scholarly journals Dietary Exposure and Risk Assessment of Aflatoxin M1 for Children Aged 1 to 9 Years Old in Serbia

2021 ◽  
Author(s):  
Dragan R Milićević ◽  
Jelena Milešević ◽  
Mirjana Gurinovic ◽  
Saša Janković ◽  
Jasna Đinović ◽  
...  
Keyword(s):  
Age Groups ◽  
Daily Intake ◽  
Dietary Exposure ◽  
Food Samples ◽  
Aflatoxin M1 ◽  
Risk Characterization ◽  
Detection Rates ◽  
Risk Of Exposure ◽  
Group 1

The present study was conducted to estimate the exposure and risk characterization of the children population of Serbia to Aflatoxin M1 (AFM1) from milk and milk-based food. A total of 3404 samples comprising of milk and different milk-based food samples were collected from various regions of Serbia from 2017 to 2019. Evaluation of the AFM1 exposure was carried out using the deterministic method, whereas risk characterization was evaluated with the calculation of the Margin of Exposure (MOE) and the risk of Hepatocellular Carcinoma (HCC). Detection rates for AFM1 in milk and milk-based food samples ranged between 2% and 79%, with the highest incidence (79%) and mean level (22.34  0,018 ng kg-1) of AFM1 was detected in pasteurized and UHT milk. According to the three consumption estimates, the values of EDI were higher for toddlers as compared with children. Children aged 1–3 years had the highest risk of exposure to AFM1 in milk, with an estimated daily intake of 0.164 and 0.193 ng kg-1 bw day-1 using a lower bound (LB) and the upper bound (UB) exposure scenarios, respectively. Such difference could result from the higher consumption versus weight. Based on the EDI found in this study, the risk of AFM1 due to consumption of milk and milk-based food was low since MOE values obtained were 10000. In addition, the risk of HCC cases/year/105 individuals of different age groups showed that the value of HCC using potency estimates of 0.0017 (mean) was maximum (0.00034) in the age group 1–3 years which indicates no health risk for the evaluated groups. The present study revealed the importance of controlling and preventing AFM1 contamination in milk through continuous monitoring and regular inspection to reduce the risk of AFM1 exposure, especially in children.

scholarly journals Dietary Exposure and Risk Assessment of Aflatoxin M1 for Children Aged 1 to 9 Years Old in Serbia

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4450
Author(s):  
Dragan R. Milićević ◽  
Jelena Milešević ◽  
Mirjana Gurinović ◽  
Saša Janković ◽  
Jasna Đinović-Stojanović ◽  
...  
Keyword(s):  
Continuous Monitoring ◽  
Age Groups ◽  
Daily Intake ◽  
Dietary Exposure ◽  
Food Samples ◽  
Aflatoxin M1 ◽  
Estimated Daily Intake ◽  
Detection Rates ◽  
Risk Of Exposure ◽  
Group 1

The present study was conducted to estimate the exposure and characterize the risk for the child population of Serbia to Aflatoxin M1 (AFM1) from milk and milk-based food. A total of 3404 samples comprising milk and different milk-based food samples were collected from various regions of Serbia from 2017 to 2019. Evaluation of AFM1 exposure was carried out using the deterministic method, whereas risk characterization was evaluated using the margin of exposure (MOE) and the risk of hepatocellular carcinoma (HCC). Detection rates for AFM1 in milk and milk-based food samples ranged between 2% and 79%, with the highest incidence (79%) and mean level (22.34 ± 0.018 ng kg−1) of AFM1 being detected in pasteurized and UHT milk. According to the three consumption estimates, the values of estimated daily intake (EDI) were higher for toddlers as compared with children aged 3–­9 years. Children aged 1–3 years had the highest risk of exposure to AFM1 in milk, with an estimated daily intake of 0.164 and 0.193 ng kg−1 bw day−1 using lower bound (LB) and upper bound (UB) exposure scenarios, respectively. Such difference could result from the higher consumption to weight in younger children. Based on the estimated daily intake (EDI) found in this study, the risk of AFM1 exposure due to consumption of milk and milk-based food was low since the MOE values obtained were > 10,000. In addition, the risk of HCC cases/year/105 individuals of different age groups showed that the value of HCC, using potency estimates of 0.0017 (mean), was maximum (0.00034) in the age group 1–3 years, which indicates no health risk for the evaluated groups. The present study revealed the importance of controlling and preventing AFM1 contamination in milk through continuous monitoring and regular inspection to reduce the risk of AFM1 exposure, especially in children.

