scholarly journals ANALYSIS OF RESULTS AND COMPLICATIONS URANOPLASTY IN CHILDREN WITH CONGENITAL CLEFT LIP AND PALATE

2020 ◽  
Vol 16 (1) ◽  
pp. 133-138
Author(s):  
Sergey Chuykin ◽  
Nail' Davletshin ◽  
Kristina Kuchuk ◽  
Oleg Chuykin ◽  
Eduard Grin' ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Petrochemical Industry ◽  
Cleft Lip ◽  
Speech Therapy ◽  
Cleft Lip And Palate ◽  
Identification System ◽  
Preoperative Stage ◽  
Analysis Of Results ◽  
Congenital Cleft ◽  
Somatic Diseases

Subject. Study of the results and complications of uranoplasty in children with congenital cleft lip and /or palate in the first year after surgical treatment. The goal is to determine the frequency of surgical and speech complications after uranoplasty in children with congenital cleft lip and/or palate in regions with a petrochemical industry and without industrial ecotoxicants. Methodology. After the uranoplasty, 80 children with various forms of cleft palate were examined at the Republican Children's Clinical Hospital. Comprehensive examination included the use of clinical (examination, palpation, percussion ― assessment of surgical status) and functional (electromyography, rheography, magnetic resonance imaging, nasopharyngoendoscopy, speech therapy speech assessment using a sound identification system) research methods. Results. Children with congenital cleft lip and/or palate born and living in regions with petrochemical ecotoxicants more often (37.5 %) have complications after uranoplasty than children from regions without petrochemical ecotoxicants (18.8 %). They have a higher prevalence of palatopharyngeal insufficiency, the frequency of fistulas of the soft and hard palate, and the need for secondary surgical intervention, more often they experience difficulties in restoring speech functions. Conclusions. Due to the presence of somatic diseases and disorders in blood counts at the preoperative stage, more pronounced postoperative complications are noted in the group of children with congenital cleft lip and/or palate from regions with the petrochemical industry, which indicates a violation of their reparative regeneration after uranoplasty. This is the rationale for the development and application of a method for the prevention of postoperative complications, which will be included in the rehabilitation algorithm to improve the physiological and speech functions of children after uranoplasty in a region with a petrochemical industry.

scholarly journals ALGOTITHM OF CHILDREN`S REHABILITATION WITH CLEFT LIP AND PALATE IN THE REGION WITH ECOTOXICANTS

2019 ◽  
Vol 15 (2) ◽  
pp. 89-96 ◽  
Author(s):  
Сергей Чуйкин ◽  
Sergey CHUYKIN ◽  
Наиль Давлетшин ◽  
Nail' Davletshin ◽  
Олег Чуйкин ◽  
...  
Keyword(s):  
Medical Records ◽  
Petrochemical Industry ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Maxillofacial Surgery ◽  
Additional Treatment ◽  
The Body ◽  
Blood Tests ◽  
Congenital Cleft ◽  
Somatic Diseases

Subject: development of an algorithm for the rehabilitation of children with congenital cleft lip and palate in a region with petrochemical ecotoxicants. Objectives: optimization of the algorithm for the rehabilitation of children with congenital cleft lip and palate in the region with ecotoxicants. Methods. A retrospective analysis of the medical records of children with a diagnosis of congenital cleft lip and palate was conducted on the basis of the Republican Children's Clinical Hospital in Ufa in the department of maxillofacial surgery. In the period from January 1, 1985 on December 31, 2018 were surveyed 3463 children with congenital cleft lip and palate. Results. Children born and living in the region with the petrochemical industry have a high percentage of concomitant somatic diseases and deviations from the norm in blood tests. An algorithm was developed for the rehabilitation of children with congenital cleft lip and palate in the region with petrochemical ecotoxicants, optimized by including a toxicologist, anesthesiologist, immunologist, otorhinolaryngologist, gastroenterologist, and endocrinologist in the algorithm of consultation and treatment. The algorithm is aimed at improving the health of the child by increasing the effectiveness of prevention and treatment of somatic diseases in the preoperative period. Conclusions. The proposed algorithm for the rehabilitation of children with congenital cleft lip and palate has been developed taking into account the adverse effects on the body of emissions into the air of large petrochemical enterprises. Children with congenital cleft lip and palate, born and living in a region with petrochemical ecotoxicants, have a high percentage of somatic diseases and contraindications to surgical treatment according to accepted terms due to the presence of comorbidities and disorders in blood tests, and need additional treatment from a toxicologist, anesthesiologist and other specialists.

