scholarly journals Evaluation Treatment Planning for Breast Cancer Based on Dose-Response Model

2021 ◽  
Vol 22 (1) ◽  
pp. 75
Author(s):  
Siti Aisyah ◽  
Aditya Prayugo Hariyanto ◽  
Endarko Endarko ◽  
Agus Rubiyanto ◽  
Nasori Nasori ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Treatment Planning ◽  
Normal Tissue ◽  
Biological Effects ◽  
Breast Cancer Patients ◽  
Medical Physicists ◽  
Homogeneous Dose ◽  
High Doses ◽  
Dicom Rt ◽  
Made In

The delivery of radiation therapy to patients requires prior planning made by medical physicists to achieve radiotherapy goals. Radiotherapy has a plan to eradicate the growth of cancer cells by giving high doses and minimizing the radiation dose to normal tissue. Evaluation of planning is generally done based on dosimetric parameters, such as minimum dose, maximum dose, and means dose obtained from the DVHs data. Based on the same DVHs, data were evaluate dinterms of biological effects to determine the highest possible toxicity in normal tissue after the tumor had been treated with radiation using the NTCP model. The evaluation was conducted by selecting three DICOM-RT data of post-mastectomy right breast cancer patients who had been prescribed a dose of 50 Gy obtained from the Hospital MRCCC Siloam Semanggi database. All data were processed using open-source software DICOManTX to get the DVH and isodose information. Matlab-based CERR software was used to calculate the NTCP model. The results show that the three patients' DVH and isodose treatment planning result in a homogeneous dose distribution result because the PTV area obtains adose limit of ≥ 95%. Moreover, normalt issue still gets adose below the tolerance limit based on the standard from RTOG 1005 and ICRU 83. Analysis of NTCP shows a complication probability below 1% for each organ, suggesting that any organ which has been irradiated has a low likelihood of complications. Therefore, it can be concluded that the treatment planning which has been made in the three patients using the IMRT technique has achieved the objectives of radiotherapy, which is to minimize toxicity to healthy organs. |Keywords: DVH, isodose, NTCP, radiotherapy.

scholarly journals Biological Effects of Green Tea Capsule Supplementation in Pre-Surgery Postmenopausal Breast Cancer Patients

2013 ◽  
Vol 3 ◽  
Author(s):  
Steven S. Yu ◽  
Darcy V. Spicer ◽  
Debra Hawes ◽  
Chiu-Chen Tseng ◽  
Chung S. Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Green Tea ◽  
Biological Effects ◽  
Postmenopausal Breast Cancer ◽  
Breast Cancer Patients

scholarly journals Rectal dosimetry in intracavitary applications of cervix carcinoma: Comparison of two methods

2002 ◽  
Vol 10 (4) ◽  
pp. 253-259 ◽  
Author(s):  
Milutin Baucal ◽  
Jovan Babic ◽  
Zoran Kuzmanovic
Keyword(s):  
Treatment Planning ◽  
The Other ◽  
Planning System ◽  
International Commission ◽  
Treatment Planning System ◽  
Cervix Carcinoma ◽  
Rectal Dose ◽  
High Doses ◽  
Dose Measurements ◽  
Made In

BACKGROUND: Brachytherapy of cervix carcinoma often results in high doses to surrounding structures, such as rectum and bladder. Therefore, these organs should be closely monitored. Purpose of this work was to evaluate rectal marker made in our institution for rectal dose measurements by comparing it with the method recommended in ICRU (International Commission on Radiation Units and Measurements) Report 38. METHODS: In this work rectal dosimetry was performed by two different methods. In one, rectal marker made in Institute of Oncology Sremska Kamenica was used, while in the other method recommended in ICRU Report 38 dose on ICRU rectal point was measured A total of 34 applications using Microselectron HDR and its standard applicator set were performed in a prospective way. The prescribed dose was 7.6 Gy to point A for each application. Rectal doses were calculated by Nucletron Plato Treatment Planning System. RESULTS: Differences found between the means of ICRU point R and rectal marker points Rref and Rmax were significant (P<0.002 and P<0.00002). The same result was obtained for Rref and Rmax pair (P<0.003). CONCLUSION: Maximal doses obtained using rectal marker were in most cases high- er than those obtained by ICRU method. It conforms well to several CT-based dosimetry studies where rectum dose was found to be higher from that obtained by ICRU method.

Carcinoembryonic Antigen, Ferritin, Tissue Polypeptide Antigen, and Ca15/3 in Breast Cancer: Relationship between Carcinoma and Normal Breast Tissue

1986 ◽  
Vol 1 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Massimo Gion ◽  
Riccardo Mione ◽  
Ruggero Dittadi ◽  
Luciano Griggio ◽  
Gabriele Munegato ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Normal Tissue ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Tissue Sample ◽  
Normal Breast ◽  
Cancer Tissue ◽  
Breast Cancer Patients ◽  
Breast Tissue Sample ◽  
Supply Information

The study of tumor markers in breast cancer tissue may supply information on the tumor's biological features and its clinical behaviour. Forty-nine primary breast cancer patients are evaluable to date. CEA, ferritin, TPA and CA15/3 were measured with radioimmu-nometric methods in the cytosol of carcinoma and normal tissue from the same breast. The concentrations of the four markers were higher in the tumor than in normal tissue in 42/49 cases for CEA, 47/49 for ferritin, 42/49 for TPA and in 24/29 for CA15/3. However, an overlap was found between carcinoma and normal tissue levels, particularly for CEA and TPA. We can conclude that the four substances studied may be markers of malignancy in breast carcinoma when nonmalignant breast tissue from the same patient is determined at the same time, whereas assays within a single, unknown breast tissue sample may be useful only in the case of ferritin and, partly, CA15/3.

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