scholarly journals The impact of primary tumor location on efficacy of cetuximab in metastatic colorectal cancer patients with different Kras status: a systematic review and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (32) ◽  
pp. 53631-53641 ◽  
Author(s):  
De-Dong Cao ◽  
Hui-Lin Xu ◽  
Xi-Ming Xu ◽  
Wei Ge
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Meta Analysis ◽  
Tumor Location ◽  
Primary Tumor Location ◽  
Kras Status ◽  
Colorectal Cancer Patients ◽  
The Impact

scholarly journals The effect of the primary tumor location on the survival of colorectal cancer patients after radical surgery

2018 ◽  
Vol 15 (14) ◽  
pp. 1640-1647
Author(s):  
Xiaona Cai ◽  
Dianna Gu ◽  
Mengfeng Chen ◽  
Linger Liu ◽  
Didi Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Radical Surgery ◽  
Tumor Location ◽  
Primary Tumor Location ◽  
Colorectal Cancer Patients

scholarly journals Plasma protein expression differs between colorectal cancer patients depending on primary tumor location

2020 ◽  
Vol 9 (14) ◽  
pp. 5221-5234
Author(s):  
Matilda Holm ◽  
Sakari Joenväärä ◽  
Mayank Saraswat ◽  
Tiialotta Tohmola ◽  
Ari Ristimäki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Protein Expression ◽  
Cancer Patients ◽  
Plasma Protein ◽  
Primary Tumor ◽  
Tumor Location ◽  
Primary Tumor Location ◽  
Colorectal Cancer Patients

Primary tumor location impacts survival in colorectal cancer patients after resection of liver metastases

2020 ◽  
Vol 122 (4) ◽  
pp. 745-752
Author(s):  
Katherine Bingmer ◽  
Asya Ofshteyn ◽  
Jonathan T. Bliggenstorfer ◽  
William Kethman ◽  
John B. Ammori ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Tumor Location ◽  
Primary Tumor Location ◽  
Colorectal Cancer Patients

Primary tumor location and bevacizumab effectiveness in metastatic colorectal cancer patients.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 3593-3593
Author(s):  
Wen-zhuo He ◽  
Chang Jiang ◽  
Fang-xin Liao ◽  
Qiong Yang ◽  
Peng-fei Kong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Tumor Location ◽  
Primary Tumor Location ◽  
Colorectal Cancer Patients

scholarly journals The Impact of Primary Tumor Location in Synchronous Metastatic Colorectal Cancer: Differences in Metastatic Sites and Survival

2019 ◽  
Vol 27 (5) ◽  
pp. 1580-1588 ◽  
Author(s):  
Nelleke P. M. Brouwer ◽  
Dave E. W. van der Kruijssen ◽  
Niek Hugen ◽  
Ignace H. J. T. de Hingh ◽  
Iris D. Nagtegaal ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Relative Survival ◽  
Tumor Location ◽  
Primary Tumor Location ◽  
Metastatic Sites ◽  
The Impact

Abstract Purpose We explored differences in survival between primary tumor locations, hereby focusing on the role of metastatic sites in synchronous metastatic colorectal cancer (mCRC). Methods Data for patients diagnosed with synchronous mCRC between 1989 and 2014 were retrieved from the Netherlands Cancer registry. Relative survival and relative excess risks (RER) were analyzed by primary tumor location (right colon (RCC), left colon (LCC), and rectum). Metastatic sites were reported per primary tumor location. Survival was analyzed for metastatic sites combined and for single metastatic sites. Results In total, 36,297 patients were included in this study. Metastatic sites differed significantly between primary tumor locations, with liver-only metastases in 43%, 54%, and 52% of RCC, LCC, and rectal cancer patients respectively (p < 0.001). Peritoneal metastases were most prevalent in RCC patients (33%), and lung metastases were most prevalent in rectal cancer patients (28%). Regardless of the location of metastases, patients with RCC had a worse survival compared with LCC (RER 0.81, 95% CI 0.78–0.83) and rectal cancer (RER 0.73, 95% CI 0.71–0.76). The survival disadvantage for RCC remained present, even in cases with metastasectomy for liver-only disease (LCC: RER 0.66, 95% CI 0.57–0.76; rectal cancer: RER 0.84, 95% CI 0.66–1.06). Conclusions This study showed significant differences in relative survival between primary tumor locations in synchronous mCRC, which can only be partially explained by distinct metastatic sites. Our findings support the concept that RCC, LCC and rectal cancer should be considered distinct entities in synchronous mCRC.

scholarly journals Primary Tumor Location as a Predictive Factor for First-line Bevacizumab Effectiveness in Metastatic Colorectal Cancer Patients

2017 ◽  
Vol 8 (3) ◽  
pp. 388-394 ◽  
Author(s):  
Wen-Zhuo He ◽  
Fang-Xin Liao ◽  
Chang Jiang ◽  
Peng-Fei Kong ◽  
Chen-Xi Yin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Predictive Factor ◽  
Primary Tumor ◽  
Tumor Location ◽  
First Line ◽  
Primary Tumor Location ◽  
Colorectal Cancer Patients
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