Intradural Extramedullary Lesions in Cervical Spine in Neurofibromatosis

2021 ◽  
pp. 22
Author(s):  
Rana Moshref

Introduction: Neurofibromatosis (NF) is isolated into three diseases: NF type 1, type 2, and schwannoma. NF type 2 could be a disorder that's found roughly in 1/25,000–33,000 births with a mutation in gene 22q11.2, and it is passed through eras in an autosomal dominant fashion. Diagnosis is made with both clinical and radiological features. A few clinical features have been characterized in conclusion counting Manchester criteria. There is a scarce number of NF type 2 patients diagnosed with cervical lesions which are 25 in number. We report a case of an intradural extramedullary cervical lesion in a patient later diagnosed with NF type 2. Case Report: A 30-year-old male presenting with gradual onset and progressive course of spastic quadriparesis of six months’ duration was admitted through the emergency unit. MRI spine showed intradural extramedullary masses in the right side of C4 and left side of C6. The patient underwent cervical intradural excision of two masses under general anesthesia with neuromonitoring. The tumor was sent for histopathology and reported as NF type 2. Conclusion: NF is a common entity, but the diagnosis of cervical mass is judicious to avoid any complication in neurological function. It further needs a multidisciplinary approach and screening modalities.

1997 ◽  
Vol 15 (7) ◽  
pp. 908-917 ◽  
Author(s):  
C. Haldoupis ◽  
D. T. Farley ◽  
K. Schlegel

Abstract. This paper presents more data on the properties of type-1 irregularities in the nighttime mid-latitude E-region ionosphere. The measurements were made with a 50-MHz Doppler radar system operating in Crete, Greece. The type-1 echoes last from several seconds to a few minutes and are characterized by narrow Doppler spectra with peaks corresponding to wave phase velocities of 250–350 m/s. The average velocity of 285 m/s is about 20% lower than nominal E-region ion-acoustic speeds, probably because of the presence of heavy metallic ions in the sporadic-E-layers that appear to be associated with the mid-latitude plasma instabilities. Sometimes the type-1 echoes are combined with a broad spectrum of type-2 echoes; at other times they dominate the spectrum or may appear in the absence of any type-2 spectral component. We believe these echoes are due to the modified two-stream plasma instability driven by a polarization electric field that must be larger than 10 mV/m. This field is similar in nature to the equatorial electrojet polarization field and can arise when patchy nighttime sporadic-E-layers have the right geometry.


ISRN Anatomy ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-6
Author(s):  
Abu Ubaida Siddiqui ◽  
Syed Rehan Hafiz Daimi ◽  
Kusum Rajendra Gandhi ◽  
Abu Talha Siddiqui ◽  
Soumitra Trivedi ◽  
...  

Background. The complex architecture of the right atrium, crista terminalis (CT), and the musculi pectinati (MP) poses enormous challenges in electrophysiology and cardiac conduction. Few studies have been undertaken to substantiate the gross features of MP, in relation to the CT, but there is still scarcity of data regarding this. We tried to reinvestigate the gross arrangement of muscle bundles in the right atrium. Methods. Utilizing 151 human hearts and orientation of MP and its variations and relationship to the CT were investigated along with taenia sagittalis (TS). Patterns of MP were grouped in 6 categories and TS under three groups. Result. A plethora of variations were observed. Analysis of all the specimen revealed that 68 samples (45%) were of type 1 category and 27 (18%) fell into type 2 category. Prominent muscular columns were reported in 12 samples (8%). 83 samples (55%) presented with a single trunk of TS. Multiple trunks of TS were reported in 38 samples (25%). Conclusion. Samples with type 6 MP and type B/type C TS, which have a more complex arrangement of fibers, have a tendency to be damaged during cardiac catheterization. Nonetheless, the area as a whole is extremely significant considering the pragmatic application during various cardiac interventions.


