scholarly journals Breathing tests and their significance in the clinic of internal diseases: the importance of non-invasive 13C bicarbonate breath test in medical diagnostics.

2018 ◽  
Vol 96 (4) ◽  
pp. 309-313
Author(s):  
S. I. Rapoport ◽  
A. M. Zyakun ◽  
Nina A. Shubina
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Developed Countries ◽  
Medical Diagnostics ◽  
Breath Tests ◽  
Non Invasive ◽  
The World

13C breath tests have been widely developed in the world gastroenterology at the beginning of the 90-ies of the last century. This technique has been used for over 20 years in many developed countries and it has long been a routine and mass procedure. 13C urease breath test for infection Helicobacter pylori detection is the most widely analysis among 13C breath tests. Researchers are developing new 13C-biomarkers and expand the list of available substrates. One of these techniques is a multifunctional 13C bicarbonate breath test. Here is a brief overview of this application.

Non-invasive Helicobacter pylori diagnosis: Stool or breath tests?

2005 ◽  
Vol 37 (10) ◽  
pp. 732-734 ◽  
Author(s):  
A.M. Hirschl ◽  
A. Makristathis
Keyword(s):  
Helicobacter Pylori ◽  
Breath Tests ◽  
Non Invasive

scholarly journals Helicobacter pylori.

1997 ◽  
Vol 10 (4) ◽  
pp. 720-741 ◽  
Author(s):  
B E Dunn ◽  
H Cohen ◽  
M J Blaser
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Lymphoma ◽  
Developed Countries ◽  
Pcr Analysis ◽  
Gastric Tissue ◽  
Negative Bacterium ◽  
Breath Tests ◽  
Ulcer Disease ◽  
Gastric Lumen ◽  
H Pylori

Helicobacter pylori is a gram-negative bacterium which causes chronic gastritis and plays important roles in peptic ulcer disease, gastric carcinoma, and gastric lymphoma. H. pylori has been found in the stomachs of humans in all parts of the world. In developing countries, 70 to 90% of the population carries H. pylori. In developed countries, the prevalence of infection is lower. There appears to be no substantial reservoir of H. pylori aside from the human stomach. Transmission can occur by iatrogenic, fecal-oral, and oral-oral routes. H. pylori is able to colonize and persist in a unique biological niche within the gastric lumen. All fresh isolates of H. pylori express significant urease activity, which appears essential to the survival and pathogenesis of the bacterium. A variety of tests to diagnose H. pylori infection are now available. Histological examination of gastric tissue, culture, rapid urease testing, DNA probes, and PCR analysis, when used to test gastric tissue, all require endoscopy. In contrast, breath tests, serology, gastric juice PCR, and urinary excretion of [15N]ammonia are noninvasive tests that do not require endoscopy. In this review, we highlight advances in the detection of the presence of the organism and methods of differentiating among types of H. pylori, and we provide a background for appropriate chemotherapy of the infection.

Tu1352 Comparison of Non-Invasive Tests; Stool HpSA ELISA and C13Urea Breath Test in the Diagnosis of Helicobacter pylori Infection in a Low Prevalence Cohort

2016 ◽  
Vol 150 (4) ◽  
pp. S881
Author(s):  
Joseph A. Omorogbe ◽  
Denise Brennan ◽  
Sinead M. Smith ◽  
MOHAMED ALSAFFAR ◽  
Deirdre McNamara
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Helicobacter Pylori Infection ◽  
Non Invasive ◽  
Low Prevalence

scholarly journals Declining Prevalence of Helicobacter Pylori Infection- A 13C Urea Breath Test (UBT) Based Study in Symptomatic

2019 ◽  
Vol 10 (2) ◽  
pp. 121-124
Author(s):  
Mian Mashhud Ahmed ◽  
Atia Saeed ◽  
Abu Shams Md Hasan Ali Masum ◽  
Md Mohiuddin ◽  
Anisur Rahman
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Eradication Therapy ◽  
Urea Breath Test ◽  
Age Group ◽  
Ulcer Disease ◽  
Medical College ◽  
The World ◽  
The Mean ◽  
13C Urea Breath Test

