scholarly journals Guillain-Barré syndrome in a child: a clinical case

2020 ◽  
Vol 48 (4) ◽  
pp. 285-289
Author(s):  
A. Yu. Ryabchenko ◽  
E. V. Grankin
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
Clinical Case ◽  
Clinical Course ◽  
Guillain Barre Syndrome ◽  
Complete Regression ◽  
Gradual Improvement ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Guillain-Barré syndrome is an orphan autoimmune disease associated with the involvement of the peripheral nervous system. The clinical course of the syndrome has four main types. We present a clinical case of Guillain-Barré syndrome in a 6-year old child. Against the background of a previous infection, he developed oculomotor dysfunction, peripheral tetraparesis, sensory abnormalities with subsequent severe weakness of the respiratory muscles. The differential diagnosis included inflammatory, infectious and neoplastic spinal cord disorders, spinal cord magnetic resonance imaging, and examination of the cerebrospinal fluid. The patient's electromyographic data confirmed peripheral nerve damage. Based on all of these, the patient was diagnosed with Guillain-Barré syndrome. Specific treatment, including plasmapheresis and intravenous human immunoglobulin G at a dose of 0.4 mg daily for 5 days, and symptomatic treatment resulted in gradual improvement and complete regression of the neurological symptoms completely resolved. Since Guillain-Barré syndrome is a rare disease of the peripheral nervous system, the awareness of the specifics of its clinical course allows for earlier correct diagnosis and effective treatment.

scholarly journals Exertional Syncope as a presenting feature in Guillain-Barré syndrome

2012 ◽  
Vol 11 (4) ◽  
pp. 231-233
Author(s):  
Tamer Shalaby ◽  
◽  
Constantinos Papoutsos ◽  
Louise Tiemens ◽  
Iain Crossingham ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Peripheral Nervous System ◽  
Autonomic Failure ◽  
Guillain Barre Syndrome ◽  
Autonomic Nervous System Dysfunction ◽  
Motor Weakness ◽  
Demyelinating Disorder ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Guillain-Barré syndrome (GBS) is an acute demyelinating disorder of the peripheral nervous system that results in motor weakness, absent reflexes and autonomic nervous system dysfunction. Autonomic failure is reported in approximately 65 % of patientswith GBS and usually follows extensive motor involvement. In this case our patient presented with syncope and other signs of autonomic failure before the motor weakness developed. Few cases in the literature have reported features of autonomic failure before established weakness in GBS; to our knowledge, syncope has not been described previously as a presenting feature of GBS.

Jules Dejerine and the peripheral nervous system

Neurology ◽  
2017 ◽  
Vol 89 (6) ◽  
pp. 611-615 ◽  
Author(s):  
Stéphane Mathis ◽  
Jean-Michel Vallat
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Neuromuscular Disorders ◽  
Guillain Barre Syndrome ◽  
Hereditary Neuropathy ◽  
Guillain Barré Syndrome ◽  
Inflammatory Neuropathies ◽  
Guillain Barré ◽  
Considerable Body

Jules Dejerine (1849–1917) was a French neurologist who contributed to the description of numerous neurologic conditions ranging from neurovascular pathology to neuromuscular disorders. A considerable body of his research was devoted to the peripheral nervous system. In this area, the eponymous Dejerine-Sottas syndrome refers to a form of infantile hereditary neuropathy. Dejerine also contributed to the description of many other disorders of the peripheral nervous system and was even a precursor in the study of acquired neuropathies (as well as acute inflammatory neuropathies, before the first description of the Guillain-Barré syndrome) and in the field of radicular pathology. In this centennial year of his death, we emphasize the variety and originality of Dejerine’s opus on diseases of the peripheral nervous system.

scholarly journals Guillain–Barré Syndrome as a Neurological Complication of COVID-19 Infection: A Case Series and Review of the Literature

2020 ◽  
Vol 7 (3) ◽  
pp. 156-161
Author(s):  
Hossein Mozhdehipanah ◽  
Sepideh Paybast ◽  
Reza Gorji
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Neurological Complication ◽  
Clinical Manifestations ◽  
Case Series ◽  
Final Diagnosis ◽  
Neurological Complications ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

The novel coronavirus disease 2019 (COVID-19) is a global pandemic. Although the main clinical manifestations of the COVID-19 infection have confined to the respiratory system, there is some evidence suggesting the neuro-invasive potential of the COVID-19. There are limited reports of Guillain–Barré syndrome (GBS) as a peripheral nervous system complication of COVID-19 infection. We described four patients with COVID-19 infection who developed acute polyneuropathy with a final diagnosis of Guillain–Barré syndrome. COVID-19 may have the potential to invade the peripheral nervous system. GBS, as one of the critical neurological complications of COVID-19, could be considered as a post-infectious event.

scholarly journals Clinical case of Guillain-Barré syndrome associated with COVID-19