scholarly journals Exposure assessment and risk characterization of n-nitrosodimethylamine (ndma) in the diet of children from 6 to 36 months in Hanoi, Vietnam

2020 ◽  
pp. 87-93
Author(s):  
Tran Cao Son ◽  
◽  
Nguyễn Thị Thanh Lam ◽  
Vu Ngoc Tu ◽  
Bui Quang Dong ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Daily Intake ◽  
Exposure Dose ◽  
Food Samples ◽  
Tolerable Daily Intake ◽  
Risk Characterization ◽  
Suburban Areas ◽  
Food Consumption Survey ◽  
Consumption Survey

N-Nitrosodimethylamine (NDMA) is a highly hepatotoxic compound and classified as group 2A according to IARC, which is probably carcinogenic to humans. The habit of consumption of grilled meat-based foods may lead to a health risk, especially in children. In this study, a food consumption survey was conducted in 4 districts (2 in urban and 2 in suburban areas) in Hanoi, Vietnam. Food samples in the diet of children from 6 to 36 months was collected and tested for NDMA by GC-MS/MS method. Total exposure dose was calculated and compared to the proposed tolerable daily intake (TDI) to characterize the risk. Among the food tested, NDMA was detected in canned puree, grilled meat and sausage. The average contents of NDMA were 1.50 μg/kg, 1.18 μg/kg and 0.20 μg/kg in grilled meat, sausage and puree, respectively. The average total daily exposure dose of NDMA was 8.23 ng/kg bw/day in all studied group, which were within the upper recommended TDI (9.3 ng/kg bw/day). With a certain assumption, the cancer risk caused by exposure to NDMA were higher than the recommended value of WHO.

scholarly journals Exposure assessment and risk characterization of n-nitrosodimethylamine (ndma) in the diet of children from 6 to 36 months in Hanoi, Vietnam

2020 ◽  
pp. 87-93
Author(s):  
Tran Cao Son ◽  
◽  
Nguyen Thi Thanh Lam ◽  
Vu Ngoc Tu ◽  
Bui Quang Dong ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Daily Intake ◽  
Exposure Dose ◽  
Food Samples ◽  
Tolerable Daily Intake ◽  
Risk Characterization ◽  
Suburban Areas ◽  
Food Consumption Survey ◽  
Consumption Survey

N-Nitrosodimethylamine (NDMA) is a highly hepatotoxic compound and classified as group 2A according to IARC, which is probably carcinogenic to humans. The habit of consumption of grilled meat-based foods may lead to a health risk, especially in children. In this study, a food consumption survey was conducted in 4 districts (2 in urban and 2 in suburban areas) in Hanoi, Vietnam. Food samples in the diet of children from 6 to 36 months was collected and tested for NDMA by GC-MS/MS method. Total exposure dose was calculated and compared to the proposed tolerable daily intake (TDI) to characterize the risk. Among the food tested, NDMA was detected in canned puree, grilled meat and sausage. The average contents of NDMA were 1.50 μg/kg, 1.18 μg/kg and 0.20 μg/kg in grilled meat, sausage and puree, respectively. The average total daily exposure dose of NDMA was 8.23 ng/kg bw/day in all studied group, which were within the upper recommended TDI (9.3 ng/kg bw/day). With a certain assumption, the cancer risk caused by exposure to NDMA were higher than the recommended value of WHO.

