The influence of dynamic response and brain deformation metrics on the occurrence of subdural hematoma in different regions of the brain

2014 ◽  
Vol 120 (2) ◽  
pp. 453-461 ◽  
Author(s):  
Andrew Post ◽  
T. Blaine Hoshizaki ◽  
Michael D. Gilchrist ◽  
Susan Brien ◽  
Michael D. Cusimano ◽  
...  
Keyword(s):  
Dynamic Response ◽  
Subdural Hematoma ◽  
Parietal Lobe ◽  
Linear Acceleration ◽  
Occipital Lobe ◽  
Von Mises Stress ◽  
Rotational Acceleration ◽  
Brain Deformation ◽  
Strain And Strain Rate ◽  
The Brain

Object The purpose of this study was to examine how the dynamic response and brain deformation of the head and brain—representing a series of injury reconstructions of which subdural hematoma (SDH) was the outcome—influence the location of the lesion in the lobes of the brain. Methods Sixteen cases of falls in which SDH was the outcome were reconstructed using a monorail drop rig and Hybrid III headform. The location of the SDH in 1 of the 4 lobes of the brain (frontal, parietal, temporal, and occipital) was confirmed by CT/MR scan examined by a neurosurgeon. Results The results indicated that there were minimal differences between locations of the SDH for linear acceleration. The peak resultant rotational acceleration and x-axis component were larger for the parietal lobe than for other lobes. There were also some differences between the parietal lobe and the other lobes in the z-axis component. Maximum principal strain, von Mises stress, shear strain, and product of strain and strain rate all had differences in magnitude depending on the lobe in which SDH was present. The parietal lobe consistently had the largest-magnitude response, followed by the frontal lobe and the occipital lobe. Conclusions The results indicated that there are differences in magnitude for rotational acceleration and brain deformation metrics that may identify the location of SDH in the brain.

scholarly journals A comparison of head dynamic response and brain tissue stress and strain using accident reconstructions for concussion, concussion with persistent postconcussive symptoms, and subdural hematoma

2015 ◽  
Vol 123 (2) ◽  
pp. 415-422 ◽  
Author(s):  
R. Anna Oeur ◽  
Clara Karton ◽  
Andrew Post ◽  
Philippe Rousseau ◽  
T. Blaine Hoshizaki ◽  
...  
Keyword(s):  
Dynamic Response ◽  
Brain Tissue ◽  
Subdural Hematoma ◽  
Von Mises Stress ◽  
Stress And Strain ◽  
Rotational Acceleration ◽  
Postconcussive Symptoms ◽  
Tissue Responses ◽  
Von Mises ◽  
Post Hoc

OBJECT Concussions typically resolve within several days, but in a few cases the symptoms last for a month or longer and are termed persistent postconcussive symptoms (PPCS). These persisting symptoms may also be associated with more serious brain trauma similar to subdural hematoma (SDH). The objective of this study was to investigate the head dynamic and brain tissue responses of injury reconstructions resulting in concussion, PPCS, and SDH. METHODS Reconstruction cases were obtained from sports medicine clinics and hospitals. All subjects received a direct blow to the head resulting in symptoms. Those symptoms that resolved in 9 days or fewer were defined as concussions (n = 3). Those with symptoms lasting longer than 18 months were defined as PPCS (n = 3), and 3 patients presented with SDHs (n = 3). A Hybrid III headform was used in reconstruction to obtain linear and rotational accelerations of the head. These dynamic response data were then input into the University College Dublin Brain Trauma Model to calculate maximum principal strain and von Mises stress. A Kruskal-Wallis test followed by Tukey post hoc tests were used to compare head dynamic and brain tissue responses between injury groups. Statistical significance was set at p < 0.05. RESULTS A significant difference was identified for peak resultant linear and rotational acceleration between injury groups. Post hoc analyses revealed the SDH group had higher linear and rotational acceleration responses (316 g and 23,181 rad/sec2, respectively) than the concussion group (149 g and 8111 rad/sec2, respectively; p < 0.05). No significant differences were found between groups for either brain tissue measures of maximum principal strain or von Mises stress. CONCLUSIONS The reconstruction of accidents resulting in a concussion with transient symptoms (low severity) and SDHs revealed a positive relationship between an increase in head dynamic response and the risk for more serious brain injury. This type of relationship was not found for brain tissue stress and strain results derived by finite element analysis. Future research should be undertaken using a larger sample size to confirm these initial findings. Understanding the relationship between the head dynamic and brain tissue response and the nature of the injury provides important information for developing strategies for injury prevention.

