Acute Q fever in third trimester pregnancy

2021 ◽  
Vol 14 (8) ◽  
pp. e242558
Author(s):  
Maxwell Braddick ◽  
Marion L Woods ◽  
Suji Prabhaharan
Keyword(s):  
Back Pain ◽  
Coxiella Burnetii ◽  
Chronic Infection ◽  
Q Fever ◽  
Third Trimester ◽  
Blood Samples ◽  
Drug Intolerance ◽  
Trimester Pregnancy ◽  
Acute Q Fever ◽  
In Pregnancy

A 29-year-old gravida 2 para 1 woman presented at 29 weeks gestation with fevers, back pain, thrombocytopenia and hepatitis. PCR testing of blood samples detected Coxiella burnetii and paired serology later confirmed the diagnosis of acute Q fever in pregnancy. The patient was treated empirically with oral clarithromycin and experienced a symptomatic and biochemical improvement. Therapy was changed to oral trimethoprim/sulphamethoxazole but was complicated by a delayed cutaneous reaction, prompting recommencement of clarithromycin. Therapy continued until delivery of a healthy girl at 39 weeks and 3 days. Q fever in pregnancy is likely under-reported and is associated with the development of chronic infection and obstetric complications. Treatment with clarithromycin is an alternative to trimethoprim/sulphamethoxazole in the setting of drug intolerance.

scholarly journals Q Fever During Pregnancy: An Emerging Cause of Prematurity and Abortion

2001 ◽  
Vol 9 (1) ◽  
pp. 47-49 ◽  
Author(s):  
Francisco Jover-Díaz ◽  
Jaqueline Robert-Gates ◽  
Lucio Andreu-Gimenez ◽  
Jaime Merino-Sanchez
Keyword(s):  
Clinical Data ◽  
Coxiella Burnetii ◽  
Chronic Infection ◽  
Q Fever ◽  
Pathogenic Role ◽  
Serious Disease ◽  
Febrile Episodes ◽  
Torch Infections ◽  
In Pregnancy

Background:Although the pathogenic role ofCoxiella burnetiiinfection during pregnancy is controversial, some cases of stillbirth and abortion occurring after an acute or chronic infection have been mentioned in the literature. Recently, Q fever has been advocated as a significant cause of morbidity and mortality in pregnancyCase:We describe an 18-year-old primipara woman admitted to our hospital for high fever and pancytopenia during an acuteC. burnetiiinfection. She was successfully treated with clarithromycin, overcoming fever and pancytopenia. Finally, she gave birth to a healthy infant, and 1 year later both remained well.Conclusion:Q fever is a potentially serious disease in pregnancy owing to the possibility of placenta infection and fetal transmission affecting its outcome. Q fever infection should be suspected in unexplained febrile episodes or abortion during pregnancy, when epidemiologic and clinical data are present.We believe thatC. burnetiiserology should be tested in cases of fever of known origin or unexplained abortions, as the TORCH infections are.

scholarly journals The prevalence of Coxiella burnetii in ticks and animals in Slovenia

2019 ◽  
Vol 15 (1) ◽  
Author(s):  
Nataša Knap ◽  
Diana Žele ◽  
Urška Glinšek Biškup ◽  
Tatjana Avšič-Županc ◽  
Gorazd Vengušt
Keyword(s):  
Coxiella Burnetii ◽  
Q Fever ◽  
Primary Source ◽  
Domestic Animals ◽  
Animal Blood ◽  
Blood Samples ◽  
Specific Antibodies ◽  
Source Of Infection ◽  
History Of ◽  
Pathogen Dna

Abstract Background The obligate intracellular bacterium Coxiella burnetii causes globally distributed zoonotic Q fever. Ruminant livestock are common reservoirs of C. burnetii. Coxiella burnetii are shed in large numbers in the waste of infected animals and are transmitted by inhalation of contaminated aerosols. This study was conducted to evaluate the prevalence of C. burnetii infection in domestic animals and ticks in areas of Slovenia associated with a history of Q fever outbreaks. Results A total of 701 ticks were collected and identified from vegetation, domestic animals and wild animals. C. burnetii DNA was detected in 17 out of 701 (2.4%) ticks. No C. burnetii DNA was found in male ticks. Ticks that tested positive in the PCR-based assay were most commonly sampled from wild deer (5.09%), followed by ticks collected from domestic animals (1.16%) and ticks collected by flagging vegetation (0.79%). Additionally, 150 animal blood samples were investigated for the presence of C. burnetii-specific antibodies and pathogen DNA. The presence of pathogen DNA was confirmed in 14 out of 150 (9.3%) blood samples, while specific antibodies were detected in sera from 60 out of 150 (40.4%) animals. Conclusions Our results indicate that ticks, although not the primary source of the bacteria, are infected with C. burnetii and may represent a potential source of infection for humans and animals. Ticks collected from animals were most likely found to harbor C. burnetii DNA, and the infection was not lost during molting. The persistence and distribution of pathogens in cattle and sheep indicates that C. burnetii is constantly present in Slovenia.

