scholarly journals Relationship between Ambulatory Pulse Pressure, Pulse Pressure Index and Coronary Artery Disease in Patients with Hypertension

2021 ◽  
Vol 10 (1) ◽  
pp. 17
Author(s):  
Jiajuan Chen ◽  
Yunjie Wei ◽  
Zhen Gao ◽  
Haijun Xu ◽  
Hezhong Zhu
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Pulse Pressure ◽  
Pressure Pulse ◽  
Control Group ◽  
Clinical Indicators ◽  
Pressure Index ◽  
Artery Disease ◽  
Ambulatory Pulse Pressure ◽  
Experimental Group

<p>Objective: To analyze the relationship between ambulatory pulse pressure, pulse pressure index, and coronary artery disease in patients with hypertension. Methods: From February 2018 to February 2019, a group of 100 patients with hypertension (control group) and a group of 100 patients with hypertension and coronary artery disease (experimental group) were selected to monitor and analyze dynamic pulse pressure and pulse pressure indicators. Results: In terms of clinical indicators, values of NPPI, 24hPP and 24hPPI in the experimental group were significantly higher than those in the control group. P &lt; 0.05 indicates that there is statistical value in the data difference. Conclusion: In the clinical diagnosis of hypertension patients, ambulatory pulse pressure, pulse pressure index are highly correlated with the risk of coronary artery disease. Therefore, researchers should actively pay attention to the relevant indicators of patients to lay a solid foundation for the effective protection of patients’ health.</p>

Preoperative Rosuvastatin Protects Patients with Coronary Artery Disease Undergoing Noncardiac Surgery

Cardiology ◽  
2015 ◽  
Vol 131 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Jinggang Xia ◽  
Yang Qu ◽  
Chunlin Yin ◽  
Dong Xu
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Emergency Surgery ◽  
Stable Coronary Artery Disease ◽  
Myocardial Necrosis ◽  
Noncardiac Surgery ◽  
Control Group ◽  
Artery Disease ◽  
Experimental Group

Objectives: We explored whether preoperative rosuvastatin could protect the cardiac health of patients with coronary artery disease undergoing emergency, noncardiac surgery. Methods: We randomized 550 noncardiac emergency surgery patients with stable coronary artery disease on long-term statin therapy to treatment with and without preoperative rosuvastatin. All patients received rosuvastatin after surgery. We evaluated the incidence of myocardial necrosis and major adverse cardiovascular and cerebrovascular events (MACCE) 30 days and 6 months after surgery. Results: Creatinine kinase-myocardial band (CK-MB) isoform elevations occurred less frequently 12 and 24 h after noncardiac emergency surgery in the experimental group than in the control group (p = 0.029). After surgery, the incidence of MACCE was also lower in the experimental group than in the control group (p = 0.019). The difference was mainly due to the incidence of perioperative myocardial infarction (p = 0.029). Multivariable analysis found that rosuvastatin reload reduced the incidence of MACCE 52% 6 months after surgery (p = 0.03). Conclusions: Preoperative rosuvastatin reload therapy decreases the incidence of myocardial necrosis and MACCE after noncardiac emergency surgery in patients with stable coronary artery disease on long-term statin therapy.

scholarly journals The effect of continuous aerobic exercise on serum angiogenic and angiostatic factors in induction model of acute myocardial infarction male rats with coronary artery disease

2021 ◽  
Vol 43 (5) ◽  
pp. 444-455
Author(s):  
Elham Dehghan ◽  
Aliasghar Ravasi ◽  
Reza Nouri ◽  
Abbasali Gaeini ◽  
Maryam Nekooei ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Aerobic Exercise ◽  
Training Session ◽  
Male Rats ◽  
Angiogenic Factor ◽  
Control Group ◽  
Control Groups ◽  
Artery Disease ◽  
Experimental Group