2019 ◽  
Vol 13 (1) ◽  
pp. 25-36
Author(s):  
Agus Lubis Fitriansyah ◽  
Heri Supomo

The government through the Ministry of Marine and Fisheries offers assistance of fishing vessel to achieve fisheries production targets. This procurement plan must be supported by the ability and selection of the right shipyard. Beacuse the information of the capability and capacity of fiber shipyards in Indonesia is unclear, so the realization of the procurement of fishing vessel in previous years did not met the planned targets. The purpose of this study was to analyze shipyard capacity to meet the planned procurement of KKP fishing vessels grant in 2019. First classification of fishing vessels is based on the size of each GT, which is 5 GT (type 1), 5-10 GT (type 2), and 20-30 GT (type 3). The second is the minimum shipyard criteria for building fishing boats. Third, an assessment of the shipyard is based on the criteria that have been made. Fourth, shipyard selection was carried out on each WPPN-RI using the load score method. The fifth calculates the number of ships that can be built by the shipyard. The results of the shipyard assessment found that 43% of shipyards have the ability to build type 1 vessels, around 38% of shipyards have the ability to build type 2 vessels, and around 19% of shipyards have the ability to build type 3 vessels. is 1625 units / period. Referring to shipyard capacity, it can be said that the entire shipyard is able to fulfill the plan to procure assistance for KKP fishing vessels in the 2019 budget year.


Perception ◽  
1997 ◽  
Vol 26 (1_suppl) ◽  
pp. 287-287
Author(s):  
J Ninio

The reliability of in-depth curvature judgements for linear elements was studied with stereograms that contained two linear targets and a background representing a hemisphere. The targets were arcs facing to the left or to the right, like parentheses. Some formed binocular pairs with (type 1) or without (type 2) in-depth curvature. The others were monocular (type 3). The hemisphere in the background was generated by a random curve (Ninio, 1981 Perception10 403 – 410); it was either concave (hollow) or convex. The arcs had their binocular centre in the plane of the centre of the hemisphere. Each stereogram contained a type 1, and either a type 2 or a type 3 target. Subjects had to judge the hemisphere curvature, then the in-depth curvature of the targets in 32 different stereograms covering all curvature combinations. There were about 15% errors on type 1 targets, and 80% of these occurred when both the hemisphere and the target were convex, the target being perceived as concave, by transparency through the hemisphere. There were also about 15% errors on type 2 targets, but spread among all situations, the trend being to perceive them as slightly concave. The monocular stimuli (type 3) were judged to be frontoparallel in 70% of the cases. Otherwise, there was no directional bias except for monocular arcs on the nasal side, in conjunction with a concave background. Then, the perceived in-depth curvature was in the ‘generic’ direction predicted by associating the monocular arc in one image with a straight vertical segment in the other image.


2018 ◽  
Vol 89 (10) ◽  
pp. A10.3-A10
Author(s):  
d’Ersu Eleanor ◽  
Anwar NurAizaan ◽  
Al-Mayhani Talal ◽  
Sidhu Meneka

A 59-year-old right-handed bus driver presented with gradually worsening erectile dysfunction, urinary frequency and nocturia over 18 months. He had a past medical history of hypertension with regular medications including amlodipine, aspirin and atorvastatin. Initial examination revealed a mild bilateral intention tremor.The patient had undergone brain imaging showing brainstem and cerebellar atrophy with a ‘hot cross bun sign’. The patient was then referred for autonomic function tests that demonstrated mild cardiovascular autonomic changes, and suggested sympathetic dysfunction. A working diagnosis of multiple system atrophy (MSA) was made.Over the next two years, his tremor worsened with the development of slurred speech and unsteady gait. On examination, he had prominent fasciculations and wasting in the right shoulder, severe bilateral intention tremor with past-pointing. In addition he had Parkinsonism and signs of a sensorimotor neuropathy.This atypical clinical evolution with prominent neuropathy and cerebellar signs led to investigations for spinocerebellar ataxia (SCA), particularly type 2 or 3 (given the autonomic dysfunction). However, the genetic testing showed a mutation in ATXN1, confirming a diagnosis of SCA type 1.To our knowledge, this is the first reported case of prominent early autonomic dysfunction associated with SCA type 1.


