scholarly journals An investigation of the inhibitory effects of dendrosomal nanocurcumin on Candida albicans and systemic candidiasis in BALB/c mice

2016 ◽  
Vol 2 (1) ◽  
pp. 7-12
Author(s):  
Farzad Katiraee ◽  
◽  
Javad Ashrafai Helan ◽  
Seyed Jamal Emami ◽  
Gholamreza Hamidian ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Systemic Candidiasis ◽  
Inhibitory Effects ◽  
Dendrosomal Nanocurcumin

scholarly journals Comparison between efficacy of allicin and fluconazole against Candida albicans in vitro and in a systemic candidiasis mouse model

2011 ◽  
Vol 315 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Alireza Khodavandi ◽  
Fahimeh Alizadeh ◽  
Nabil S. Harmal ◽  
Shiran M. Sidik ◽  
Fauziah Othman ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Mouse Model ◽  
Systemic Candidiasis

Antifungal and allelopathic activities of sesquiterpenes from Solidago canadensis

2021 ◽  
Vol 25 ◽  
Author(s):  
Na Liu ◽  
Meina Song ◽  
Yulin Sun ◽  
Fengying Yang ◽  
Haina Yu ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Seed Germination ◽  
Invasive Plant ◽  
2D Nmr ◽  
Solidago Canadensis ◽  
Significant Activity ◽  
Inhibitory Effects ◽  
Ic50 Values ◽  
Allelopathic Effects

: One new eudesmane sesquiterpene (1) and one new chromolaevane sesquiterpene (2), along with 19 known compounds, have been isolated from the invasive plant Solidago canadensis. Their structures were established by spectroscopic means including 1D/2D-NMR and HR-ESIMS analyses. Compounds 10 and 12, in combination with fluconazole, showed significant activity in an in vitro synergistic antifungal assay against Candida albicans, with FIC values of <0.15625 and <0.28125, respectively. Meanwhile, the allelopathic effects of these sesquiterpenes on Arabidopsis seed germination were also tested. Compounds 5, 7, 17 and 18 retarded the seed germination of Arabidopsis with IC50 values ranging from 9.1 to 41 μg/mL, while other compounds showed no obvious inhibitory effects.

Impact of serial systemic infection on Candida albicans virulence factors

2020 ◽  
Vol 15 (13) ◽  
pp. 1249-1263
Author(s):  
Glaucia S Arita ◽  
Daniella R Faria ◽  
Karina M Sakita ◽  
Franciele AV Rodrigues-Vendramini ◽  
Isis RG Capoci ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Virulence Factors ◽  
Murine Model ◽  
Systemic Infection ◽  
Systemic Candidiasis ◽  
Fungal Burden ◽  
Histopathological Findings ◽  
Phenotypic Profile ◽  
Proteomic Data ◽  
Repeated Contact

Aim: To evaluate changes in virulence and pathogenicity approaches from Candida albicans after successive passages in a murine model of systemic candidiasis. Materials & methods: Phenotypic assays were performed using colonies recovered from animals infected serially, totalizing five passages. Results: A progressive infection was observed along the passages, with increased fungal burden and the presence of greater inflammatory areas in the histopathological findings. Recovered strains exhibited increased filamentation and biofilm abilities, along with modulation of phospholipase and proteinase activities. Conclusion: Repeated contact between yeast and host increased the expression of virulence factors. Furthermore, a correspondence between phenotypic profile and proteomic data obtained previously was observed.

scholarly journals CX3CR1 Is Dispensable for Control of Mucosal Candida albicans Infections in Mice and Humans

2014 ◽  
Vol 83 (3) ◽  
pp. 958-965 ◽  
Author(s):  
Timothy J. Break ◽  
Martin Jaeger ◽  
Norma V. Solis ◽  
Scott G. Filler ◽  
Carlos A. Rodriguez ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Human Population ◽  
Systemic Candidiasis ◽  
Gi Tract ◽  
Content Type ◽  
Commensal Microbiota ◽  
Interleukin 17A ◽  
Mucosal Surfaces ◽  
Bacterial Microbiota ◽  
Mucosal Candidiasis

