Metaplastic carcinoma breast (IDC and chondrosarcoma): a rare entity

Metaplastic breast carcinoma is very rare neoplasm. Authors report a case of metaplastic breast carcinoma containing characteristic features of infiltrating ductal carcinoma and chondrosarcoma. A 62-year-old female presented with complaint of a lump in the right breast for the last 2 years. FNAC was suggestive of mucinous tumour. Tru-cut biopsy had been performed outside the institution, which was suggestive of a Ductal carcinoma with mucinous component. Modified radical mastectomy of the right breast was performed and histopathology was suggestive of infiltrating ductal carcinoma and chondrosarcoma of the right breast. All resected lymph nodes were free of metastasis. Immunohistochemistry was suggestive of a metaplastic carcinoma with components of ductal carcinoma and chondrosarcoma with moderately positive ER, negative PR, positive Pancytokeratin in ductal carcinoma component, positive S-100 and KI-67.

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Radiologic Findings of a Rare Subtype of Invasive Breast Cancer with Poor Prognosis: Metaplastic Carcinoma of the Breast

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405614666180813120227 ◽

2019 ◽

Vol 15 (3) ◽

pp. 338-348

Author(s):

Hale Aydin ◽

Bahar Guner ◽

Isil Esen Bostanci ◽

Nazan Ciledag ◽

Melda Boyacioglu Bulut ◽

...

Keyword(s):

Breast Carcinoma ◽

Multimodality Imaging ◽

Metaplastic Carcinoma ◽

Imaging Features ◽

Mri Findings ◽

Radiologic Findings ◽

Round Shape ◽

Malignant Feature ◽

Imaging Results ◽

Metaplastic Breast Carcinoma

Background and Objectives: The purpose of this study was to evaluate the mammographic, sonographic and MRI findings of metaplastic breast carcinoma. Methods: In this retrospective review study, we analyzed the medical files of 9600 patients who were treated for invasive breast cancers. Clinical information, histopathologic and radiologic findings of 65 patients were included in this study. All existing radiologic images and medical reports were reviewed retrospectively. Thirty-three patients had MG, 58 patients had US and 7 patients had MRI imaging results. Results: Mammographically, the most frequent presentations of MPBC were round shape, microlobulated margin and high density masses. Calcifications with or without masses were not a frequent finding. The most common sonographic findings were round shape, partially indistinct angular margin, hypoechoic and heterogeneous echo patterns and no posterior feature masses. All lesions were presented as masses rather than non-mass enhancements on magnetic resonance imaging. Features of masses had more malignant feature on MRI than other modalities in all 7 patients. Conclusion: Metaplastic breast carcinoma is one of the rarest poorly differentiated invasive breast carcinomas. Interestingly, these aggressive tumors demonstrate benign or moderately malign features on imaging methods. This appearance of MPBC can cause it to be misdiagnosed as a benign breast lesion especially in young women. MPBC should be kept in mind in the differential diagnosis of large palpable breast masses. Therefore, follow-up at short intervals and/or multimodality imaging studies which include breast MRI are important for the diagnosis of MPBC.

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Spindle Cell Metaplastic Breast Carcinoma

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405617666211004114041 ◽

2021 ◽

Vol 17 ◽

Author(s):

Vithya Sanmugasiva ◽

Marlina Tanty Ramli Hamid ◽

Farhana Fadzli ◽

Nazimah Ab Mumin ◽

Kartini Rahmat

Keyword(s):