scholarly journals ANALYSIS OF THE FREQUENCY OF BIRTH OF CHILDREN WITH CONGENITAL DEVELOPMENT DISORDERS IN A CITY WITH A PETROCHEMICAL INDUSTRY

2020 ◽  
Vol 16 (1) ◽  
pp. 139-142
Author(s):  
Sergey Chuykin ◽  
Julia Andrianova ◽  
Natal'ya Makusheva ◽  
Oleg Chuykin ◽  
Kristina Kuchuk ◽  
...  
Keyword(s):  
Petrochemical Industry ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Average Rate ◽  
Maxillofacial Surgery ◽  
Northern Region ◽  
Medical Documentation ◽  
Oral And Maxillofacial Surgery ◽  
Industrial Emissions ◽  
Congenital Cleft

Thing. Studying the frequency of birth of children with congenital malformations in a city with a petrochemical industry. The goal is to identify the effect of industrial emissions from enterprises in Ufa on the frequency of birth of children with congenital cleft lip and palate. Methodology. In the Department of Oral and Maxillofacial Surgery of the Republican Children's Clinical Hospital from 1985 to 2019, the medical documentation of children born in the city with a petrochemical industry with a cleft lip and palate was studied. Results. In industrial areas of Ufa, the average rate of birth of children with clefts is 3.65 ± 0.31 (Kalininsky) and 2.34 ± 0.29 (Ordzhonikidzevsky). According to our studies, it was found that in the industrial zone, the frequency of birth of children with congenital facial pathology is significantly higher than in environmentally safe areas, and ranges from 1: 282 (3.5) in the Kalinin industrial northern region to 1:859 (1.1) in the southernmost, ecologically safe Demsky district (p<0.01). On the whole, in Ufa, the average rates of the birth rate of children with congenital cleft lip and palate were 1:454 (2.204 ± 0.11). Conclusions. The correlation between the value of gross emissions of harmful substances into the atmospheric air and the frequency of congenital cleft lip and palate in the zone with emissions of 135,114―180,120 tons per year, then in the zone with the amount of emissions of 20,000―135,114 tons per year, and the frequency in the zone with emissions of 11,000 is less ― 20,000 tons per year. The average birth rates for children with ARVH in the cities of the Republic of Bashkortostan were per 1000 children born: in cities with NHP ― 2.44; in cities without NHP ― 1.13. The frequency of birth of children with ADV in cities with NHP is more than 2 times higher than the frequency of birth of children with ADV in cities without NHP (p <0.001).

scholarly journals SOMATIC DISEASES IN CHILDREN WITH CONGENITAL LIP AND PALATE IN A REGION WITH INDUSTRIAL PETROCHEMICAL ECOTOXICANTS

2021 ◽  
Vol 17 (2) ◽  
pp. 121-126
Author(s):  
Oleg Chuykin ◽  
Galina AKATYEVA ◽  
Natal'ya Makusheva ◽  
Kristina Kuchuk ◽  
Marsel' Gil'manov
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Maxillofacial Surgery ◽  
Congenital Cleft ◽  
Functional Features ◽  
The Moment ◽  
Systemic Pathology ◽  
Somatic Diseases ◽  
Somatic State ◽  
Primary Section