Background: Helicobacter pylori (HP) infection is an important cause of peptic ulcer disease (PUD) in the world. This study was aimed to know the trend of H.P. infection among the symptomatic subjects Method: This was a retrospective observational study conducted from January 2015 to July 2018 in three different hospitals in Dhaka city. Patient who presented with dyspepsia underwent 13C urea breath test. Positive cases were analyzed. Results: A total 1343 patients were taken for UBT where 308 (23%) patients were found positive. The mean age group was 41.21+13.6. Male were more infected (61%) than female (39%). Conclusion: Improving sanitary and hygienic condition of this region along with significantly increasing HP eradication therapy and PPI use by the symptomatic individuals might have contributed to the decreasing trend of infection Anwer Khan Modern Medical College Journal Vol. 10, No. 2: July 2019, P 121-124

scholarly journals VALIDATION OF 14C-UREA BREATH TEST FOR DIAGNOSIS OF Helicobacter pylori

1999 ◽  
Vol 41 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Rejane MATTAR ◽  
Fernando Marcuz SILVA ◽  
Ana Maria ALEXANDRINO ◽  
Antonio Atílio LAUDANNA
Keyword(s):  
Helicobacter Pylori ◽  
Sensitivity And Specificity ◽  
Breath Test ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
Time Intervals ◽  
Non Invasive ◽  
Invasive Test ◽  
The Difference ◽  
H Pylori

The aim of this study was to validate the 14C-urea breath test for use in diagnosis of Helicobacter pylori infection. Thirty H. pylori positive patients, based on histologic test and thirty H. pylori negative patients by histology and anti-H. pylori IgG entered the study. Fasting patients drank 5 uCi of 14C-urea in 20 ml of water. Breath samples were collected at 0, 5, 10, 15, 20 and 30 min. The difference of cpm values between the two groups was significant at all the time intervals, besides time 0 (p<0.0001). At 20 min, the test gave 100% sensitivity and specificity with a cut-off value of 562 cpm. Females were higher expirers than males (p=0.005). 14C-urea breath test is highly accurate for Helicobacter pylori diagnosis. It is fast, simple and should be the non-invasive test used after treating Helicobacter pylori infection.

scholarly journals Evaluation of invasive and non-invasive methods for the diagnosis of Helicobacter pylori infection in symptomatic children and adolescents

2001 ◽  
Vol 119 (2) ◽  
pp. 67-71 ◽  
Author(s):  
Silvio Kazuo Ogata ◽  
Elisabete Kawakami ◽  
Francy Reis Silva Patrício ◽  
Margareth Zabeu Pedroso ◽  
Antonio Mario Santos
Keyword(s):  
Helicobacter Pylori ◽  
Children And Adolescents ◽  
Breath Test ◽  
Urea Breath Test ◽  
Diagnostic Methods ◽  
Helicobacter Pylori Infection ◽  
Rapid Urease Test ◽  
Predictive Values ◽  
Non Invasive ◽  
Urease Test

CONTEXT: Multiple diagnostic methods are available for the detection of Helicobacter pylori infection, but at present no single one can be used as the gold standard. OBJECTIVE: The aim of this study was to evaluate the diagnostic accuracy of 3 invasive and 2 non-invasive methods for detection of Helicobacter pylori infection in symptomatic children and adolescents. DESIGN: Prospective cohort study SETTING: Peptic Disease outpatients service, Discipline of Pediatric Gastroenterology, Universidade Federal de São Paulo / Escola Paulista de Medicina. PATIENTS: Forty-seven patients who underwent endoscopy because of dyspeptic symptoms. DIAGNOSTIC METHODS: Endoscopy with gastric biopsies for 3 invasive (rapid urease test, histology and culture) and 2 non-invasive methods (a commercial ELISA serology and 13carbon urea breath test - isotope ratio mass spectrometry) for detection of Helicobacter pylori infection. MAIN MEASUREMENTS: Sensitivity, specificity, positive and negative predictive values of each method and agreement and disagreement rates between the methods. RESULTS: Forty-seven patients [mean age, 11y9mo (SD 2y10mo), 27 female and 20 male]; 62% of them were Helicobacter pylori-positive. All methods agreed in 61%, and were negative in 21% and positive in 40%. The greatest concordance between 2 methods occurred between the invasive methods: histology and rapid urease test (89.6%) and histology and culture (87.5%). The greatest sensitivity, considering Helicobacter pylori-positive cases, for any combination of 3 or more tests, was achieved by the rapid urease test (S=100%), followed by histology, serology and 13carbon-urea breath test (S=93.1%) and lastly by culture (S=79.3%). The highest specificity was obtained by histology (100%) and culture (100%), followed by the rapid urease test (84.2%), serology (78.9%) and 13carbon-urea breath test (78.9%). CONCLUSIONS: Our results suggest that among invasive methods, an association between the rapid urease test and histology constituted the best choice for the detection of Helicobacter pylori infection. If results of histology and the rapid urease test are different, serology may be recommended.

