scholarly journals Visual Disturbance Caused by a Nail Gun-Induced Penetrating Brain Injury

2021 ◽  
Vol 34 (3) ◽  
pp. 203-207
Author(s):  
Jin Bong Ye ◽  
Young Hoon Sul ◽  
Se Heon Kim ◽  
Jin Young Lee ◽  
Jin Suk Lee ◽  
...  
Keyword(s):  
Brain Injury ◽  
Parietal Lobe ◽  
Superior Sagittal Sinus ◽  
Occipital Lobe ◽  
Visual Disturbance ◽  
Neurological Deficits ◽  
Penetrating Brain Injury ◽  
Sagittal Sinus ◽  
Neurologically Intact ◽  
The Brain

Penetrating brain injury caused by a nail gun is an uncommon clinical scenario reported in the literature. A 36-year-old male presented with a nail that had penetrated through the occipital bone. He was alert and neurologically intact except for visual disturbance. Computed tomography (CT) of the brain showed the nail lodged at the occipital lobe and the parietal lobe, with minimal intracerebral hemorrhage. The nail was placed in the occipital lobe close to the superior sagittal sinus. We removed the nail with craniotomy since the entrance of the nail was close to the superior sagittal sinus. There were no newly developed neurological deficits postoperatively. Immediate postoperative CT showed no newly developed lesions. The patient recovered well without any significant complications. Two weeks postoperatively, magnetic resonance imaging showed no remarkable lesions. The visual disturbance was followed up at the outpatient department. To summarize, we report a rare case of penetrating head injury by a nail gun and discuss relevant aspects of the clinical management.

scholarly journals Virtual Simulation of the Effects of Intracranial Fluid Cavitation in Blast-Induced Traumatic Brain Injury

2015 ◽  
Author(s):  
Shivonne Haniff ◽  
Paul Taylor ◽  
Aaron Brundage ◽  
Damon Burnett ◽  
Candice Cooper ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cavitation Bubble ◽  
Superior Sagittal Sinus ◽  
Von Mises Stress ◽  
Bubble Collapse ◽  
Compressive Wave ◽  
Sagittal Sinus ◽  
Microscale Model ◽  
Von Mises

A microscale model of the brain was developed in order to understand the details of intracranial fluid cavitation and the damage mechanisms associated with cavitation bubble collapse due to blast-induced traumatic brain injury (TBI). Our macroscale model predicted cavitation in regions of high concentration of cerebrospinal fluid (CSF) and blood. The results from this macroscale simulation directed the development of the microscale model of the superior sagittal sinus (SSS) region. The microscale model includes layers of scalp, skull, dura, superior sagittal sinus, falx, arachnoid, subarachnoid spacing, pia, and gray matter. We conducted numerical simulations to understand the effects of a blast load applied to the scalp with the pressure wave propagating through the layers and eventually causing the cavitation bubbles to collapse. Collapse of these bubbles creates spikes in pressure and von Mises stress downstream from the bubble locations. We investigate the influence of cavitation bubble size, compressive wave amplitude, and internal bubble pressure. The results indicate that these factors may contribute to a greater downstream pressure and von Mises stress which could lead to significant tissue damage.

scholarly journals Annexin A2 Deficiency Exacerbates Neuroinflammation and Long-Term Neurological Deficits after Traumatic Brain Injury in Mice

2019 ◽  
Vol 20 (24) ◽  
pp. 6125 ◽  
Author(s):  
Ning Liu ◽  
Yinghua Jiang ◽  
Joon Yong Chung ◽  
Yadan Li ◽  
Zhanyang Yu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Inflammatory Response ◽  
Neurovascular Unit ◽  
Annexin A2 ◽  
Tissue Loss ◽  
Neurological Deficits ◽  
Endogenous Factors ◽  
The Brain

