The quality of life of women with subclinical hypothyroidism, depending on the level of thyroid stimulating hormone

2016 ◽  
pp. 69-71
Author(s):  
S. I. Ismailov ◽  
D. S. Abdurazakova
Keyword(s):  
Quality Of Life ◽  
Subclinical Hypothyroidism ◽  
Thyroid Stimulating Hormone ◽  
Stimulating Hormone

scholarly journals THE EFFECT OF ANTICONVULSANT DRUGS ON SERUM THYROID-STIMULATING HORMONE

2021 ◽  
pp. 144-146
Author(s):  
NEETHU T T ◽  
SYAM S ◽  
BEENA V ◽  
DHANYA S P
Keyword(s):  
Quality Of Life ◽  
Thyroid Function ◽  
Sodium Valproate ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Significant Difference ◽  
Epileptic Patients ◽  
The Mean ◽  
Stimulating Hormone

Objective: Antiepileptic (AED) drugs are an integral component of the management of seizure disorder; however, they have a wide spectrum of adverse effects. It is important to be aware of these side effects as they have a major impact on the quality of life and are sometimes partially reversible after drug discontinuation. Among them, the influence of AED on thyroid function is an important one. However, there is only limited data available. The objective of this study is to evaluate the effect of AED on thyroid-stimulating hormone (TSH). Methods: A cross-sectional study of 1-year duration (march 2017 – march 2018) was conducted among 150 epileptic patients receiving phenytoin, carbamazepine, and sodium valproate for more than 6 months in a tertiary care center in central Kerala. Serum levels of TSH of patients on AED were compared with that of 50 healthy age- and sex-matched control groups. Data regarding the same were analyzed using SPSS version 16 with the Chi-square test, ANOVA, and independent t-test. Results: A total of 150 epileptic patients with a mean age of 35.54 + 10.72, including 66 males (44%) and 84 females (56%) were enrolled in this study. Fifty adults of mean age 36.5+ 8.4 and male to female ratio 1.10:1 formed the control group. It was found that the mean TSH value of patients on phenytoin (3.97+ 1.47), carbamazepine (3.57+ 1.44), and sodium valproate 3.03 + 1.41 significantly higher than that of the control group (1.91 + 0.72). On comparing the mean serum TSH of the drug group significant difference noted between phenytoin and sodium valproate treated group. Among the 12 patients develop subclinical hypothyroidism 65% taking drugs for more than 5 years. Conclusion: There is a positive correlation between the use of anticonvulsants and thyroid dysfunction and the association increases with the duration of therapy. The clinicians should be encouraged for regular monitoring of thyroid function test to impart a better quality of life to the patients.

scholarly journals To Treat or Not to Treat Subclinical Hypothyroidism, What Is the Evidence?

Medicina ◽  
2020 ◽  
Vol 56 (1) ◽  
pp. 40
Author(s):  
Jan Calissendorff ◽  
Henrik Falhammar
Keyword(s):  
Quality Of Life ◽  
Cardiovascular Risk ◽  
Subclinical Hypothyroidism ◽  
Thyroid Stimulating Hormone ◽  
Term Treatment ◽  
Elderly Subjects ◽  
Subclinical Disease ◽  
Wait And See ◽  
Levothyroxine Treatment

Objective: levothyroxine prescriptions have increased remarkably during the last decade, and it is most likely to be prescribed in subclinical hypothyroidism. The aim of this review was to present data on when levothyroxine treatment should be initiated, and the effects of treatment in subclinical hypothyroidism on symptoms such as weight, quality of life, vitality, cognition, and cardiovascular disease. We also discuss evidence for different thyroid-hormone medications. In addition, the option to withhold medication when there is uncertain diagnosis or lack of clinical improvement is discussed. Methods: a literature search in PubMed on the term “treatment of subclinical hypothyroidism” in combination with “quality of life”, “weight”, “cognition”, and “cerebrovascular disease”. Results: current research supports that levothyroxine should be initiated in patients with a thyroid stimulating hormone (TSH) >10 mIU/L. Treatment for hypothyroidism is becoming more frequent. Symptoms related to vitality, weight, and quality of life in subclinical disease often persist with levothyroxine treatment, and other causes should be explored. Patients with cardiovascular-risk factors may benefit from treatment, especially younger patients. Caution is necessary when treating elderly subjects with levothyroxine. Conclusion: lifelong treatment with levothyroxine should normally only be considered in manifest hypothyroidism. However, in subclinical hypothyroidism with a TSH >10 mIU/L, therapy is indicated. In milder subclinical forms, a wait-and-see strategy is advocated to see if normalization occurs. Subgroups with cardiovascular risk and subclinical hypothyroidism may benefit from levothyroxine therapy.

scholarly journals Long-Term Results after Treatment of Very Low-, Low-, and High-Risk Thyroid Cancers in a Combined Setting of Thyroidectomy and Radio Ablation Therapy in Euthyroidism