scholarly journals Hydrogen and Methane Breath Test in the Diagnosis of Lactose Intolerance

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3261
Author(s):  
Charlotte De Geyter ◽  
Kris Van de Maele ◽  
Bruno Hauser ◽  
Yvan Vandenplas
Keyword(s):  
Breath Test ◽  
Lactose Intolerance ◽  
Symptom Improvement ◽  
Breath Tests ◽  
Non Invasive ◽  
Almost All ◽  
Additional Value ◽  
H2 Breath Test ◽  
Test Result ◽  
Significant Symptom

The hydrogen (H2) breath test is a non-invasive investigation used to diagnose lactose intolerance (LI). Patients with LI may also expire increased amounts of methane (CH4) during a lactose test. The aim of this study is to evaluate the contribution of CH4 measurements. We tested 209 children (1–17 years old) with symptoms suggesting LI with lactose H2 and CH4 breath tests. The result was positive when the H2 excretion exceeded 20 parts per million (ppm) and the CH4 was 10 ppm above the baseline. A clinician, blinded for the results of the breath test, registered the symptoms. Of the patient population, 101/209 (48%) were negative for both H2 and CH4; 96/209 (46%) had a positive H2 breath test result; 31/96 (32%) were also positive for CH4; 12/209 (6%) patients were only positive for CH4. The majority of hydrogen producers showed symptoms, whereas this was only the case in half of the H2-negative CH4 producers. Almost all patients treated with a lactose-poor diet reported significant symptom improvement. These results indicate that CH4 measurements may possibly be of additional value for the diagnosis of LI, since 5.7% of patients were negative for H2 and positive for CH4, and half of them experienced symptoms during the test.

Conflicting results of non-invasive methods for detection of Helicobacter pylori infection in children with celiac disease - a preliminary study.

2016 ◽  
Vol 63 (1) ◽  
Author(s):  
Jan Józefczuk ◽  
Edyta Mądry ◽  
Jan Nowak ◽  
Marek Walkowiak ◽  
Klaudia Łochocka ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Celiac Disease ◽  
Healthy Subjects ◽  
Breath Test ◽  
Urea Breath Test ◽  
Antigen Test ◽  
Non Invasive ◽  
Preliminary Study ◽  
Level Of Significance ◽  
Positive Results

There are no data addressing the usefulness of non-invasive tests for the detection of Helicobacter pylori (HP) infection in celiac disease (CD). The aim of this study was to compare two most sensitive and specific tests - urea breath test (UBT) and fecal antigen test (FAT) in HP diagnosis in CD patients. The study comprised of 76 CD patients, 49 healthy subjects (HS) and 35 patients who underwent differential diagnosis due to abdominal pain (AP patients). The presence of HP infection was evaluated using the (13)C isotope-labeled UBT and FAT (ELISA). HP infection was diagnosed based on UBT and FAT in 8 (16.3%) and 7 (14.3%) HS, and in 8 (10.5%) CD patients and 12 (34.3%) AP patients, respectively, using both tests. The prevalence of conflicting results in comparison with positive results (obtained with any of the two tests) was distinctly higher (54.5%) in CD group than in other subjects (23.3%); however, due to low HP prevalence, it did not reach the level of significance (p

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