Monitoring of congenital malformations and concomitant somatic diseases in children is one of the important indicators of the causal influence of environmental factors on the health of the population. From the moment of birth, a child with congenital cleft lip and palate differs significantly from healthy peers not only externally, but also morpho-functional features of the structure of the primary section of the digestive and respiratory systems and often has a greater number of previous diseases in the history. Purpose: To determine the structure and frequency of somatic morbidity in children with congenital cleft lip and palate in regions with petrochemical ecotoxicants. Materials and methods: During the study, 3463 children from birth to 16 years old with congenital cleft lip were treated and monitored at the Department of Maxillofacial Surgery at the Republican Children's Clinical Hospital, Ufa for the period from January 1, 1985 to December 31, 2019 and / or sky. The diagnosis of concomitant systemic pathology was recorded based on the findings of the district pediatricians, ENT doctor, gastroenterologist, immunologist, allergist, rheumatologist from outpatient and inpatient records of the examined patients. Conclusion. In the course of our study, a direct relationship was noted between the level of environmental pollution by ecotoxicants and the frequency of concomitant somatic diseases in children with congenital cleft lip and palate. This must be taken into account in the pre- and postoperative algorithm for the rehabilitation of children with congenital cleft lip and palate with the involvement of pediatricians to improve the general somatic state of children when planning reconstructive surgery.

scholarly journals CLINICAL AND ANATOMICAL FORMS OF CONGENITAL CLEFT LIP AND PALATE IN THE REGION WITH ECOTOXICANTS

2019 ◽  
Vol 15 (3) ◽  
pp. 127-132 ◽  
Author(s):  
Сергей Чуйкин ◽  
Sergey Chuykin ◽  
Назим Джумартов ◽  
Nazim Dzhumartov ◽  
Олег Чуйкин ◽  
...  
Keyword(s):  
Petrochemical Industry ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Maxillofacial Surgery ◽  
Industrial Area ◽  
Medical Documentation ◽  
Number Of Children ◽  
Republic Of Bashkortostan ◽  
Congenital Cleft ◽  
The Republic

Subject: the study of the features of clinical and anatomical forms of congenital cleft lip and palate in the region with the petrochemical industry. Objectives ― determination of the clinical-anatomical forms of congenital cleft lip and palate, the identification of the frequency of severe forms in the region with the petrochemical industry and in the region without industrial eco-toxicants. Methods. We have studied medical documentation in the Department of Maxillofacial Surgery of the Republican Children's Clinical Hospital for the period from January 1, 1985 to December 31, 2018 to study the structure of the clinical and anatomical forms of congenital clefts of the lips and palate in children living in the Republic of Bashkortostan. During the analyzed period, 3463 children from birth to 16 years with congenital cleft lip and palate underwent treatment and dispensary observation. Results. Our data suggest that in the area with petrochemical ecotoxicants, the percentage of severe forms of congenital cleft lip and palate is higher (77.5%) than in an area without petrochemical ecotoxicants (68.7%). Conclusions. Thus, environmental pollution by petrochemical ecotoxicants leads to an increase in the number of children with congenital cleft lip and palate. There is a relationship between the level of air pollution by gross emissions from petrochemical enterprises and the severity of the clinical-anatomical forms of congenital cleft lip and palate in children living in an industrial area. It is important and important in the prenatal prevention of congenital clefts of the lip and palate.

scholarly journals SPECIFIC FEATURES OF DENTAL STATUS OF CHILDREN WITH CONGENITAL LIP AND PALATE IN A REGION WITH PETROCHEMICAL ECOTOXICANTS

2021 ◽  
Vol 16 (4) ◽  
pp. 147-154
Author(s):  
Sergey Chuykin ◽  
Galina AKATYEVA ◽  
Natal'ya Makusheva ◽  
Oleg Chuykin ◽  
Elena Egorova ◽  
...  
Keyword(s):  
Dental Caries ◽  
Oral Cavity ◽  
Petrochemical Industry ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Periodontal Diseases ◽  
Dental Status ◽  
Dental Tissues ◽  
Dental Examination ◽  
Congenital Cleft

