scholarly journals Intraductal Papillary Carcinoma of the Breast: A Case Presentation

2021 ◽  
Author(s):  
Luisa Paulina Chafla Romero ◽  
Diana Belén Cuenca Mora ◽  
Nidia Narcisa Auqui Calle ◽  
María Romyna Delli Villavicencio ◽  
Felipe Antonio Larrea Lara
Keyword(s):  
Papillary Carcinoma ◽  
Ductal Carcinoma ◽  
Lymphatic Vessels ◽  
Radical Mastectomy ◽  
Good Prognosis ◽  
Incidence Rates ◽  
Carcinoma Papilar ◽  
Nodular Lesions ◽  
The Right

Intraductal papillary carcinoma, also known as papillary ductal carcinoma in situ, forms part of a heterogeneous group of breast lesions, the reported incidence rates are very low and occurs in 27.7/100,000 in women, although the percentage of mortality is only 1%. This carcinoma is characterized because it can affect the inside portion of the mammary ducts, respecting the basement membrane, with proliferation of neoplasic cells, and since it is not in contact with the lymphatic vessels the possibility of metastasis is almost null. However, the risk of progressing to invasive cancer is nevertheless multifactorial as well as its size, histology, and resection margin. Clinically, it can be characterized by the presence of a single or multiple mass of moderate size, and on a mammograph it’s seen as nodular lesions with irregular edges. The case of an older adult female patient with a mammary nodule with 5 months of evolution, until it forms into a mass and later the execution of routine and laboratory examinations, allowing the diagnosis of intraductal papillary carcinoma to be confirmed. Due to the complexity of the clinical presentation and the age of the patient, a radical mastectomy and physiotherapy of the right upper limb was performed. intraductal papillary carcinoma represents less than 1% of all mammary carcinomas, and has a good prognosis. Keywords: carcinoma, mom, papillary. RESUMEN El carcinoma papilar intraductal, también conocido como carcinoma ductal in situ papilar, forma parte de un grupo heterogéneo de lesiones de la mama, la tasa de incidencia es muy baja y se presenta en 27,7/100.000 en mujeres, aunque el porcentaje de mortalidad es de tan solo el 1%. Se caracteriza porque en el interior de los ductos mamarios y respetando la membrana basal hay proliferación de células neoplasias, y al no encontrarse en contacto con los vasos linfáticos la posibilidad de metástasis es casi nula, más sin embargo el riesgo de progresar a cáncer invasor es multifactorial como su tamaño su histología y el margen de resección. Clínicamente se caracteriza por ser masas únicas o múltiples de tamaño moderado y en la mamografía se observan como lesiones nodulares de bordes irregulares. Se presenta el caso de una paciente adulta mayor que presenta un nódulo mamario de 5 meses de evolución, hasta tornarse en una masa y posterior a la ejecución de exámenes de gabinete y de laboratorio se confirma el diagnóstico de carcinoma papilar intraductal, por la complejidad del cuadro y por la edad de la paciente, se realiza como tratamiento mastectomía radical y fisioterapia del miembro superior derecho. El carcinoma papilar intraductal representa menos del 1% de todos los carcinomas mamarios, y es de buen pronóstico. Palabras claves: carcinoma, mama, papilar.

scholarly journals Encapsulated Papillary Carcinoma of the Breast: Imaging Features with Histopathologic Correlation

2020 ◽  
Vol 2 (6) ◽  
pp. 590-597
Author(s):  
Sarah E Bonnet ◽  
Gloria J Carter ◽  
Wendie A Berg
Keyword(s):  
Papillary Carcinoma ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Breast Imaging ◽  
Ductal Carcinoma ◽  
Imaging Features ◽  
Term Survival ◽  
Core Needle ◽  
Cystic Component

Abstract Encapsulated papillary carcinoma (EPC) is a rare, clinically indolent breast malignancy most common in postmenopausal women. Absence of myoepithelial cells at the periphery is a characteristic feature. Mammographically, EPC typically presents as a mostly circumscribed, noncalcified, dense mass that can have focally indistinct margins when there is associated frank invasive carcinoma. Ultrasound shows a circumscribed solid or complex cystic and solid mass, and occasional hemorrhage in the cystic component may produce a fluid-debris level; the solid components typically show intense washout enhancement on MRI. Color Doppler may demonstrate a prominent vascular pedicle and blood flow within solid papillary fronds. Encapsulated papillary carcinoma can exist in pure form; however, EPC is often associated with conventional ductal carcinoma in-situ and/or invasive ductal carcinoma, no special type. Adjacent in-situ and invasive disease may be only focally present at the periphery of EPC and potentially unsampled at core-needle biopsy. In order to facilitate diagnosis, the mass wall should be included on core-needle biopsy, which will show absence of myoepithelial markers. Staging and prognosis are determined by any associated frankly invasive component, with usually excellent long-term survival and rare distant metastases.