Background. Aerobic training somewhat corrects endothelial dysfunction in patients with coronary artery disease (CAD), but the most effective form of exercise is still unclear; therefore, the purpose of the present study was to investigate the effect of 8 weeks of continuous aerobic exercise on serum vascular endothelial growth factor (VEGF) as an angiogenic factor and endostatin (ES) as an angiostatic factor in male rats with coronary artery disease. Methods. The subjects of the present experimental study were 30 healthy male 2-months old Wistar rats divided into three groups: the experimental group, the control group with coronary artery disease, and the healthy control group. After rupturing 20 of the rats by isoproterenol, 10 rats in the experimental group performed eight weeks of continuous aerobic exercise on a treadmill, with an incremental intensity of 50% in the first session to 78% in the last session, whereas both control groups did not exercise. Seventy-two hours after the final training session, blood samples were taken for serum VEGF and ES indices, and one-way ANOVA with Scheffer posthoc tests was used to compare the mean of variables among the studied groups. Results. The results showed that discontinuous aerobic exercise could increase the blood VEGF in rats with coronary artery disease (P≤0.01), while there was no difference in the level of endostatin in the experimental group compared with control groups (P>0.05). Conclusion. It seems that continuous aerobic exercises can be used in the rehabilitation of patients with coronary artery disease and might be effective in the process of angiogenesis.

scholarly journals Optimizing diagnosis of obstructive coronary artery disease by CT angiography: RCT's final results and 12-months follow-up

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
J.P Dias Ferreira Reis ◽  
R Ramos ◽  
P Modas Daniel ◽  
S Aguiar Rosa ◽  
L Almeida Morais ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Functional Test ◽  
Control Group ◽  
Diagnostic Strategy ◽  
Coronary Syndrome ◽  
Tertiary Center ◽  
Safety Endpoint ◽  
Artery Disease ◽  
Primary Safety Endpoint

Abstract Aim In patients (pts) with suspected coronary artery disease (CAD), computed tomographic angiography (CTA) may improve pt selection for invasive coronary angiography (ICA) as alternative to functional testing. However. the role of CTA in symptomatic pts after abnormal functional test (FT) is incompletely defined. Methods and results This randomized clinical trial conducted in single academic tertiary center selected 218 symptomatic pts with mild to moderately abnormal FT referred to ICA to receive either the originally intended ICA (n=103) or CTA (n=115). CTA interpretation and subsequent care decisions were made by the clinical team. Pts with high risk features on FT, previous acute coronary syndrome, previously documented CAD, chronic kidney disease (GFR&lt;60ml/min/1.73m2) or persistent atrial fibrillation were excluded. The primary endpoint was the percentage of ICA with no significant obstructive CAD (no stenosis ≥50%) in each group. Diagnostic (DY) and revascularization (RY) yields of ICA in either group were also assessed. Pts were followed up for at least 1 year for the primary safety endpoint of all cause death/ nonfatal myocardial infarction/ stroke. Unplanned revascularization (UP) and symptomatic status (SS) were also evaluated. Pts averaged 68±9 years of age, 60% were male, 29% were diabetic. Nuclear perfusion stress test was used in 33.9% in CTA group and 31.1% in control group (p=0.655). Mean post (functional) test probability of obstructive CAD was 34%. Overall prevalence of obstructive CAD was 32.1%. In the CTA group, ICA was cancelled by referring physicians in 83 of the pts (72.2%) after receiving CTA results. For those undergoing ICA, non-obstructive CAD was found in 5 pts (15.6%) in the CTA-guided arm and 60 (58.3%) in the usual care arm (p&lt;0.001 Mean cumulative radiation exposure related to diagnostic work up was similar in both groups (6±14 vs 5±14mSv, p=0.152). Both DY (84.4% vs 41.7, p&lt;0.001) and RY (71.9% vs 38.8%, p=0.001) yields were significantly higher for CTA-guided ICA as compared to standard FT-guided ICA. The rate of the primary safety endpoint was similar between both groups (1.9% vs 0%, p=0.244), as well as the rates of UP (0.9% vs 0.9%, p=1.000) and SS (persistent angina: 29.6% vs 24.8%, p=0.425). Conclusions In pts with suspected CAD and mild to moderately abnormal ischemia test, a diagnostic strategy including CTA as gatekeeper is safe, effective and significantly improves diagnostic and revascularization yields of ICA. Funding Acknowledgement Type of funding source: None

scholarly journals Importance of the Ankle-Brachial Pressure Index in the Diagnosis of Coronary Artery Disease in Women With Diabetes Without Anginal Pain

