blood and its components to donors. Efforts should be made to include females in the blood donor pool by increasing awareness and through dedicated efforts to improve female health and nutrition.

scholarly journals Prevalence of hepatitis C among pregnant females attending antenatal clinic at a tertiary care hospital in Lucknow, Uttar Pradesh, India

2020 ◽  
Vol 7 (2) ◽  
pp. 314
Author(s):  
Noor Jahan ◽  
Nitin Chaudhary ◽  
Asma Nigar ◽  
Siraj Ahmad ◽  
Razia Khatoon ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Rural Areas ◽  
Urban Areas ◽  
Tertiary Care ◽  
Antenatal Clinic ◽  
Enzyme Linked Immunosorbent Assay ◽  
Care Hospital ◽  
Hepatitis C Infection ◽  
Cross Sectional ◽  
Pregnant Females

Background: Hepatitis C virus (HCV) is a major causative agent of parenterally acquired hepatitis. Vertical transmission of HCV occurs from mother to infant during pregnancy, delivery, or neonatal period. Hepatitis C infection among pregnant females can adversely affect both mother and fetus, leading to chronic infection in infants who later develop liver cirrhosis and hepatocellular carcinoma. Objective of the study was to evaluate the prevalence of hepatitis C among pregnant females attending antenatal clinic.Methods: A hospital based cross-sectional study was done over a period of six months from January to June 2019. A total of 550 pregnant females were included in the study who attended Antenatal Clinic for routine check-up and whose blood samples were sent to Microbiology Laboratory for screening of anti-HCV antibodies by Enzyme linked Immunosorbent Assay (ELISA) method.Results: Out of 550 pregnant females tested, 3 were found to be reactive to anti-HCV antibodies by ELISA; hence the prevalence was found to be 0.5%. All 3 seropositive females belonged to age group 26-35 years, were indoor patients (IPD) and belonged to lower socio-economic class. Majority of seropositive females belonged to urban areas (66.7%, 2/3) as compared to those from rural areas (33.3%, 1/3).Conclusions: Although, prevalence of hepatitis C was found to be less among pregnant females attending ANC of this institute, still routine screening of all pregnant females for anti-HCV antibodies is highly recommended, for timely detection of disease in mothers and prevention of its transmission to infants.

scholarly journals Seroprevalence of Hepatitis B and Hepatitis C Virus among Healthy Blood Donors in Tertiary Care Hospital

2018 ◽  
Vol 28 (1) ◽  
pp. 26-31
Author(s):  
SH Pramanik ◽  
Abu Shahin Mohammed Mahbubur Rahman ◽  
Md Nurul Islam ◽  
Md Golam Rabbani ◽  
Md Khalilur Rahman
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Tertiary Care ◽  
Care Hospital ◽  
College Hospital ◽  
Medical College ◽  
Post Transfusion Hepatitis

Hepatitis B virus (HBV) & Hepatitis C virus (HCV) are transfusion transmissible infections. A study was conducted from September, 2015 to March, 2016 at the Transfusion Medicine Department of Rajshahi Medical College Hospital to determine the prevalence of asymptomatic hepatitis B and C virus in apparently healthy blood donors, were subjected to ELISA for screening of hepatitis B surface antigen and Hepatitis C virus. A total of 200 blood donors were screened, the seroprevalence of HBV & HCV infection was 5.0% & 2.0% respectively. The HBV seroprevalence in male donors was 182/8 (4.4%) and in female donors was 18/2 (11.1%). Four donors were found seropositive for HCV giving a seroprevalence of 2%. HCV seroprevalence in male was 182/4 (2.2%) and no female. Seroprevalence of HCV and HBV were higher in younger donors, service holders, married respondents and middle class donors. To reduce the prevalence of post-transfusion hepatitis and stringent donor screening procedure, routine screening for HBV & HCV in blood banks should be performed using more sensitive methods (ELISA).TAJ 2015; 28(1): 26-31

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