The role of immunohistochemistry in the differential diagnosis of papillary lesions of the breast

2009 ◽  
Vol 62 (5) ◽  
pp. 407-413 ◽  
Author(s):  
G M Tse ◽  
P H Tan ◽  
T Moriya
Keyword(s):  
Papillary Carcinoma ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Correct Diagnosis ◽  
Cross Reactivity ◽  
Biological Behaviour ◽  
Neuroendocrine Markers ◽  
Papillary Lesions

Papillary lesions of the breast represent a heterogeneous group with differing biological behaviour. Correct diagnosis is crucial but may be difficult, as many benign and malignant papillary lesions have similar appearances. Immunohistochemistry plays a useful role in their differentiation. Myoepithelial markers can help in differentiating papilloma from papillary carcinoma, as the former usually shows a continuous layer of myoepithelial cells. In intracystic papillary carcinoma, there is controversy as to the presence of a complete myoepithelial cell layer around these lesions. p63 is the marker of choice as the staining is nuclear, cross-reactivity is minimal, and sensitivity is high. Papilloma may frequently be complicated by superimposed different types of epithelial hyperplasia, which range from usual to atypical or even ductal carcinoma in situ, and they many be morphologically similar. Basal cytokeratins (CKs) are useful to differentiate these entities; as usual hyperplasia is positive for basal CKs with a mosaic staining pattern. CK5/6 is probably the best marker. Neuroendocrine markers (chromogranin A and synaptophysin) may be positive in papillary carcinoma, particularly in the solid type, and there may be some overlap with the ductal carcinoma in situ with spindle cells or endocrine ductal carcinoma in situ. A panel of CK5/6, p63 and neuroendocrine markers can be useful in the diagnostic investigation of problematic papillary lesions of the breast. As the experience with these markers remains rather limited, it is too early to recommend basing treatment choices on these marker studies alone. Complete removal of lesion is probably still the treatment of choice.

scholarly journals Invasive papillary carcinoma of the breast: a rare case report

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Pratibha Issar ◽  
M. Ravindranath ◽  
Manish Dewangan
Keyword(s):  
Papillary Carcinoma ◽  
Rare Case ◽  
Radical Mastectomy ◽  
Myoepithelial Cells ◽  
Left Breast ◽  
Good Prognosis ◽  
Menopausal Women ◽  
Malignant Breast ◽  
Post Menopausal ◽  
Invasive Papillary Carcinoma

Abstract Background Invasive Papillary Carcinomas (IPC) are rare and account for approximately 0.5% of all invasive breast carcinomas. Most of them are seen in post-menopausal women and have a good prognosis. These tumors lack the myoepithelial cell layer (MCL) within the papillae or at the periphery of the tumor with areas showing stromal invasion or invasion into lymphovascular spaces. Immunohistochemistry (IHC) for myoepithelial cells and basement membrane is essential for the diagnosis of invasive cancer. Case presentation We present a rare case of IPC in a 74-year-old woman who presented with complaints of gradually increasing painless retroaerolar mass in the left breast of two months duration. The mass was irregular, having an oblong as well an adjacent high density mass lesion on mammography. Ultrasound (US), and Magnetic Resonance Imaging (MRI) helped in the diagnosis of the possibility of a malignant breast lesion. Left-sided modified radical mastectomy was performed and the specimen was histopathologically diagnosed as Invasive Papillary carcinoma. Immunohistochemistry confirmed the diagnosis. Conclusions Invasive Papillary Carcinomas of the breast are rare cancers in post-menopausal women. We have highlighted the role of Mammography, US, and MRI in early diagnosis so that timely management is possible.

scholarly journals A Clinical Case Study of Synchronous Breast Cancer

2021 ◽  
Vol 28 (3) ◽  
pp. 329-332
Author(s):  
Mihai MEHEDINTU-IONESCU ◽  
◽  
Stefan-Andrei COMAN ◽  
Horia-Alexandru TOADER ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carcinoma In Situ ◽  
Clinical Case ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Clinical Case Study ◽  
The Right ◽  
Synchronous Breast Cancer

The following article represents a clinical case study of a synchronous breast cancer in a 47 year old woman with no prior significant comorbidities.Up to 10% of all breast cancers can be synchronous (usually found with the help of breast MRI). The occurrence of bilaterally is considerable with invasive lobular carcinoma. The patient observed after self-palpating her breast a nodule in the infero-external quadrant of the right breast. During almost 4 months the patient underwent punch biopsy of the right breast, lumpectomy and finally double mastectomy with immediate reconstruction using Mentor implants and AMD. The histopathological result showed ductal carcinoma in situ in the right breast and lobular carcinoma in situ in both breasts. Postoperatively the patient is free of cancer, but under clinical and imagistic surveillance.

scholarly journals Metaplastic carcinoma breast (IDC and chondrosarcoma): a rare entity