Candida albicansis part of the normal commensal microbiota of mucosal surfaces in a large percentage of the human population. However, perturbations of the host's immune response or bacterial microbiota have been shown to predispose individuals to the development of opportunisticCandidainfections. It was recently discovered that a defect in the chemokine receptor CX3CR1 increases susceptibility of mice and humans to systemic candidiasis. However, whether CX3CR1 confers protection against mucosalC. albicansinfection has not been investigated. Using two different mouse models, we found that Cx3cr1 is dispensable for the induction of interleukin 17A (IL-17A), IL-22, and IL-23 in the tongue after infection, as well as for the clearance of mucosal candidiasis from the tongue or lower gastrointestinal (GI) tract colonization. Furthermore, the dysfunctional human CX3CR1 alleleCX3CR1-M280was not associated with development of recurrent vulvovaginal candidiasis (RVVC) in women. Taken together, these data indicate that CX3CR1 is not essential for protection of the host against mucosal candidiasis, underscoring the dependence on different mammalian immune factors for control of mucosal versus systemicCandidainfections.

Candida albicans stress mannoproteins expression in superficial and systemic candidiasis

1996 ◽  
Vol 133 (2) ◽  
pp. 89-94 ◽  
Author(s):  
Jose Pontón ◽  
Fernando L. Hernando ◽  
Maria Dolores Moragues ◽  
Pedro L. Barea ◽  
Mara Gerloni ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Systemic Candidiasis

scholarly journals Spontaneous (Primary) Candida peritonitis

1995 ◽  
Vol 9 (3) ◽  
pp. 144-146
Author(s):  
Joe Sukhabote ◽  
Hugh J Freeman
Keyword(s):  
Candida Albicans ◽  
Abdominal Pain ◽  
Gastrointestinal Tract ◽  
Amphotericin B ◽  
Ascitic Fluid ◽  
Systemic Candidiasis ◽  
Local Infection ◽  
Immunological Disorder ◽  
Candida Peritonitis

A 49-year-old female presented with abdominal pain and ascites. Subsequent investigations revealedCandida albicansin the ascitic fluid without evidence of systemic candidiasis or a source of local infection in another site. Additional studies revealed no evident underlying immunological disorder and the gastrointestinal tract was intact. Therapy with amphotericin B led to resolution of abdominal pain and ascites with no recurrence.

scholarly journals Candida albicans RIM101 pH Response Pathway Is Required for Host-Pathogen Interactions

2000 ◽  
Vol 68 (10) ◽  
pp. 5953-5959 ◽  
Author(s):  
Dana Davis ◽  
John E. Edwards ◽  
Aaron P. Mitchell ◽  
Ashraf S. Ibrahim
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Candida Albicans ◽  
Marked Reduction ◽  
Endothelial Damage ◽  
Systemic Candidiasis ◽  
Ph Response

ABSTRACT The ability of Candida albicans to respond to diverse environments is critical for its success as a pathogen. TheRIM101 pathway controls gene expression and the yeast-to-hyphal transition in C. albicans in response to changes in environmental pH in vitro. In this study, we found that theRIM101 pathway is necessary in vivo for pathogenesis. First, we show thatrim101−/rim101− andrim8−/rim8− mutants have a significant reduction in virulence using the mouse model of hematogenously disseminated systemic candidiasis. Second, these mutants show a marked reduction in kidney pathology. Third, therim101−/rim101− andrim8−/rim8− mutants show defects in the ability to damage endothelial cells in situ. Finally, we show that an activated allele of RIM101, RIM101-405, is a suppressor of the rim8− mutation in vivo as it rescues the virulence, histological, and endothelial damage defects of the rim8−/rim8− mutant. These results demonstrate that the RIM101 pathway is required for C. albicans virulence in vivo and that the function of Rim8p in pathogenesis is to activate Rim101p.

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