scholarly journals Neck Flexion Induces Larger Deformation of the Brain Than Extension at a Rotational Acceleration, Closed Head Trauma

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Hans-Arne Hansson ◽  
Ulrika Krave ◽  
Svante Höjer ◽  
Johan Davidsson
Keyword(s):  
Head Trauma ◽  
Sagittal Plane ◽  
Positive Pressure ◽  
High Time Resolution ◽  
Rotational Acceleration ◽  
Brain Deformation ◽  
Closed Head ◽  
Negative Pressures ◽  
Closed Head Trauma ◽  
The Brain

A closed head trauma induces incompletely characterized temporary movement and deformation of the brain, contributing to the primary traumatic brain injury. We used the pressure patterns recorded with light-operated miniature sensors in anaesthetized adult rabbits exposed to a sagittal plane rotational acceleration of the head, lasting 1 ms, as a measure of brain deformation. Two exposure levels were used and scaled to correspond to force levels reported to cause mild and moderate diffuse injury in an adult man, respectively. Flexion induced transient, strong, extended, and predominantly negative pressures while extension generated a short positive pressure peak followed by a minor negative peak. Low level flexion caused as strong, extended negative pressures as did high level extension. Time differences were demonstrated between the deformation of the cerebrum, brainstem, and cerebellum. Available X-ray and MRI techniques do not have as high time resolution as pressure recordings in demonstrating complex, sequential compression and stretching of the brain during a trauma. The exposure to flexion caused more protracted and extensive deformation of the brain than extension, in agreement with a published histopathological report. The severity and extent of the brain deformation generated at a head trauma thus related to the direction at equal force.

scholarly journals Visual Disturbance Caused by a Nail Gun-Induced Penetrating Brain Injury

2021 ◽  
Vol 34 (3) ◽  
pp. 203-207
Author(s):  
Jin Bong Ye ◽  
Young Hoon Sul ◽  
Se Heon Kim ◽  
Jin Young Lee ◽  
Jin Suk Lee ◽  
...  
Keyword(s):  
Brain Injury ◽  
Parietal Lobe ◽  
Superior Sagittal Sinus ◽  
Occipital Lobe ◽  
Visual Disturbance ◽  
Neurological Deficits ◽  
Penetrating Brain Injury ◽  
Sagittal Sinus ◽  
Neurologically Intact ◽  
The Brain

Penetrating brain injury caused by a nail gun is an uncommon clinical scenario reported in the literature. A 36-year-old male presented with a nail that had penetrated through the occipital bone. He was alert and neurologically intact except for visual disturbance. Computed tomography (CT) of the brain showed the nail lodged at the occipital lobe and the parietal lobe, with minimal intracerebral hemorrhage. The nail was placed in the occipital lobe close to the superior sagittal sinus. We removed the nail with craniotomy since the entrance of the nail was close to the superior sagittal sinus. There were no newly developed neurological deficits postoperatively. Immediate postoperative CT showed no newly developed lesions. The patient recovered well without any significant complications. Two weeks postoperatively, magnetic resonance imaging showed no remarkable lesions. The visual disturbance was followed up at the outpatient department. To summarize, we report a rare case of penetrating head injury by a nail gun and discuss relevant aspects of the clinical management.

