scholarly journals Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review

2021 ◽  
Author(s):  
César Rivera ◽  
Antonieta Muñoz ◽  
Carolina Puentes ◽  
Esteban Aguayo
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Immune System ◽  
Genetic Polymorphisms ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Tnf Alpha ◽  
Single Nucleotide ◽  
Aphthous Ulcers

The cause and prevention of recurrent aphthous stomatitis (also called aphthous ulcers or canker sores) are still unknown. This may be due in part to ignorance of the risk factors present in susceptible people. In this systematic review (PROSPERO record #CRD42019122214), we show that most of the risk factors for the disease are single nucleotide genetic polymorphisms in genes related to the functioning of immune system (TLR4, MMP9, E-selectin, IL-1 beta and TNF-alpha). Single nucleotide genetic polymorphisms do not constitute a modifiable risk. This indicates that, at least in part, susceptibility to recurrent aphthous stomatitis is hereditary, and that these factors cannot be modified.

scholarly journals Awareness Regarding Oral Aphthous Ulcers and its Risk Factors Among BDS and MBBS Students-A Cross-Sectional Survey

2021 ◽  
Vol 30 (03) ◽  
pp. 215-218
Author(s):  
Marium Azfar ◽  
◽  
Saima Qureshi ◽  
Syeda Noureen Iqbal ◽  
Sadia Rizwan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Medical Students ◽  
Dental Students ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Oral Ulceration ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Adequate Knowledge ◽  
Aphthous Ulcers

OBJECTIVE: The objective of this paper was to assess the awareness regarding oral aphthous ulcers and its risk factors among BDS and MBBS students in private institute of Karachi, Pakistan. METHODOLOGY: A cross-sectional survey was conducted at a private institute of Karachi Pakistan for the duration of six months. Medical and dental students of age more than 18 years of either gender were enrolled in the study using non-probability convenience sampling technique. Pre-designed proforma was used to collect data regarding demographics, history of recurrent aphthous stomatitis and knowledge of oral aphthous ulcers and its risk factors. The knowledge score of 4 out of 6 was considered as adequate knowledge. SPSS version 25 was used to analyze data. RESULTS: Of 150 participants, the mean age was reported as 22.94±1.65 years (range: 21-25 years). In those 150 participants 46 were males (30.7%) and 104 were females (69.3%). Overall mean score of knowledge was 4.35±1.29. Wherein 73% had adequate knowledge regarding oral ulceration and its risk factors. The dental students had significantly higher proportion of adequate knowledge regarding oral ulceration than medical students [p=0.024]. CONCLUSION: Overall students had good knowledge of oral ulceration and its risk factors, wherein knowledge of dental students was better than medical students. KEYWORDS: Oral ulcers; Recurrent Aphthous stomatitis; awareness, oral ulceration, risk factors, eating habits

scholarly journals Association of the genetic polymorphisms in inhibiting and activating molecules of immune system with rheumatoid arthritis: A systematic review and meta-analysis

2021 ◽  
Vol 26 (1) ◽  
pp. 22
Author(s):  
Nima Rezaei ◽  
MohammadJavad Mousavi ◽  
MohammadReza Hooshangi Shayesteh ◽  
Sirous Jamalzehi ◽  
Reza Alimohammadi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Immune System ◽  
Genetic Polymorphisms ◽  
Meta Analysis

scholarly journals Analysis of Dietary Related Factors of Recurrent Aphthous Stomatitis among College Students

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Qian Du ◽  
Shenglou Ni ◽  
Yanling Fu ◽  
Sanhai Liu
Keyword(s):  
Risk Factors ◽  
College Students ◽  
Protective Factor ◽  
Dietary Habits ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Binary Logistic Regression Analysis ◽  
Fruit Intake ◽  
Carbonated Beverages ◽  
Frequent Drinking

Objective. We investigated the occurrence of recurrent aphthous stomatitis (RAS) among college students and its potential influence by dietary habits. Methods. Study of dietary habits and RAS among students in Beijing University of Chinese Medicine was carried by homemade questionnaire. Multivariate binary logistic regression analysis was used to identify RAS risk factors and explore their relations. Results. Among 1011 investigated college students, family history (odds ratio (OR) 1.678, 95% confidence intervals (CI) 1.192 to 2.364, p<0.05), bed late (OR 1.515, 95% CI 1.005 to 2.285, p<0.05), frequent thirst (OR 1.842, 95% CI 1.393 to 2.435, p<0.001), and frequent drinking carbonated beverages (OR 1.369, 95% CI 1.029 to 1.821, p<0.05) were independent risk factors for RAS, but preference for nuts (OR 0.607, 95% CI 0.448 to 0.824, p<0.001) was a protective factor. There was no statistical difference in fruit intake between RAS and non-RAS groups (χ2 = 5.249, p>0.05). Conclusions. Among college students, frequent drinking carbonated beverages or frequent thirst will increase its possibility, whereas preference for nuts provides protection. In addition, fruit intake does not have a positive effect.

scholarly journals Effectiveness of Laser Therapy in the Management of Recurrent Aphthous Stomatitis: A Systematic Review

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Min Han ◽  
Hui Fang ◽  
Quan-Li Li ◽  
Ying Cao ◽  
Rong Xia ◽  
...  
Keyword(s):  
Systematic Review ◽  
Laser Treatment ◽  
Laser Therapy ◽  
Clinical Effectiveness ◽  
Healing Time ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Cochrane Library ◽  
Large Sample Size ◽  
Security Issue

Objectives. Laser therapy is a promising new treatment for patients with recurrent aphthous stomatitis (RAS). However, the clinical effect and security issue of laser therapy remain controversial. This systematic review was conducted to evaluate the clinical effectiveness and security of laser treatment in RAS patients. Methods. Five electronic databases were searched (MEDLINE (PubMed), EMBASE, ScienceDirect, the Cochrane Library, and Web of Science) to identify all studies that were about randomized controlled clinical trials, involving the effect of laser therapy in RAS patients. Conclusion. Twenty-three studies were retained for full-text analysis after screening the titles and abstracts of potential articles, but only 10 studies satisfied the inclusion criteria after the full texts were reviewed. The included studies reported a comparison of the effectiveness between the laser treatment and placebo laser therapy (or conventional drug therapy) when managing the RAS patients. It can be concluded that laser therapy has the superiority in relieving ulcer pain and shortening healing time when compared with placebo group or medical treatment group. Although laser therapy is a promising effective treatment for RAS, high-quality clinical studies with large sample size must be further performed to confirm the effectiveness of this therapy.

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