COVID-19 and kidney damage

This study aimed to evaluate the liver, kidney damage caused by S. typhimurium and to estimate the oxidative damage in association with this bacteria. A highly virulent isolates of S. typhimurium were obtained from the department of internal and preventive medicine/ College of Veterinary Medicine/ University of Baghdad. A twenty five local rabbits of both genders with age range (2-4 months) weeks old were used for this study, the rabbits were divided randomly into five groups each group contains 5 rabbits :- group 1: drenched orally with 5 ml of normal saline and consider as control group, group 2: were drenched orally with (5 ml) suspension which contain (5��109 CFU) of Salmonella typhimurium and regarded as infected group, group 3 were drenched orally with (5 ml) suspension which have (5��109 CFU) of Salmonella typhimurium then treated with a single dose of gentamicin alone at 0.05ml/kg (5mg/ml) orally after presence of signs (after 24hrs. post inoculation), group 4 were drenched (5 ml) suspension having (5��109 CFU) of Salmonella typhimurium then treated with a single dose of Ca-EDTA alone at 40mg/kg orally after presence of signs (after 24hrs. post inoculation) and group 5 were drenched (5 ml) suspension that contain (5��109 CFU) of Salmonella typhimurium then treated with a single dose of combined gentamicin at 0.05ml/kg (5mg/ml) orally after presence of signs (after 24hrs. post inoculation) and Ca-EDTA 40mg/kg after presence of signs (after 24hrs. post inoculation).The results of biochemical profile showed a significant increase (p less than 0.05) in ALT, creatinine and urea levels in infected group as compared with control group, while, the treated groups especially group 5 showed a significant improvement in ALT, Urea and creatinine levels which returned to relative normal levels as compared with infected group after 96hrs. post treatment. Also, the results of oxidative stress showed a significant increase in the levels of MDA in G2, G3, G4 and G5 after 48 hrs. post treatment, while the level of GSH showed a significant decrease in the level at 48hrs., both were returned to relative normal levels after 96hrs.post treatment especially in group 5.In conclusion, S. typhimurium can causing liver and kidney damage which is manifested by increase ALT, Urea and Creatinine. Also, MDA and GSH is increased due to salmonellosis.

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Diagnostics of kidney damage in the medium and large vessels vasculitis - review and presentation of three cases

Nephrology and Dialysis ◽

10.28996/2618-9801-2020-1-108-130 ◽

2020 ◽

Vol 22 (1) ◽

pp. 108-130

Author(s):

E.V. Zakharova ◽

◽

T.A. Makarova ◽

E.S. Leonova ◽

E.S. Stolyarevich ◽

...

Keyword(s):

Kidney Damage ◽

Large Vessels

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Kidney damage in Covid-19: clinical and morphological manifestations of renal pathology in 220 patients died from Covid-19

Nephrology and Dialysis ◽

10.28996/2618-9801-2020-special_issue-46-55 ◽

2020 ◽

Vol 22 (Special_Issue) ◽

pp. 46-55

Author(s):

E.S. Stolyarevich ◽

◽

N.F. Frolova ◽

L.Y. Artyukhina ◽

V.V. Varyasin ◽

...

Keyword(s):

Kidney Damage ◽

Renal Pathology

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Faculty Opinions recommendation of T lymphocytes mediate hypertension and kidney damage in Dahl salt-sensitive rats.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3004961.2683060 ◽

2010 ◽

Author(s):

David Pollock

Keyword(s):

T Lymphocytes ◽

Kidney Damage

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Faculty Opinions recommendation of Subclinical kidney damage in hypertensive patients: A renal window opened on the cardiovascular system. focus on microalbuminuria.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727020443.793564573 ◽

2019 ◽

Author(s):

Luis Ruilope

Keyword(s):

Cardiovascular System ◽

Kidney Damage ◽

Hypertensive Patients ◽

System Focus

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Characteristics of the course of nephritis associated with Iga-vasculitis Henoch-Schoenlein in children

Nephrology (Saint-Petersburg) ◽

10.36485/1561-6274-2020-24-3-64-71 ◽

2020 ◽

Vol 24 (3) ◽

pp. 64-71

Author(s):

A. V. Sukalo ◽

I. A. Kazyra

Keyword(s):