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Nikos Emmanouilidis ◽  
Harald Schrem ◽  
Michael Winkler ◽  
Jürgen Klempnauer ◽  
Georg F. W. Scheumann
Keyword(s):  
Quality Of Life ◽  
High Risk ◽  
Job Performance ◽  
Sick Leave ◽  
Tumor Recurrence ◽  
Thyroid Stimulating Hormone ◽  
Human Thyroid ◽  
Thyroid Cancers ◽  
Stimulating Hormone

Introduction. Differentiated thyroid cancer treatment usually consists of thyroidectomy and radio ablation in hypothyroidism 4-6 weeks after surgery. Replacing hypothyroidism by recombinant human thyroid stimulating hormone can facilitate radio ablation in euthyroidism within one week after surgery. The outcome of this approach was investigated.Methods. This is a prospective randomized trial to compare thyroidectomy and radio ablation within a few days after preconditioning with recombinant human thyroid stimulating hormone versus thyroidectomy and radio ablation separated by four weeks of L-T4withdrawal. Tumors were graded into very low-, low- , or high-risk tumors. Recurrence-free survival was confirmed at follow-up controls by neck ultrasound and serum thyroglobulin. Suspected tumor recurrence was treated by additional radio ablation or surgery. Quality-of-life questionnaires with additional evaluation of job performance and sick-leave time were used in all patients.Results. Radio ablation in euthyroidism in quick succession after thyroidectomy did not lead to higher tumor recurrence rates of differentiated thyroid cancers in any risk category and was significantly advantageous with respect to quality-of-life (P<0.001), sick-leave time (P<0.001), and job performance (P=0.002).Conclusion. Recombinant human thyroid stimulating hormone can be used safely and with good efficacy to allow radio ablation under sustained euthyroidism within one week after thyroidectomy.

scholarly journals Thyrotropin levels and severity of symptoms in migraine patients of tertiary headache center

Cephalalgia ◽  
2018 ◽  
Vol 39 (1) ◽  
pp. 148-152 ◽  
Author(s):  
Natalia L Starikova ◽  
Tatiana V Baidina ◽  
Tatiana P Kalashnikova
Keyword(s):  
Quality Of Life ◽  
Thyroid Stimulating Hormone ◽  
Current Therapy ◽  
Life Questionnaire ◽  
Open Label ◽  
Cross Sectional ◽  
Quality Of Life Questionnaire ◽  
Headache Center ◽  
Stimulating Hormone

Background The role of thyroid regulation in migraine is poorly understood, and data is contradictory. Objective To study the possible association of clinical features of migraine with patients’ thyroid function. Patients and methods One hundred and thirty migraine patients of a tertiary headache center took part in an open-label, cross-sectional comparative study. The Migraine Disability Assessment questionnaire, Spielberger State-Trait Anxiety Inventory, Beck Depression Inventory, Vanderbilt’s Questionnaire of Pain Management, Gothenburg Quality of Life Questionnaire and Migraine-Specific Quality of Life questionnaire were used. The effectiveness of the attacks’ therapy was assessed according to the Migraine Assessment of Current Therapy questionnaire. Levels of thyrotropine (thyroid stimulating hormone), thyroxine, and triiodothyronine were studied by standard immune chemiluminescent method using the Immulite-2000 set. Results An inverse correlation between levels of thyroid stimulating hormone in serum and duration of headache attacks was revealed. The effectiveness of abortive therapy for attacks showed a statistically significant positive correlation with thyroid stimulating hormone level. Quality of life measured by a general quality of life questionnaire, as well as the functional and social indices of a migraine-specific questionnaire, showed direct correlation with serum thyroid stimulating hormone. Conclusion These results show an association of a more severe clinical course of migraine with lower thyroid stimulating hormone levels.

scholarly journals Short-term Withdrawal of Levothyroxine, Induced Increase of Thyroid-stimulating Hormone and an Increase Ratio of Triiodothyronine to Thyroxine

2010 ◽  
Vol 9 (1) ◽  
pp. 37
Author(s):  
Martin Carlwe ◽  
Thomas Schaffer ◽  
◽  
Keyword(s):  
Quality Of Life ◽  
Pilot Study ◽  
Thyroid Stimulating Hormone ◽  
Complete Regression ◽  
Free T4 ◽  
Dosing Intervals ◽  
Hypothyroid Patients ◽  
Tsh Levels ◽  
Stimulating Hormone

