scholarly journals Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer’s disease spectrum

Aging ◽  
2019 ◽  
Vol 11 (20) ◽  
pp. 9188-9208 ◽  
Author(s):  
Claudia Drummond ◽  
Gabriel Coutinho ◽  
Marina Carneiro Monteiro ◽  
Naima Assuncao ◽  
Alina Teldeschi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Csf Biomarkers ◽  
White Matter Damage ◽  
Disease Spectrum

scholarly journals Independent Component Analysis-Based Identification of Covariance Patterns of Microstructural White Matter Damage in Alzheimer’s Disease

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119714 ◽  
Author(s):  
Xin Ouyang ◽  
Kewei Chen ◽  
Li Yao ◽  
Xia Wu ◽  
Jiacai Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Independent Component Analysis ◽  
Component Analysis ◽  
Independent Component ◽  
White Matter Damage

Contributors to white matter damage in the frontal lobe in Alzheimer's disease

2005 ◽  
Vol 31 (6) ◽  
pp. 623-631 ◽  
Author(s):  
K. Chalmers ◽  
G. Wilcock ◽  
S Love
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Frontal Lobe ◽  
White Matter Damage

scholarly journals Plasma neurofilament light and cerebrospinal fluid biomarkers are associated with white matter damage in Alzheimer's disease

2020 ◽  
Author(s):  
Fardin Nabizadeh ◽  
Mohammad Balabandian ◽  
Mohammad Reza Rostami ◽  
Samuel Berchi Kankam
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Diffusion Tensor ◽  
Brain Regions ◽  
Csf Biomarkers ◽  
Cross Sectional ◽  
Neurofilament Light ◽  
Microstructural Changes ◽  
Cerebrospinal Fluid Biomarkers

Abstract The most replicated blood biomarker for monitoring Alzheimer’s disease is neurofilament light (NFL). Recent evidence revealed that the plasma level of the NFL has a strong predictive value in cognitive decline and is elevated in AD patients. The Diffusion Tensor Imaging (DTI) is understood to reflect white matter disruption, neurodegeneration largely, and synaptic damage in AD. However, there is no investigation of the association between plasma NFL and white matter microstructure integrity. we have investigated the cross-sectional associations of plasma NFL, CSF tau, p tau, and Aβ with white matter microstructural changes as measured by DTI in 92 mild cognitive impairment (MCI) participants. We investigated potential correlations of the DTI values of each region of the MNI atlas, with plasma NFL, CSF total tau, CSF p tau, and as well as CSF Aβ, separately using a partial correlation model controlled for the effect of age, sex and APOE ε4 genotype. Our findings revealed a significant correlation between plasma and CSF biomarkers with altered white matter microstructural changes in widespread brain regions. Plasma NFL has a negative correlation with FA and positive correlation with RD, AD, and MD values in different regions. Plasma NFL promises to be an early biomarker of microstructural changes in MCI and for MCI progression to AD.

scholarly journals White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI

Brain ◽  
2009 ◽  
Vol 132 (9) ◽  
pp. 2579-2592 ◽  
Author(s):  
Y. Zhang ◽  
N. Schuff ◽  
A.-T. Du ◽  
H. J. Rosen ◽  
J. H. Kramer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Frontotemporal Dementia ◽  
Diffusion Mri ◽  
White Matter Damage

Patterns of Microstructural White Matter Damage in Early and Late Age of Onset Alzheimer's Disease Patients (P05.044)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P05.044-P05.044
Author(s):  
E. Canu ◽  
F. Agosta ◽  
E. Scola ◽  
G. Magnani ◽  
A. Marcone ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Age Of Onset ◽  
White Matter Damage

Unravelling the Association Between Amyloid-PET and Cerebrospinal Fluid Biomarkers in the Alzheimer’s Disease Spectrum: Who Really Deserves an A+?

2021 ◽  
pp. 1-12
Author(s):  
Luca Sacchi ◽  
Tiziana Carandini ◽  
Giorgio Giulio Fumagalli ◽  
Anna Margherita Pietroboni ◽  
Valeria Elisa Contarino ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Amyloid Β ◽  
Standardized Uptake Value ◽  
Csf Biomarkers ◽  
Amyloid Pet ◽  
Linear Regression Models ◽  
Csf Analysis ◽  
Disease Spectrum

Background: Association between cerebrospinal fluid (CSF)-amyloid-β (Aβ)42 and amyloid-PET measures is inconstant across the Alzheimer’s disease (AD) spectrum. However, they are considered interchangeable, along with Aβ 42/40 ratio, for defining ‘Alzheimer’s Disease pathologic change’ (A+). Objective: Herein, we further characterized the association between amyloid-PET and CSF biomarkers and tested their agreement in a cohort of AD spectrum patients. Methods: We include ed 23 patients who underwent amyloid-PET, MRI, and CSF analysis showing reduced levels of Aβ 42 within a 365-days interval. Thresholds used for dichotomization were: Aβ 42 <  640 pg/mL (Aβ 42+); pTau >  61 pg/mL (pTau+); and Aβ 42/40 <  0.069 (ADratio+). Amyloid-PET scans were visually assessed and processed by four pipelines (SPMCL, SPMAAL, FSGM, FSWC). Results: Different pipelines gave highly inter-correlated standardized uptake value ratios (SUVRs) (rho = 0.93–0.99). The most significant findings were: pTau positive correlation with SPMCL SUVR (rho = 0.56, p = 0.0063) and Aβ 42/40 negative correlation with SPMCL and SPMAAL SUVRs (rho = –0.56, p = 0.0058; rho = –0.52, p = 0.0117 respectively). No correlations between CSF-Aβ 42 and global SUVRs were observed. In subregion analysis, both pTau and Aβ 42/40 values significantly correlated with cingulate SUVRs from any pipeline (R2 = 0.55–0.59, p <  0.0083), with the strongest associations observed for the posterior/isthmus cingulate areas. However, only associations observed for Aβ 42/40 ratio were still significant in linear regression models. Moreover, combining pTau with Aβ 42 or using Aβ 42/40, instead of Aβ 42 alone, increased concordance with amyloid-PET status from 74% to 91% based on visual reads and from 78% to 96% based on Centiloids. Conclusion: We confirmed that, in the AD spectrum, amyloid-PET measures show a stronger association and a better agreement with CSF-Aβ 42/40 and secondarily pTau rather than Aβ 42 levels.

Comparison of diffusion tensor imaging and voxel-based morphometry to detect white matter damage in Alzheimer's disease

2011 ◽  
Vol 302 (1-2) ◽  
pp. 89-95 ◽  
Author(s):  
Bora Yoon ◽  
Yong-S. Shim ◽  
Yun-Jeong Hong ◽  
Bang-Bon Koo ◽  
Yong-Duk Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Voxel Based Morphometry ◽  
White Matter Damage

Insights into White Matter Damage in Alzheimer's Disease: From Postmortem to in vivo Diffusion Tensor MRI Studies

2015 ◽  
Vol 16 (1-2) ◽  
pp. 26-33 ◽  
Author(s):  
Francesca Caso ◽  
Federica Agosta ◽  
Massimo Filippi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Diffusion Tensor ◽  
Diffusion Tensor Mri ◽  
White Matter Damage ◽  
Mri Studies
Sign in / Sign up

Export Citation Format

Share Document