Breast Carcinoma ◽

Cell Carcinoma ◽

Spindle Cell ◽

Final Diagnosis ◽

Spindle Cell Carcinoma ◽

Left Breast ◽

Metaplastic Carcinoma ◽

Breast Cancers ◽

Breast Lump ◽

Metaplastic Breast Carcinoma

Introduction: Metaplastic breast carcinoma is an uncommon malignancy that constitutes < 5% of all breast cancers. There are 5 subtypes which are spindle cell, squamous cell, carcinosarcoma, matrix-producing and metaplastic with osteoclastic giant cells. Spindle cell carcinoma represents approximately <0.3% of invasive breast carcinomas. It is typically a triple-negative cancer with distinct pathological characteristics, but relatively a non-conclusive imaging findings. Case report: An elderly lady presented with an enlarging painful left breast lump for 1 year. Palpable left breast lump noted on clinical examination. Mammography demonstrated a high density, oval lesion with a partially indistinct margin. Corresponding ultrasound showed a large irregular heterogeneous lesion with solid-cystic areas. Histopathology showed atypical spindle-shaped cells which stained positive for cytokeratins and negative for hormone and human epidermal growth factor receptors, which favours spindle cell metaplastic carcinoma. Left mastectomy and axillary dissection were performed, and the final diagnosis was consistent with metaplastic spindle cell carcinoma. Conclusion: Spindle cell carcinoma of the breast is a rare aggressive histological type of carcinoma which may present with benign features on imaging. Tissue diagnosis is essential for prompt diagnosis with multidisciplinary team discussion to guide management and improve patient’s outcome.

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Metaplastic Carcinoma of the Breast with Neuroectodermal Stromal Component

Pathology Research International ◽

10.4061/2011/191274 ◽

2011 ◽

Vol 2011 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Tibor Tot ◽

Juan José Badani De La Parra ◽

Leif Bergkvist

Keyword(s):

Lymph Node ◽

Breast Carcinoma ◽

Brain Metastases ◽

Lymph Node Metastases ◽

Metaplastic Carcinoma ◽

Unique Case ◽

Carcinoma Of The Breast ◽

Stromal Component ◽

Node Metastases ◽

Metaplastic Breast Carcinoma

A unique case of metaplastic breast carcinoma with an epithelial component showing tumoral necrosis and neuroectodermal stromal component is described. The tumor grew rapidly and measured 9 cm at the time of diagnosis. No lymph node metastases were present. The disease progressed rapidly and the patient died two years after the diagnosis from a hemorrhage caused by brain metastases. The morphology and phenotype of the tumor are described in detail and the differential diagnostic options are discussed.

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Right Breast Metaplastic Carcinoma with Chondroid Diff erentiation (Chondrosarcoma)

Journal of King Abdulaziz University-Medical Sciences ◽

10.4197/med.22-4.6 ◽

2018 ◽

Vol 22 (4) ◽

pp. 45-51

Author(s):

Alya S. Binmahfouz

Keyword(s):

Breast Cancer ◽

Metaplastic Carcinoma ◽

Adjuvant Radiation ◽

Resonance Imaging ◽

Metaplastic Breast Cancer ◽

Diagnostic Features ◽

Palpable Mass ◽

Adjuvant Radiation Therapy ◽

The Right ◽

Metaplastic Breast Carcinoma

Metaplastic breast cancer is rare, representing < 5% of breast cancer (only eight cases have been reported so far). We present here a 42-year-old female complaining of a painless lump in the right breast for the previous two months. Physical examination revealed a palpable mass. Lumpectomy was performed and histopathologic examination revealed metaplastic breast carcinoma with foci of chondrosarcoma. The patient received adjuvant radiation therapy and chemotherapy and is currently following up as an outpatient. We also discuss diff erentimaging diagnostic features of this specifi c type of breast cancer using mammography, ultrasonography, and magnetic resonance imaging.

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Clinicopathological significance of WT1 expression in invasive breast carcinoma with >90% mucinous component

Journal of Clinical Pathology ◽

10.1136/jclinpath-2021-207464 ◽

2021 ◽

pp. jclinpath-2021-207464

Author(s):

Xiaoli Xu ◽

Rui Bi ◽

Ruohong Shui ◽

Baohua Yu ◽

Yufan Cheng ◽

...

Keyword(s):

