scholarly journals Association between the Interleukin-1 Receptor Antagonist (IL1RN) Variable Number of Tandem Repeats (VNTR) Polymorphism and Lymphoma

2021 ◽  
Author(s):  
Hosna Sarani ◽  
Behrouz Molashahi ◽  
Mohsen Taheri ◽  
Gholamreza Bahari ◽  
Seyed Mahdi Hashemi ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Tandem Repeats ◽  
Interleukin 1 ◽  
Population Sample ◽  
Variable Number ◽  
Vntr Polymorphism ◽  
Non Hodgkin Lymphoma ◽  
Polymerase Chain ◽  
The Impact ◽  
Hematopoietic Cancer

Introduction: Lymphoma is a common hematopoietic cancer. Immunosuppression is one of the main risk factors for the development of lymphoma. The interleukin (IL)-1 receptor antagonist IL1RN, which binds to the IL-1 receptor, moderates a variety of immune responses related to IL-1. We aimed to assess the impact of IL1RN variable number of tandem repeats (VNTR) polymorphism on lymphoma risk in an Iranian population sample. Materials and Methods: DNA was extracted from peripheral blood of 120 subjects with non-Hodgkin Lymphoma (NHL), 50 subjects with Hodgkin’s lymphoma (HL), and 186 unrelated healthy individuals. IL1RN VNTR polymorphism was detected using polymerase chain reaction. Results: Our findings revealed that the IL1RN VNTR polymorphism was associated with protection against NHL (P≤0.001, OR: 0.30, 95% CI: 0.18-0.53). The IL1RN 2 allele significantly decreased the risk of NHL (p = 0.023, OR = 0.66, 95%CI = 0.46–0.93). In addition, we found that IL1RN 1/2 was associated with a lower risk of HL (p ≤0.001, OR = 0.24, 95%CI = 0.12–0.50). Conclusion: Our results suggest that the presence of IL1RN VNTR polymorphism is associated with a decreased risk of lymphoma in an Iranian subpopulation in southeast Iran.

Association Between the Aggrecan Gene and Rheumatoid Arthritis

2008 ◽  
Vol 35 (12) ◽  
pp. 2325-2328 ◽  
Author(s):  
THAIS B. de SOUZA ◽  
ELISA F. MENTZ ◽  
CLAITON V. BRENOL ◽  
RICARDO M. XAVIER ◽  
JOÃO C.T. BRENOL ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Blood Donors ◽  
Tandem Repeats ◽  
Dna Amplification ◽  
Variable Number ◽  
Control Group ◽  
Vntr Polymorphism ◽  
Study Population ◽  
Polymerase Chain ◽  
Genetic And Environmental Factors

ObjectiveGenetic and environmental factors seem to be involved in the onset of rheumatoid arthritis (RA). We analyzed whether a variable number of tandem repeats (VNTR) polymorphism in the aggrecan gene was associated to RA.MethodsThe study population comprised 170 European-derived Brazilian patients with diagnosis of RA. The control group comprised 148 European-derived Brazilian healthy blood donors. The aggrecan VNTR polymorphism was genotyped by DNA amplification by polymerase chain reaction, followed by electrophoresis in polyacrylamide gel.ResultsThere was a statistically significant higher frequency of alleles of shorter length in the patient group compared to controls (p = 0.001), suggesting that individuals carrying short alleles are more likely to develop RA. There was no association between short alleles and clinical characteristics of RA.ConclusionOur results provide evidence of an association between the aggrecan gene VNTR polymorphism and RA.

scholarly journals Interleukin-1 Receptor Antagonist and Interleukin-4 Genes Variable Number Tandem Repeats Are Associated with Adiposity in Malaysian Subjects