Exposure assessment and risk characterization of Aflatoxin M1 through consumption of market milk and milk products in Ludhiana, Punjab

Food Control ◽  
2021 ◽  
pp. 107991
Author(s):  
Simranjot Kaur ◽  
Jasbir Singh Bedi ◽  
Pankaj Dhaka ◽  
Deepthi Vijay ◽  
Rabinder Singh Aulakh
Keyword(s):  
Exposure Assessment ◽  
Aflatoxin M1 ◽  
Risk Characterization ◽  
Milk Products

Dietary exposure and health risk characterization of aflatoxin B1, ochratoxin A, fumonisin B1, and zearalenone in food from different provinces in Northern Vietnam

Food Control ◽  
2020 ◽  
Vol 112 ◽  
pp. 107108 ◽  
Author(s):  
Tuan Huu Do ◽  
Son Cao Tran ◽  
Chi Dinh Le ◽  
Ha-Binh Thi Nguyen ◽  
Phuong-Thao Thi Le ◽  
...  
Keyword(s):  
Health Risk ◽  
Ochratoxin A ◽  
Aflatoxin B1 ◽  
Fumonisin B1 ◽  
Dietary Exposure ◽  
Risk Characterization ◽  
Northern Vietnam

scholarly journals FODMAP Intake in Spanish Population: Open Approach for Risk Assessment

2020 ◽  
Vol 17 (16) ◽  
pp. 5882
Author(s):  
Jonatan Miranda ◽  
Maialen Vázquez-Polo ◽  
Gesala Pérez-Junkera ◽  
María del Pilar Fernández-Gil ◽  
María Ángeles Bustamante ◽  
...  
Keyword(s):  
Nutrient Intake ◽  
Adult Population ◽  
Age Groups ◽  
Daily Intake ◽  
Food Samples ◽  
Food Composition ◽  
Food Sources ◽  
Open Approach ◽  
Adolescents And Adults ◽  
Fermentable Carbohydrates

Fermentable oligo-, di- and monosaccharides and polyols’ (FODMAP) were related with intestinal complications. The present study aimed to determine the FODMAP consumption of Spanish children, adolescents and adults, analyzing the real FODMAP risk of foods, and to set an open methodology for the measurement of this intake in other regions as well as nutrient intake assurance. Total fructan analysis was performed analytically in eighty-seven food samples. Daily intake of FODMAPs, fiber and micronutrients was calculated by combining the food composition for selected fermentable carbohydrates with the national food consumption stratified by age in an open software. Spanish child and adolescent total FODMAP consumption was settled as 33.4 ± 92.4 and 27.3 ± 69.0 g/day, respectively. Both intakes were higher than that of the adult population (21.4 ± 56.7 g/day). The most important food sources of lactose, excess of fructose and total fructan, considering their content and dietary intake were different between age groups. The contribution of these foods to dietary calcium and fiber and the consequent risk of deficiency if they are withdrawn was highlighted. We demonstrated the relevance of stratifying the total FODMAP intake by age. An open approach for FODMAP intake quantification and nutrient control was provided.

Dietary exposure assessment and risk characterization of citrinin and ochratoxin A in Belgium

2021 ◽  
Vol 147 ◽  
pp. 111914
Author(s):  
Celine Meerpoel ◽  
Arnau Vidal ◽  
Mirjana Andjelkovic ◽  
Marthe De Boevre ◽  
Emmanuel K. Tangni ◽  
...  
Keyword(s):  
Exposure Assessment ◽  
Ochratoxin A ◽  
Dietary Exposure ◽  
Risk Characterization

scholarly journals Bisphenol A and Its Analogues in Chinese Total Diets: Contaminated Levels and Risk Assessment