Breast Carcinoma ◽

Growth Pattern ◽

Histological Grade ◽

Invasive Breast Carcinoma ◽

Nuclear Grade ◽

Proliferation Index ◽

Her2 Overexpression ◽

Ki 67 ◽

Mucinous Component ◽

Clinicopathological Significance

AimsThis study was aimed to investigate the clinicopathological significance of immunohistochemical (IHC) Wilm’s tumour 1 (WT1) expression in invasive breast carcinoma with >90% mucinous components.MethodsOne hundred specimens of invasive breast carcinoma with >90% mucinous component were collected. All H&E-stained slides were reviewed, and the clinicopathological data, including sex, age, tumour size, nuclear grade, histological grade, growth pattern and lymph node (LN) status, were collected. IHC staining of WT1, oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 was performed. Fluorescence in situ hybridisation was used to verify the amplification of the HER2 gene. The relationship between WT1 expression and clinicopathological features was analysed statistically.ResultsWT1 expression was detected in 67% (67/100) of invasive breast carcinoma with >90% mucinous components. WT1 expression was significantly associated with low-to-intermediate nuclear grade/histological grade, ER and PR positivity, HER2 negativity, Ki-67 proliferation index <30% and noLN metastasis (all p<0.001). Micropapillary architecture was observed in 80% of cases. WT1 expression was not significantly correlated with different percentage of micropapillary components (p=0.422). None of the histological grade 3 tumours, tumours with HER2 overexpression/amplification and triple-negative specimens showed WT1 expression.ConclusionsWT1 expression was significantly related with low-intermediate nuclear/histological grade, ER positivity, HER2 negativity, a lower Ki-67 proliferation index and no LN metastasis in invasive breast carcinoma with >90% mucinous component. The micropapillary growth pattern in this type of tumour did not show a specific relationship with WT1 expression.

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A CROSS SECTIONAL STUDY OF BREAST CANCER HISTOMORPHOLOGY AND ITS CORRELATION WITH ER/PR, HER 2NEU AND KI-67 EXPRESSION IN A TERTIARY CARE HOSPITAL AT KANPUR

10.36106/ijar/9500487 ◽

2021 ◽

pp. 9-12

Author(s):

Mahendra Singh ◽

Shobha Dwivedi ◽

Yukteshwar Mishra ◽

Sakshi Tripathi

Keyword(s):

Prognostic Factors ◽

Breast Carcinoma ◽

Tertiary Care ◽

Radical Mastectomy ◽

Cross Sectional Study ◽

Low Grade ◽

Care Hospital ◽

Sectional Study ◽

Ki 67 ◽

Cross Sectional

BACKGROUND Breast carcinoma is the most well-known malignancy in women. Different predictive and prognostic factors, for example, estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptor (Her2neu), and Ki67 could inuence breast carcinoma behaviour, yet to date no authoritative connection has been set up among them and breast carcinoma subtypes. In this way present study was done to determine the interrelationships of these predictive and prognostic factors for breast carcinoma. METHODS In this cross sectional study, a total of 50 lumpectomy, modied radical mastectomy specimens of diagnosed carcinoma breast were included in this study. The histopathological grading of the breast carcinoma was performed by Nottingham modication of the Bloom Richardson grading system. All the cases went through immunohistochemistry for ER, PR, Her2neu and Ki67 expression. Association of ER, PR, Her2neu and Ki67 with different histomorphology was established. RESULTS The ER positivity was signicantly lower in tumors >5 cm size whereas Ki67was signicantly increased with increased tumor size. The ER positivity was signicantly lower in high grade tumors as compared to low grade tumors. The positive ER, PR, Her2neu and Ki67 were comparable in between premenopausal and post-menopausal age groups CONCLUSION The present study concludes that ER, PR show inverse while ki67 showed a direct relationship with the tumor grade. Correlation of histomorphology of breast tumor and Her2neu status could not be established.

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Postirradiation Multiple Minute Digitate Porokeratosis

Journal of Cutaneous Medicine and Surgery ◽

10.1177/120347540100500205 ◽

2001 ◽

Vol 5 (2) ◽

pp. 126-130 ◽

Cited By ~ 1

Author(s):

Ramon M. Pujol ◽

Eugenia Perez–Losada ◽

Xavier Matias–Guiu ◽

Josefina Fuentes ◽

Carmen M. Alonso ◽

...

Keyword(s):

Granular Layer ◽

Ductal Carcinoma ◽

Histopathological Examination ◽

Infiltrating Ductal Carcinoma ◽

Anterior Aspect ◽

Irradiation Therapy ◽

Irradiation Field ◽

Cornoid Lamella ◽

Radiation Induced ◽

The Right

Background: Development of multiple minute digitate hyperkeratoses (MMDH) after irradiation has been reported previously. The keratotic lesions in these cases were confined within the irradiation field, and histopathological examination disclosed a focal column of parakeratosis (cornoid lamella) arising from an epidermis devoid of granular layer. Objective: We describe a 78-year-old woman who developed multiple, discrete, tiny, filiform, keratotic papules on the anterior aspect of the right chest wall, 13 months after postmastectomy cobalt irradiation therapy for mammary infiltrating ductal carcinoma. Conclusion: Postirradiation MMDH represents a peculiar radiation-induced disorder that we believe should be distinguished from other cases of MMDH and included within the spectrum of porokeratosis.

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