Hypercoagulable disorders in polycystic ovary syndrome: myth or reality?

A review of studies on the features of the hemostasis system in patients with polycystic ovary syndrome (PCOS), the relationship between hypercoagulable disorders and PCOS, including on the background of additional risk factors. The data on the risk of venous thromboembolic complications in patients with PCOS at different age periods against hormonal contraception and in ART programs are presented. The possible role of hypercoagulable disorders in the prevention of pregnancy in patients with PCOS is discussed. The data on the impact of PCOS on total life expectancy and on the main causes of death in case of this disease are also provided. Key words: pregnancy, venous thromboembolism, hypercoagulable disorders, strokes, polycystic ovary syndrome, combined oral contraceptives, assisted reproductive technology programs, ovarian hyperstimulation syndrome, cardiovascular diseases

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The Relationship of Non-dipper Blood Pressure Pattern with the Fragmented QRS Morphology on ECG and the Role of Inflammatory Biomarkers in Polycystic Ovary Syndrome

THE ULUTAS MEDICAL JOURNAL ◽

10.5455/umj.20210520114119 ◽

2021 ◽

Vol 7 (3) ◽

pp. 157

Author(s):

Ugurkan Erkayiran ◽

Ekrem Aksu ◽

Tufan Arslanca

Keyword(s):

Blood Pressure ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Inflammatory Biomarkers ◽

Ovary Syndrome ◽

Pressure Pattern ◽

Qrs Morphology ◽

Relationship Of ◽

The Relationship

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Non-contraceptive benefits of hormonal contraception

Journal of Prescribing Practice ◽

10.12968/jprp.2019.1.8.394 ◽

2019 ◽

Vol 1 (8) ◽

pp. 394-399

Author(s):

Michelle Cooper ◽

Katie Boog

Keyword(s):

Polycystic Ovary Syndrome ◽

Premenstrual Syndrome ◽

Polycystic Ovary ◽

Hormonal Contraception ◽

Hormonal Contraceptives ◽

Primary Role ◽

Menstrual Pain ◽

Ovary Syndrome ◽

Risk Of Cancer

Beyond their primary role of preventing pregnancy, hormonal contraceptives provide a number of non-contraceptive benefits including a reduction in menstrual pain and bleeding, improvement in acne and a decrease in the lifetime risk of cancer of the ovaries and endometrium. They are also widely used in the management of a number of gynaecological conditions including endometriosis, premenstrual syndrome and polycystic ovary syndrome. Although the risks may outweigh the benefits when a method is used solely for contraception, the risk-benefit profile may change when it is also used for a medical indication. Potential non-contraceptive benefits should be discussed with all women when considering the most appropriate form of contraception to suit their needs.

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Circulating leptin concentrations and ovarian function in polycystic ovary syndrome

Acta Endocrinologica ◽

10.1530/eje.0.1450289 ◽

2001 ◽

pp. 289-294 ◽

Cited By ~ 20

Author(s):

IR Pirwany ◽

R Fleming ◽

N Sattar ◽

IA Greer ◽

AM Wallace

Keyword(s):

Polycystic Ovary Syndrome ◽

Ovarian Function ◽

Polycystic Ovary ◽

Ovarian Dysfunction ◽

Ovary Syndrome ◽

Cross Sectional ◽

Serum Leptin ◽

Significant Difference ◽

The Relationship

OBJECTIVE: Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction. Although the role of leptin in the control of reproduction is unclear, it may be involved in the control of ovulation. The aim of this cross-sectional study was to determine the relationship between circulating leptin concentrations, and anthropometric, metabolic and endocrine variables as well as to examine a possible role of leptin in ovarian dysfunction associated with PCOS. DESIGN: Prospective observational study. METHODS: Seventy-one subjects with PCOS and 23 body mass index (BMI)-matched control subjects were recruited from infertility clinics. The association between serum leptin concentrations and the above variables was measured outwith the luteal phase. A subgroup of 24 PCOS subjects underwent more frequent blood sampling to monitor follicular growth and ovulation. The association between variables was measured by univariate, multivariate and partial correlation analyses. RESULTS: Serum leptin concentrations were not different in subjects with PCOS and controls, and were strongly associated with BMI in both groups. Twelve patients ovulated during the study period. There was no significant difference in serum leptin concentrations between ovulatory and anovulatory subjects. The relationship between BMI and leptin was similar in both groups. CONCLUSION: The results indicated that circulating leptin concentrations relate principally to total body fat in subjects with PCOS and controls, and that this is not associated with the facility for follicular development and ovulation in these patients.