Objective:Treatment with levothyroxine in primary hypothyroid patients does not always provide complete regression of associated symptoms despite normalised TSH levels. Several sources report ratios of triiodothyronine (T3) to thyroxine (T4) are diminished in hypothyroid patients following a daily levothyroxine regimen. It is known that thyroid-stimulating hormone (TSH) increases de-iodination of T4 to T3. We hypothesise that a raise in TSH levels caused by a temporary withdrawal of oral levothyroxine will be followed by an increased conversion of T4 to T3.Methods:Thirteen patients treated with monotherapy of levothyroxine were included in our pilot study. Treatment was temporarily discontinued for one week in which TSH, free T3 (fT3) and free T4 (fT4) were monitored. TSH and fT3 to fT4 ratios were compared with baseline values.Results:Statistically significant elevations in TSH and fT3 plasma levels relative to fT4 were demonstrated in all patients after withdrawal of levothyroxine.Conclusion:Both TSH and fT3 to fT4 ratios rose following temporary discontinuation of levothyroxine. The effect on symptoms and quality of life is not evaluated in this pilot study. Our results warrant further investigation into whether or not longer dosing intervals would demonstrate commensurate hormone elevations that better reflects the hormonal ratios in healthy subjects and if this also has an effect on quality of life scores.

scholarly journals Thyroid Related Quality of Life in Elderly with Subclinical Hypothyroidism and Improvement on Levothyroxine is Distinct from that in Young Patients (TSAGE)

2019 ◽  
Vol 51 (09) ◽  
pp. 568-574 ◽  
Author(s):  
Stefanie Recker ◽  
Richard Voigtländer ◽  
Anja Viehmann ◽  
Karin Dunschen ◽  
Helena Kerp ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Subclinical Hypothyroidism ◽  
Young Patients ◽  
Thyroid Stimulating Hormone ◽  
Similar Degree ◽  
Old Patients ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related

AbstractThe aim of this study was to investigate in a longitudinal approach whether levothyroxine (LT4) substitution has a different impact on quality of life (QoL) and thyroid related QoL in younger (<40 years) and older subjects (>60 years) with elevated thyroid-stimulating hormone (TSH) concentrations. The study included male and female patients with newly diagnosed, untreated subclinical hypothyroidism defined by TSH>8 mU/l. Patients were recruited throughout Germany from 2013–2016 and evaluated by clinical assessment, blood sampling and questionnaires for health related QoL and thyroid-disease thyroid-related QoL (ThyPRO) at time of diagnosis and six months after initiation of LT4 treatment. We found significantly lower QoL in both young and old patients with subclinical hypothyroidism compared to age-matched healthy individuals. Higher scores on follow-up were found in all patients irrespective of age, indicating better QoL on LT4 therapy. Analysis of the ThyPRO questionnaire showed that old patients experienced less Emotional Susceptibility, Tiredness, and Impaired Day Life on LT4, while young patients reported less Cognitive Complaints, Emotional Susceptibility, and Impaired Day Life compared to baseline assessment. Hypothyroidism with TSH concentrations>8 mU/l is associated with impairment in general and ThyPRO QoL in young and old age. Older patients benefited from LT4 therapy and remarkably show similar degree of improvement as younger patients, albeit with some thematic variation in ThyPRO QoL. Our data confirm current recommendations on initiation of LT4 substitution and suggest that this should not be withheld in elderly with TSH concentration above 8–10 mU/l.

scholarly journals Influence of a Medium-Impact Exercise Program on Health-Related Quality of Life and Cardiorespiratory Fitness in Females with Subclinical Hypothyroidism: An Open-Label Pilot Study

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Andrea Garces-Arteaga ◽  
Nataly Nieto-Garcia ◽  
Freddy Suarez-Sanchez ◽  
Héctor Reynaldo Triana-Reina ◽  
Robinson Ramírez-Vélez
Keyword(s):  
Quality Of Life ◽  
Cardiorespiratory Fitness ◽  
Subclinical Hypothyroidism ◽  
Exercise Program ◽  
Health Related Quality ◽  
Health Domain ◽  
Related Quality ◽  
Health Related ◽  
Impact Exercise

Objective.To examine the influence of a medium-impact exercise program (MIEP) on health-related quality of life (HRQoL) and cardiorespiratory fitness (VO2max) in females with subclinical hypothyroidism (sHT).Materials and Methods.We selected 17 sedentary women with sHT (mean age: 43.1 (standard deviation: 9.7) years). Participants carried out an MIEP consisting of 3 weekly sessions of 60 minutes during 12 weeks. Before and after the exercise program HRQoL was assessed by the SF-12v2 questionnaire, andVO2maxwas evaluated by Rockport walk test.Results.After the 12-week intervention, the participants that performed an MIEP showed improvements in HRQoL in most domains, particularly the vitality domain by 7 points, the social functioning domain by 10 points, the mental health domain by 7 points, and the mental component summary by 7 points. One of the four domains within the physical component summary (general health domain) showed significant effect of the exercise intervention: 6 points. Moreover, the participants that performed exercise showed a higherVO2max(28%;P<0.01).Conclusion.After 12 weeks of medium-impact exercise program, there were remarkable improvements in HRQoL in most domains. Moreover, this exercise program proved to have a positive influence on cardiorespiratory fitness.

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