scholarly journals Conclusions from a behavioral aging study on male and female F2 hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan

Aging ◽  
2019 ◽  
Vol 11 (17) ◽  
pp. 7150-7168 ◽  
Author(s):  
Julia Adelöf ◽  
Jaime M. Ross ◽  
Stanley E. Lazic ◽  
Madeleine Zetterberg ◽  
John Wiseman ◽  
...  
Keyword(s):  
Male And Female ◽  
Age Related ◽  
Water Based ◽  
Aging Study ◽  
Behavioral Aging ◽  
Hybrid Mice

scholarly journals Age-related differences in working hours among male and female GPs: an SMS-based time use study

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Daniël van Hassel ◽  
Lud van der Velden ◽  
Dinny de Bakker ◽  
Ronald Batenburg
Keyword(s):  
Time Use ◽  
Working Hours ◽  
Male And Female ◽  
Age Related

scholarly journals Appropriate Age-Related Behavior for Male and Female Adolescents

1985 ◽  
Vol 17 (2) ◽  
pp. 115-130 ◽  
Author(s):  
ROBERT J. BURSIK ◽  
DON MERTEN ◽  
GARY SCHWARTZ
Keyword(s):  
Female Adolescents ◽  
Male And Female ◽  
Age Related

Age-related changes in ischemic tolerance in male and female mouse hearts

2005 ◽  
Vol 38 (2) ◽  
pp. 245-256 ◽  
Author(s):  
L WILLEMS ◽  
A ZATTA ◽  
K HOLMGREN ◽  
K ASHTON ◽  
J HEADRICK
Keyword(s):  
Female Mouse ◽  
Ischemic Tolerance ◽  
Male And Female ◽  
Age Related ◽  
Age Related Changes

scholarly journals NPY Deficiency Prevents Postmenopausal Adiposity by Augmenting Estradiol-Mediated Browning

2018 ◽  
Vol 75 (6) ◽  
pp. 1042-1049
Author(s):  
Seongjoon Park ◽  
Erkhembayar Nayantai ◽  
Toshimitsu Komatsu ◽  
Hiroko Hayashi ◽  
Ryoichi Mori ◽  
...  
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Fat Metabolism ◽  
Male Mice ◽  
Wild Type ◽  
Male And Female ◽  
Female Mice ◽  
Age Related ◽  
Promising Target ◽  
Intracellular Mechanism

Abstract The orexigenic hormone neuropeptide Y (NPY) plays a pivotal role in the peripheral regulation of fat metabolism. However, the mechanisms underlying the effects of sex on NPY function have not been extensively analyzed. In this study, we examined the effects of NPY deficiency on fat metabolism in male and female mice. Body weight was slightly decreased, whereas white adipose tissue (WAT) mass was significantly decreased as the thermogenic program was upregulated in NPY-/- female mice compared with that in wild-type mice; these factors were not altered in response to NPY deficiency in male mice. Moreover, lack of NPY resulted in an increase in luteinizing hormone (LH) expression in the pituitary gland, with concomitant activation of the estradiol-mediated thermogenic program in inguinal WAT, and alleviated age-related modification of adiposity in female mice. Taken together, these data revealed a novel intracellular mechanism of NPY in the regulation of fat metabolism and highlighted the sexual dimorphism of NPY as a promising target for drug development to reduce postmenopausal adiposity.

Sex Differences in the Relation Between Frailty and Endothelial Dysfunction in Old Mice

2021 ◽  
Author(s):  
Jazmin A Cole ◽  
Mackenzie N Kehmeier ◽  
Bradley R Bedell ◽  
Sahana Krishna Kumaran ◽  
Grant D Henson ◽  
...  
Keyword(s):  
Sex Differences ◽  
Endothelial Function ◽  
Vascular Function ◽  
Mesenteric Artery ◽  
Frailty Index ◽  
Mesenteric Arteries ◽  
Male Mice ◽  
Male And Female ◽  
Female Mice ◽  
Age Related