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Kai Yao ◽  
Jing Zhang ◽  
Jie Yin ◽  
Yunfeng Zhao ◽  
Jianzhong Shen ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Food Packaging ◽  
Endocrine Disrupting Chemicals ◽  
Daily Intake ◽  
Dietary Exposure ◽  
Food Samples ◽  
Dietary Intakes ◽  
Bisphenol S ◽  
Endocrine Disrupting ◽  
Exposure Levels

Bisphenol A (BPA) and its analogues (BPs) are suspected posing potential endocrine disrupting properties. They might migrate into foodstuffs through food packaging materials or contaminated water and soil. Dietary exposure is of paramount importance way for human health. European Food Safety Authority (EFSA) lowered the value of tolerable daily intake (TDI) from 50 μg/kg bw/day (d) to a temporary (t) TDI (t-TDI) of 4 μg/kg bw/d. In this study, the Chinese total dietary samples were analyzed for assessing the exposure risk of BPs by diets. BPA, bisphenol F (BPF), bisphenol S (BPS), and bisphenol AF (BPAF) were found in 12 kinds of food samples except for bisphenol B (BPB). A deterministic approach was used to calculate the dietary intakes of 4 kinds of compounds. For different age and gender groups, the exposure levels of BPA (178.440-403.672 ng/kg bw/d) was the highest, followed by BPS (21.372-52.112 ng/kg bw/d), BPF (20.641-50.507 ng/kg bw/d), and BPAF (0.434-1.210 ng/kg bw/d). Based on the t-TDI set by EFSA (4 μg/kg bw/d for BPA), the BPs through dietary intake pose low risks on the Chinese general population even summarization exposure levels of different BPs. However, human can be exposed to multiple endocrine disrupting chemicals rather than BPs alone; combined exposure risks should be further considered.

scholarly journals Extremely Elevated Total Mercury and Methylmercury in Forage Plants in a World Large-scale Abandoned Hg Mining Site: A Potential Risk of Exposure to Grazing Animals

2021 ◽  
Author(s):  
Xiaoli Qian ◽  
Chendong Yang ◽  
Xiaohang Xu ◽  
Ming Ao ◽  
Zhidong Xu ◽  
...  
Keyword(s):  
Potential Risk ◽  
Large Scale ◽  
Daily Intake ◽  
Dietary Exposure ◽  
Dry Weight ◽  
Plant Parts ◽  
Forage Plants ◽  
Tolerable Weekly Intake ◽  
Risk Of Exposure ◽  
Hg Mining

Abstract Ninety-five wild forage plants (belonging to 22 species of 18 families) and their corresponding rhizosphere soil samples were collected from wastelands of a world large-scale abandoned Hg mining region for total Hg (THg) and methylmercury (MeHg) analysis. The forage plant communities on the wastelands were dominated by the Asteraceae, Crassulaceae and Polygonaceae families. The THg and MeHg concentrations in the forage plants varied widely and were in the range of 0.10 to 13 mg/kg and 0.19 to 23 μg/kg, respectively. Shoots of Aster ageratoides showed the highest average THg concentration of 12±1.1 mg/kg, while those of Aster subulatus had the highest average MeHg concentrations of 7.4±6.1 μg/kg. Both the THg and MeHg concentrations in the aboveground plant parts exhibited positive correlations with the THg (r=0.70, P<0.01) and MeHg (r=0.68, P<0.01) concentrations in the roots but these were not correlated with the THg and MeHg concentrations in their rhizosphere soils. The species A. ageratoides, A. subulatus, and S. brachyotus showed strong accumulation of Hg and are of concern for herbivorous/omnivorous wildlife and feeding livestock. Taking the provisional tolerable weekly intake (PTWI) values for IHg recommended by the JECFA (2010) for human dietary exposure of 4 ng/g into account, grazing on 1.0 kg of forage (dry weight) by a 65 kg animal would mean that the daily intake of IHg was between 190-13200 μg, which reaches 3-5 order of magnitude higher than the permitted limit, suggesting a potential risk of exposure.

Sign in / Sign up

Export Citation Format

Share Document