Ovarian stimulation in the lutein phase of the menstrual cycle and in the double stimulation mode in patients with lower diminished ovarian reserve values

2021 ◽  
Vol 12_2021 ◽  
pp. 24-30
Author(s):  
Krutova V.A. Krutova ◽  
Golovko A.K. Golovko ◽  
◽  
Keyword(s):  
Menstrual Cycle ◽  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Diminished Ovarian Reserve ◽  
Stimulation Mode ◽  
Double Stimulation

The transcriptional profile of cumulus cells in women with diminished ovarian reserve in ovarian stimulation protocols in different phases of the menstrual cycle in in vitro fertilization programs

2017 ◽  
Vol 12_2017 ◽  
pp. 68-77
Author(s):  
Bogatyreva Kh.A. Bogatyreva ◽  
Mishieva N.G. Mishieva ◽  
Burmenskaya O.V. Burmenskaya ◽  
Trofimov D.Yu. Trofimov D ◽  
Martazanova B.A. Martazanova ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
In Vitro Fertilization ◽  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Cumulus Cells ◽  
Transcriptional Profile ◽  
Diminished Ovarian Reserve ◽  
Vitro Fertilization

scholarly journals Is ABO blood type associated with ovarian stimulation response in patients with diminished ovarian reserve?

2015 ◽  
Vol 32 (6) ◽  
pp. 985-990 ◽  
Author(s):  
Nigel Pereira ◽  
Anne P. Hutchinson ◽  
Jennifer L. Bender ◽  
Jovana P. Lekovich ◽  
Rony T. Elias ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Diminished Ovarian Reserve ◽  
Blood Type ◽  
Abo Blood Type

scholarly journals Progestin-primed Ovarian Stimulation With Clomiphene Citrate Compared With the Standard Progestin-primed Ovarian Stimulation in Various Aged Women With Diminished Ovarian Reserve: a Retrospective Study

2021 ◽  
Author(s):  
Yue Lin ◽  
Qianqian Chen ◽  
Jing Zhu ◽  
Yili Teng ◽  
Xuefeng Huang ◽  
...  
Keyword(s):  
Oocyte Maturation ◽  
Young Women ◽  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Positive Impact ◽  
Clomiphene Citrate ◽  
Diminished Ovarian Reserve ◽  
Lower Percentage ◽  
High Quality ◽  
Pituitary Suppression

Abstract Background: Clomiphene citrate (CC) supplementation in the progestin-primed ovarian stimulation (PPOS) protocol effectively alleviated profound pituitary suppression from progestin administration and reduced the gonadotropin (Gn) dose in the population of women with normal-ovarian-reserve or polycystic ovarian syndrome. Limited data are available about the role of CC in PPOS for women with diminished ovarian reserve (DOR). This study aimed to compare the efficiency of the PPOS protocol with CC supplementation and the standard PPOS protocol for various aged women with DOR.Methods: A total of 364 patients with DOR were recruited for this retrospective cohort study. They were divided into subgroups based on female age, ≤35 years and ＞35 years. The clinical characteristics and outcome were compared between the groups in subgroups.Results: In all patients with DOR, the PPOS protocol with CC supplementation was associated with a lower percentage of women with profound pituitary suppression (0.0% vs 18.6%, P ＜0.001 and 1.3% vs 11.0%, P ＝0.002) and a higher mean luteinizing hormone (LH) level during controlled ovarian stimulation (COS) than the standard PPOS protocol (P ＜0.05＝. In young women with DOR, more number of high-quality cleavage-stage embryos (1.96 vs. 1.38, P ＝0.018) was achieved in the PPOS protocol with CC supplementation. In elderly women with DOR, PPOS protocol with CC supplementation led to an increase in the incidence of LH levels above 10 IU/L on the trigger day (12.7% vs. 4.9%, P ＝0.028) and decrease in the rate of oocyte maturation (84.7% vs. 89.9%, P ＝0.034) compared to the standard PPOS protocol. No significant differences were observed in the Gn duration, total dosage of Gn, and pregnancy outcomes between the groups. Conclusions: CC is an effective adjuvant to alleviate pituitary suppression in the PPOS protocol. For young women with DOR, CC supplementation has a positive impact on the number of high-quality embryos in PPOS protocol. However, elderly patients with DOR would be at risk of developing premature LH surge and poor oocyte maturation rate after the PPOS protocol with CC supplementation was applied.