Subject. Dental examination and identification of the features of the dental status of children with congenital cleft lip and palate, born and living in the region with industrial ecotoxicants. Objectives. To study the dental morbidity in children with congenital cleft lip and palate living in a region with industrial ecotoxicants, compare the data with a group of children with congenital cleft lip and palate from an ecologically safe region. Methods. The article presents the results of a dental examination of 195 children with congenital cleft lip and palate, including 108 children aged 3 years, 87 children aged 6 years. Children were divided into two groups depending on the place of birth and residence: 113 children were born and lived in regions with a developed petrochemical industry, 82 children from relatively ecologically safe regions. In the examined children, the prevalence and intensity of dental caries, malformations of hard dental tissues, periodontal diseases, dentoalveolar anomalies, and the hygienic state of the oral cavity were assessed. To determine the intensity of dental caries in children of 3 years old, the index "KPU" was used, in children of 6 years old - the index "KPU+kp". The hygienic state of the oral cavity was assessed by the Fedorov-Volodkina index (1968), the periodontal condition in children of 6 years old was assessed by the KPI index (Leus P.A., 1988). Results. Our data indicate that children from regions with the petrochemical industry have higher rates of dental caries intensity in the age groups of 3 and 6 years, there is a decrease in the resistance of the tooth enamel, and periodontal diseases are more common. Conclusions. The results of the study made it possible to obtain clinical and dental data characterizing the negative impact of industrial petrochemical ecotoxicants on the condition of the dentition in children with congenital cleft lip and palate, which is the rationale for the development of methods for optimizing and increasing the effectiveness of therapeutic and prophylactic measures in this group of patients.

Perceptual Speech Outcomes After Early Primary Palatal Repair in Ugandan Patients With Cleft Palate

2020 ◽  
pp. 105566562098024
Author(s):  
Kim Bettens ◽  
Laura Bruneel ◽  
Cassandra Alighieri ◽  
Daniel Sseremba ◽  
Duncan Musasizib ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Cleft Lip ◽  
Speech Therapy ◽  
Cleft Lip And Palate ◽  
Control Group ◽  
English Speaking ◽  
And Gender ◽  
Early Primary ◽  
Velopharyngeal Function ◽  
Normal Speech

Objective: To provide speech outcomes of English-speaking Ugandan patients with a cleft palate with or without cleft lip (CP±L). Design: Prospective case–control study. Setting: Referral hospital for patients with cleft lip and palate in Uganda. Participants: Twenty-four English-speaking Ugandan children with a CP±L (15 boys, 9 girls, mean 8.4 years) who received palatal closure prior to 6 months of age and an age- and gender-matched control group of Ugandan children without cleft palate. Interventions: Comparison of speech outcomes of the patient and control group. Main Outcome Measures: Perceptual speech outcomes including articulation, resonance, speech understandability and acceptability, and velopharyngeal composite score (VPC-sum). Information regarding speech therapy, fistula rate, and secondary surgery. Results: Normal speech understandability was observed in 42% of the patients, and 38% were judged with normal speech acceptability. Only 16% showed compensatory articulation. Acceptable resonance was found in 71%, and 75% of the patients were judged perceptually to present with competent velopharyngeal function based on the VPC-sum. Additional speech intervention was recommended in 25% of the patients. Statistically significant differences for all these variables were still observed with the control children ( P < .05). Conclusions: Overall, acceptable speech outcomes were found after early primary palatal closure. Comparable or even better results were found in comparison with international benchmarks, especially regarding the presence of compensatory articulation. Whether this approach is transferable to Western countries is the subject for further research.

