Geraniin inhibits oral cancer cell migration by suppressing matrix metalloproteinase‐2 activation through the FAK/Src and ERK pathways

2019 ◽  
Vol 34 (10) ◽  
pp. 1085-1093 ◽  
Author(s):  
Chia‐Ming Yeh ◽  
Ming‐Ju Hsieh ◽  
Jia‐Sin Yang ◽  
Shun‐Fa Yang ◽  
Yi‐Ting Chuang ◽  
...  
Keyword(s):  
Cell Migration ◽  
Oral Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Cell ◽  
Matrix Metalloproteinase 2 ◽  
Cancer Cell Migration ◽  
Oral Cancer Cell

scholarly journals Melatonin inhibits TPA-induced oral cancer cell migration by suppressing matrix metalloproteinase-9 activation through the histone acetylation

Oncotarget ◽  
2016 ◽  
Vol 7 (16) ◽  
pp. 21952-21967 ◽  
Author(s):  
Chia-Ming Yeh ◽  
Chiao-Wen Lin ◽  
Jia-Sin Yang ◽  
Wei-En Yang ◽  
Shih-Chi Su ◽  
...  
Keyword(s):  
Cell Migration ◽  
Oral Cancer ◽  
Matrix Metalloproteinase ◽  
Histone Acetylation ◽  
Cancer Cell ◽  
Matrix Metalloproteinase 9 ◽  
Cancer Cell Migration ◽  
Oral Cancer Cell ◽  
Metalloproteinase 9

scholarly journals Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway

Biomolecules ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 502 ◽  
Author(s):  
Bharath Kumar Velmurugan ◽  
Jen-Tsun Lin ◽  
B. Mahalakshmi ◽  
Yi-Ching Chuang ◽  
Chia-Chieh Lin ◽  
...  
Keyword(s):  
Cell Migration ◽  
Oral Cancer ◽  
Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion ◽  
Extracellular Signal Regulated Kinase ◽  
Oral Cancer Cell ◽  
Extracellular Signal ◽  
Kinase Pathway

Oral squamous cell carcinoma is the sixth most common type of cancer globally, which is associated with high rates of cancer-related deaths. Metastasis to distant organs is the main reason behind worst prognostic outcome of oral cancer. In the present study, we aimed at evaluating the effects of a natural plant flavonoid, luteolin-7-O-glucoside, on oral cancer cell migration and invasion. The study findings showed that in addition to preventing cell proliferation, luteolin-7-O-glucoside caused a significant reduction in oral cancer cell migration and invasion. Mechanistically, luteolin-7-O-glucoside caused a reduction in cancer metastasis by reducing p38 phosphorylation and downregulating matrix metalloproteinase (MMP)-2 expression. Using a p38 inhibitor, SB203580, we proved that luteolin-7-O-glucoside exerts anti-migratory effects by suppressing p38-mediated increased expression of MMP-2. This is the first study to demonstrate the luteolin-7-O-glucoside inhibits cell migration and invasion by regulating MMP-2 expression and extracellular signal-regulated kinase pathway in human oral cancer cell. The study identifies luteolin-7-O-glucoside as a potential anti-cancer candidate that can be utilized clinically for improving oral cancer prognosis.

scholarly journals Caffeic Acid Phenethyl Ester Inhibits Oral Cancer Cell Metastasis by Regulating Matrix Metalloproteinase-2 and the Mitogen-Activated Protein Kinase Pathway

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Chih-Yu Peng ◽  
Hui-Wen Yang ◽  
Yin-Hung Chu ◽  
Yu-Chao Chang ◽  
Ming-Ju Hsieh ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Matrix Metalloproteinase ◽  
Caffeic Acid ◽  
Cancer Cell ◽  
Cancer Metastasis ◽  
Caffeic Acid Phenethyl Ester ◽  
Matrix Metalloproteinase 2 ◽  
Migration And Invasion ◽  
Oral Cancer Cell ◽  
Cell Metastasis

Caffeic acid phenethyl ester (CAPE), an active component extracted from honeybee hives, exhibits anti-inflammatory and anticancer activities. However, the molecular mechanism by which CAPE affects oral cancer cell metastasis has yet to be elucidated. In this study, we investigated the potential mechanisms underlying the effects of CAPE on the invasive ability of SCC-9 oral cancer cells. Results showed that CAPE attenuated SCC-9 cell migration and invasion at noncytotoxic concentrations (0 μM to 40 μM). Western blot and gelatin zymography analysis findings further indicated that CAPE downregulated matrix metalloproteinase-2 (MMP-2) protein expression and inhibited its enzymatic activity. CAPE exerted its inhibitory effects on MMP-2 expression and activity by upregulating tissue inhibitor of metalloproteinase-2 (TIMP-2) and potently decreased migration by reducing focal adhesion kinase (FAK) phosphorylation and the activation of its downstream signaling molecules p38/MAPK and JNK. These data indicate that CAPE could potentially be used as a chemoagent to prevent oral cancer metastasis.

scholarly journals N-Glycosylation Induces the CTHRC1 Protein and Drives Oral Cancer Cell Migration

2013 ◽  
Vol 288 (28) ◽  
pp. 20217-20227 ◽  
Author(s):  
Gangli Liu ◽  
Pritam K. Sengupta ◽  
Basem Jamal ◽  
Hsiao-Ying Yang ◽  
Meghan P. Bouchie ◽  
...  
Keyword(s):  
Cell Migration ◽  
Oral Cancer ◽  
Cancer Cell ◽  
Cancer Cell Migration ◽  
Oral Cancer Cell

scholarly journals Sulforaphane suppresses oral cancer cell migration by regulating cathepsin S expression

Oncotarget ◽  
2018 ◽  
Vol 9 (25) ◽  
pp. 17564-17575 ◽  
Author(s):  
Chang-Tai Chen ◽  
Ming-Ju Hsieh ◽  
Yi-Hsien Hsieh ◽  
Min-Chieh Hsin ◽  
Yi-Ting Chuang ◽  
...  
Keyword(s):  
Cell Migration ◽  
Oral Cancer ◽  
Cancer Cell ◽  
Cathepsin S ◽  
Cancer Cell Migration ◽  
Oral Cancer Cell
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