Evaluating the Effectiveness of a Fixed Combination of Amlodipine and Bisoprolol in Ambulatory Patients With Arterial Hypertension and Ischemic Heart Disease

In a group of 32 patients with combined ischemic heart disease (IHD) and arterial hypertension (AH) we studied dynamics of parameters of blood pressure and ECG 24-hour monitoring, as well as ultrasound structural and functional parameters of left and right ventricles during 3-month therapy with fixed dose combination of perindopril arginine (10.0 mg) and amlodipine (5.0 mg). The obtained results demonstrated significant positive effect of this combination on the geometry, structure and diastolic function of both left and right ventricles, as well as confirmed its high antiischemic and antihypertensive effects.

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Psychosocial Risk Factors in Ambulatory Patients With Arterial Hypertension and Ischemic Heart Disease of 30 Cities in Russia: Data from the КОМЕТА (Сomet) Study

Kardiologiia ◽

10.18087/cardio.2018.11.10193 ◽

2018 ◽

Vol 58 (11) ◽

pp. 5-16 ◽

Cited By ~ 3

Author(s):

N. V. Pogosova ◽

S. A. Boitsov ◽

R. G. Oganov ◽

G. P. Kostyuk ◽

O. Yu. Sokolova ◽

...

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Arterial Hypertension ◽

Ischemic Heart ◽

Substantial Contribution ◽

Anxiety And Depression ◽

Therapy Assessment ◽

Type D ◽

Ambulatory Patients

Background.Psychosocial (PS) risk factors (RF) make a substantial contribution in populational burden of cardio-vascular diseases (CVD) and their complications.Purpose.The KOMETA (Comet) study was directed to obtaining actual information on PSRF among ambulatory patients with arterial hypertension (AH) and / or ischemic heart disease (IHD) in 30 cities of Russian Federation.Materials and methods.This multicenter cross-sectional study was conducted in 2016–2017. Doctors participating in the study (n=325) recruited in state polyclinics 2775 patients aged ≥55 years with AH and / or IHD. Information collected from these patients comprised social-demographic and clinical characteristics, data on RF, adherence to therapy. Assessment of PSRF was carried out with consideration of levels of anxiety, depression and stress, presence of personality type D. Results. Population of patients studied (72 % women) was characterized by considerable prevalence of PSRFs. Low levels of education and income were found in 24.5 and 44.2 % of patients, respectively; 25.2 % of patients reported living alone, 6.3 % – felt social isolation. Elevated, extremely high levels of stress, type D personality were detected in 67.8, 10, and 37.6 % of patients, respectively; clinically significant symptoms of anxiety and depression were found in 25.5 and 16.3 %, respectively. Most RFs were significantly more often detected in women, and older people. One third of patients (33.1 %) during a year preceding inclusion took some psychotropic drugs mainly herbal or barbiturate-containing (27.1 %). Moreover, 30 % of patients had lowering of cognitive functioning.Conclusion.In this large-scale study we revealed high prevalence of PSRFs among ambulatory patients with AH and / or IHD in Russia. Despite positive dynamics of prevalence of states of anxiety and depression relative to earlier studies in this country their negative impact on prognosis of CVD and quality of life of affected patients requires optimization of efforts for organization of adequate care and directed to timely diagnosis and correction of these states.

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The association of arterial hypertension and ischemic heart disease is the main problem in modern cardiology practice

Systemic Hypertension ◽

10.26442/sg29101 ◽

2015 ◽

Vol 12 (1) ◽

pp. 70-75

Author(s):

O D Ostroumova ◽

V A Dudaev ◽

V M Fomina

Keyword(s):

Blood Pressure ◽

Risk Factor ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Arterial Hypertension ◽

Fixed Combination ◽

Antihypertensive Drugs ◽

Ischemic Heart ◽

Actual Clinical Practice ◽

Basic Characteristics

This article deals with the epidemiological datashowing higher frequency of arterial hypertension (AH) in patients with ischemic heart disease (IHD). We discussed the basic characteristics of modern domestic and foreign recommendations for treating patients with combination of AH and IHD. We showed the target of blood pressure (BP) in this category of patients. This article deals with the priority groups of antihypertensive drugs, which have the advantages in the combination usage in patients with association of these diseases. We fixed special attention to the problem of BP variability (BPV) as a new risk factor for the development of coronary complications in patients with AH. We showed the possibility of fixed combination of perindopril and amlodipine in reducing interand intervisit BPV in patients with AH and IHD in actual clinical practice.