2011 ◽  
Vol 75 (9) ◽  
pp. 2206-2212 ◽  
Author(s):  
Yuko Igarashi ◽  
Taishiro Chikamori ◽  
Satoshi Hida ◽  
Hirokazu Tanaka ◽  
Chie Shiba ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Ankle Brachial Pressure Index ◽  
Pressure Index ◽  
Anginal Pain ◽  
Artery Disease

scholarly journals Assessment of structural and functional myocardial characteristics in patients with chronic coronary artery disease and various glycemic status

2021 ◽  
Vol 20 (7) ◽  
pp. 3077
Author(s):  
M. A. Kokozheva ◽  
B. U. Mardanov ◽  
E. A. Poddubskaya ◽  
V. A. Kutsenko ◽  
M. A. Umetov ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Exercise Tolerance ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Control Group ◽  
Glycemic Status ◽  
Artery Disease

Aim. To study the structural and functional myocardial characteristics in patients with exertional angina and type 2 diabetes in comparison with those without diabetes to identify combined hemodynamic changes.Material and methods. Patients were divided into two groups depen - ding on the glycemic status. The first group consisted of 49 patients (mean age, 57,9±1,04 years; male/female, 35/14) with coronary artery disease (CAD) and type 2 diabetes, while the second one (control)  — 51 patients (60,2±0,9 years, 34/17) with CAD and without diabetes. Patients were surveyed using a standard questionnaire that included socio-demographic parameters, behavioral risk factors, clinical status, medications received, and comorbidities. Diagnostic investigations were carried out, including resting electrocardiography, transthoracic echocardiography and cycle ergometry.Results. Among patients with CAD and type 2 diabetes, hypertension occurred 20% more often compared with the control group  — 98 vs 78% (p<0,004). According to the electrocardiography, the combination of diabetes and CAD was characterized by various arrhythmias, which were recorded 2,8 times more often than in the group without diabetes. According to echocardiography, signs of left ventricular hypertrophy, systolic and diastolic dysfunction prevailed in people with diabetes. Mean pulmonary artery pressure in patients with diabetes were higher than in patients without carbohydrate metabolism disorders (p<0,004). According to the stress test, exercise tolerance in experimental group patients was lower than in patients in the control group.Conclusion. The combination of chronic CAD and type 2 diabetes is cha - racterized by a more common combination with hypertension, impaired central and intracardiac hemodynamics, as well as left ventricular hypertrophy. In people with diabetes, impaired systolic and diastolic myocardial function is combined with reduced exercise tolerance.

scholarly journals Patients with New-Onset Tumor of Severe Coronary Artery Disease May be at a Higher Risk of Arrhythmia

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Palisha Alimu ◽  
Dezhi Yang ◽  
Huatao Zhou ◽  
Yan Wu ◽  
Huiping Guo
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Patient ◽  
Control Group ◽  
Severe Coronary Artery Disease ◽  
Tumor Treatment ◽  
Severe Coronary Artery ◽  
The Difference ◽  
Artery Disease ◽  
New Onset

Background. Arrhythmia is one of the causes of death in severe coronary artery disease patients who also suffered from cancer. Our research aims to compare the incidence of arrhythmia between severe coronary artery disease patient with and without new-onset tumor. Methodology. We enrolled 79 patients (December 2019–December 2020) with severe coronary artery disease in this study, and 40 of them were complicated with new-onset tumor. The details of all subjects were thoroughly obtained; the laboratory tests were implemented including creatinine before coronary angiography. The appraisal of the severity of coronary artery disease was applied by Gensini score. The cardiac inspection includes UCG, 12-lead ECG, and Holter monitor. Results. Among them, there were 40 patients in the experimental group and 39 patients in the control group. The difference at the baseline between the two sets of figures was not statistically significant ( P > 0.05 ). The incidence of arrhythmia between the two groups was statistically significant ( P < 0.05 ). Conclusions. The incidence of arrhythmia in severe coronary artery disease patients who were complicated with new-onset tumor was higher than that in patients with severe coronary artery disease alone, and attention should be paid to arrhythmia before tumor treatment.