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Yung-Yean Kok ◽  
Hing-Huat Ong ◽  
Yee-How Say
Keyword(s):  
Receptor Antagonist ◽  
Tandem Repeats ◽  
Interleukin 1 ◽  
Variable Number ◽  
Interleukin 4 ◽  
Ethnic Chinese ◽  
Interleukin 1 Receptor Antagonist ◽  
Total Body ◽  
Variable Number Tandem Repeats ◽  
Intron 2

Interleukin-1 receptor antagonist (IL1RA) intron 2 86 bp repeat and interleukin-4 (IL4) intron 3 70 bp repeat are variable number tandem repeats (VNTRs) that have been associated with various diseases, but their role in obesity is elusive. The objective of this study was to investigate the association ofIL1RAandIL4VNTRs with obesity and adiposity in 315 Malaysian subjects (128 M/187 F; 23 Malays/251 ethnic Chinese/41 ethnic Indians). The allelic distributions ofIL1RAandIL4were significantly different among ethnicities, and the alleles were associated with total body fat (TBF) classes. Individuals withIL1RAI/II genotype or allele II had greater risk of having higher overall adiposity, relative to those having the I/I genotype or I allele, respectively, even after controlling for ethnicity [Odds Ratio (OR) of I/II genotype = 12.21 (CI = 2.54, 58.79;p=0.002); II allele = 5.78 (CI = 1.73, 19.29;p=0.004)]. However,IL4VNTR B2 allele was only significantly associated with overall adiposity status before adjusting for ethnicity [OR = 1.53 (CI = 1.04, 2.23;p=0.03)]. Individuals withIL1RAII allele had significantly higher TBF than those with I allele (31.79±2.52versus23.51±0.40;p=0.005). Taken together,IL1RAintron 2 VNTR seems to be a genetic marker for overall adiposity status in Malaysian subjects.

scholarly journals IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Zornitsa Kamenarska ◽  
Gyulnas Dzhebir ◽  
Maria Hristova ◽  
Alexey Savov ◽  
Anton Vinkov ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Receptor Antagonist ◽  
Lupus Erythematosus ◽  
Interleukin 1 ◽  
Variable Number Tandem Repeat ◽  
Variable Number ◽  
Systemic Lupus ◽  
Vntr Polymorphism ◽  
Interleukin 1 Receptor Antagonist ◽  
Control Study

Polymorphisms in the cytokine genes and their natural antagonists are thought to influence the predisposition to dermatomyositis (DM) and systemic lupus erythematosus (SLE). A variable number tandem repeat (VNTR) polymorphism of 86 bp in intron 2 of the interleukin-1 receptor antagonist (IL-1RN) gene leads to the existence of five different alleles which cause differences in the production of both IL-1RA (interleukin-1 receptor antagonist) and IL-1β. The aim of this case-control study was to investigate the association between the IL-1RN VNTR polymorphism and the susceptibility to DM and SLE in Bulgarian patients. Altogether 91 patients, 55 with SLE and 36 with DM, as well as 112 unrelated healthy controls, were included in this study. Only three alleles were identified in both patients and controls ((1) four repeats, (2) two repeats, and (3) five repeats). The IL-1RN*2 allele (P=0.02, OR 2.5, and 95% CI 1.2–5.4) and the 1/2+2/2 genotypes were found prevalent among the SLE patients (P=0.05, OR 2.6, and 95% CI 1–6.3). No association was found between this polymorphism and the ACR criteria for SLE as well as with the susceptibility to DM. Our results indicate that the IL-1RN VNTR polymorphism might play a role in the susceptibility of SLE but not DM.

scholarly journals Interleukin 1 receptor antagonist gene variable number of tandem repeats polymorphism and cutaneous melanoma

2019 ◽  
Author(s):  
Sabina Cauci ◽  
Cinzia Buligan ◽  
Francesco Rocchi ◽  
Ilaria Salvador ◽  
Luigi Xodo ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Cutaneous Melanoma ◽  
Tandem Repeats ◽  
Interleukin 1 ◽  
Variable Number ◽  
Interleukin 1 Receptor Antagonist
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