scholarly journals Lower diastolic blood pressure in healthy subjects with vitamin K deficiency: a preliminary cross-sectional study

2016 ◽  
Vol 85 (4) ◽  
pp. 276-280
Author(s):  
Jan Krzysztof Nowak ◽  
Andrzej Wykrętowicz ◽  
Patrycja Krzyżanowska ◽  
Agnieszka Górna ◽  
Jarosław Tobolski ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Vitamin K ◽  
Healthy Subjects ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Vitamin K Deficiency ◽  
Cross Sectional ◽  
K Deficiency ◽  
The Relationship

Introduction. There is a growing body of evidence for the role of vitamin K in cardiovascular health. As a cofactor of carboxylation of the matrix Gla protein it prevents arterial calcification. However, the data on the relationship between vitamin K status and the blood pressure are scarce, and particularly so in persons without the burden of cardiovascular risk factors. Material and Methods. We performed a pilot cross-sectional study, in which we hypothesized that vitamin K deficiency is associated with a higher blood pressure in young, healthy people. The concentration of protein induced by vitamin K absence-II (PIVKA-II) larger than 2 ng/mL was chosen as a proxy for vitamin K deficiency; it was assessed in serum using ELISA. Blood pressure was measured using a validated, automated oscillometric monitor in triplicate.Results. Twenty-three healthy subjects were enrolled (16 female; mean age 21.3 ± 1.6 years; body mass index 20.6 ± 2.4 kg/m2). The diastolic blood pressure (DBP) was lower in vitamin K-deficient subjects (58 ± 9 vs. 67 ± 5 mmHg, p = 0.01). The mean arterial blood pressure also differed (75 ± 9 vs. 83 ± 6, p = 0.02). PIVKA-II levels correlated with DBP only (Pearson’s R = -0.41, p < 0.05; Spearman’s ? ns.). Stepwise regression identified PIVKA-II concentrations as the only independent parameter associated with DBP (adjusted R2 = 13.1%; PIVKA-II: ß = -0.41; 95%CI -1.87-(-0.00098), t = -2.08, p < 0.05).Conclusions. The relationship between vitamin K deficiency and low DBP in young adults should be investigated further.

Lower diastolic blood pressure in healthy subjects with vitamin K deficiency: a preliminary cross-sectional study

10.20883/181 ◽  
2016 ◽  
Vol 85 (4) ◽  
pp. 276
Author(s):  
Jan Krzysztof Nowak ◽  
Andrzej Wykrętowicz ◽  
Patrycja Krzyżanowska ◽  
Agnieszka Górna ◽  
Jarosław Tobolski ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Vitamin K ◽  
Healthy Subjects ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Vitamin K Deficiency ◽  
Cross Sectional ◽  
K Deficiency ◽  
The Relationship

Introduction. There is a growing body of evidence for the role of vitamin K in cardiovascular health. As a cofactor of carboxylation of the matrix Gla protein it prevents arterial calcification. However, the data on the relationship between vitamin K status and the blood pressure are scarce, and particularly so in persons without the burden of cardiovascular risk factors. Material and Methods. We performed a pilot cross‑sectional study, in which we hypothesized that vitamin K deficiency is associated with a higher blood pressure in young, healthy people. The concentration of protein induced by vitamin K absence‑II (PIVKA‑II) larger than 2 ng/mL was chosen as a proxy for vitamin K deficiency; it was assessed in serum using ELISA. Blood pressure was measured using a validated, automated oscillometric monitor in triplicate.Results. Twenty‑three healthy subjects were enrolled (16 female; mean age 21.3 ± 1.6 years; body mass index 20.6 ± 2.4 kg/m2). The diastolic blood pressure (DBP) was lower in vitamin K‑deficient subjects (58 ± 9 vs. 67 ± 5 mmHg, p = 0.01). The mean arterial blood pressure also differed (75 ± 9 vs. 83 ± 6, p = 0.02). PIVKA‑II levels correlated with DBP only (Pearson’s R = -0.41, p < 0.05; Spearman’s ρ ns.). Stepwise regression identified PIVKA‑II concentrations as the only independent parameter associated with DBP (adjusted R2 = 13.1%; PIVKA‑II: β = -0.41; 95%CI -1.87-(-0.00098), t = -2.08, p < 0.05).Conclusions. The relationship between vitamin K deficiency and low DBP in young adults should be investigated further.

scholarly journals The relationship between ambulatory blood pressure variability and enlarged perivascular spaces: a cross-sectional study

BMJ Open ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. e015719 ◽  
Author(s):  
Shuna Yang ◽  
Wei Qin ◽  
Lei Yang ◽  
Huimin Fan ◽  
Yue Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
White Matter ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Variability ◽  
Cross Sectional Study ◽  
Perivascular Spaces ◽  
Spearman Correlation ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship

ObjectivesRecent studies reported that 24-hour ambulatory blood pressure variability (ABPV) was associated with lacunar infarction and white matter hyperintensities (WMH). However, the relationship between ABPV and enlarged perivascular spaces (EPVS) has not been investigated. Thus, our study aimed to investigate whether ABPV is associated with EPVS by 24-hour ambulatory blood pressure monitoring (ABPM).DesignWe conducted this study as a cross-sectional study.SettingsThe study was based on patients who presented for physical examinations in our hospital from May 2013 to June 2016.ParticipantsPatients with both brain MRI scans and 24-hour ABPM were included and patients with acute stroke, a history of severe stroke and some other severe diseases were excluded. A total of 573 Chinese patients were prospectively enrolled in this study.Primary and secondary outcome measuresEPVS in basal ganglia (BG) and white matter (WM) were identified on MRI and classified into three categories by the severity. WMH were scored by the Fazekas scale. Coefficient of variation (CV) and SD were considered as metrics of ABPV. Spearman correlation analysis and ordinal logistic regression analysis were used to assess the relationship between ABPV and EPVS.ResultsThere were statistical differences among the subgroups stratified by the severity of EPVS in BG in the following ABPV metrics: SD and CV of systolic blood pressure (SBP), CV of diastolic blood pressure (DBP) in 24 hours, daytime and nighttime and SD of DBP in nighttime. The above ABPV metrics were positively associated with the degree of EPVS. The association was unchanged after adjusting for confounders. Spearman correlation analysis showed ABPV was not related to the degree of EPVS in the WM.ConclusionABPV was independently associated with EPVS in BG after controlling for blood pressure, but not in the WM. Pathogenesis of EPVS in BG and WM might be different.