scholarly journals Composition of the Oral Microbiome in Patients with Coronary Artery Disease

2020 ◽  
Author(s):  
Thangam Menon ◽  
Supraja Kalyanaraman ◽  
Seethalakshmi Srinivasan
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Bacterial Flora ◽  
Human Microbiome ◽  
Oral Microbiome ◽  
Metagenomic Analysis ◽  
Control Group ◽  
Oral Microbiota ◽  
Normal Human ◽  
Artery Disease

Introduction: Distinct microbial communities reside in the oral cavity and the composition of the oral microbiota has important implications for human health and disease. Identification of bacterial flora of the microbiome is done by metagenomic analysis of 16S ribosomal RNA sequences. Aim: The aim of this study was to characterise the human microbiome in patients with Coronary Artery Disease (CAD) in comparison with the normal human microbiome. Materials and Methods: A pilot study was carried out in tertiary hospital, Chennai. Oral mouthwash samples collected from nine patients with CAD were selected, with one control group. They were studied by metagenomic analysis of V3-V4 region of 16SrRNA gene sequences.. Sequencing of the variable V3 and V4 regions was done using Illumina platform. Results: The six major phyla, Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, Spirochaetes, and Fusobacteriacontained 99% of the taxa in all the samples analysed. Conclusion: Diversity of the microbiome in patients with CAD was similar to the normal human microbiome.

scholarly journals Impact of Calcium Channel Blockers on Aspirin Reactivity in Patients With Coronary Artery Disease

2021 ◽  
Author(s):  
Afek Kodesh ◽  
Eli Lev ◽  
Dorit Leshem-Lev ◽  
Alejandro Solodky ◽  
Ran Kornowski ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Platelet Reactivity ◽  
Aspirin Resistance ◽  
Control Group ◽  
Channel Blockers ◽  
Artery Disease ◽  
Stable Cad

Abstract Purpose: Calcium channel blockers (CCBs) do not reduce the risk of initial or recurrent myocardial infarction (MI) in patients diagnosed with stable coronary artery disease (CAD). The aim of this current study was to evaluate the association between CCBs and aspirin resistance in patients with CAD. Methods: Patients with stable CAD who were regularly taking aspirin (75-100 mg qd) for at least one month prior to enrollment in the study were included. The VerifyNow system was used for platelet function testing with high on-aspirin platelet reactivity (HAPR) defined as aspirin reaction units (ARU) >550. We compared patients treated with CCBs versus control group. Results: 503 patients with CAD were included in this study, 88 were treated with CCBs; Mean age (67.9±9.7 in the CCB group vs 66.5±11.4 in the control group, p=0.288), gender (77.3 male vs. 82.9%, p=0.214) and rates of diabetes mellitus (34.7 vs. 36.9%, p=.121) were similar. Rates of hypertension were higher in the CCB group (83.9 vs. 63.5%, p<0.01), but rates of past MI were lower (47.1 vs. 59.7%, p=0.039). The mean ARU was 465.4P70.0 for patients treated with CCBs versus 445.2u60.0 in controls (p=0.006). Similarly, 15.9% of CCB patients demonstrated HAPR compared to 7.0% (p=0.006). In a multivariate analysis, the administration of CCBs was independently associated with HAPR (OR- 1.72, 95% CI 1.04 – 8.91, p=0.047). Conclusions: Usage of CCBs is positively correlated with aspirin resistance. These findings may suggest an adverse pharmacologic effect of CCBs among patients with stable CAD treated with aspirin.

scholarly journals Effects of exercise training on sleep apnoea in patients with coronary artery disease: a randomised trial