scholarly journals Bacteriostatic and Bactericidal Activities of Tigecycline against Coxiella burnetii and Comparison with Those of Six Other Antibiotics

2009 ◽  
Vol 53 (6) ◽  
pp. 2690-2692 ◽  
Author(s):  
Ioanna Spyridaki ◽  
Anna Psaroulaki ◽  
Iosif Vranakis ◽  
Yannis Tselentis ◽  
Achilleas Gikas
Keyword(s):  
Coxiella Burnetii ◽  
Q Fever ◽  
Vero Cells ◽  
In Vitro Susceptibility ◽  
Shell Vial ◽  
Bactericidal Activities ◽  
Acute Q Fever ◽  
Reference Strains ◽  
Shell Vial Assay

ABSTRACT The present article is a study of the in vitro susceptibility of eight Greek Coxiella burnetii isolates, derived from patients with acute Q fever, and two reference strains of Coxiella burnetii to tigecycline. The bacteriostatic activity of tigecycline was compared with those of six other antibiotics using a shell vial assay. The MICs of the examined antibiotics were as follows: tigecycline ranged from 0.25 to 0.5 μg/ml; doxycycline, trovafloxacin, and ofloxacin ranged from 1 to 2 μg/ml; linezolid and clarithromycin ranged from 2 to 4 μg/ml; and ciprofloxacin ranged from 4 to 8 μg/ml. Tigecycline was effective in inhibiting the infection of Vero cells by C. burnetii. No bactericidal activity was observed against C. burnetii at 4 μg/ml.

scholarly journals Follow-up of 686 Patients With Acute Q Fever and Detection of Chronic Infection

2011 ◽  
Vol 52 (12) ◽  
pp. 1431-1436 ◽  
Author(s):  
W. van der Hoek ◽  
B. Versteeg ◽  
J. C. E. Meekelenkamp ◽  
N. H. M. Renders ◽  
A. C. A. P. Leenders ◽  
...  
Keyword(s):  
Chronic Infection ◽  
Q Fever ◽  
Acute Q Fever

scholarly journals Isolation of Coxiella burnetii from serum of patients with acute Q fever

2015 ◽  
Vol 119 ◽  
pp. 74-78 ◽  
Author(s):  
Gemma A. Vincent ◽  
Stephen R. Graves ◽  
Jennifer M. Robson ◽  
Chelsea Nguyen ◽  
Hazizul Hussain-Yusuf ◽  
...  
Keyword(s):  
Coxiella Burnetii ◽  
Q Fever ◽  
Acute Q Fever

scholarly journals Pengaruh Teknik Akupressure Terhadap Nyeri Punggung Pada Ibu Hamil Di Wilayah Puskesmas Jogonalan I Klaten

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Niken Tri Sukeksi ◽  
Gita Kostania ◽  
Emy Suryani
Keyword(s):  
Back Pain ◽  
Data Analysis ◽  
Experimental Design ◽  
Pregnant Women ◽  
Test Data ◽  
Gestational Age ◽  
Severe Pain ◽  
Third Trimester ◽  
Labour Process ◽  
In Pregnancy