The Relationship Between Blood Pressure, Anthropometric Indices and Metabolic Profile in Adolescents: A Cross Sectional Study

2014 ◽  
Vol 82 (5) ◽  
pp. 445-449 ◽  
Author(s):  
Setila Dalili ◽  
Hamid Mohammadi ◽  
Seyed Mahmood Rezvany ◽  
Arsalan Dadashi ◽  
Mohammad Hassan Novin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Profile ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Anthropometric Indices ◽  
Cross Sectional ◽  
The Relationship

scholarly journals The Relationship Between Blood Pressure and Sleep Duration in Turkish Children: A Cross-Sectional Study

2018 ◽  
Vol 10 (1) ◽  
pp. 51-58 ◽  
Author(s):  
Cengiz Bal ◽  
Ahmet Öztürk ◽  
Betül Çiçek ◽  
Ahmet Özdemir ◽  
Gökmen Zararsız ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sleep Duration ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Turkish Children ◽  
The Relationship

scholarly journals Vitamin K Status in Adherent and Non-Adherent Patients with Phenylketonuria: A Cross-Sectional Study

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1772
Author(s):  
Renata Mozrzymas ◽  
Dariusz Walkowiak ◽  
Sławomira Drzymała-Czyż ◽  
Patrycja Krzyżanowska-Jankowska ◽  
Monika Duś-Żuchowska ◽  
...  
Keyword(s):  
Vitamin K ◽  
Cross Sectional Study ◽  
Dietary Vitamin ◽  
Dietary Recommendations ◽  
Vitamin K Deficiency ◽  
Cross Sectional ◽  
Dietary Compliance ◽  
Dietary Consumption ◽  
Vitamin Intake ◽  
K Deficiency

This is the first study to evaluate vitamin K status in relation to dietary intake and phenylalanine dietary compliance in patients with phenylketonuria (PKU). The dietary and PKU formula intake of vitamin K was calculated in 34 PKU patients, with vitamin K status determined by the measurement of prothrombin induced by vitamin K absence (PIVKA-II). Blood phenylalanine concentrations in the preceding 12 months were considered. There were significantly more phenylalanine results exceeding 6 mg/dL in patients with normal PIVKA-II concentrations than in those with abnormal PIVKA-II levels (p = 0.035). Similarly, a higher total intake of vitamin K and dietary vitamin intake expressed as μg/day (p = 0.033 for both) and %RDA (p = 0.0002 and p = 0.003, respectively) was observed in patients with normal PIVKA-II levels. Abnormal PIVKA-II concentrations were associated with a lower OR (0.1607; 95%CI: 0.0273–0.9445, p = 0.043) of having a median phenylalanine concentration higher than 6 mg/dL. In conclusion, vitamin K deficiency is not uncommon in phenylketonuria and may also occur in patients with adequate vitamin K intake. PKU patients with better dietary compliance have a higher risk of vitamin K deficiency. The present findings highlight the need for further studies to re-evaluate dietary recommendations regarding vitamin K intake, both concerning formula-based and dietary consumption of natural products.

scholarly journals HUBUNGAN ASUPAN ASAM LEMAK OMEGA-3 DAN OMEGA-6 DENGAN TEKANAN DARAH WANITA USIA 30 – 50 TAHUN

2017 ◽  
Vol 6 (4) ◽  
pp. 313
Author(s):  
Mega Lucyta Sari ◽  
Enny Probosari ◽  
Hartanti Sandi Wijayanti
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Cross Sectional Study ◽  
Observational Research ◽  
Omega 3 ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Omega 6

Background: Hypertension is one of the major risk factors for cardiovascular disease. Decreased intake of omega-3 and increased intake of omega-6 can increase the risk of hypertension. Hypertension cases in Indonesia are highest in women especially aged 30 - 50 years. This study aimed to determine correlation of omega-3 and omega-6 intake with blood pressure in women aged 30-50 years.Method : This was an observational research with cross-sectional study design. Fifty four subjects were selecting using consecutive sampling. Intakes were assessed by food recall 2x24 hours. Blood pressure levels were measured by Sphygmomanometer. Data were analyzed by Chi Square and Fisher Exact.Result : Systolic and diastolic blood pressure mean were 115.92 ± 14.5 mmHg and 75 ± 7.45 mmHg, while omega-3 and omega-6 mean were of 3. 1.03 ± 0.52 g and 14.17 ± 5 , 8 g. More than one third of the subjects (37.9%) with pre-hypertension/hypertension had omega-3 intake less than 1.1 g and 52.7% of them had omega-6 intake less than 12 g.There was correlation of omega-6 intake with systolic blood pressure (p <0.05) but there were no correlation between omega-3 intake with systolic blood pressure, omega-3 and omega-6 intake with diastolic blood pressure (p >0,05). Conclusion: There was correlation of omega-6 intake with systolic blood pressure, there were no correlation between omega-3 intake with systolic blood pressure, omega-3 and omega-6 intake with diastolic blood pressure

Sign in / Sign up

Export Citation Format

Share Document