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Non-contraceptive benefits of hormonal contraception

Practice Nursing ◽

10.12968/pnur.2019.30.11.528 ◽

2019 ◽

Vol 30 (11) ◽

pp. 528-535

Author(s):

Michelle Cooper ◽

Katie Boog

Keyword(s):

Polycystic Ovary Syndrome ◽

Premenstrual Syndrome ◽

Polycystic Ovary ◽

Hormonal Contraception ◽

Hormonal Contraceptives ◽

Primary Role ◽

Menstrual Pain ◽

Ovary Syndrome ◽

Risk Of Cancer

Hormonal contraception can provide reliable protection against unintended pregnancy, as well as a broad range of non-contraceptive benefits. Dr Michelle Cooper and Dr Katie Boog give an overview of these benefits Beyond their primary role of preventing pregnancy, hormonal contraceptives provide a number of non-contraceptive benefits including a reduction in menstrual pain and bleeding, improvement in acne and a decrease in the lifetime risk of cancer of the ovaries and endometrium. They are also widely used in the management of a number of gynaecological conditions including endometriosis, premenstrual syndrome and polycystic ovary syndrome. Although the risks may outweigh the benefits when a method is used solely for contraception, the risk-benefit profile may change when it is also used for a medical indication. Potential non-contraceptive benefits should be discussed with all women when considering the most appropriate form of contraception to suit their needs.

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The pathomechanism of polycystic ovary syndrome in the light of novel research findings

Orvosi Hetilap ◽

10.1556/oh.2012.29467 ◽

2012 ◽

Vol 153 (40) ◽

pp. 1567-1569 ◽

Cited By ~ 2

Author(s):

Zoltán Károlyi

Keyword(s):

Polycystic Ovary Syndrome ◽

Genetic Programming ◽

Environmental Effects ◽

Endocrine Disruptor ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Research Findings ◽

The Impact ◽

Receptor Modulators

The author summarizes the factors which play a role in the development of polycystic ovary syndrome highlighting the impact of intrauterine genetic programming and the importance of the maternal steroid environment. Environmental effects, steroid receptor modulators, endocrine disruptor compounds, and the role of obesity in the development of polycystic ovary syndrome are also discussed. Orv. Hetil., 2012, 153, 1567–1569.

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Metabolic and hormonal aspects of polycystic ovary syndrome: the impact of diet

Proceedings of The Nutrition Society ◽

10.1017/s0029665110002016 ◽

2010 ◽

Vol 69 (4) ◽

pp. 628-635 ◽

Cited By ~ 10

Author(s):

Annalouise O'Connor ◽

James Gibney ◽

Helen M. Roche

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Overweight And Obesity ◽

Dietary Guidelines ◽

Dietary Fatty Acids ◽

Reproductive Age ◽

Low Grade ◽

Ovary Syndrome ◽

The Impact

Polycystic ovary syndrome (PCOS) is a common, chronic endocrine condition affecting young women of reproductive age. It is characterised by hyperandrogenaemia, and profound menstrual and ovulatory dysfunction with consequent sub-fertility. A clustering of metabolic aberrations is commonly associated with this condition and these include insulin resistance, disordered lipid metabolism and chronic low-grade inflammation. Overweight and obesity, as well as a degree of adipose tissue dysfunction, are present in a large proportion of women with PCOS, and where present, magnify the inherent hyperandrogenaemia characteristic of the condition, in addition to worsening the metabolic profile. Diet and lifestyle interventions are among the first-line treatments for PCOS, and weight reduction through energy restriction has been shown to exert positive influences on both metabolic and hormonal aspects of this condition. Alterations in carbohydrate amount and type have also been investigated, and more recently, dietary fatty acids, with a particular emphasis on PUFA, have been shown to have a positive impact within this population group. Although it is likely that diet is not the root cause of PCOS, it represents a modifiable variable with the potential to improve the health of women with this condition. Work to date has provided insights into the role of diet in PCOS; however, further work is required to determine the role of nutrients specifically within the context of PCOS, in order to develop more effective, evidence-based dietary guidelines for this condition.

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The role of vitamin D in metabolic and reproductive disturbances of polycystic ovary syndrome: A narrative mini-review

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000691 ◽

2020 ◽

pp. 1-8

Author(s):

Daniela Menichini ◽

Gianpiero Forte ◽

Beatrice Orrù ◽

Giuseppe Gullo ◽

Vittorio Unfer ◽

...

Keyword(s):

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Embryo Quality ◽

Polycystic Ovary ◽

Vitamin D Supplementation ◽

Endometrial Receptivity ◽

Metabolic Disturbances ◽

Ovary Syndrome ◽

Beneficial Role

Abstract. Vitamin D is a secosteroid hormone that plays a pivotal role in several metabolic and reproductive pathways in humans. Increasing evidence supports the role of vitamin D deficiency in metabolic disturbances and infertility in women with polycystic ovary syndrome (PCOS). Indeed, supplementation with vitamin D seems to have a beneficial role on insulin resistance and endometrial receptivity. On the other hand, exceedingly high levels of vitamin D appear to play a detrimental role on oocytes development and embryo quality. In the current review, we summarize the available evidence about the topic, aiming to suggest the best supplementation strategy in women with PCOS or, more generally, in those with metabolic disturbances and infertility. Based on the retrieved data, vitamin D seems to have a beneficial role on IR, insulin sensitivity and endometrial receptivity, but high levels and incorrect timing of administration seem to have a detrimental role on oocytes development and embryo quality. Therefore, we encourage a low dose supplementation (400–800 IU/day) particularly in vitamin D deficient women that present metabolic disturbances like PCOS. As far as the reproductive health, we advise vitamin D supplementation in selected populations, only during specific moments of the ovarian cycle, to support the luteal phase. However, ambiguities about dosage and timing of the supplementation still emerge from the clinical studies published to date and further studies are required.

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