scholarly journals Melatonin inhibits TPA-induced oral cancer cell migration by suppressing matrix metalloproteinase-9 activation through the histone acetylation

Oncotarget ◽  
2016 ◽  
Vol 7 (16) ◽  
pp. 21952-21967 ◽  
Author(s):  
Chia-Ming Yeh ◽  
Chiao-Wen Lin ◽  
Jia-Sin Yang ◽  
Wei-En Yang ◽  
Shih-Chi Su ◽  
...  
Keyword(s):  
Cell Migration ◽  
Oral Cancer ◽  
Matrix Metalloproteinase ◽  
Histone Acetylation ◽  
Cancer Cell ◽  
Matrix Metalloproteinase 9 ◽  
Cancer Cell Migration ◽  
Oral Cancer Cell ◽  
Metalloproteinase 9

Geraniin inhibits oral cancer cell migration by suppressing matrix metalloproteinase‐2 activation through the FAK/Src and ERK pathways

2019 ◽  
Vol 34 (10) ◽  
pp. 1085-1093 ◽  
Author(s):  
Chia‐Ming Yeh ◽  
Ming‐Ju Hsieh ◽  
Jia‐Sin Yang ◽  
Shun‐Fa Yang ◽  
Yi‐Ting Chuang ◽  
...  
Keyword(s):  
Cell Migration ◽  
Oral Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Cell ◽  
Matrix Metalloproteinase 2 ◽  
Cancer Cell Migration ◽  
Oral Cancer Cell

scholarly journals Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway

Biomolecules ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 502 ◽  
Author(s):  
Bharath Kumar Velmurugan ◽  
Jen-Tsun Lin ◽  
B. Mahalakshmi ◽  
Yi-Ching Chuang ◽  
Chia-Chieh Lin ◽  
...  
Keyword(s):  
Cell Migration ◽  
Oral Cancer ◽  
Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion ◽  
Extracellular Signal Regulated Kinase ◽  
Oral Cancer Cell ◽  
Extracellular Signal ◽  
Kinase Pathway

Oral squamous cell carcinoma is the sixth most common type of cancer globally, which is associated with high rates of cancer-related deaths. Metastasis to distant organs is the main reason behind worst prognostic outcome of oral cancer. In the present study, we aimed at evaluating the effects of a natural plant flavonoid, luteolin-7-O-glucoside, on oral cancer cell migration and invasion. The study findings showed that in addition to preventing cell proliferation, luteolin-7-O-glucoside caused a significant reduction in oral cancer cell migration and invasion. Mechanistically, luteolin-7-O-glucoside caused a reduction in cancer metastasis by reducing p38 phosphorylation and downregulating matrix metalloproteinase (MMP)-2 expression. Using a p38 inhibitor, SB203580, we proved that luteolin-7-O-glucoside exerts anti-migratory effects by suppressing p38-mediated increased expression of MMP-2. This is the first study to demonstrate the luteolin-7-O-glucoside inhibits cell migration and invasion by regulating MMP-2 expression and extracellular signal-regulated kinase pathway in human oral cancer cell. The study identifies luteolin-7-O-glucoside as a potential anti-cancer candidate that can be utilized clinically for improving oral cancer prognosis.

scholarly journals N-Glycosylation Induces the CTHRC1 Protein and Drives Oral Cancer Cell Migration

2013 ◽  
Vol 288 (28) ◽  
pp. 20217-20227 ◽  
Author(s):  
Gangli Liu ◽  
Pritam K. Sengupta ◽  
Basem Jamal ◽  
Hsiao-Ying Yang ◽  
Meghan P. Bouchie ◽  
...  
Keyword(s):  
Cell Migration ◽  
Oral Cancer ◽  
Cancer Cell ◽  
Cancer Cell Migration ◽  
Oral Cancer Cell
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