Distribution and histopathological changes induced by cysts ofTaenia soliumin the brain of pigs from Tanzania

2014 ◽  
Vol 89 (5) ◽  
pp. 559-564 ◽  
Author(s):  
E.M. Mkupasi ◽  
H.A. Ngowi ◽  
C.S. Sikasunge ◽  
P.S. Leifsson ◽  
M.V. Johansen
Keyword(s):  
Parietal Lobe ◽  
Taenia Solium ◽  
Clinical Signs ◽  
Occipital Lobe ◽  
Loss Of Consciousness ◽  
Parasitic Disease ◽  
Histopathological Changes ◽  
The Central Nervous System ◽  
Spinal Cord Cysts ◽  
The Brain

AbstractNeurocysticercosis (NCC) caused byTaenia soliumcysts is a frequent but neglected parasitic disease of the central nervous system (CNS) worldwide. The aim of this study was to describe anatomical locations of cysts in the CNS and the corresponding inflammation. A total of 17 naturally infected pigs were used to evaluate the distribution of cysts and, of these, seven were used to evaluate the corresponding inflammation further, through histopathology. Clinical signs in the pigs included dullness, sluggishness, somnolence, apathy and loss of consciousness. Cysts were distributed in all cerebral lobes, i.e. 39.7% in the frontal lobe, 20.3% in the parietal lobe, 20.0% in the occipital lobe and 19.7% in the temporal lobe, and only 0.4% in the cerebellum. No cysts were found in the spinal cord. Cysts were localized as follows: 47.9% in the dorsal subarachnoid, 46.9% in the parenchyma, 4.4% in the subarachnoid base and 0.9% in the ventricles. The results of the histopathology revealed lesions in an early inflammatory stage, i.e. stage I, in all anatomical locations except for two, which showed more of an inflammatory reaction, stage III, in one pig. It was concluded that clinical signs in pigs were neither pathognomonic nor consistent. These signs, therefore, cannot be used as a reliable indicator of porcine NCC. Furthermore,T. soliumcysts were found to be in abundance in all cerebral lobes, and only a few were found in the cerebellum. Regarding the inflammatory response, no significant differences were found in the location and total number of cysts. Thus, further studies are needed to explain the determinants of cyst distribution in the CNS and assess in detail clinical signs associated with porcine NCC.

scholarly journals Computational Modeling, Neuroscience, and Visual Algorithm

2018 ◽  
Vol 3 (9) ◽  
Keyword(s):  
Decision Making ◽  
Computational Modeling ◽  
Frontal Lobe ◽  
Parietal Lobe ◽  
Human Perception ◽  
Occipital Lobe ◽  
Information Process ◽  
Cognitive Hierarchy ◽  
The Creation ◽  
The Brain

Computational Modeling and Visual Algorithm allows for the creation of a Visual cognitive diagram that explains areas of the brain they represent to spatial abstraction and mental calculation. For example, the temporal lobe is associated with memory and the occipital lobe is associated with vision. The cerebral cortex is where decision- making, thinking, and information process takes place. Moreover, in the frontal lobe is where decision making, takes place and the parietal lobe influences areas of the brain that correlate to spatial calculation and mind mapping. This is created in a diagram that expresses each area like a visual algorithm. A visual algorithm is created in different scales that are associated with numerical numbers and the frontal lobe sub division [1]. The creation of this visual algorithm explains the nodes and the functioning of the levels of the brain and neuroscience. The connection and the functions of the brain control our learning, motor content, and mayor nerve connections. The visual algorithm present an abstract and perception pattern to look at thinks. It connects with the nodes that affect our cognitive human perception factor. The lobes of the brain resemble this area and provide an in-depth understanding to what a cognitive hierarchy is. The lobes are important factor to the perception of thinking, learning, and memory. Each one with a significant function to learning and neuroscience [2]

Chemistry and Effects of Brainstem Acting Drugs

2019 ◽  
Vol 19 (3) ◽  
pp. 180-186
Author(s):  
Saganuwan Alhaji Saganuwan
Keyword(s):  
Risk Assessment ◽  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Parietal Lobe ◽  
Occipital Lobe ◽  
Sensitive Organ ◽  
Brain And Spinal Cord ◽  
The Brain ◽  
Benefit And Risk