O-112 Outcomes of random-start ovarian stimulation protocols as a possible evidence of the theory of antral follicles continuous recruitment

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Y Martirosyan ◽  
T Nazarenko ◽  
A Birukova ◽  
I Dmitrieva
Keyword(s):  
Menstrual Cycle ◽  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Luteal Phase ◽  
Young Patients ◽  
Serum Levels ◽  
Prospective Clinical Study ◽  
Antral Follicles ◽  
Informed Consent Form ◽  
Significant Difference

Abstract Study question We tried to validate the possibility and efficiency of ovarian stimulation (OS) started on any day of the menstrual cycle, based on a theory of continuous recruitment of antral follicles. Summary answer Formation of a pool of follicles with higher sensitivity to gonadotropic stimulation occurs several times during the menstrual cycle (MC). What is known already According to classical concepts and fundamental positions formulated in the middle of the last century, follicular recruitment occurs only once during the menstrual cycle - in the early follicular phase. Nowadays there is increasing evidence to suggest that there are multiple (two or three) antral follicular waves of recruitment during the MC. Also some researchers state that the process of follicle recruitment is continuous. Study design, size, duration This prospective clinical study was conducted at the V.I. Kulakov NMRC for OG&Pof Russia. The study included female cancer patients seeking retrieval and cryopreservation of oocytes and/or embryos before cancer treatment. 240 patients were selected for the study. The patients were divided into 5 groups depending on the cycle day on the moment when ovarian stimulation was initiated. All patients signed an informed consent form approved by the Ethics Committee. Participants/materials, setting, methods The 1st group consisted of patients who started standart OS from 1 to 5 days of the cycle (n = 65); the 2nd - from 6 to 10 (n = 36), the 3rd - from 11 to 15 (n = 45), the 4th - from 16 to 22 (n = 44), the 5th - from 23 to 28 (n = 50). In the late follicular and luteal phase we performed OS without a pituitary modulator. The comparative analysis included features of oo-, embryogenesis and steroidogenesis. Main results and the role of chance The mean age, BMI and AMH were not different among groups. There were no LH rise or OHSS signs noticed in any groups, despite that OS in late follicular and luteal phase of the MC was performed with no GnRH antagonist addition.There was no statistically significant difference in the duration of stimulation, starting doses, total dose of FSH and HMG. The largest number of oocyte cumulus complexes was obtained in the 5th group (11 (9–21) vs 7 (3,5–15,5) in the 1st group, p = 0,030). The greatest number of mature oocytes was obtained in the 4th and 1st groups. In the 2nd group the largest number of immature oocytes was obtained (37 (9.1%)). A smaller number of mature oocytes (165 (61.8%) vs 492 (72.9%) and 314 (77.5%), p = 0.001) was obtained in group 2 (compared with the 1st and the 4th groups), when stimulation was started in the presence of a dominant follicle . These periods coincided with higher estradiol and lower FSH serum levels. Based on our data the optimal moment for effective OS initiation starts with the decrease in serum estradiol which is approximately 48 hours before the menstrual bleeding. Limitations, reasons for caution The presented results could be applied mainly to young patients with high and normal ovarian reserve, who were in the main study group. In patients with low ovarian reserve, short menstrual cycle and early ovulation an issue of favorable time points for the initiation of OS should be resolved individually. Wider implications of the findings The data collected during our research could possibly contribute to future personification of OS protocols. Tailoring the ovarian stimulation protocols to the needs of the patients could decrease time needed for completing the protocol without affecting oocyte yield or their maturity. Trial registration number none

scholarly journals Different ovarian stimulation protocols for women with diminished ovarian reserve

2007 ◽  
Vol 24 (12) ◽  
pp. 597-611 ◽  
Author(s):  
D. Loutradis ◽  
P. Drakakis ◽  
E. Vomvolaki ◽  
A. Antsaklis
Keyword(s):  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Diminished Ovarian Reserve
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