Abstract: Acupressure, Back Pain, Pregnancy. Acupressure is effective to relieve back pain in Meridian point. Acupressure technique is done to help pregnant women in relieving complaints in pregnancy such as nausea and vomiting. In labour process, this technique can be an induction of labor, and can reduce anxiety. The purpose is to know the influence of acupressure technique to relieve back pain for pregnant women in Puskesmas Jogonalan I area of Klaten. Research is pre experimental design with one group pretest posttest approach. The population is all pregnant women in Puskesmas Jogonalan I area of Klaten. The population target is all third trimester of pregnant women in Puskesmas Jogonalan I area of Klaten. Technique sampling is purposive sampling with 30 peopole, ang using t-test data analysis. The characteristics of respondents showed that most of them are 20-35 years old, their gestational age are 3137 weeks, their occupation are housewives, and most of them have 2-3 children. Degree of back pain in pregnant women before acupressure as many as 21 people (70%) are in severe pain. Degree of back pain in pregnant women after given acupressure as many as 24 people (80%) are in mild pain. There is influence of acupressure technique to relieve back pain for pregnant women in Puskesmas Jogonalan I area of Klaten (t =9,893; p=0,001<0,05).

scholarly journals Remdesivir Treatment for Severe COVID-19 in Third-Trimester Pregnancy: Case Report and Management Discussion

2020 ◽  
Vol 7 (9) ◽  
Author(s):  
Grace A Maldarelli ◽  
Megan Savage ◽  
Shawn Mazur ◽  
Corrina Oxford-Horrey ◽  
Mirella Salvatore ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Case Report ◽  
Vaginal Delivery ◽  
Third Trimester ◽  
Trimester Pregnancy ◽  
In Pregnancy

Abstract We report a case of COVID-19 in third-trimester pregnancy, who required support in an intensive care unit and received remdesivir. After discharge, she had an uncomplicated vaginal delivery at term. COVID-19 in pregnancy may be managed without emergent delivery; a multispecialty team is critical in caring for these patients.

scholarly journals Draft Genome Sequences of Three Coxiella burnetii Strains Isolated from Q Fever Patients

2017 ◽  
Vol 5 (38) ◽  
Author(s):  
Paul A. Beare ◽  
Brendan M. Jeffrey ◽  
Craig A. Martens ◽  
Robert A. Heinzen
Keyword(s):  
Coxiella Burnetii ◽  
Human Disease ◽  
Q Fever ◽  
Draft Genome ◽  
Genome Sequences ◽  
Content Type ◽  
Acute Q Fever

ABSTRACT In the current study, we determined the draft genome sequences of three Coxiella burnetii human disease isolates. The Coxiella burnetii Turkey (RSA315) and Dyer (RSA345) strains were isolated from acute Q fever patients, while the Ko (Q229) strain was isolated from a Q fever endocarditis patient.

scholarly journals Musculoskeletal pain and symptoms in pregnancy: a descriptive study

2018 ◽  
Vol 10 (12) ◽  
pp. 229-234 ◽  
Author(s):  
Serdar Kesikburun ◽  
Ümüt Güzelküçük ◽  
Ulaş Fidan ◽  
Yasin Demir ◽  
Ali Ergün ◽  
...  
Keyword(s):  
Back Pain ◽  
Musculoskeletal Pain ◽  
Tertiary Hospital ◽  
Low Back ◽  
Third Trimester ◽  
Face To Face ◽  
The Third ◽  
Musculoskeletal Problems ◽  
Index Weight ◽  
In Pregnancy

Background: Pregnancy-induced hormonal and physiologic changes increase the risk of musculoskeletal problems in pregnancy. The purpose of this report is to provide a comprehensive look at the musculoskeletal pain and symptoms experienced during pregnancy. Methods: A total of 184 women (mean age 30.9 ± 5.0 years) who gave birth in the obstetrics clinic of a tertiary hospital were included in the study. The participants who had given birth at 37–42 weeks of pregnancy (term pregnancy) and aged over 18 years were selected for participation. Basic demographic and clinical characteristics of the participants including age, body mass index, weight gained during pregnancy, education level, occupation, parity, sex of baby, and exercise habits were collected from the medical chart and face-to-face interviews. Musculoskeletal pain sites were defined as hand–wrist, elbow, shoulder, neck, back, low back, hip, knee, and ankle–foot in a diagram of the human body. The interviews with participants were performed to assess their musculoskeletal pain separately at each trimester follow-up visit. Results: The most frequent musculoskeletal complaints during pregnancy were low back pain ( n = 130, 70.7%), back pain ( n = 80, 43.5%), hand–wrist ( n = 61, 33.2%) and hip pain ( n = 59, 32.1%). The participants experienced musculoskeletal pain most in the third trimester except for elbow, shoulder and neck pain compared with the first and second trimesters ( p < 0.05). Conclusions: The results of the study suggest that numerous musculoskeletal problems may complicate pregnancy especially in the third trimester.

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