2016 ◽  
Vol 48 (1) ◽  
pp. 142-150 ◽  
Author(s):  
Monique Mendelson ◽  
Owen D. Lyons ◽  
Azadeh Yadollahi ◽  
Toru Inami ◽  
Paul Oh ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Exercise Training ◽  
Randomised Trial ◽  
Exercise Group ◽  
Sleep Apnoea ◽  
Control Group ◽  
Fluid Shift ◽  
Obstructive Sleep ◽  
Artery Disease

Overnight fluid shift from the legs to the neck and lungs may contribute to the pathogenesis of obstructive sleep apnoea (OSA) and central sleep apnoea (CSA). We hypothesised that exercise training will decrease the severity of OSA and CSA in patients with coronary artery disease (CAD) by decreasing daytime leg fluid accumulation and overnight rostral fluid shift.Patients with CAD and OSA or CSA (apnoea–hypopnoea index >15 events per h) were randomised to 4 weeks of aerobic exercise training or to a control group. Polysomnography, with measurement of leg, thoracic and neck fluid volumes and upper-airway cross-sectional area (UA-XSA) before and after sleep, was performed at baseline and follow-up.17 patients per group completed the study. Apnoea–hypopnoea index decreased significantly more in the exercise group than in the control group (31.1±12.9 to 20.5±9.4versus28.1±13.5 to 27.0±15.1 events per h, p=0.047), in association with a greater reduction in the overnight change in leg fluid volume (579±222 to 466±163versus453±164 to 434±141 mL, p=0.04) and by a significantly greater increase in the overnight change in UA-XSA in the exercise group (p=0.04).In patients with CAD and sleep apnoea, exercise training decreases sleep apnoea severityviaattenuation of overnight fluid shift and an increase in UA-XSA.

Abstract 150: Association Between Serum Ghrelin Levels and Coronary Artery Disease: a Meta-analysis

2015 ◽  
Vol 117 (suppl_1) ◽  
Author(s):  
Pradyumna Agasthi ◽  
Sivakanth Aloor ◽  
Avantika Chenna ◽  
Anekwe Onwuanyi
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Meta Analysis ◽  
Control Group ◽  
Cross Sectional ◽  
Median Serum ◽  
Artery Disease ◽  
Differentiation And Proliferation ◽  
And Control ◽  
Serum Gh

Background: Ghrelin (GH) is a gastrointestinal endocrine peptide regulating multiple biological processes including adipogenesis, glucose metabolism, cell differentiation and proliferation. Recent studies demonstrated that GH inhibits pro-atherogenic changes in vessel wall via inhibition of nuclear factor - B activity, a transcriptional factor mediating production pro-inflammatory cytokines and adhesion molecule expression in the endothelium. The aim of the current study is to conduct a meta-analysis to evaluate the relationship between serum GH levels and coronary artery disease (CAD). Methods: We searched MEDLINE, CINHAL and COCHRANE databases for studies reporting serum GH levels in the CAD and non CAD study population. We included case controls, cohort and cross-sectional studies. We calculated the weighted standardized mean difference (SMD) in serum GH levels between the CAD and control groups. Results: Our search strategy yielded 285 articles and we included 10 studies enrolling 1855 participants. The median age of the CAD group was 62 yrs. (IQR 60 - 63) compared to 61 yrs. (IQR 58 - 65) in the control group. The median body mass index in the CAD group was 28 kg/m2 (IQR 27.9 - 28) compared to 27 kg/m2 (IQR 26 - 27) in the control group. The unweighted median serum GH levels in the CAD group were 0.66 ng/ml (IQR 0.3 - 1.6) compared to 0.76 ng/ml (IQR 0.38 - 4.9) in the control group. The SMD of GH level was -0.44 (95% CI -0.56,-0.31) p<0.001 comparing those in the CAD group and control group. Conclusion: Serum GH levels are significantly and inversely associated with CAD. Current findings warrant the need to further investigate the role of GH in the pathogenesis of CAD.

Sign in / Sign up

Export Citation Format

Share Document