2018 ◽  
Vol 5 (7) ◽  
pp. 2646
Author(s):  
Deepesh Kalra ◽  
Bhanu Kaushik ◽  
Shalu Gupta ◽  
Pradeep Tanwar ◽  
Sami Anwar Khan
Keyword(s):  
Breast Carcinoma ◽  
Ductal Carcinoma ◽  
Radical Mastectomy ◽  
Metaplastic Carcinoma ◽  
Ki 67 ◽  
Mucinous Component ◽  
Infiltrating Ductal Carcinoma ◽  
Characteristic Features ◽  
The Right ◽  
Metaplastic Breast Carcinoma

Metaplastic breast carcinoma is very rare neoplasm. Authors report a case of metaplastic breast carcinoma containing characteristic features of infiltrating ductal carcinoma and chondrosarcoma. A 62-year-old female presented with complaint of a lump in the right breast for the last 2 years. FNAC was suggestive of mucinous tumour. Tru-cut biopsy had been performed outside the institution, which was suggestive of a Ductal carcinoma with mucinous component. Modified radical mastectomy of the right breast was performed and histopathology was suggestive of infiltrating ductal carcinoma and chondrosarcoma of the right breast. All resected lymph nodes were free of metastasis. Immunohistochemistry was suggestive of a metaplastic carcinoma with components of ductal carcinoma and chondrosarcoma with moderately positive ER, negative PR, positive Pancytokeratin in ductal carcinoma component, positive S-100 and KI-67.

scholarly journals Granular Cell Tumor of the Breast Coexisting with Ductal Carcinoma in situ: Case Report

2021 ◽  
pp. 303-308
Author(s):  
Yuko Ueki ◽  
Yoshiya Horimoto ◽  
Akihiko Shiraishi ◽  
Atsushi Arakawa ◽  
Hyonmi Sai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carcinoma In Situ ◽  
Granular Cell Tumor ◽  
Ductal Carcinoma ◽  
Granular Cell ◽  
Cell Tumor ◽  
Lower Mass ◽  
Contrast Enhanced ◽  
The Right

Granular cell tumor (GCT) is a benign tumor arising from Schwann cells. GCT of the breast is rare and while predominantly benign, it can be difficult to differentiate from breast cancer by imaging. While it is not generally associated with breast cancer, we here report a rare case of GCT coexisting with ductal carcinoma in situ (DCIS). A 38-year-old Japanese woman had microcalcification suggestive of malignancy in the right upper breast and a 6-cm well-defined mass in the right lower breast. Ultrasonography showed that the lower mass was circular in shape with a clear border, and internal echo level was slightly uneven. Contrast-enhanced magnetic resonance imaging found that the inside was unevenly contrast-enhanced and showed fast/washout enhanced pattern. Hence, imaging could not exclude malignancy. Pathological diagnosis from biopsies taken from the upper calcification and lower mass was DCIS and GCT, respectively. Imaging showed no evidence of continuity between the two, but the patient elected for mastectomy. Final pathological diagnosis confirmed an S-100-positive and keratin-negative GCT for the lower lesion and no histological evidence of continuity. Although GCT is a rare disease, greater awareness of the disease and its imaging findings is needed to avoid overdiagnosis, particularly when it coexists with breast cancer.

scholarly journals Invasive papillary ductal carcinoma of the breast: A case report

2020 ◽  
Vol 10 (1) ◽  
pp. 17
Author(s):  
Amani S Hadi ◽  
Gamal Abdul Hamid ◽  
Refaat Al-Areqee ◽  
Wafa Abdullah
Keyword(s):  
Papillary Carcinoma ◽  
Ductal Carcinoma ◽  
Radical Mastectomy ◽  
Residual Tumor ◽  
Excisional Biopsy ◽  
Breast Mass ◽  
Low Grade ◽  
Breast Cancers ◽  
History Of ◽  
Invasive Papillary Carcinoma

The general rate of intrusive papillary carcinoma (IPC) is uncommon, representing for less than 1-2 % of invasive breast cancers. They are most generally observed in postmenposal females and uncommon in males. Invasive papillary carcinomas are low grade tumors originating from large or dilated ducts. They are make out of all around outlined solid nodules of monotones neoplastic cell separated by network of fibrovascular cores, IPC is a remarkable sort of breast cancer and regarded of whether it is in-situ or invasive, it has brilliant prognosis. We presenting two cases of invasive papillary carcinoma in male and female; A case of 55years postmenoposal female who presented with history of left breast mass, which this mass notice after trauma same site for 1 year ago the mass gradually increase in size no tenderness, no signs of inflammation. Excisional biopsy was performed and specimen was histopathology diagnosed as invasive papillary carcinoma, left MRM was performed and histopathology diagnosis confirmed and without residual tumor seen in submitted slides and all submitted lymph nodes were free of tumor infiltration (0/14). IHC show ER and PR negative with HER-2 positive. The second case 70 years male presented with right breast mass and history of post-trauma since one year back with gradual increase in size, right radical mastectomy done and histopathology diagnosed as invasive papillary carcinoma, IHC was done ER and PR positive with HER2- negative.

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