2020 ◽  
Vol 44 (1) ◽  
pp. 1-12
Author(s):  
Leonid Kalichman ◽  
Valery Batsevich ◽  
Eugene Kobiliansky

This study aimed to evaluate the association between the index to ring (2D:4D) finger length ratio and aging-related traits (hand osteoarthritis (OA), the osseographic score (OSS), and reproductive period), as well as to assess the heritability of finger length. A Chuvashian population-based sample included 802 males (mean age 46.98±17.10 years) and 738 females (mean age 48.65±16.62 years). Age, sex, basic demographics, anthropometric data, reproductive indices (age at menarche, menopausal age, and length of the reproductive period), and x-rays of both hands were collected. Finger length ratio was measured on x-ray and each hand was visually classified as either type 1 – 2D>4D; type 2 ― 2D=4D; or type 3 ― 2D<4D. Hand OA was defined by the number of affected joints (Kellgren-Lawrence score ≥2) and the total of Kellgren-Lawrence scores (total OA score). OSS is a skeletal biomarker that comprises osteoporotic and OA changes observable on a hands x-ray. We calculated the familial correlations and performed a heritability analysis of 2D:4D ratio traits in a studied sample. After comparing the OA variables of individuals with different finger length ratio types (after adjustment for age and BMI) significant differences were found only in females between finger ratio types of the right hand in a number of affected joints (F=3.153, p=0. 043) and finger ratio types of the left (F=3.330, p=0. 036) and right (F=2.397, p=0. 047) hands of the total OA score. Females with type 3 ratio had the highest adjusted values of hand OA parameters. Results of one-way ANCOVA for finger length ratio types of the right hand showed a significant difference in OSS (df =2, F=7.569, P=0.001), after adjustment for age, sex, and BMI. The posthoc comparison showed that individuals with type 3 (2D<4D) ratio showed significantly higher OSS scores than ones with type 1 (p=0.012) and type 2 (p=0.003). In an analysis of finger length ratio types of left hand also a significant difference in OSS was found (df=2, F=3.290, P=0.038). The posthoc comparison showed that individuals with type 3 ratio showed significantly higher OSS scores than ones with type 2 (p=0.33) ratio. We found that a low finger length ratio, a masculine visually evaluated finger length ratio type, was associated with later menarche and a shorter reproductive period. No association was found with menopausal age. Familial correlations of finger length ratio traits showed no significant correlation for spouses, however, parent-offspring (0.15―0.28, p<0.001) and sibling correlations (0.13―0.38, p<0.009) were found significant. Heritability (H2) of visual classification of finger length ratio was 0.36 for the left and 0.28 for the right hand; finger ratio was 0.55 and 0.66, respectively; the ray ratio was 0.49 and 0.59, respectively, thus indicating the existence of a clear familial aggregation of finger length ratio variation in the Chuvashian pedigrees, which cannot be explained by pure common environmental effects.


2019 ◽  
Vol 32 (3) ◽  
pp. 126-150
Author(s):  
V. V. Hanoshenko ◽  
Ya. V. Volodarets-Urbanovich

Article presents jewelry findings from Pravi Solontsi in the Lower Dnieper. The assemblage belongs to the circle of Dnieper early medieval hoards of first chronological group by O. A. Shcheglova or Martynivka type. The complex comprises 20 whole and fragmented metal items and 1 glass bead. All jewelry is represented by elements of women’s attire: details of collar (chain with link of «snake head», tubular beads Volodarets-Urbanovich / type 1, trapezoidal pendants ornamented with two / three punches circles in mid and blue bead) and bracelets (Rodinkova / type 5, subtype 3 and 2, Rodinkova / type 2, subtype of ornamented). The items existed in the Middle Dnieper region and the Dnieper left bank starting from the end of the 6th / turn of the 6th—7th cc. to the middle / third quarter of the 7th c. We have three explanations for the reasons for the appearance of the Slavic complex of Martynivka type in the Lower Dnieper. The first is connected with the relations between Slavs and nomads. The owner of the Pravi Solontsi complex could be in depending or in marital relations with a representative of the nomadic tribal union. Other variants are a trade or migration from the Middle Dnieper to the Crimea. Their confirmation is the jewelry of the Dnieper origin in the Crimea and the Pre-Caucasus. In addition, a series of things of Crimean origin is known in the Middle Dnieper and Left Bank Dnieper. Near the town Oleshky (next to the village of Pravi Solontsi), was find а small bronze fibula without ornament — brooch of the Danube circle (Joachim Werner’s class IH). V. Ye. Rodinkova believes that this find belongs to type Pergamon-Tai-zee, subtype undecorated according to I. O. Gavritukhin and is already a local modification. Thus, the treasure from the Right Solonets is already the second Slavic finds of the early Middle Ages from this micro-region.