Our laboratory and others previously showed that Annexin A2 knockout (A2KO) mice had impaired blood–brain barrier (BBB) development and elevated pro-inflammatory response in macrophages, implying that Annexin A2 (AnxA2) might be one of the key endogenous factors for maintaining homeostasis of the neurovascular unit in the brain. Traumatic brain injury (TBI) is an important cause of disability and mortality worldwide, and neurovascular inflammation plays an important role in the TBI pathophysiology. In the present study, we aimed to test the hypothesis that A2KO promotes pro-inflammatory response in the brain and worsens neurobehavioral outcomes after TBI. TBI was conducted by a controlled cortical impact (CCI) device in mice. Our experimental results showed AnxA2 expression was significantly up-regulated in response to TBI at day three post-TBI. We also found more production of pro-inflammatory cytokines in the A2KO mouse brain, while there was a significant increase of inflammatory adhesion molecules mRNA expression in isolated cerebral micro-vessels of A2KO mice compared with wild-type (WT) mice. Consistently, the A2KO mice brains had a significant increase in leukocyte brain infiltration at two days after TBI. Importantly, A2KO mice had significantly worse sensorimotor and cognitive function deficits up to 28 days after TBI and significantly larger brain tissue loss. Therefore, these results suggested that AnxA2 deficiency results in exacerbated early neurovascular pro-inflammation, which leads to a worse long-term neurologic outcome after TBI.

scholarly journals Lack of mitochondrial ferritin aggravated neurological deficits via enhancing oxidative stress in a traumatic brain injury murine model

2017 ◽  
Vol 37 (6) ◽  
Author(s):  
Ligang Wang ◽  
Libo Wang ◽  
Zhibo Dai ◽  
Pei Wu ◽  
Huaizhang Shi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Knockout Mice ◽  
Brain Injuries ◽  
Brain Infarction ◽  
Neurological Deficits ◽  
Important Correlation ◽  
The Brain ◽  
And Oxidative Stress

Oxidative stress has been strongly implicated in the pathogenesis of traumatic brain injury (TBI). Mitochondrial ferritin (Ftmt) is reported to be closely related to oxidative stress. However, whether Ftmt is involved in TBI-induced oxidative stress and neurological deficits remains unknown. In the present study, the controlled cortical impact model was established in wild-type and Ftmt knockout mice as a TBI model. The Ftmt expression, oxidative stress, neurological deficits, and brain injury were measured. We found that Ftmt expression was gradually decreased from 3 to 14 days post-TBI, while oxidative stress was gradually increased, as evidenced by reduced GSH and superoxide dismutase levels and elevated malondialdehyde and nitric oxide levels. Interestingly, the extent of reduced Ftmt expression in the brain was linearly correlated with oxidative stress. Knockout of Ftmt significantly exacerbated TBI-induced oxidative stress, intracerebral hemorrhage, brain infarction, edema, neurological severity score, memory impairment, and neurological deficits. However, all these effects in Ftmt knockout mice were markedly mitigated by pharmacological inhibition of oxidative stress using an antioxidant, N-acetylcysteine. Taken together, these results reveal an important correlation between Ftmt and oxidative stress after TBI. Ftmt deficiency aggravates TBI-induced brain injuries and neurological deficits, which at least partially through increasing oxidative stress levels. Our data suggest that Ftmt may be a promising molecular target for the treatment of TBI.

scholarly journals A Primo Vascular System Underneath the Superior Sagittal Sinus in the Brain of a Rabbit

2012 ◽  
Vol 5 (5) ◽  
pp. 210-217 ◽  
Author(s):  
Min-Ho Nam ◽  
Jaekwan Lim ◽  
Seung-Hoon Choi ◽  
Sungchul Kim ◽  
Kwang-Sup Soh
Keyword(s):  
Vascular System ◽  
Superior Sagittal Sinus ◽  
Sagittal Sinus ◽  
The Brain

scholarly journals Penetrating brain injury with a metal bar and a knife: Report of two interesting cases