Abstract Vascular endothelial function declines with age on average, but there is high variability in the magnitude of this decline within populations. Measurements of frailty, known as frailty index (FI), can be used as surrogates for biological age, but it is unknown if frailty relates to the age-related decline in vascular function. To examine this relation, we studied young (4-9 months) and old (23-32 months) C57BL6 mice of both sexes. We found that FI was greater in old compared with young mice, but did not differ between old male and female mice. Middle cerebral artery (MCA) and mesenteric artery endothelium-dependent dilation (EDD) also did not differ between old male and female mice; however, there were sex differences in the relations between FI and EDD. For the MCA, FI was inversely related to EDD among old female mice, but not old male mice. In contrast, for the mesenteric artery, FI was inversely related to EDD among old male mice, but not old female mice. A higher FI was related to a greater improvement in EDD with the superoxide scavenger TEMPOL in the MCAs for old female mice and in the mesenteric arteries for old male mice. FI related to mesenteric artery gene expression negatively for extracellular superoxide dismutase (Sod3) and positively for interleukin-1β (Il1b). In summary, we found that the relation between frailty and endothelial function is dependent on sex and the artery examined. Arterial oxidative stress and pro-inflammatory signaling are potential mediators of the relations of frailty and endothelial function.

scholarly journals The Myelin Water Fraction Serves as a Marker for Age-Related Myelin Alterations in the Cerebral White Matter – A Multiparametric MRI Aging Study

2020 ◽  
Vol 14 ◽  
Author(s):  
Tobias D. Faizy ◽  
Christian Thaler ◽  
Gabriel Broocks ◽  
Fabian Flottmann ◽  
Hannes Leischner ◽  
...  
Keyword(s):  
White Matter ◽  
Multiparametric Mri ◽  
Cerebral White Matter ◽  
Water Fraction ◽  
Age Related ◽  
Aging Study ◽  
Myelin Water Fraction

Age-related changes in the soluble and the membrane-bound Tyr-aminopeptidase activities in several areas of the male and female rat brain

1996 ◽  
Vol 8 (3) ◽  
pp. 465 ◽  
Author(s):  
Gandarias JM de ◽  
J Irazusta ◽  
E Echevarria ◽  
J Gil ◽  
L Casis
Keyword(s):  
Rat Brain ◽  
Peptidase Activity ◽  
Female Rat ◽  
Major Pathway ◽  
Male And Female ◽  
Aminopeptidase M ◽  
Age Related ◽  
Female Brain ◽  
Membrane Bound ◽  
Cellular Development

It has been recently suggested that enkephalins might play a normal role in the regulation of cellular development in brain. Since the major pathway of enkephalin degradation seems to occur under the action of aminopeptidases, in the present paper we describe the changes in Tyr-aminopeptidase activities during several stages of the rat (male and female) brain development (9, 12, 15, 20 and 25 days postbirth). The enzyme activities (soluble and membrane-bound) were detected using Tyr-2-naphthylamide as substrate. No sexual differences were observed. However, significant rises from the 9th to the 15th postnatal day in the soluble peptidase activity were appreciated. Aminopeptidase M shows decreases in the activity with age. It is suggested that not only the enkephalins but also the enkephalin-degrading enzymes could play a part in the maturation of the rat brain.

Age‐related deterioration of motor function in male and female 5xFAD mice from 3 to 16 months of age

2018 ◽  
Vol 19 (3) ◽  
Author(s):  
Timothy P. O'Leary ◽  
Hector M. Mantolino ◽  
Kurt R. Stover ◽  
Richard E. Brown
Keyword(s):  
Motor Function ◽  
Male And Female ◽  
Age Related ◽  
5Xfad Mice

Age-related changes in the carcass yield and meat quality of male and female nutrias ( Myocastor coypus ) under intensive production system

Meat Science ◽  
2017 ◽  
Vol 133 ◽  
pp. 51-55 ◽  
Author(s):  
Eva Tůmová ◽  
Darina Chodová ◽  
Jana Vlčková ◽  
Tomáš Němeček ◽  
Linda Uhlířová ◽  
...  
Keyword(s):  
Meat Quality ◽  
Production System ◽  
Myocastor Coypus ◽  
Male And Female ◽  
Carcass Yield ◽  
Intensive Production ◽  
Age Related ◽  
Age Related Changes
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