2009 ◽  
Vol 05 (01) ◽  
pp. 22
Author(s):  
Olga S Chajewski ◽  
James H Nichols ◽  
◽  

Diabetes is one of the most prevalent chronic diseases affecting the US healthcare system today, and increasing emphasis is being placed on disease prevention and screening. Early detection of pre-diabetes can be of great benefit to patients as studies have shown that signs of early diabetic complications often exist at the time of diagnosis. Early intervention has been shown to delay, and in some cases prevent, the progression from pre-diabetes to diabetes. Venous blood sampling and core laboratory analysis remain the gold standard for diagnosis. While point-of-care testing (POCT) devices are convenient and readily available, many variables affect the technical performance of POCT devices to allow their use as a reliable diagnostic method. Future diagnostic techniques may include glycated hemoglobin (HbA1c) testing or genotyping and antibody screening. Currently, the HbA1c assay is used in the monitoring of diabetes, but its potential for diagnosis of diabetes is currently being examined. Genotyping and antibody screening for type 1 diabetes are showing promise as they add to the understanding of type 2 diabetes. However, this research is still in the early stages and is not yet available for clinical use.


1998 ◽  
Vol 86 (2) ◽  
pp. 375-382 ◽  
Author(s):  
Mitsuo Hayashi ◽  
Yuriko Kayamoto ◽  
Hideki Tanaka ◽  
Jun Yamada

In a character-judgment paradigm, the subject quickly pressed a key when a hiragana (Japanese syllabary) appeared on a display and did nothing when a kanji (Japanese logograph) appeared. The amplitude of the N400 component was compared when four types of visual stimuli were used: (Type 1) single kanji—Grade 1- to 3-level words, (Type 2) single kanji—Grade 1- to 3-level bound morphemes, (Type 3) single kanji—high school- and college-level bound morphemes, and (Type 4) obsolete kanji. Analysis showed that N400 was largest in the temporal-occipital areas for the Type 1 stimuli and larger in the right parietal area for Type 2 than Type 3 stimuli. The analyses of N400 to semantic stimulations have been conducted and discussed in terms of their meaningfulness, age when writing of these kanji was mastered, and linguistic status (kanji versus nonkanji). Most interestingly, the Types 3 and 4 kanji did not activate semantic responses, showing that they did not function as linguistic units, i.e., kanji, in the mental lexicon.


1997 ◽  
Vol 20 (1) ◽  
pp. 57-66 ◽  
Author(s):  
Andy Clark ◽  
Chris Thornton

Some regularities enjoy only an attenuated existence in a body of training data. These are regularities whose statistical visibility depends on some systematic recoding of the data. The space of possible recodings is, however, infinitely large – it is the space of applicable Turing machines. As a result, mappings that pivot on such attenuated regularities cannot, in general, be found by brute-force search. The class of problems that present such mappings we call the class of “type-2 problems.” Type-1 problems, by contrast, present tractable problems of search insofar as the relevant regularities can be found by sampling the input data as originally coded. Type-2 problems, we suggest, present neither rare nor pathological cases. They are rife in biologically realistic settings and in domains ranging from simple animat (simulated animal or autonomous robot) behaviors to language acquisition. Not only are such problems rife – they are standardly solved! This presents a puzzle. How, given the statistical intractability of these type-2 cases, does nature turn the trick? One answer, which we do not pursue, is to suppose that evolution gifts us with exactly the right set of recoding biases so as to reduce specific type-2 problems to (tractable) type-1 mappings. Such a heavy-duty nativism is no doubt sometimes plausible. But we believe there are other, more general mechanisms also at work. Such mechanisms provide general (not task-specific) strategies for managing problems of type-2 complexity. Several such mechanisms are investigated. At the heart of each is a fundamental ploy – namely, the maximal exploitation of states of representation already achieved by prior, simpler (type-1) learning so as to reduce the amount of subsequent computational search. Such exploitation both characterizes and helps make unitary sense of a diverse range of mechanisms. These include simple incremental learning (Elman 1993), modular connectionism (Jacobs et al. 1991), and the developmental hypothesis of “representational redescription” (Karmiloff-Smith 1979; 1992). In addition, the most distinctive features of human cognition – language and culture – may themselves be viewed as adaptations enabling this representation/computation trade-off to be pursued on an even grander scale.


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