2017 ◽  
Vol 31 (2) ◽  
pp. 203-206 ◽  
Author(s):  
Alireza Tabibkhooei ◽  
Morteza Taheri ◽  
Sadra Rohani ◽  
Iran Chanideh ◽  
Hessam Rahatlou
Keyword(s):  
Brain Injury ◽  
Surgical Intervention ◽  
Wide Spectrum ◽  
Good Health ◽  
Brain Parenchyma ◽  
Antibiotic Administration ◽  
Case Presentation ◽  
Penetrating Brain Injury ◽  
Magnetic Resonance Imaging Mri ◽  
The Brain

Introduction Penetrating brain injury (PBI) is uncommon among the civilian population. Here, we report two interesting cases of PBI. Case presentation The first patient was a 20-year-old male who sustained a penetrating head injury with a metal bar during an accident at work. The patient underwent early surgical intervention, and related meningitis was treated with antibiotics. The patient was discharged 45 days later with no deficit. The second patient was a 34-year-old male who was the victim of a violence attack and was admitted to hospital. He was struck by a knife to his right temporal bone. A brain computed tomography scan and magnetic resonance imaging (MRI) demonstrated the tract of the knife within the brain parenchyma. The patient underwent conservative treatment. After several weeks, the patient was discharged in good health. Conclusion Although severe PBI has a poorer prognosis than a blunt brain injury, in treating of these patients, aggressive and timely surgical intervention, proper wide-spectrum antibiotic administration, stringent and diligent care in the intensive-care unit and careful management of the associated complications are mandated.

Severe brain injury with rupture of the superior sagittal sinus after vacuum extraction birth

2008 ◽  
Vol 1 (6) ◽  
pp. 471-473 ◽  
Author(s):  
Christian Musahl ◽  
Uta Schick
Keyword(s):  
Brain Injury ◽  
Brain Damage ◽  
Surgical Repair ◽  
Superior Sagittal Sinus ◽  
Vacuum Extraction ◽  
Safe Procedure ◽  
Dural Tear ◽  
Severe Brain Injury ◽  
Sagittal Sinus ◽  
Major Complications

✓ Vacuum extraction in nonprogressive labor is a relatively safe procedure. Only a few major complications have been reported in the literature. The authors present a case of severe brain damage with rupture of the sinus after vacuum extraction delivery for which surgical repair of the dural tear and brain prolapse was required.

The influence of dynamic response and brain deformation metrics on the occurrence of subdural hematoma in different regions of the brain

2014 ◽  
Vol 120 (2) ◽  
pp. 453-461 ◽  
Author(s):  
Andrew Post ◽  
T. Blaine Hoshizaki ◽  
Michael D. Gilchrist ◽  
Susan Brien ◽  
Michael D. Cusimano ◽  
...  
Keyword(s):  
Dynamic Response ◽  
Subdural Hematoma ◽  
Parietal Lobe ◽  
Linear Acceleration ◽  
Occipital Lobe ◽  
Von Mises Stress ◽  
Rotational Acceleration ◽  
Brain Deformation ◽  
Strain And Strain Rate ◽  
The Brain

Object The purpose of this study was to examine how the dynamic response and brain deformation of the head and brain—representing a series of injury reconstructions of which subdural hematoma (SDH) was the outcome—influence the location of the lesion in the lobes of the brain. Methods Sixteen cases of falls in which SDH was the outcome were reconstructed using a monorail drop rig and Hybrid III headform. The location of the SDH in 1 of the 4 lobes of the brain (frontal, parietal, temporal, and occipital) was confirmed by CT/MR scan examined by a neurosurgeon. Results The results indicated that there were minimal differences between locations of the SDH for linear acceleration. The peak resultant rotational acceleration and x-axis component were larger for the parietal lobe than for other lobes. There were also some differences between the parietal lobe and the other lobes in the z-axis component. Maximum principal strain, von Mises stress, shear strain, and product of strain and strain rate all had differences in magnitude depending on the lobe in which SDH was present. The parietal lobe consistently had the largest-magnitude response, followed by the frontal lobe and the occipital lobe. Conclusions The results indicated that there are differences in magnitude for rotational acceleration and brain deformation metrics that may identify the location of SDH in the brain.

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