Impact of cleft palate repair on speech and development of dentoalveolar deformities

2021 ◽  
Vol 16 (3) ◽  
pp. 47-53
Author(s):  
Yu.V. Stebeleva ◽  
◽  
Ad.A. Mamedov ◽  
Yu.O. Volkov ◽  
A.B. McLennan ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Surgical Techniques ◽  
Normal Functioning ◽  
Primary Surgery ◽  
Cleft Palate Repair ◽  
Congenital Cleft ◽  
Palate Repair ◽  
Late Postoperative Period

Surgical repair of cleft palate is quite difficult because it aims not only to eliminate the anatomical defect of the palate, but also to ensure normal functioning, including speech. Moreover, successful surgery implies no or minimal deformation of the middle face that can be corrected in the late postoperative period. No doubt that primary surgery (both in terms of technique and time) is crucial for further growth and development of the maxilla. However, surgical techniques and the age of primary cleft palate repair vary between different clinics, which makes this literature review highly relevant. Key words: cleft palate repair, cleft palate, congenital cleft lip and palate

scholarly journals MOLECULAR GENETIC STUDY OF THE IMPACT OF SNP C677T OF THE GENE MTHFR IN THE DEVELOPMENT OF CONGENITAL ISOLATED CLEFT LIP AND PALATE

2018 ◽  
Vol 25 (5) ◽  
pp. 104-110
Author(s):  
V. S. Uchaeva ◽  
Yu. A. Vasiliev ◽  
A. S. Gracheva ◽  
O. V. Gulenko ◽  
I. G. Udina
Keyword(s):  
Genetic Study ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Control Group ◽  
Population Genetic Study ◽  
Molecular Genetic Study ◽  
Increased Risk ◽  
Significant Difference ◽  
Congenital Cleft ◽  
The Impact

Aim. This research was designed to conduct an associative population genetic study for the consideration of the impact of SNP C677T of the gene MTHFR in the congenital maxillofacial developmental anomalies (CMDA): congenital cleft lip (CCL), congenital cleft palate (CCP), congenital cleft lip and palate (CCLP) in the Krasnodar territory. The aim of the study is to establish the associations between SNP C677T of the gene MTHFR and the development of congenital cleft lip and/ or palate.Materials and methods. In this research, the peculiarities of distribution of SNP C667T of the gene MTHFR in children with congenital cleft lip and/or palate (n=223) and their mothers (n=78) in comparison with the control group (n=124) were studied in the Krasnodar territory. The genetic demographic questionnaires were gathered for children with CMDA, the information about diagnosis was obtained from the medical records. The biological samples, including blood or scrapings of oral mucosa, were collected from children with the pathology and their mothers. The DNA was extracted from the samples by the standard method. The study of the peculiarities of distribution of alleles of SNP C677T of the gene MTHFR was performed by PCR-PFLP with endonuclease Hinf I or by tetra-primer ARMS-PCR method in children with CCL, CCP, CCLP, their mothers and the control group. Statistical processing of the obtained data was performed by the algorithms of the “Statistica” program.Results. While comparing the profiles of frequencies of SNP C677T in children with CCL, CCP and CCLP with the control group, there were identified no significant differences in the frequency of this SNP and no peculiarities of genotypes distribution. There was identified a significant difference in the peculiarities of genotypes distribution with the control group (G=19,5232, d.f.=1, p<0,001) as well as united genotypes (С/C и С/T) in accordance to T/T (G=10,4657, d.f.=1; p<0,001) and united genotypes (C/T и T/T) in accordance to C/C (G=15,1896, d.f.=1, p<0,001) for the mothers of children with CCL, CCP and CCLP.Conclusion. As a result of the study, we established the association of SNP C677T of the MTHFR gene with the development of congenital cleft lip and/or palate: mothers’ T/T genotype is associated with the increased risk of giving birth to a child with CCL, CCP and CCLP (in comparison with mothers with C/C+C/T genotype): odds ratio [OR]=16,63, 95% CI: 3,86-71,71; p=0,0003 and also for mothers with genotypes (C/T+T/T) in comparison with mothers with genotypes C/C: OR=3,22, CI:1,71-6,08; p=0,0002. The amount of risk is not significant in children with CMDA for T/T genotype. So it is possible to make a conclusion about the impact of C677T of the gene MTHFR in the development of CCL, CCP and CCLP only in mother’s genotype. 

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