scholarly journals Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

2018 ◽  
Author(s):  
Sophia G. Antimisiaris ◽  
Spyridon Mourtas ◽  
Antonia Marazioti
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
State Of The Art ◽  
Current State ◽  
Targeted Drug

The similarities between exosomes and liposomes, together with the high organotropism of several types of exosomes, have recently prompted the development of engineered-exosomes or exosome-mimetics, which may be artificial (liposomal) or cell-derived vesicles, as advanced platforms for targeted drug delivery. Here we provide the current state-of-the-art of using exosome or exosome-inspired systems for drug delivery. We review the various approaches investigated and the shortcomings of each approach. Finally the challenges identified up-to-date in this field are summarized.

scholarly journals Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 218 ◽  
Author(s):  
Sophia Antimisiaris ◽  
Spyridon Mourtas ◽  
Antonia Marazioti
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
State Of The Art ◽  
Current State ◽  
Targeted Drug

The similarities between exosomes and liposomes, together with the high organotropism of several types of exosomes, have recently prompted the development of engineered-exosomes or exosome-mimetics, which may be artificial (liposomal) or cell-derived vesicles, as advanced platforms for targeted drug delivery. Here, we provide the current state-of-the-art of using exosome or exosome-inspired systems for drug delivery. We review the various approaches investigated and the shortcomings of each approach. Finally the challenges which have been identified to date in this field are summarized.

Surface receptor‐mediated targeted drug delivery systems for enhanced cancer treatment: A state‐of‐the‐art review

2020 ◽  
Author(s):  
Selvaraj Kunjiappan ◽  
Parasuraman Pavadai ◽  
Sivakumar Vellaichamy ◽  
Sureshbabu Ram Kumar Pandian ◽  
Vigneshwaran Ravishankar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
State Of The Art ◽  
Delivery Systems ◽  
Surface Receptor ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

scholarly journals A Contactless and Biocompatible Approach for 3D Active Microrobotic Targeted Drug Delivery

Micromachines ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 504 ◽  
Author(s):  
Federico Ongaro ◽  
Dennis Niehoff ◽  
Sumit Mohanty ◽  
Sarthak Misra
Keyword(s):  
Drug Delivery ◽  
Motion Control ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Three Dimensional ◽  
Surgical Interventions ◽  
Current State ◽  
Controlled Environments ◽  
Targeted Drug

As robotic tools are becoming a fundamental part of present day surgical interventions, microrobotic surgery is steadily approaching clinically-relevant scenarios. In particular, minimally invasive microrobotic targeted drug deliveries are reaching the grasp of the current state-of-the-art technology. However, clinically-relevant issues, such as lack of biocompatibility and dexterity, complicate the clinical application of the results obtained in controlled environments. Consequently, in this work we present a proof-of-concept fully contactless and biocompatible approach for active targeted delivery of a drug-model. In order to achieve full biocompatiblity and contacless actuation, magnetic fields are used for motion control, ultrasound is used for imaging, and induction heating is used for active drug-model release. The presented system is validated in a three-dimensional phantom of human vessels, performing ten trials that mimic targeted drug delivery using a drug-coated microrobot. The system is capable of closed-loop motion control with average velocity and positioning error of 0.3 mm/s and 0.4 mm, respectively. Overall, our findings suggest that the presented approach could augment the current capabilities of microrobotic tools, helping the development of clinically-relevant approaches for active in-vivo targeted drug delivery.

scholarly journals Recent Advances in Magnetic Upconversion Nanocomposites for Bioapplications

2019 ◽  
Vol 25 (17) ◽  
pp. 2007-2015 ◽  
Author(s):  
Yadan Ding ◽  
Xia Hong ◽  
Yichun Liu ◽  
Hong Zhang
Keyword(s):  
Drug Delivery ◽  
Luminescent Property ◽  
Targeted Drug Delivery ◽  
Surface Engineering ◽  
State Of The Art ◽  
Structure Design ◽  
Synthesis Methods ◽  
Design Synthesis ◽  
Targeted Drug ◽  
Guided Therapy

The combination of magnetism and upconversion luminescent property into one single nanostructure is fascinating for biological fields, such as multimodal bioimaging, targeted drug delivery, and imaging-guided therapy. In this review, we will provide the state-of-the-art advances on magnetic upconversion nanocomposites towards their bioapplications. Their structure design, synthesis methods, surface engineering and applications in bioimaging, drug delivery, therapy as well as biodetection will be covered.

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