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«MEMORIES OF FUTURE»: CHANGE IN VERAPAMIL SIGNIFICANCE IN THE TREATMENT OF PATIENTS WITH ISCHEMIC HEART DISEASE AND ARTERIAL HYPERTENSION

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2014-10-6-672-678 ◽

2014 ◽

Vol 10 (6) ◽

pp. 672-678

Author(s):

S. R. Gilyarevskiy

Keyword(s):

Heart Disease ◽

Ischemic Heart Disease ◽

Arterial Hypertension ◽

Ischemic Heart ◽

Future Change

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MYOCARDIUM REMODELING AND THE RISK OF CARDIOVASCULAR COMPLICATIONS WITH PATIENTS WITH ISCHEMIC HEART DISEASE AND ARTERIAL HYPERTENSION

Современные проблемы науки и образования (Modern Problems of Science and Education) ◽

10.17513/spno.27173 ◽

2017 ◽

Author(s):

I.Yu. Evtyukhin ◽

D.V. Dedov ◽

V.P. Mazaev ◽

I.A. Elgardt ◽

S.V. Ryazanova ◽

...

Keyword(s):

Heart Disease ◽

Ischemic Heart Disease ◽

Arterial Hypertension ◽

Cardiovascular Complications ◽

Ischemic Heart ◽

Myocardium Remodeling

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Felodipine in Treatment of Arterial Hypertension and Ischemic Heart Disease

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2020-08-13 ◽

2020 ◽

Vol 16 (4) ◽

pp. 654-662

Author(s):

O. D. Ostroumova ◽

I. A. Alautdinova ◽

A. I. Kochetkov ◽

S. N. Litvinova

Keyword(s):

Chronic Kidney Disease ◽

Heart Disease ◽

Kidney Disease ◽

Ischemic Heart Disease ◽

Arterial Hypertension ◽

Ischemic Heart ◽

Sufficient Evidence ◽

Clinical Effects ◽

First Line ◽

Wide Range

Cardiovascular diseases are the leading cause of death both in the world and in the Russian Federation. The most significant contributors to the increase in mortality are arterial hypertension (AH) and ischemic heart disease (IHD). Dihydropyridine calcium channel blockers (CCBs) are the first line of treatment for these conditions. This is noted in the clinical guidelines for the diagnosis and treatment of AH and in the guidelines for the management of patients with chronic coronary syndromes. CCBs are a heterogeneous group of drugs that have both general and individual pharmacokinetic and pharmacodynamic properties. They are used in patients with AH and/or IHD, including those with concomitant diseases (diabetes mellitus, chronic kidney disease, bronchial asthma, chronic obstructive pulmonary disease, peripheral arterial disease). Felodipine is one of the CCBs. It has a combination of clinical effects, allowing the drug to be prescribed as a first-line therapy for AH, IHD and a combination of these diseases. This is noted in the registered indications for its use. This CCB has a sufficient evidence base of clinical trials demonstrating not only good antihypertensive and antianginal potential of the drug, but also the nephroprotection and cerebroprotection properties. The nephroprotective effect of felodipine is associated with a slowdown in the progression of chronic kidney disease, and the cerebroprotective effect is associated with a decrease in the risk of stroke and an improvement in cognitive functioning. The safety profile of felodipine is favorable: peripheral edema develops much less frequently. This is confirmed by the results of comparative studies. Felodipine is recommended for a wide range of patients with AH, IHD and their combination due to such clinical and pharmacological properties.

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