Clinical Laboratory ◽

Morphological Changes ◽

Pediatric Nephrology ◽

Morphological Characteristics ◽

Lymphocyte Activation ◽

Renal Tissue ◽

Kidney Damage ◽

Iga Vasculitis ◽

Factors Affecting ◽

Treatment Regimens

INTRODUCTION. Among systemic vasopathies in children, IgA vasculitis Henoch Schoenlein (HS) is the most common, according to various authors, kidney damage is noted in 25-80 % and usually determines the prognosis of the disease.THE AIM of the study was to analyze clinical, laboratory, immunological, morphological characteristics, features of the course and treatment of nephritis associated with IgA vasculitis HS in children, as well as factors affecting the prognosis.PATIENTS AND METHODS. The study included 31 patients with morphologically verified nephritis due to IgA vasculitis HS (18 – boys, 13 – girls) aged 3 to 17 years, who were monitored at the Nephrology Department of the "2nd Children's City Clinical Hospital" of the National Center for Pediatric Nephrology and Renal Replacement therapy in Minsk from 2010 to 2019 yrs.The following parameters were analyzed: the clinical variant of kidney damage, laboratory tests (including the study of BAFF, RANTES lymphocyte activation molecules, pro-inflammatory IL1β, caspase1, TNFα, growth factors VEGF, TGF), 24 hours monitoring and office blood pressure measurements, ECHO cardiography with indicescalculation, ultrasound of the carotid arteries with the thickness of intima-media complex, morphological changes in the renal tissue, as well as treatment regimens.RESULTS. The contribution of deGal-IgA1, markers of T and B lymphocytes activation, pro-inflammatory and profibrotic molecules in the development of the disease is shown. Arterial hypertension was registered in 42 % of children, signs of heart remodeling according to the calculated indices in 19,3 %. Decrease level of adiponectin, vitamin D, leptin, increase concentration of obestatin, Pro-BNP, hs-CRP, and TSAT indicator classify patients with nephritis due to IgA vasculitis HS at moderate risk for the developmentof cardio-vascular disorders, which suggests the need for timely correction.CONCLUSION. In most cases, nephritis with IgA vasculitis HS has a benign course with rare relapses and progression to the end stage of chronic kidney disease (6,5 %).

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Nephroprotective role and antioxidant capacity of Atriplex halimus on carbon tetrachloride-induced kidney damage in rats

Comparative Clinical Pathology ◽

10.1007/s00580-021-03195-3 ◽

2021 ◽

Vol 30 (1) ◽

pp. 75-87

Author(s):

Kheira Slama ◽

Meriem Rouag ◽

Lazhari Tichati ◽

Faiza Taibi ◽

Mahieddine Boumendjel ◽

...

Keyword(s):

Carbon Tetrachloride ◽

Antioxidant Capacity ◽

Kidney Damage ◽

Atriplex Halimus

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Suppression of Inflammation-Associated Kidney Damage Post-Transplant Using the New PrC-210 Free Radical Scavenger in Rats

Biomolecules ◽

10.3390/biom11071054 ◽

2021 ◽

Vol 11 (7) ◽

pp. 1054

Author(s):

Torsten R. Goesch ◽

Nancy A. Wilson ◽

Weifeng Zeng ◽

Bret M. Verhoven ◽

Weixiong Zhong ◽

...

Keyword(s):

Protective Efficacy ◽

Serum Levels ◽

Rat Plasma ◽

Free Radical Scavenger ◽

Kidney Damage ◽

Brown Norway ◽

Radical Scavenger ◽

Organ Protection ◽

Antibody Mediated Rejection ◽

Allograft Kidney

Allograft kidney transplantation, which triggers host cellular- and antibody-mediated rejection of the kidney, is a major contributor to kidney damage during transplant. Here, we asked whether PrC-210 would suppress damage seen in allograft kidney transplant. Brown Norway (BN) rat kidneys were perfused in situ (UW Solution) with or without added 30 mM PrC-210, and then immediately transplanted into Lewis (LEW) rats. 20 h later, the transplanted BN kidneys and LEW rat plasma were analyzed. Kidney histology, and kidney/serum levels of several inflammation-associated cytokines, were measured to assess mismatch-related kidney pathology, and PrC-210 protective efficacy. Twenty hours after the allograft transplants: (i) significant histologic kidney tubule damage and mononuclear inflammatory cell infiltration were seen in allograft kidneys; (ii) kidney function metrics (creatinine and BUN) were significantly elevated; (iii) significant changes in key cytokines, i.e., TIMP-1, TNF-alpha and MIP-3A/CCL20, and kidney activated caspase levels were seen. In PrC-210-treated kidneys and recipient rats, (i) kidney histologic damage (Banff Scores) and mononuclear infiltration were reduced to untreated background levels; (ii) creatinine and BUN were significantly reduced; and (iii) activated caspase and cytokine changes were significantly reduced, some to background. In conclusion, the results suggest that PrC-210 could provide broadly applicable organ protection for many allograft transplantation conditions; it could protect transplanted kidneys during and after all stages of the transplantation process—from organ donation, through transportation, re-implantation and the post-operative inflammation—to minimize acute and chronic rejection.

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