scholarly journals Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents

Oncotarget ◽  
2015 ◽  
Vol 6 (27) ◽  
pp. 24277-24290 ◽  
Author(s):  
Yun-Kai Zhang ◽  
Hengyuan Zhang ◽  
Guan-Nan Zhang ◽  
Yi-Jun Wang ◽  
Rishil J. Kathawala ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Reversal Agents ◽  
Resistance Reversal

Synthesis and Biological Evaluation of C-Aromataxane Derivatives as P-Glycoprotein-Mediated Multi Drug Resistance Reversal Agents

Heterocycles ◽  
2015 ◽  
Vol 90 (1) ◽  
pp. 482
Author(s):  
Takayuki Doi ◽  
Naoko Yamaguchi ◽  
Kosuke Ohsawa ◽  
Kazuoki Nakai ◽  
Masahito Yoshida ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Biological Evaluation ◽  
Multi Drug Resistance ◽  
Reversal Agents ◽  
P Glycoprotein ◽  
Resistance Reversal ◽  
Synthesis And Biological Evaluation

Therapeutic Potential of Endophytic Compounds: A Special Reference to Drug Transporter Inhibitors

2019 ◽  
Vol 19 (10) ◽  
pp. 754-783 ◽  
Author(s):  
Khusbu Singh ◽  
Gaurav Raj Dwivedi ◽  
A. Swaroop Sanket ◽  
Sanghamitra Pati
Keyword(s):  
Drug Resistance ◽  
Multidrug Resistance ◽  
Therapeutic Potential ◽  
Drug Transporters ◽  
Chemotherapeutic Agents ◽  
Chemical Diversity ◽  
Drug Transporter ◽  
Reversal Agents ◽  
Resistance Reversal ◽  
Novel Drug

From the discovery to the golden age of antibiotics (miracle), millions of lives have been saved. The era of negligence towards chemotherapeutic agents gave birth to drug resistance. Among all the regulators of drug resistance, drug transporters are considered to be the key regulators for multidrug resistance. These transporters are prevalent from prokaryotes to eukaryotes. Endophytes are one of the unexplored wealths of nature. Endophytes are a model mutualistic partner of plants. They are the reservoir of novel therapeutics. The present review deals with endophytes as novel drug resistance reversal agents by inhibiting the drug transporters across the genera. This review also focuses on drug transporters, and mutualistic chemical diversity, exploring drug transporter modulating potential of endophytes.

4-Hydroxy-α-Tetralone and its Derivative as Drug Resistance Reversal Agents in Multi Drug ResistantEscherichia coli

2014 ◽  
Vol 83 (4) ◽  
pp. 482-492 ◽  
Author(s):  
Gaurav R. Dwivedi ◽  
Harish C. Upadhyay ◽  
Dharmendra K. Yadav ◽  
Vigyasa Singh ◽  
Santosh K. Srivastava ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Reversal Agents ◽  
Resistance Reversal

Phenothiazines and Related Drugs as Multi Drug Resistance Reversal Agents in Cancer Chemotherapy Mediated by p-glycoprotein

2017 ◽  
Vol 13 (1) ◽  
Author(s):  
Ravinesh Mishra ◽  
Swati Sareen ◽  
Bhartendu Sharma ◽  
Shubham Goyal ◽  
Gurpreet Kaur ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Chemotherapy ◽  
Multi Drug Resistance ◽  
Reversal Agents ◽  
P Glycoprotein ◽  
Resistance Reversal

Phytol Derivatives as Drug Resistance Reversal Agents

ChemMedChem ◽  
2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
Harish C. Upadhyay ◽  
Gaurav R. Dwivedi ◽  
Sudeep Roy ◽  
Ashok Sharma ◽  
Mahendra P. Darokar ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Reversal Agents ◽  
Resistance Reversal ◽  
Phytol Derivatives

Synthesis and biological evaluation of novel H6 analogues as drug resistance reversal agents

2019 ◽  
Vol 161 ◽  
pp. 364-377 ◽  
Author(s):  
Xiao Wang ◽  
Qian-wen Ren ◽  
Xian-xuan Liu ◽  
Yan-ting Yang ◽  
Bing-hua Wang ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Biological Evaluation ◽  
Reversal Agents ◽  
Resistance Reversal ◽  
Synthesis And Biological Evaluation

Medicinal and Biological Significance of Phenoxazine Derivatives

2020 ◽  
Vol 20 ◽  
Author(s):  
Jaya Dwivedi ◽  
Neetu Yaduvanshi ◽  
Shruti Shukla ◽  
Sonika Jain
Keyword(s):  
Drug Resistance ◽  
Biological Significance ◽  
Biological Application ◽  
Pharmacological Activities ◽  
Resistance Reversal ◽  
Anti Inflammatory ◽  
Pharmacological Application

: Since 1887, phenoxazine derivatives have attracted attention of chemist due to its versatile utility, industrially and pharmacologically. Literature is found abundant with various pharmacological activities of phenoxazine derivatives like antitumor, anticancer, antifungal, antibacterial, anti-inflammatory, anti-diabetic, anti-viral, anti-malarial, antidepressant, analgesic and many other drug resistance reversal activities. This review covers detailed over-view on pharmacological application of phenoxazine nucleus, its chemistry and reactivity and also illustrating the incorporation of different group at different positions enhancing its biological application, besides some synthetic procedures.

Polyprodrug with Glutathione Depletion and Cascade Drug Activation for Multi-drug Resistance Reversal

Biomaterials ◽  
2021 ◽  
pp. 120649
Author(s):  
Xuan Xiao ◽  
Kewei Wang ◽  
Qingyu Zong ◽  
Yalan Tu ◽  
Yansong Dong ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Glutathione Depletion ◽  
Multi Drug Resistance ◽  
Resistance Reversal ◽  
Drug Activation

Cisplatin Resistance Reversal of Lung Cancers by Tumor Acidity-Activable Vesicular Nanoreactors via Tumor Oxidative Stress Amplification

2021 ◽  
Author(s):  
Jean Felix Mukerabigwi ◽  
Yu Han ◽  
Nannan Lu ◽  
Wendong Ke ◽  
Yuheng Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drug Resistance ◽  
Therapeutic Efficacy ◽  
Cisplatin Resistance ◽  
Clinical Applications ◽  
Lung Cancers ◽  
Resistance Reversal ◽  
Tumor Acidity ◽  
Stress Amplification ◽  
Novel Strategy

Drug resistance of cisplatin significantly limits its therapeutic efficacy in clinical applications against a variety of cancers. Herein, we develop a novel strategy to overcome cisplatin drug resistance through sensitizing...

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