scholarly journals Brain White Matter Changes in Four Patients with Classical Homocystinuria: Two of Them were Reversible

Author(s):  
Haitham El Bashir
2012 ◽  
Vol 81 (10) ◽  
pp. 2826-2832 ◽  
Author(s):  
Yaou Liu ◽  
Yunyun Duan ◽  
Yong He ◽  
Chunshui Yu ◽  
Jun Wang ◽  
...  

2012 ◽  
Vol 201 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Michael J. Firbank ◽  
Andrew Teodorczuk ◽  
Wiesje M. Van Der Flier ◽  
Alida A. Gouw ◽  
Anders Wallin ◽  
...  

BackgroundBrain white matter changes (WMC) and depressive symptoms are linked, but the directionality of this association remains unclear.AimsTo investigate the relationship between baseline and incident depression and progression of white matter changes.MethodIn a longitudinal multicentre pan-European study (Leukoaraiosis and Disability in the elderly, LADIS), participants aged over 64 underwent baseline magnetic resonance imaging (MRI) and clinical assessments. Repeat scans were obtained at 3 years. Depressive outcomes were assessed in terms of depressive episodes and the Geriatric Depression Scale (GDS). Progression of WMC was measured using the modified Rotterdam Progression scale.ResultsProgression of WMC was significantly associated with incident depression during year 3 of the study (P = 0.002) and remained significant after controlling for transition to disability, baseline WMC and baseline history of depression. There was no significant association between progression of WMC and GDS score, and no significant relationship between progression of WMC and history of depression at baseline.ConclusionsOur results support the vascular depression hypothesis and implicate WMC as causal in the pathogenesis of late-life depression.


2020 ◽  
Vol 169 (5) ◽  
pp. 630-634
Author(s):  
A. B. Berdalin ◽  
A. K. Nikogosova ◽  
I. L. Gubskiy ◽  
E. A. Kovrazhkina ◽  
L. V. Gubskiy ◽  
...  

2005 ◽  
Vol 72 (5) ◽  
pp. 252-253 ◽  
Author(s):  
Miho Maeda ◽  
Jun Hayakawa ◽  
Takahiro Ueda ◽  
Makoto Migita ◽  
Takeshi Asano ◽  
...  

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