Background: Brain is the most sensitive organ, whereas brainstem is the most important part of Central Nervous System (CNS). It connects the brain and the spinal cord. However, a myriad of drugs and chemicals affects CNS with severe resultant effects on the brainstem. Methods: In view of this, a number of literature were assessed for information on the most sensitive part of brain, drugs and chemicals that act on the brainstem and clinical benefit and risk assessment of such drugs and chemicals. Results: Findings have shown that brainstem regulates heartbeat, respiration and because it connects the brain and spinal cord, all the drugs that act on the spinal cord may overall affect the systems controlled by the spinal cord and brain. The message is sent and received by temporal lobe, occipital lobe, frontal lobe, parietal lobe and cerebellum. Conclusion: Hence, the chemical functional groups of the brainstem and drugs acting on brainstem are complementary, and may produce either stimulation or depression of CNS.

scholarly journals Impact Performance Comparison of Advanced Snow Sport Helmets with Dedicated Rotation-Damping Systems

2021 ◽  
Author(s):  
Gina DiGiacomo ◽  
Stanley Tsai ◽  
Michael Bottlang
Keyword(s):  
Linear Acceleration ◽  
Performance Comparison ◽  
Rotational Acceleration ◽  
Head Acceleration ◽  
Impact Performance ◽  
Predicted Probability ◽  
Rotational Kinematics ◽  
Hybrid Iii ◽  
The Brain ◽  
Damping Systems

AbstractRotational acceleration of the head is a principal cause of concussion and traumatic brain injury. Several rotation-damping systems for helmets have been introduced to better protect the brain from rotational forces. But these systems have not been evaluated in snow sport helmets. This study investigated two snow sport helmets with different rotation-damping systems, termed MIPS and WaveCel, in comparison to a standard snow sport helmet without a rotation-damping system. Impact performance was evaluated by vertical drops of a helmeted Hybrid III head and neck onto an oblique anvil. Six impact conditions were tested, comprising two impact speeds of 4.8 and 6.2 m/s, and three impact locations. Helmet performance was quantified in terms of the linear and rotational kinematics, and the predicted probability of concussion. Both rotation-damping systems significantly reduced rotational acceleration under all six impact conditions compared to the standard helmet, but their effect on linear acceleration was less consistent. The highest probability of concussion for the standard helmet was 89%, while helmets with MIPS and WaveCel systems exhibited a maximal probability of concussion of 67 and 7%, respectively. In conclusion, rotation-damping systems of advanced snow sport helmets can significantly reduce rotational head acceleration and the associated concussion risk.

scholarly journals Investigation of the Head’s Dynamic Response to Boxing Punch Using Computer Simulation

2021 ◽  
Vol 10 (1) ◽  
pp. 31-35
Author(s):  
Neda Boroushak ◽  
◽  
Hasan Khoshnoodi ◽  
Mostafa Rostami ◽  
◽  
...  
Keyword(s):  
Computer Simulation ◽  
Head Injury ◽  
Dynamic Response ◽  
Head Injuries ◽  
Linear Acceleration ◽  
Rotational Acceleration ◽  
Future Studies ◽  
Software Model ◽  
Adams Software ◽  
The Impact

Head injuries are dangerous injuries that are common in combat sports. Nevertheless, the mechanisms of concussion in sport have are not precisely known. Thus, this study aimed to investigate the dynamic response of the head based on linear and rotational accelerations in boxing using computer simulation. The ADAMS software model was used to determine the linear and rotational acceleration of boxing’s straight punch. The peak linear acceleration, average linear acceleration, peak rotational acceleration, and average rotational acceleration resulted from the straight punch to head were obtained: 75 g, 20 g, 4036 rad/s², 1140 rad/s², respectively; the impact times were 30 ms and 3 ms, respectively. The comparison of acceleration tolerance thresholds of head injury and obtained results of this study showed the rotational acceleration only leads to head injury. Furthermore, it is biomechanically improbable that the head would be moved only translationally or rotationally as a result of a straight punch. Therefore, both rotational and linear accelerations should be observed together for future studies.