2021 ◽  
Vol 12 (2) ◽  
pp. 110-118
Author(s):  
Elena V. Shirshova ◽  
Vladimir V. Knaub ◽  
Vladimir P. Baklaushev
Keyword(s):  
Nervous System ◽  
Clinical Case ◽  
Disease Onset ◽  
Pathological Process ◽  
Lung Damage ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Psychopathological Disorders ◽  
Guillain Barré ◽  
High Level

Background: The coronavirus infection caused by SARS-Cov-2 is characterized by a damage to many organs and systems of the human body. To date, convincing information has been obtained about the involvement of various parts of the nervous system in the pathological process in patients with COVID-19. Among the most frequently described impairments, there are disorders of smell and taste, common disorders of the central nervous system, characterized by general cerebral symptoms, such as headache, asthenization, psychopathological disorders. One of the rare and severe forms of the peripheral nervous system damage in COVID-19 is Guillain-Barre syndrome (GBS), characterized by acute post-infectious inflammatory polyneuropathy with an autoimmune etiology. Clinical case description. We present a clinical case of GBS associated with COVID-19. The disease debuted as a peripheral tetraparesis with a progredient course of up to 21 days. Systemic administration of immunoglobulin stopped the disease progression. The association of GBS with COVID-19 was clarified a month after the disease onset, when bilateral polysegmental pneumonia was diagnosed, and a high level of IgG to the S-protein of SARS-CoV-2 was found, 3 times higher than the level of IgM, which indicated the duration of the disease was not less than three weeks. Conclusion: The GBS development upon infection with SARS-CoV-2 may precede the lung damage. The debut of GBS during the COVID-19 pandemic requires the exclusion of the SARS-CoV-2 etiological role in each case.

scholarly journals Difficulties of differential diagnostics of Guillain–Barré syndrome in children. The discussion of two clinical cases

2020 ◽  
Vol 15 (2) ◽  
pp. 55-59
Author(s):  
A. S. Kotov ◽  
E. V. Mukhina ◽  
A. V. Shatalin ◽  
M. V. Panteleeva ◽  
M. S. Bunak
Keyword(s):  
Nervous System ◽  
Autoimmune Disease ◽  
Peripheral Nervous System ◽  
Acute Flaccid Paralysis ◽  
Flaccid Paralysis ◽  
Guillain Barre Syndrome ◽  
Differential Diagnostics ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
Clinical Cases

Guillain–Barré syndrome – an acute demyelinating autoimmune disease characterized by lesions of the peripheral nervous system and consequently peripheral paralysis, paresthesias and/or pain. Guillain–Barré syndrome is a predominant cause of acute flaccid paralysis, which may occur at any age. We present two clinical cases of flaccid paralysis with patients at the age of 7 and 5 years requiring verification of the diagnosis.

scholarly journals Biomarkers of Guillain-Barré Syndrome: Some Recent Progress, More Still to Be Explored

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Ying Wang ◽  
Shuang Sun ◽  
Jie Zhu ◽  
Li Cui ◽  
Hong-Liang Zhang
Keyword(s):  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Disease Progression ◽  
Peripheral Nervous System ◽  
Clinical Diagnosis ◽  
Recent Progress ◽  
Guillain Barre Syndrome ◽  
Immune Mediated ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Guillain-Barré syndrome (GBS), the axonal subtype of which is mainly triggered byC. jejuniwith ganglioside-mimicking lipooligosaccharides (LOS), is an immune-mediated disorder in the peripheral nervous system (PNS) accompanied by the disruption of the blood-nerve barrier (BNB) and the blood-cerebrospinal fluid barrier (B-CSF-B). Biomarkers of GBS have been extensively explored and some of them are proved to assist in the clinical diagnosis and in monitoring disease progression as well as in assessing the efficacy of immunotherapy. Herein, we systemically review the literature on biomarkers of GBS, including infection-/immune-/BNB, B-CSF-B, and PNS damage-associated biomarkers, aiming at providing an overview of GBS biomarkers and guiding further investigations. Furthermore, we point out further directions for studies on GBS biomarkers.

scholarly journals Lighting Strikes Twice: Recurrent Guillain–Barré Syndrome (GBS) after Influenza Vaccination

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Gregory Griffin ◽  
Brittany Cunningham ◽  
Jonathan M. Beary ◽  
Yonatan Spolter ◽  
Richard Gandee ◽  
...  
Keyword(s):  
Nervous System ◽  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Peripheral Nervous System ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Guillain Barré

Guillain–Barré syndrome (GBS) is a rare acute demyelinating syndrome of the peripheral nervous system that is commonly preceded by infection. Vaccinations have also been associated with an increased incidence of GBS, though the risk is low. Caution with revaccination is recommended in patients with a history of GBS. Risks of revaccination compared with the risks of influenza complications should be considered. Patients who experience GBS after vaccination have not been shown to have an increased incidence of recurrent GBS after the influenza vaccine, though evidence is limited. We report a case of recurrent GBS in a patient following the influenza vaccine.

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