Alice in Wonderland Syndrome: An Update of Present Data With A Special View to Body Position, Traumatic and Genetic Aspects

2020 ◽  
Author(s):  
Stefan Bittmann
Keyword(s):  
Depressive Disorders ◽  
Parietal Lobe ◽  
Body Position ◽  
Occipital Lobe ◽  
Brain Regions ◽  
Lewis Carroll ◽  
Temporoparietal Junction ◽  
Alice In Wonderland ◽  
First Time ◽  
The Brain

Alice in Wonderland Syndrome (AIWS) was named after the description of Lewis Carroll in his novel. In 1955, John Todd, a psychiatrist described this entity for the first time and results in a distortion of perception. Todd described it as „Alice's Adventures in Wonderland“ by Lewis Carroll. The author Carroll suffered from severe migraine attacks. Alice in Wonderland Syndrome is a disorienting condition of seizures affecting visual perception. AIWS is a neurological form of seizures influencing the brain, thereby causing a disturbed perception. Patients describe visual, auditory, and tactile hallucinations and disturbed perceptions. The causes of AIWS are still not known exactly. Cases of migraine, brain tumors, depression episodes, epilepsy, delirium, psychoactive drugs, ischemic stroke, depressive disorders, and EBV, mycoplasma, and malaria infections are correlating with AIWS like seizures. Often no EEG correlate is found. Neuroimaging studies reveal disturbances of brain regions including the temporoparietal junction, the temporal and occipital lobe as typical localization of the visual pathway. A decrease of perfusion of the visual pathways could induce these disturbances, especially in the temporal lobe in patients with AIWS. Other theories suggest distorted body illusions stem from the parietal lobe. The concrete origin of this mysterious syndrome is to date not clearly defined.

scholarly journals A Case of Hydranencephaly in Which Ophthalmic Examinations Were Performed

2016 ◽  
Vol 7 (3) ◽  
pp. 420-425
Author(s):  
Shohei Eda ◽  
Tomoko Terai ◽  
Yuko Nishikawa ◽  
Masahiro Tonari ◽  
Teruyo Kida ◽  
...  
Keyword(s):  
Gestational Age ◽  
Ganglion Cell Layer ◽  
Parietal Lobe ◽  
Cell Layer ◽  
Normal Wave ◽  
Occipital Lobe ◽  
Brain Parenchyma ◽  
Visual Reaction ◽  
Magnetic Resonance Imaging Mri ◽  
The Brain

Purpose: We performed ophthalmic examinations, including optical coherence tomography (OCT), on a case diagnosed with hydranencephaly. Case Report: This case involved a female infant born at the gestational age of 35 weeks and 4 days, with the birth weight of 2,152 g, who was one of monochorionic diamniotic twins, and the identical twin died in utero at the gestational age of 24 weeks. After that, examination by fetal echo indicated that she had microcephaly and ventriculomegaly. Postnatal magnetic resonance imaging (MRI) of her head indicated microcephaly and significant enlargement of the lateral ventricle on both sides, with no obvious signs of elevated intracranial pressure. The brain parenchyma of both sides of the frontal lobe, parietal lobe, and occipital lobe had marked thinning, yet that of the temporal lobe, basal ganglia, thalamus, brain stem, and cerebellum had been maintained. Moreover, no obvious hematoma or neoplastic lesions were observed. Ophthalmic examinations indicated that both of her eyes had slight light reflex, attributed to optic nerve atrophy. Examination by use of a hand-held OCT system indicated a layered structure of the retina and thinning of the ganglion cell layer. Flicker electroretinogram (ERG) examination by use of a hand-held ERG system indicated an almost normal wave. However, no clear visual reaction was observed when she was 10 months old. Conclusion: Our findings in this case of hydranencephaly revealed that even though the outer layer functions of the patient’s retina were maintained, extensive damage to her cerebral cortex resulted in poor visual function.

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